ÌÇÐÄvlog

In this Viewpoint, Roger I. Glass traces the discovery of the oral rehydration solution during a cholera epidemic in Bangladesh in the 1960s to treat severe diarrhea by promoting electrolyte balance and attributes oral rehydration therapy with saving hundreds of thousands of lives in the last 50 years.

In this Viewpoint, Janet Woodcock and CDER colleagues discuss recent FDA initiatives to investigate the adequacy of electronic health record (EHR) and patient database data for research purposes and to understand if and how real-world observational data might be analyzed in ways that mimic or can be as reliable as randomized trials.

This Viewpoint reviews provisions of the US Right to Try Act, which allows patients with life-threatening conditions access to investigational drugs without FDA approval, and calls for clarifications around patient and drug eligibility, reporting requirements, and differences from the FDA’s Expanded Access program to minimize potential harms from the law.

This JAMA Viewpoint discusses trends towards implementing palliative care for patients with serious chronic illness earlier than end of life, and it highlights challenges around the use of opioids for pain control in this broader population of patients due to longer periods of use and greater likelihood of mood and substance use disorders.

This Viewpoint summarizes the scope, perspective, and recommendations of a National Academies of Sciences, Engineering, and Medicine (NASEM) 2018 report on climate, culture, and consequences of sexual harassment of women in the academic sciences.