January 5, 2016 Issue of JAMA

January 5, 2016, Vol 315, No. 1, Pages 5-100

This Week in JAMA

Highlights

Abstract Full Text

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JAMA. 2016;315(1):5-7. doi:10.1001/jama.2015.14032

Podcast: Lifestyle interventions for heart failure with preserved ejection fraction, safety of fluconazole during pregnency, new Innovations in Health Care Delivery series, and more.

Original Investigation

Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial

Dalane W. Kitzman, MD; Peter Brubaker, PhD; Timothy Morgan, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(1):36-46. doi:10.1001/jama.2015.17346

This randomized clinical trial determines whether diet or exercise improves exercise capacity and quality of life among obese older patients with heart failure with preserved ejection fraction (HFPEF).

Podcast: Diet vs Exercise in Obese Older Patients With HFPEF

Editorial
Lifestyle Interventions to Improve Exercise Tolerance in Obese Older Patients With Heart Failure and Preserved Ejection Fraction
Nanette K. Wenger, MD

JAMA

Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records

Sara L. Van Driest, MD, PhD; Quinn S. Wells, MD, PharmD, MSCI; Sarah Stallings, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(1):47-57. doi:10.1001/jama.2015.17701

This prospective cohort study investigates the association of rare, potentially pathogenic variants in 2 cardiac arrhythmia susceptibility genes with arrhythmia and electrocardiographic phenotypes using electronic medical record data.

Editorial
Establishing the Clinical Validity of Arrhythmia-Related Genetic Variations Using the Electronic Medical Record: A Valid Take on Precision Medicine?
William Gregory Feero, MD, PhD

JAMA

Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth

Ditte Mølgaard-Nielsen, MSc; Henrik Svanström, PhD; Mads Melbye, MD, DrMedSci; et al.

Abstract Full Text

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JAMA. 2016;315(1):58-67. doi:10.1001/jama.2015.17844

This nationwide, register-based, matched-cohort study evaluates the potential association between fluconazole exposure during pregnancy and risk of spontaneous abortion and stillbirth among women in Denmark.

Familial Risk and Heritability of Cancer Among Twins in Nordic Countries

Lorelei A. Mucci, ScD, MPH; Jacob B. Hjelmborg, PhD; Jennifer R. Harris, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(1):68-76. doi:10.1001/jama.2015.17703

This study estimates familial risk and heritability of cancer types in a large twin cohort using data from population-based registers in Denmark, Finland, Norway, and Sweden.

Research Letter

Subsequent Maltreatment in Children With Disabilities After an Unsubstantiated Report for Neglect

Caroline J. Kistin, MD, MSc; Martha C. Tompson, PhD; Howard J. Cabral, PhD; et al.

Abstract Full Text

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JAMA. 2016;315(1):85-87. doi:10.1001/jama.2015.12912

This cohort study uses data from the US National Child Abuse and Neglect Data System to examine the incidence and timing of re-referral of children with disabilities to child protective services after an initial referral for neglect in fiscal years 2008 through 2012.

Viewpoint

Innovations in Health Care Delivery

Reimagining Electronic Clinical Communication in the Post-Pager, Smartphone Era

Raman R. Khanna, MD, MAS; Robert M. Wachter, MD; Michael Blum, MD

Abstract Full Text

JAMA. 2016;315(1):21-22. doi:10.1001/jama.2015.17025

This Viewpoint proposes requirements for smartphone paging applications that facilitate team-based care and replace conventional pager systems.

Innovations in Health Care Delivery

Delivery Models for High-Risk Older Patients: Back to the Future?

Brian W. Powers, AB; Arnold Milstein, MD, MPH; Sachin H. Jain, MD, MBA

Abstract Full Text

JAMA. 2016;315(1):23-24. doi:10.1001/jama.2015.17029

This Viewpoint discusses health care delivery models intended to improve the continuity of inpatient and outpatient care for high-risk older patients.

Valsartan/Sacubitril for Heart Failure: Reconciling Disparities Between Preclinical and Clinical Investigations

Arthur M. Feldman, MD, PhD; Julia A. Haller, MD; Steven T. DeKosky, MD

Abstract Full Text

JAMA. 2016;315(1):25-26. doi:10.1001/jama.2015.17632

This Viewpoint discusses the importantance of developing effective mechanisms for reconciling differences that emerge when information accrual from genetic animal models outpace the data collection from patients enrolled in clinical trials.

A Piece of My Mind

Thinking Outside the (Lunch) Box

Sean C. Lucan, MD, MPH, MS

Abstract Full Text

JAMA. 2016;315(1):27-29. doi:10.1001/jama.2015.15971

Editorial

Innovations in Health Care Delivery and the Future of Medicine

Howard Bauchner, MD; Donald Berwick, MD; Phil B. Fontanarosa, MD, MBA

Abstract Full Text

JAMA. 2016;315(1):30-31. doi:10.1001/jama.2015.17452

Lifestyle Interventions to Improve Exercise Tolerance in Obese Older Patients With Heart Failure and Preserved Ejection Fraction

Nanette K. Wenger, MD

Abstract Full Text

JAMA. 2016;315(1):31-33. doi:10.1001/jama.2015.17347

Establishing the Clinical Validity of Arrhythmia-Related Genetic Variations Using the Electronic Medical Record: A Valid Take on Precision Medicine?

William Gregory Feero, MD, PhD

Abstract Full Text

JAMA. 2016;315(1):33-35. doi:10.1001/jama.2015.17702

From the 糖心vlog

Computed Tomography Screening for Lung Cancer: A High-Value Proposition?

Joshua A. Roth, PhD, MHA; Scott D. Ramsey, MD, PhD

Abstract Full Text

JAMA. 2016;315(1):77-78. doi:10.1001/jama.2015.17877

This commentary discusses a cost-effectiveness study published in JAMA Oncology that found CT screening for lung cancer would be cost-effective in a Canadian population.

JAMA Clinical Challenge

Erythematous Plaques on the Buttock

Caroline Z. Tan, BA; Roberto Novoa, MD; Jennifer K. Chen, MD

Abstract Full Text

JAMA. 2016;315(1):79-80. doi:10.1001/jama.2015.13562

A 75-year-old woman with rheumatoid arthritis and genital herpes simplex virus 2 presented with painful, pruritic plaques on her buttock. She denied recent trauma to the area, skin exposures, fever, or lymphadenopathy. She takes prednisone, pregabalin, and valacyclovir. What would you do next?

JAMA Diagnostic Test Interpretation

Antitissue Transglutaminase IgA for Celiac Disease Testing

Benjamin Lebwohl, MD, MS; Peter H. R. Green, MD

Abstract Full Text

JAMA. 2016;315(1):81-82. doi:10.1001/jama.2015.15283

An asymptomatic 23-year-old woman with dental enamel defects and a family history of celiac disease presented for assessment of positive celiac disease serologic testing. How do you interpret the test results?

Medical News & Perspectives

Can Nonhormonal Treatments Dial Down the Heat During Menopause?

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2016;315(1):14-16. doi:10.1001/jama.2015.15910

This Medical News & Perspectives article examines new recommendations on nonhormonal management of vasomotor symptoms associated with menopause.

News From the Food and Drug Administration

New on the Menu: Genetically Modified Salmon

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;315(1):20. doi:10.1001/jama.2015.17339

Nasal Spray to Stop Overdose

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;315(1):20. doi:10.1001/jama.2015.17505

More Oversight Needed for LDTs

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2016;315(1):20. doi:10.1001/jama.2015.17506

The JAMA Forum

Campaign Wars: Health Policy in a Fantasy World

David M. Cutler, PhD

Abstract Full Text

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JAMA. 2016;315(1):16-17. doi:10.1001/jama.2015.17587

JAMA Infographic

Recent Trends in Employer-Sponsored Health Insurance Premiums

Michelle Long, MPH; Matthew Rae, MPH, MPA; Gary Claxton; et al.

Abstract Full Text

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JAMA. 2016;315(1):18. doi:10.1001/jama.2015.17349

Lab Reports

Modified Gene Transfer Approach Evaluated in Model of Brain Disease

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;315(1):19. doi:10.1001/jama.2015.16891

Circulating Tumor DNA Helps Track Cancer

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;315(1):19. doi:10.1001/jama.2015.17482

First-Line Antibiotics May Worsen MRSA infection

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;315(1):19. doi:10.1001/jama.2015.17484

Stem Cell Dysfunction Exacerbates Muscular Dystrophy

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2016;315(1):19. doi:10.1001/jama.2015.17486

The Art of JAMA

Day of Sounds: Alice Baber

Jeanette M. Smith, MD

Abstract Full Text

JAMA. 2016;315(1):12-13. doi:10.1001/jama.2015.14034

Poetry and Medicine

Jesse鈥檚 Song

Gary Stein

Abstract Full Text

JAMA. 2016;315(1):91. doi:10.1001/jama.2015.12723

JAMA Revisited

Coffee and Protein Metabolism

Abstract Full Text

JAMA. 2016;315(1):92. doi:10.1001/jama.2015.17069

JAMA Patient Page

Treatment of Liver Cancer

Ali A. Mokdad, MD, MS; Amit G. Singal, MD, MS; Adam C. Yopp, MD

Abstract Full Text

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JAMA. 2016;315(1):100. doi:10.1001/jama.2015.15431

Comment & Response

Mindfulness-Based Stress Reduction for Veterans With PTSD

Beatriz Goulao, MSc; Graeme S. MacLennan, MSc

Abstract Full Text

JAMA. 2016;315(1):87-88. doi:10.1001/jama.2015.15170

Mindfulness-Based Stress Reduction for Veterans With PTSD鈥擱eply

Paul Thuras, PhD; Melissa A. Polusny, PhD; Kelvin O. Lim, MD

Abstract Full Text

JAMA. 2016;315(1):88-89. doi:10.1001/jama.2015.15173

Bedside Ultrasonography for Diagnosis of Septic Shock

Robert C. Hyzy, MD

Abstract Full Text

JAMA. 2016;315(1):89. doi:10.1001/jama.2015.15061

Bedside Ultrasonography for Diagnosis of Septic Shock鈥擱eply

Christopher W. Seymour, MD, MSc; Matthew R. Rosengart, MD

Abstract Full Text

JAMA. 2016;315(1):89-90. doi:10.1001/jama.2015.15073

Correction

Value Errors in Tables and Abstract

Abstract Full Text

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JAMA. 2016;315(1):90. doi:10.1001/jama.2015.16955

Incomplete Dosage Information

Abstract Full Text

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JAMA. 2016;315(1):90. doi:10.1001/jama.2015.16998

Incorrect Data in Tables and eFigure

Abstract Full Text

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JAMA. 2016;315(1):90. doi:10.1001/jama.2015.17311

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January 5, 2016, Vol 315, No. 1, Pages 5-100

Innovations in Health Care Delivery

Innovations in Health Care Delivery

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