January 2, 2018 Issue of JAMA

January 2, 2018, Vol 319, No. 1, Pages 1-91

This Week in JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2018;319(1):1-3. doi:10.1001/jama.2017.12174

Podcast: Comparison of Transcatheter Aortic Valves, Infant Formula and Type 1 Diabetes, Racial Disparities in Live Donor Kidney Transplantation, and more

Original Investigation

Effect of Mechanically Expanded vs Self-Expanding Transcatheter Aortic Valve Replacement on Mortality and Major Adverse Clinical Events in High-Risk Patients With Aortic Stenosis: The REPRISE III Randomized Clinical Trial

Ted E. Feldman, MD; Michael J. Reardon, MD; Vivek Rajagopal, MD; et al.

Abstract Full Text

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JAMA. 2018;319(1):27-37. doi:10.1001/jama.2017.19132

This randomized noninferiority trial compares the effect of mechanically expanded vs self-expanding transcatheter aortic valve replacement (TAVR) on mortality and major adverse clinical events in patients with aortic stenosis at high or extreme risk of adverse outcomes.

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial

Writing Group for the TRIGR Study Group

Abstract Full Text

free access

JAMA. 2018;319(1):38-48. doi:10.1001/jama.2017.19826

This randomized clinical trial tested the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children.

Association of Race and Ethnicity With Live Donor Kidney Transplantation in the United States From 1995 to 2014

Tanjala S. Purnell, PhD, MPH; Xun Luo, MD, MPH; Lisa A. Cooper, MD, MPH; et al.

Abstract Full Text

free access

JAMA. 2018;319(1):49-61. doi:10.1001/jama.2017.19152

This study uses Scientific Registry of Transplant Recipients registry data to compare kidney transplantation rates among white, black, Hispanic, and Asian recipient candidates in 1995-1999 vs 2010-2014.

Editorial
Disparities in Live Donor Kidney Transplantation: Related to Poverty, Race, or Ethnicity?
Colleen L. Jay, MD, MSCI; Francisco G. Cigarroa, MD

JAMA

Research Letter

Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016

Guifeng Xu, MD; Lane Strathearn, MBBS, PhD; Buyun Liu, MD, PhD; et al.

Abstract Full Text

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JAMA. 2018;319(1):81-82. doi:10.1001/jama.2017.17812

This study estimates the current prevalence of autism spectrum disorder among US children and adolescents from 2014 to 2016 using nationally representative data from the National Health Interview Survey.

Viewpoint

Is Single Payer the Answer for the US Health Care System?

Victor R. Fuchs, PhD

Abstract Full Text

JAMA. 2018;319(1):15-16. doi:10.1001/jama.2017.18739

In this Viewpoint, Victor Fuchs discusses the prospects that a single-payer health system can solve the 3 principal problems that bedevil US health care: the uninsured, poor outcomes, and high costs.

Canada as Single-Payer Exemplar for Universal Health Care in the United States: A Borderline Option

C. David Naylor, MD, DPhil

Abstract Full Text

JAMA. 2018;319(1):17-18. doi:10.1001/jama.2017.19668

In this Viewpoint, David Naylor reviews the many differences between the United States and Canada that preclude the Canadian single-payer system from being a useful exemplar for US health reform.

What This Computer Needs Is a Physician: Humanism and Artificial Intelligence

Abraham Verghese, MD; Nigam H. Shah, MBBS, PhD; Robert A. Harrington, MD

Abstract Full Text

JAMA. 2018;319(1):19-20. doi:10.1001/jama.2017.19198

In this Viewpoint, Verghese and colleagues discuss the promise and challenges of integrating artificial intelligence (AI) into clinical care and argue that AI will always need guidance by physicians if it is to improve the care of patients.

Pediatric Exclusivity and Regulatory Authority: Implications of Amgen v HHS

Jeanie Kim, JD; Joseph S. Ross, MD, MHS; Amy Kapczynski, JD

Abstract Full Text

JAMA. 2018;319(1):21-22. doi:10.1001/jama.2017.16477

This Viewpoint uses the legal dispute between Amgen and the US Food and Drug Administration (FDA) regarding the FDA鈥檚 denial of market exclusivity for cinacalcet to discuss the FDA policy granting 6 months of market exclusivity as an incentive for manufacturers to conduct efficacy and safety studies in child populations.

A Piece of My Mind

The Envelope

Jeffrey H. Millstein, MD

Abstract Full Text

JAMA. 2018;319(1):23. doi:10.1001/jama.2017.19273

In this essay, the author ponders how his 70-year-old patient鈥檚 need to tell his story before talking about his own health care needs reminds him of the necessity of listening to patients to know them enough to provide precise care.

Editorial

Disparities in Live Donor Kidney Transplantation: Related to Poverty, Race, or Ethnicity?

Colleen L. Jay, MD, MSCI; Francisco G. Cigarroa, MD

Abstract Full Text

JAMA. 2018;319(1):24-26. doi:10.1001/jama.2017.19617

Review

Enhancing Recovery From Sepsis: A Review

Hallie C. Prescott, MD, MSc; Derek C. Angus, MD, MPH

Abstract Full Text

JAMA. 2018;319(1):62-75. doi:10.1001/jama.2017.17687

This narrative review summarizes the epidemiology and pathophysiology of sepsis, management of post-sepsis sequelae in the months following hospital discharge, and directions for future research to reduce long-term sequelae and improve patient recovery.

From the 糖心vlog

Expanding the Options for Patient-Guided Decision Making in Papillary Thyroid Cancer

Linwah Yip, MD; Sally E. Carty, MD

Abstract Full Text

has audio

JAMA. 2018;319(1):76-77. doi:10.1001/jama.2017.18608

This commentary discusses a cohort study published in JAMA Otolaryngology鈥揌ead & Neck Surgery examining the probability, rate, and magnitude of tumor growth in patients with papillary thyroid cancer during active surveillance.

Podcast: Surveillance for Thyroid Cancer

Invited Commentary
Achieving Active Surveillance for Thyroid Cancer鈥擭ot a Euphemism for Watching a Ticking Time Bomb
Joseph Scharpf, MD

JAMA Otolaryngol Head Neck Surg
- Podcast: Surveillance for Thyroid Cancer

JAMA Clinical Challenge

A Woman With a Large Ulcerated Nodule on the Finger

Ramya Vangipuram, MD; Christopher Haley, MD; Stephen K. Tyring, MD, PhD

Abstract Full Text

JAMA. 2018;319(1):78-79. doi:10.1001/jama.2017.19282

A 59-year-old African American woman had a rapidly enlarging, nonfluctuant, noninflamed nodule with central ulceration on one finger. She had no history of hand trauma, joint pain, stiffness, or lymphadenopathy; results of a recent complete blood cell count and comprehensive metabolic profile were unremarkable. What would you do next?

Medical News & Perspectives