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November 6, 2018, Vol 320, No. 17, Pages 1721-1830 | Hypertension

This Week in JAMA

Highlights

Abstract Full Text
free access has audio
JAMA. 2018;320(17):1721-1723. doi:10.1001/jama.2017.12614
  • Podcast: Global Hypertension Theme Issue
Original Investigation

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial

Barry A. Borlaug, MD; Kevin J. Anstrom, PhD; Gregory D. Lewis, MD; et al.
Abstract Full Text
free access has audio
JAMA. 2018;320(17):1764-1773. doi:10.1001/jama.2018.14852

This randomized clinical trial compares the effect of 4 weeks鈥� administration of inhaled, nebulized inorganic nitrite vs placebo on exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF).

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?

Association of Blood Pressure Classification in Young Adults Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline With Cardiovascular Events Later in Life

Yuichiro Yano, MD, PhD; Jared P. Reis, PhD; Laura A. Colangelo, MS; et al.
Abstract Full Text
free access has audio
JAMA. 2018;320(17):1774-1782. doi:10.1001/jama.2018.13551

This cohort study investigates associations between blood pressure classifications defined by the 2017 ACC/AHA guidelines in adults younger than 40 years and long-term CVD events including myocardial infarction, heart failure, and stroke.

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?

Association of Blood Pressure Classification in Korean Young Adults According to the 2017 American College of Cardiology/American Heart Association Guidelines With Subsequent Cardiovascular Disease Events

Joung Sik Son, MD, MSc; Seulggie Choi, MD; Kyuwoong Kim, BSc; et al.
Abstract Full Text
free access has audio
JAMA. 2018;320(17):1783-1792. doi:10.1001/jama.2018.16501

This population-based cohort study uses a national insurance database data to estimate long-term rates of cardiovascular disease among young Korean adults with elevated blood pressure and stage 1 and 2 hypertension defined by the 2017 ACC/AHA High Blood Pressure Clinical Practice Guideline.

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?

Association of Change in Cardiovascular Risk Factors With Incident Cardiovascular Events

Thomas T. van Sloten, MD, PhD; Muriel Tafflet, MSc; Marie-Cécile Périer, MSc; et al.
Abstract Full Text
free access has audio
JAMA. 2018;320(17):1793-1804. doi:10.1001/jama.2018.16975

This cohort study uses UK Whitehall II study data to characterize changes in cardiovascular risk factors over 10 years and associations between change in risk and incident cardiovascular events among people without baseline cardiovascular disease.

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?
Research Letter

Cumulative Incidence of Autism Into Adulthood for Birth Cohorts in Denmark, 1980-2012

Diana E. Schendel, PhD; Erla Thorsteinsson, MS
Abstract Full Text
free access
JAMA. 2018;320(17):1811-1813. doi:10.1001/jama.2018.11328

This Research Letter examines cumulative incidence on autism spectrum disorder in Denmark using nationwide registered diagnosis data from 1980 to 2012 and assesses whether prevalence was stabilized.

Evaluation of Lowering the P Value Threshold for Statistical Significance From .05 to .005 in Previously Published Randomized Clinical Trials in Major Medical Journals

Cole Wayant, BS; Jared Scott, BS; Matt Vassar, PhD
Abstract Full Text
free access
JAMA. 2018;320(17):1813-1815. doi:10.1001/jama.2018.12288

This study evaluates primary end points in randomized clinical trials (RCTs) published in 3 major general medical journals to determine how changing the P value threshold for statistical significance from .05 to .005 could affect the interpretation of previously published RCTs.

Viewpoint

The 2018 European Society of Cardiology/European Society of Hypertension and 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines: More Similar Than Different

Paul K. Whelton, MB, MD, MSc; Bryan Williams, MD
Abstract Full Text
has audio
JAMA. 2018;320(17):1749-1750. doi:10.1001/jama.2018.16755

This Viewpoint compares and contrasts recommendations in the 2018 European Society of Cardiology/European Society of Hypertension (ESC/ESH) and 2017 American College of Cardiology/American Heart Association (ACC/AHA) blood pressure (BP) guidelines, focusing on definitions of high BP, treatment targets, and BP management for CKD and at older ages.

  • Podcast: Battle of the Heart Societies: Who Is Right--the US or Europe--Regarding How to Manage Hypertension?
  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?

Treatment of Hypertension: Addressing a Global Health Problem

Arman Qamar, MD; Eugene Braunwald, MD
Abstract Full Text
has audio
JAMA. 2018;320(17):1751-1752. doi:10.1001/jama.2018.16579

In this Viewpoint, Eugene Braunwald and coauthor characterize the global prevalence of hypertension as an epidemic and call for collaborative efforts on the part of physicians, other health professionals, and governmental and nongovernmental agencies to develop innovative strategies to manage it, including screening and intervention in nontraditional settings such as barbershops and grocery stores.

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?

Use of Home Blood Pressure Results for Assessing the Quality of Care for Hypertension

Kevin O. Hwang, MD, MPH; Eric J. Thomas, MD, MPH; Laura A. Petersen, MD, MPH
Abstract Full Text
has audio
JAMA. 2018;320(17):1753-1754. doi:10.1001/jama.2018.12365

This Viewpoint argues for incorporating home blood pressure monitoring measures in primary care pay-for-performance (P4P) quality reporting.

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?
A Piece of My Mind

A Letter to Our Daughter

Ravi N. Sharaf, MD, MS; Lisa C. Diamond, MD, MPH
Abstract Full Text
JAMA. 2018;320(17):1755-1756. doi:10.1001/jama.2018.14956

In this narrative medicine essay, two physicians write to their gravely ill 4-year-old daughter promising to try and remain hopeful despite their inability to protect her.

Editorial

Hypertension鈥擜 Public Health Challenge of Global Proportions

Naomi D. L. Fisher, MD; Gregory Curfman, MD
Abstract Full Text
has audio
JAMA. 2018;320(17):1757-1759. doi:10.1001/jama.2018.16760
  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?

High Blood Pressure in Young Adulthood and Risk of Premature Cardiovascular Disease: Calibrating Treatment Benefits to Potential Harm

Ramachandran S. Vasan, MD
Abstract Full Text
has audio
JAMA. 2018;320(17):1760-1763. doi:10.1001/jama.2018.16068
  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?
JAMA Insights

Clinical Update

Out-of-Office Blood Pressure Monitoring in 2018

Sarah Melville, BSc, CRA; James Brian Byrd, MD, MS
Abstract Full Text
has audio
JAMA. 2018;320(17):1805-1806. doi:10.1001/jama.2018.14865

This Clinical Update summarizes the main approaches to out-of-office blood pressure monitoring鈥攈ome monitoring and ambulatory monitoring and the benefits and challenges of each in the management of hypertension.

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?
JAMA Diagnostic Test Interpretation

Ambulatory Blood Pressure Monitoring

Tamar S. Polonsky, MD, MSCI; George L. Bakris, MD, MA
Abstract Full Text
has audio
JAMA. 2018;320(17):1807-1808. doi:10.1001/jama.2018.14856

A 65-year-old woman with prior RCA NSTEMI treated with PCI presents with home BP fluctuations from <120/80 mm Hg to 200/100 mm Hg and mean 24-hour ambulatory measures of <160/90 mm Hg. How do you interpret the results?

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?
Medical News & Perspectives

To Prevent Cardiovascular Disease, Pay Attention to Pregnancy Complications

Jennifer Abbasi
Abstract Full Text
has audio
JAMA. 2018;320(17):1741-1743. doi:10.1001/jama.2018.14645

This Medical News article discusses the increased risk of future heart disease and stroke in women who experienced preeclampsia and other pregnancy complications.

  • Podcast: Adverse Pregnancy Outcomes and Long-term Health Risks
News From the Food and Drug Administration

New Treatment for Certain Types of Leukemia and Lymphoma

Rebecca Voelker, MSJ
Abstract Full Text
JAMA. 2018;320(17):1746. doi:10.1001/jama.2018.16523

Preventive Migraine Drug Approved

Rebecca Voelker, MSJ
Abstract Full Text
JAMA. 2018;320(17):1746. doi:10.1001/jama.2018.16485

Test Detects One in a Million Cancer Cells

Rebecca Voelker, MSJ
Abstract Full Text
JAMA. 2018;320(17):1746. doi:10.1001/jama.2018.16483
The JAMA Forum

Public Health Emergency Preparedness: Globalizing Risk, Localizing Threats

Lawrence O. Gostin, JD
Abstract Full Text
free access
JAMA. 2018;320(17):1743-1744. doi:10.1001/jama.2018.16491
Bench to Bedside

Researchers Reprogram Cells In Vivo to Restore Vision in Mice

Tracy Hampton, PhD
Abstract Full Text
JAMA. 2018;320(17):1745. doi:10.1001/jama.2017.12866
The Arts and Medicine

Expanding the Time We Have With Patients Through Poetry

Rafael Campo, MA, MD; Mark Doty
Abstract Full Text
has multimedia
JAMA. 2018;320(17):1734-1735. doi:10.1001/jama.2018.13761

This Arts and Medicine essay discusses the relevance of poetry to clinical medicine in an edited transcript of a conversation between physician-poet Rafael Campo and National Book Award鈥搘inning poet Mark Doty.

  • Video: Expanding the Time We Have With Patients - The Relevance of Poetry to Clinical Medicine
Poetry and Medicine

Yerushalayim

Carol Snyder Halberstadt
Abstract Full Text
JAMA. 2018;320(17):1820. doi:10.1001/jama.2018.7872
JAMA Revisited

Indications of Physical Overexertion

Abstract Full Text
JAMA. 2018;320(17):1821. doi:10.1001/jama.2017.12644
JAMA Patient Page

Monitoring Blood Pressure Outside of the Doctor鈥檚 Office

Sarah Melville, CRA; James Brian Byrd, MD, MS
Abstract Full Text
free access has audio
JAMA. 2018;320(17):1830. doi:10.1001/jama.2018.11644

This JAMA Patient Page describes reasons for blood pressure self-monitoring and the steps involved in the procedure.

  • Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?
Comment & Response

Medications With Depression as an Adverse Effect

Bruno Agustini, MD; Michael Berk, MD, PhD
Abstract Full Text
JAMA. 2018;320(17):1815. doi:10.1001/jama.2018.12390

Medications With Depression as an Adverse Effect

Patrick B. M. Burch, MBBS, DCH, MRCGP
Abstract Full Text
JAMA. 2018;320(17):1815-1816. doi:10.1001/jama.2018.12386

Medications With Depression as an Adverse Effect鈥擱eply

Dima M. Qato, PharmD, MPH, PhD; Mark Olfson, MD, MPH
Abstract Full Text
JAMA. 2018;320(17):1816. doi:10.1001/jama.2018.12398

Stress-Related Disorders and Autoimmune Disease

Jianbo Liu, MD, PhD; Jianping Lu, MM; Xuerong Luo, MD, PhD
Abstract Full Text
JAMA. 2018;320(17):1816-1817. doi:10.1001/jama.2018.12394

Stress-Related Disorders and Autoimmune Disease鈥擱eply

Huan Song, MD, PhD; Fang Fang, MD, PhD; Unnur A. Valdimarsdóttir, PhD
Abstract Full Text
JAMA. 2018;320(17):1817-1818. doi:10.1001/jama.2018.12402

Diagnostic vs Management Reasoning

Jayshil J. Patel, MD; Paul A. Bergl, MD
Abstract Full Text
JAMA. 2018;320(17):1818. doi:10.1001/jama.2018.13354

Diagnostic vs Management Reasoning鈥擱eply

David A. Cook, MD, MHPE; Jonathan Sherbino, MD, MEd; Steven J. Durning, MD, PhD
Abstract Full Text
JAMA. 2018;320(17):1818-1819. doi:10.1001/jama.2018.13358
JAMA Masthead

JAMA

Abstract Full Text
free access
JAMA. 2018;320(17):1725-1726. doi:10.1001/jama.2017.12615

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