September 25, 2018 Issue of JAMA

September 25, 2018, Vol 320, No. 12, Pages 1213-1294

This Week in JAMA

Highlights

Abstract Full Text

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JAMA. 2018;320(12):1213-1215. doi:10.1001/jama.2017.12559

Podcast: Staph Bacteremia Treatment Algorithm, Long-Term Outcomes of Antibiotics for Appendicitis, 2018 Lasker Awards, and more

Original Investigation

Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial

Thomas L. Holland, MD; Issam Raad, MD; Helen W. Boucher, MD; et al.

Abstract Full Text

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JAMA. 2018;320(12):1249-1258. doi:10.1001/jama.2018.13155

This noninferiority trial compares the effects on clinical success and adverse events of an algorithm that defines diagnostic evaluation, antibiotic selection, and duration of therapy for staphylococcal bacteremia vs standard clinical care.

Podcast: Update in Clinical Infectious Diseases 2019-2020

Editorial
Treatment Algorithms for Staphylococcal Bacteremia: Improving Clinical Care and Enhancing Antimicrobial Stewardship
Eli N. Perencevich, MD, MS; Preeti N. Malani, MD, MSJ

JAMA

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

Paulina Salminen, MD, PhD; Risto Tuominen, MPH, PhD; Hannu Paajanen, MD, PhD; et al.

Abstract Full Text

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JAMA. 2018;320(12):1259-1265. doi:10.1001/jama.2018.13201

During a 5-year follow-up of patients initially treated with antibiotics for uncomplicated acute appendicitis, this observational study assesses the rate of late recurrence.

Video: Five-Year Follow-up of Patients Given Antibiotic Therapy for Uncomplicated Acute Appendicitis

Podcast: Treating Appendicitis Without Surgery 鈥� 5-Year Follow-up From a Randomized Clinical Trial of Antibiotic Treatment

Editorial
Antibiotic Treatment for Uncomplicated Appendicitis Really Works: Results From 5 Years of Observation in the APPAC Trial
Edward H. Livingston, MD

JAMA

Prevalence of Variant Reclassification Following Hereditary Cancer Genetic Testing

Jacqueline Mersch, MS, CGC; Nichole Brown, MS, CGC; Sara Pirzadeh-Miller, MS, CGC; et al.

Abstract Full Text

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JAMA. 2018;320(12):1266-1274. doi:10.1001/jama.2018.13152

This genetic epidemiology study uses data from a commercial genetic test laboratory to characterize the proportion of genes of uncertain clinical significance that were reclassified into more determinate benign or pathogenic categories of risk based on emerging evidence among patients undergoing hereditary cancer risk assessment between 2006 and 2016.

Editorial
Making Sense of the Genome Remains a Work in Progress
Wylie Burke, MD, PhD

JAMA
Multitiered Questions Regarding Multigene Testing for Cancer Susceptibility
Lisa A. Newman, MD, MPH

JAMA Surg

Research Letter

Temporal Trends and Characteristics of Reportable Health Data Breaches, 2010-2017

Thomas H. McCoy Jr, MD; Roy H. Perlis, MD, MSc

Abstract Full Text

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JAMA. 2018;320(12):1282-1284. doi:10.1001/jama.2018.9222

This study uses public data to examine the nature and extent of health data confidentiality breaches from 2010 through 2017

Editorial
Keeping Personal Health Information Safe: The Importance of Good Data Hygiene
David Blumenthal, MD, MPP; Deven McGraw, JD, LLM, MPH

JAMA

Viewpoint

Genetics, Biochemistry, and 鈥淪imple鈥� Organisms Converge to Unlock Secrets in Histone Biology: The 2018 Albert Lasker Basic Medical Research Award

Michael Grunstein, PhD; C. David Allis, PhD

Abstract Full Text

JAMA. 2018;320(12):1233-1234. doi:10.1001/jama.2018.12437

In this Viewpoint, 2018 Albert Lasker Basic Medical Research Award winners Michael Grunstein and C. David Allis discuss the discovery and influence of histones on human genetic expression.

The Discovery and Development of Propofol Anesthesia: The 2018 Lasker-DeBakey Clinical Medical Research Award

John Baird (Iain) Glen, BVMS, PhD

Abstract Full Text

JAMA. 2018;320(12):1235-1236. doi:10.1001/jama.2018.12756

In this Viewpoint, 2018 Lasker-DeBakey Clinical Medical Research Award winner John B. Glen discusses the discovery and development of propofol, one of the most widely used anesthetics for patient care.

Reducing Maternal Mortality in the United States

Michael C. Lu, MD, MS, MPH

Abstract Full Text

JAMA. 2018;320(12):1237-1238. doi:10.1001/jama.2018.11652

This Viewpoint suggests strategies for reducing maternal mortality in the United States, including creation of a national maternal mortality surveillance system, use of maternal safety bundles within health systems, and improving access to quality health care for all women.

The Acute Stroke Care Revolution: Enhancing Access to Therapeutic Advances

S. Andrew Josephson, MD; Hooman Kamel, MD

Abstract Full Text

JAMA. 2018;320(12):1239-1240. doi:10.1001/jama.2018.11122

This Viewpoint reviews evidence of the benefits of thrombectomy for patients with ischemic stroke due to large vessel occlusion, and details the systems of care that need to be developed to ensure that all patients who might benefit from the procedure can be rapidly identified, transported, imaged, and treated under the care of qualified specialists.

A Piece of My Mind

Letting Her Be in Charge

Lynn E. Fiellin, MD

Abstract Full Text

JAMA. 2018;320(12):1241-1242. doi:10.1001/jama.2018.13098

In this narrative medicine essay, a physician and her family struggle with their mother鈥檚 intention to continue chemotherapy when treatment will cause more harm than good.

Editorial

Treatment Algorithms for Staphylococcal Bacteremia: Improving Clinical Care and Enhancing Antimicrobial Stewardship

Eli N. Perencevich, MD, MS; Preeti N. Malani, MD, MSJ

Abstract Full Text

JAMA. 2018;320(12):1243-1244. doi:10.1001/jama.2018.13315

Antibiotic Treatment for Uncomplicated Appendicitis Really Works: Results From 5 Years of Observation in the APPAC Trial

Edward H. Livingston, MD

Abstract Full Text

JAMA. 2018;320(12):1245-1246. doi:10.1001/jama.2018.13368

Making Sense of the Genome Remains a Work in Progress

Wylie Burke, MD, PhD

Abstract Full Text

JAMA. 2018;320(12):1247-1248. doi:10.1001/jama.2018.11784

JAMA Insights

Clinical Update

Fractional Flow Reserve Measurement for the Physiological Assessment of Coronary Artery Stenosis Severity

Deepak L. Bhatt, MD, MPH

Abstract Full Text

JAMA. 2018;320(12):1275-1276. doi:10.1001/jama.2018.10683

This Clinical Update explains the uses and interpretation of fractional flow reserve (FFR) measures that quantify the pressure gradient proximal and distal to intracoronary lesions and determine the clinical significance of angiographically detected coronary artery stenoses.

Clinical Update

Breast Reconstruction Following Breast Cancer Treatment鈥�2018

Gordon K. Lee, MD; Clifford C. Sheckter, MD

Abstract Full Text

JAMA. 2018;320(12):1277-1278. doi:10.1001/jama.2018.12190

This Clinical Update summarizes contemporary prosthetic and autologous breast reconstruction options for women undergoing lumpectomy or mastectomy for breast cancer, and reviews data on indications, safety, and timing for the procedures.

JAMA Diagnostic Test Interpretation

Esophageal High-Resolution Manometry in Gastroesophageal Reflux Disease

Amit Patel, MD; Shai Posner, MD; C. Prakash Gyawali, MD, MRCP

Abstract Full Text

JAMA. 2018;320(12):1279-1280. doi:10.1001/jama.2018.8694

A 22-year-old man with a 10-year history of gastroesophageal reflux disease (GERD)鈥搇ike symptoms and taking 20 mg/d of omeprazole had a normal esophagogastroduodenoscopy (EGD) and was diagnosed with achalasia following a high-resolution manometry (HRM) study. What would you do next?

Medical News & Perspectives

The Path to the First FDA-Approved Cannabis-Derived Treatment and What Comes Next

Rita Rubin, MA

Abstract Full Text

JAMA. 2018;320(12):1227-1229. doi:10.1001/jama.2018.11914

This Medical News story discusses the history of Epidiolex and whether its approval to treat 2 rare epilepsy syndromes will foster the development of more cannabis-derived therapies.

News From the Centers for Disease Control and Prevention

Opioid Use Disorder During Pregnancy

Bridget Kuehn, MSJ

Abstract Full Text

JAMA. 2018;320(12):1232. doi:10.1001/jama.2018.13546

Disability and Access to Care

Bridget Kuehn, MSJ

Abstract Full Text

JAMA. 2018;320(12):1232. doi:10.1001/jama.2018.13336

Clinical Trials Update

Mosaic HIV Vaccine Shows Promise

Anita Slomski, MA

Abstract Full Text

JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13249

Antipsychotics May Affect Metabolism

Anita Slomski, MA

Abstract Full Text

JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13871

Study Lays Foundation for TB Vaccine

Anita Slomski, MA

Abstract Full Text

JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13872

Direct-mail FIT Improves Cancer Screening Rates

Anita Slomski, MA

Abstract Full Text

JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13874

Informing Physicians of Fatal Overdose Curbs Opioid Prescribing

Anita Slomski, MA

Abstract Full Text

JAMA. 2018;320(12):1231. doi:10.1001/jama.2018.13875

Health Agencies Update

Obesity and Influenza A Shedding

Rita Rubin, MA

Abstract Full Text

JAMA. 2018;320(12):1230. doi:10.1001/jama.2018.13078

Diversifying the NIH-Funded Workforce

Rita Rubin, MA

Abstract Full Text

JAMA. 2018;320(12):1230. doi:10.1001/jama.2018.13868

Indian Health Service Launches Opioids Website

Rita Rubin, MA

Abstract Full Text

JAMA. 2018;320(12):1230. doi:10.1001/jama.2018.13869

The Arts and Medicine

Cystic Fibrosis in Art

Eliza Jane Temple Milliken

Abstract Full Text

JAMA. 2018;320(12):1224-1226. doi:10.1001/jama.2018.12769

This JAMA Arts & Medicine article features work in which artists living with cystic fibrosis express their experiences.

Poetry and Medicine

Runner Heal Thyself

Erin McConnell, MD

Abstract Full Text

JAMA. 2018;320(12):1289. doi:10.1001/jama.2018.6658

JAMA Revisited

The Daily Press and the 鈥淔utilities of Contemporary Science鈥�

Abstract Full Text

JAMA. 2018;320(12):1290. doi:10.1001/jama.2017.12589

JAMA Patient Page

Gallbladder Cancer

Ioana Baiu, MD, MPH; Brendan Visser, MD

Abstract Full Text

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JAMA. 2018;320(12):1294. doi:10.1001/jama.2018.11815

This JAMA Patient Page describes the symptoms, diagnosis, and treatment of gallbladder cancer.

Comment & Response

Antibiotic Treatment for Uncomplicated Urinary Tract Infections

Bernardo Silveira Barros, MD

Abstract Full Text

JAMA. 2018;320(12):1284. doi:10.1001/jama.2018.10011

Antibiotic Treatment for Uncomplicated Urinary Tract Infections鈥擱eply

Angela Huttner, MD; Leonard Leibovici, MD; Stephan Harbarth, MD

Abstract Full Text

JAMA. 2018;320(12):1284-1285. doi:10.1001/jama.2018.10018

Use of a Wearable Activity Monitor in a Home-Based Exercise Intervention for Peripheral Artery Disease

Pierre-Yves de Müllenheim, PhD; Pierre Abraham, MD, PhD; Bénédicte Noury-Desvaux, PhD

Abstract Full Text

JAMA. 2018;320(12):1285-1286. doi:10.1001/jama.2018.10771

Use of a Wearable Activity Monitor in a Home-Based Exercise Intervention for Peripheral Artery Disease鈥擱eply

Mary M. McDermott, MD; Bonnie Spring, PhD; Diane Treat-Jacobson, PhD

Abstract Full Text

JAMA. 2018;320(12):1286. doi:10.1001/jama.2018.10775

Improving Health Care Value by Considering Cost-effectiveness

José A. Sacristán, MD, PhD, MBA

Abstract Full Text

JAMA. 2018;320(12):1287. doi:10.1001/jama.2018.10620

Improving Health Care Value by Considering Cost-effectiveness鈥擱eply

Ankur Pandya, PhD

Abstract Full Text

JAMA. 2018;320(12):1287-1288. doi:10.1001/jama.2018.10624

Correction

Adjusted Data for 2013 Birth Cohort in a Table

Abstract Full Text

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JAMA. 2018;320(12):1288. doi:10.1001/jama.2018.13235

Incorrect Values in Results Subsections

Abstract Full Text

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JAMA. 2018;320(12):1288. doi:10.1001/jama.2018.13590

Unit of Measure Error

Abstract Full Text

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JAMA. 2018;320(12):1288. doi:10.1001/jama.2018.13694

Omission of Conflicts of Interest

Abstract Full Text

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JAMA. 2018;320(12):1288. doi:10.1001/jama.2018.13704

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September 25, 2018, Vol 320, No. 12, Pages 1213-1294

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