January 9, 2018 Issue of JAMA

January 9, 2018, Vol 319, No. 2, Pages 103-202

This Week in JAMA

Highlights

Abstract Full Text

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JAMA. 2018;319(2):103-105. doi:10.1001/jama.2017.12185

Podcast: Idalopirdine for Dementia, Anesthesia Handovers During Surgery, Screening for Scoliosis, and more

Original Investigation

Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials

Alireza Atri, MD, PhD; Lutz Frölich, MD, PhD; Clive Ballard, MD; et al.

Abstract Full Text

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JAMA. 2018;319(2):130-142. doi:10.1001/jama.2017.20373

This report describes findings from 3 randomized trials comparing the cognitive effects of 10, 30, or 60 mg/d of idalopirdine added to stable cholinesterase inhibitor treatment or placebo for symptomatic treatment of mild to moderate Alzheimer disease.

Editorial
Lack of Benefit With Idalopirdine for Alzheimer Disease: Another Therapeutic Failure in a Complex Disease Process
David A. Bennett, MD

JAMA

Association Between Handover of Anesthesia Care and Adverse Postoperative Outcomes Among Patients Undergoing Major Surgery

Philip M. Jones, MD, MSc; Richard A. Cherry, MD; Britney N. Allen, MSc; et al.

Abstract Full Text

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JAMA. 2018;319(2):143-153. doi:10.1001/jama.2017.20040

This cohort study uses Canadian administrative health care data to investigate associations between handover of intraoperative anesthesia care between one physician and another and risk of adverse postoperative outcomes among patients undergoing major surgery.

Editorial
Handovers During Anesthesia Care: Patient Safety Risk or Opportunity for Improvement?
James P. Bagian, MD, PE; Douglas E. Paull, MD, MS

JAMA

Association of Screening and Treatment With Breast Cancer Mortality by Molecular Subtype in US Women, 2000-2012

Sylvia K. Plevritis, PhD; Diego Munoz, MS, PhD; Allison W. Kurian, MD, MS; et al.

Abstract Full Text

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JAMA. 2018;319(2):154-164. doi:10.1001/jama.2017.19130

This simulation study estimates reductions in breast cancer mortality associated with screening and treatment by estrogen-receptor and human epidermal growth factor receptor 2 (ERBB2) status.

Research Letter

Participation and Dropout in the Bundled Payments for Care Improvement Initiative

Karen E. Joynt Maddox, MD, MPH; E. John Orav, PhD; Jie Zheng, PhD; et al.

Abstract Full Text

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JAMA. 2018;319(2):191-193. doi:10.1001/jama.2017.14771

This study describes hospital participation and dropout in the Centers for Medicare & Medicaid Innovation鈥檚 Bundled Payments for Care Improvement Initiative, which allows hospitals and practices to retain savings if they meet quality targets.

US Preventive Services Task Force

Recommendation Statement

Screening for Adolescent Idiopathic Scoliosis: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force

Abstract Full Text

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JAMA. 2018;319(2):165-172. doi:10.1001/jama.2017.19342

This Recommendation Statement from the US Preventive Services Task Force concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for adolescent idiopathic scoliosis in children and adolescents aged 10 to 18 years (I statement).

Podcast: USPSTF Recommendation: Screening for Adolescent Idiopathic Scoliosis

Editorial
Evolving Recommendations for Scoliosis Screening: A Compelling Need for Further Research
John F. Sarwark, MD; Matthew M. Davis, MD, MAPP

JAMA
Early Detection of Scoliosis鈥擶hat the USPSTF 鈥淚鈥� Means for Us
M. Timothy Hresko, MD; Richard M. Schwend, MD; Richard A. Hostin, MD

JAMA Pediatr

Evidence Report

Screening for Adolescent Idiopathic Scoliosis: Evidence Report and Systematic Review for the US Preventive Services Task Force

John Dunn, MD, MPH; Nora B. Henrikson, PhD, MPH; Caitlin C. Morrison, MPH; et al.

Abstract Full Text

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JAMA. 2018;319(2):173-187. doi:10.1001/jama.2017.11669

This systematic review to support the 2018 update of the US Preventive Services Task Force Recommendation Statement on screening for adolescent idiopathic scoliosis (AIS) summarizes published evidence on the benefits and harms of AIS screening and treatment for children and adolescents aged 10 to 18 years.

Editorial
Evolving Recommendations for Scoliosis Screening: A Compelling Need for Further Research
John F. Sarwark, MD; Matthew M. Davis, MD, MAPP

JAMA
Early Detection of Scoliosis鈥擶hat the USPSTF 鈥淚鈥� Means for Us
M. Timothy Hresko, MD; Richard M. Schwend, MD; Richard A. Hostin, MD

JAMA Pediatr

Viewpoint

Diagnosis and Treatment of Hypertension in the 2017 ACC/AHA Guidelines and in the Real World

John P. A. Ioannidis, MD, DSc

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JAMA. 2018;319(2):115-116. doi:10.1001/jama.2017.19672

In this Viewpoint, John Ioannidis discusses implications of the 2017 hypertension guidelines for real-world management of blood pressure (BP), including labeling healthy people as having disease and possible adverse treatment effects at lower BP treatment targets..

Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?

Cardiovascular Guideline Skepticism vs Lifestyle Realism?

Philip Greenland, MD

Abstract Full Text

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JAMA. 2018;319(2):117-118. doi:10.1001/jama.2017.19675

This Viewpoint discusses practical applications of the recent 2017 ACC?AHA guidelines on hypertension management and the importance of emphasizing healthier lifestyles in the United States.

Podcast: Battle of the Heart Societies, Part 2: Who Is Right 鈥� the US or Europe 鈥� Regarding How to Manage Hypertension?

Funding Innovation in a Learning Health Care System

Andrew B. Bindman, MD; Peter J. Pronovost, MD, PhD; David A. Asch, MD

Abstract Full Text

JAMA. 2018;319(2):119-120. doi:10.1001/jama.2017.18205

This Viewpoint discusses reforms to federal funding strategies and systems that might incentivize health care delivery innovation and create learning health care systems focused on improving health more than financial outcomes.

A Piece of My Mind

She Smiled as She Walked Away

Kathleen C. Gallagher, BS

Abstract Full Text

JAMA. 2018;319(2):121-122. doi:10.1001/jama.2017.19760

In this humanities essay, a former combat medic recalls an encounter with a patient whose smile and calm demeanor belied acute physical signs of torture.

Editorial

Lack of Benefit With Idalopirdine for Alzheimer Disease: Another Therapeutic Failure in a Complex Disease Process

David A. Bennett, MD

Abstract Full Text

JAMA. 2018;319(2):123-125. doi:10.1001/jama.2017.19700

Handovers During Anesthesia Care: Patient Safety Risk or Opportunity for Improvement?

James P. Bagian, MD, PE; Douglas E. Paull, MD, MS

Abstract Full Text

JAMA. 2018;319(2):125-127. doi:10.1001/jama.2017.20602

Evolving Recommendations for Scoliosis Screening: A Compelling Need for Further Research

John F. Sarwark, MD; Matthew M. Davis, MD, MAPP

Abstract Full Text

JAMA. 2018;319(2):127-129. doi:10.1001/jama.2017.20190

From The Medical Letter on Drugs and Therapeutics

Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia

Abstract Full Text

JAMA. 2018;319(2):188-189. doi:10.1001/jama.2017.20189

This Medical Letter review summarizes the mechanism of action and adverse effects of combination lesinurad, an uric acid transporter 1, and allopurinol, a xanthine oxidase inhibitor, for treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels with allopurinol alone.

Medical News & Perspectives