August 7, 2018 Issue of JAMA

August 7, 2018, Vol 320, No. 5, Pages 419-516

This Week in JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2018;320(5):419-421. doi:10.1001/jama.2017.12482

Podcast: Genomic Sequencing and NSCLC Survival, Childhood Obesity Interventions, Atrial Fibrillation Screening Guidelines, and more

Original Investigation

Effect of a Behavioral Intervention for Underserved Preschool-Age Children on Change in Body Mass Index: A Randomized Clinical Trial

Shari L. Barkin, MD, MSHS; William J. Heerman, MD, MPH; Evan C. Sommer, BS, BA; et al.

Abstract Full Text

free access

JAMA. 2018;320(5):450-460. doi:10.1001/jama.2018.9128

This randomized clinical trial compares the effects of a 36-month multicomponent behavioral intervention for obesity prevention vs a school-readiness control on body mass index (BMI) trajectories in underserved preschool-age children at risk for obesity but not yet obese.

Editorial
Preventing Obesity in Children: A Glimmer of Hope
Jody W. Zylke, MD; Howard Bauchner, MD

JAMA

Effect of a Responsive Parenting Educational Intervention on Childhood Weight Outcomes at 3 Years of Age: The INSIGHT Randomized Clinical Trial

Ian M. Paul, MD, MSc; Jennifer S. Savage, PhD; Stephanie Anzman-Frasca, PhD; et al.

Abstract Full Text

free access

JAMA. 2018;320(5):461-468. doi:10.1001/jama.2018.9432

This randomized clinical trial compares the effects of a responsive parenting intervention designed to promote developmentally appropriate, prompt, and contingent responses to an infant鈥檚 needs vs a home safety intervention on child weight outcomes at 3 years.

Editorial
Preventing Obesity in Children: A Glimmer of Hope
Jody W. Zylke, MD; Howard Bauchner, MD

JAMA

Association of Broad-Based Genomic Sequencing With Survival Among Patients With Advanced Non鈥揝mall Cell Lung Cancer in the Community Oncology Setting

Carolyn J. Presley, MD; Daiwei Tang, BS; Pamela R. Soulos, MPH; et al.

Abstract Full Text

free access

JAMA. 2018;320(5):469-477. doi:10.1001/jama.2018.9824

This cohort study examines associations between use of broad-based genomic screening vs routine testing (for EGFR and ALK alterations only) to target treatment of advanced non鈥搒mall cell lung cancer and mortality at 1 year and overall survival.

Editorial
Broad-Based Molecular Testing for Lung Cancer: Precisely the Time for Precision
Paul A. Bunn Jr, MD; Dara L. Aisner, MD, PhD

JAMA

Research Letter

Opioid Overdose After Surgical Discharge

Karim S. Ladha, MD, MSc; Joshua J. Gagne, PharmD, ScD; Elisabetta Patorno, MD, DrPH; et al.

Abstract Full Text

free access

JAMA. 2018;320(5):502-504. doi:10.1001/jama.2018.6933

This pharmacoepidemiology study uses commercial claims database data to describe the rate of opioid overdose 1 to 3 months after surgical discharge by dose and procedure from 2004 to 2015.

Persistent Opioid Use After Wisdom Tooth Extraction

Calista M. Harbaugh, MD; Romesh P. Nalliah, DDS, MHCM; Hsou Mei Hu, PhD, MBA; et al.

Abstract Full Text

free access

JAMA. 2018;320(5):504-506. doi:10.1001/jama.2018.9023

This pharmacoepidemiology study uses commercial claims database data to describe the rate of persistent opioid use among patients aged 13 to 30 years prescribed perioperative opioids for wisdom tooth extraction.

US Preventive Services Task Force

Recommendation Statement

Screening for Atrial Fibrillation With Electrocardiography: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force

Abstract Full Text

free access has audio

JAMA. 2018;320(5):478-484. doi:10.1001/jama.2018.10321

This 2018 Recommendation Statement from the US Preventive Services Task Force concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for atrial fibrillation (AF) with ECG (I statement).

Podcast: USPSTF Recommendation: Screening for Atrial Fibrillation With Electrocardiography

Editorial
Electrocardiographic Monitoring for Prevention of Atrial Fibrillation鈥揂ssociated Cardioembolic Stroke
Jeffrey J. Goldberger, MD; Raul D. Mitrani, MD

JAMA
Screening for Atrial Fibrillation Comes With Many Snags
John Mandrola, MD; Andrew Foy, MD; Gerald Naccarelli, MD

JAMA Intern Med
Electrocardiography Screening for Atrial Fibrillation: We Can Do Better
Rod Passman, MD, MSCE; Jonathan Piccini, MD, MHSc

JAMA Cardiol

Evidence Report

Screening for Atrial Fibrillation With Electrocardiography: Evidence Report and Systematic Review for the US Preventive Services Task Force

Daniel E. Jonas, MD, MPH; Leila C. Kahwati, MD, MPH; Jonathan D. Y. Yun, MD; et al.

Abstract Full Text

free access

JAMA. 2018;320(5):485-498. doi:10.1001/jama.2018.4190

This systematic review to support the 2018 US Preventive Services Task Force Recommendation Statement on screening for atrial fibrillation (AF) with electrocardiography (ECG) summarizes published evidence on the benefits and harms of screening and treatment of nonvalvular AF in asymptomatic adults 65 years and older.

Editorial
Electrocardiographic Monitoring for Prevention of Atrial Fibrillation鈥揂ssociated Cardioembolic Stroke
Jeffrey J. Goldberger, MD; Raul D. Mitrani, MD

JAMA
Screening for Atrial Fibrillation Comes With Many Snags
John Mandrola, MD; Andrew Foy, MD; Gerald Naccarelli, MD

JAMA Intern Med
Electrocardiography Screening for Atrial Fibrillation: We Can Do Better
Rod Passman, MD, MSCE; Jonathan Piccini, MD, MHSc

JAMA Cardiol

Viewpoint

Type 2 Myocardial Infarction鈥擠iagnosis, Prognosis, and Treatment

Cian P. McCarthy, MB, BCh, BAO; Muthiah Vaduganathan, MD, MPH; James L. Januzzi Jr, MD

Abstract Full Text

JAMA. 2018;320(5):433-434. doi:10.1001/jama.2018.7125

This Viewpoint reviews what is known about myocardial infarction (MI) caused by oxygen supply-and-demand mismatch (type 2 MI) and differences from MI caused by coronary artery disease, as well as proposes areas for further investigation to identify optimal management strategies.

Return of Research Results to Study Participants: Uncharted and Untested

Charlene A. Wong, MD, MSHP; Adrian F. Hernandez, MD, MHS; Robert M. Califf, MD

Abstract Full Text

JAMA. 2018;320(5):435-436. doi:10.1001/jama.2018.7898

This Viewpoint encourages the development of approaches to share the results of research with study participants to reinforce the value of patient participation, to incentivize engagement in research, and to honor the belief that individuals have a right to their own data.

Progress in Prevention and Treatment of Acute Kidney Injury: Moving Beyond Kidney Attack

John A. Kellum, MD; Rinaldo Bellomo, MD; Claudio Ronco, MD

Abstract Full Text

JAMA. 2018;320(5):437-438. doi:10.1001/jama.2018.7160

This Viewpoint discusses progress in the recognition and management of acute kidney injury (AKI) since publication in 2012 of KDIGO clinical practice guidelines to improve AKI outcomes, and proposes next steps in management, including use of biomarkers, risk alerts, and care bundles, to improve AKI prevention and outcomes.

Protecting NIH鈥檚 Integrity and Trustworthiness in Public-Private Partnerships

Bernard Lo, MD; Deborah Grady, MD, MPH

Abstract Full Text

JAMA. 2018;320(5):439-440. doi:10.1001/jama.2018.7625

This Viewpoint uses the case of an NIH trial funded by alcohol manufacturers and designed to determine the effects of moderate alcohol consumption on health outcomes to discuss the need for transparency in NIH-private partnerships and ways the NIH can administer those partnerships to preserve its integrity and trustworthiness.

A Piece of My Mind

This Is My Body

Kathryn E. Norman, BA

Abstract Full Text

JAMA. 2018;320(5):441-442. doi:10.1001/jama.2018.10452

In this narrative medicine essay, a medical student is reminded of Communion service at her New England Protestant church when she sees the beauty of the human anatomy in a cadaver, a former teacher who offered her body as the ultimate teaching moment, in an echo of Jesus鈥� words at the Last Supper: 鈥淭his is my body, broken for you. Do this in memory of me.鈥�

Editorial

Preventing Obesity in Children: A Glimmer of Hope

Jody W. Zylke, MD; Howard Bauchner, MD

Abstract Full Text

JAMA. 2018;320(5):443-444. doi:10.1001/jama.2018.9442

Broad-Based Molecular Testing for Lung Cancer: Precisely the Time for Precision

Paul A. Bunn Jr, MD; Dara L. Aisner, MD, PhD

Abstract Full Text

JAMA. 2018;320(5):445-446. doi:10.1001/jama.2018.10096

Electrocardiographic Monitoring for Prevention of Atrial Fibrillation鈥揂ssociated Cardioembolic Stroke

Jeffrey J. Goldberger, MD; Raul D. Mitrani, MD

Abstract Full Text

JAMA. 2018;320(5):447-449. doi:10.1001/jama.2018.9185

JAMA Clinical Evidence Synopsis

Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics

Joshua Z. Goldenberg, ND; Dominik Mertz, MD; Bradley C. Johnston, PhD

Abstract Full Text

JAMA. 2018;320(5):499-500. doi:10.1001/jama.2018.9064

This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of co-administration of an antibiotic and a probiotic vs placebo or no treatment in adults and children diagnosed with Clostridium difficile infection.

Medical News & Perspectives

At 鈥淐risis Pregnancy Centers,鈥� Critics Say, Ideology Trumps Evidence

Rita Rubin, MA

Abstract Full Text

JAMA. 2018;320(5):425-427. doi:10.1001/jama.2018.8661

This Medical News story examines the controversy surrounding crisis pregnancy centers.

News From the Food and Drug Administration

Relieving Severe Emphysema Symptoms

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2018;320(5):431. doi:10.1001/jama.2018.10737

Another Option for Hyperhidrosis

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2018;320(5):431. doi:10.1001/jama.2018.10789

Kratom Investigation Concludes

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2018;320(5):431. doi:10.1001/jama.2018.10791

The JAMA Forum

The Health Innovation We Need

Dave A. Chokshi, MD, MSc

Abstract Full Text

free access

JAMA. 2018;320(5):427-429. doi:10.1001/jama.2018.9545

Bench to Bedside

Research Uncovers How Commensal Bacteria Contribute to Multiple Sclerosis

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2018;320(5):429-430. doi:10.1001/jama.2017.12863

Poetry and Medicine

Monument

Andrew Thurston, MD

Abstract Full Text

JAMA. 2018;320(5):511. doi:10.1001/jama.2018.2357

JAMA Revisited

Discoveries and Discoverers

Abstract Full Text

JAMA. 2018;320(5):512. doi:10.1001/jama.2017.12501

JAMA Patient Page

Screening for Atrial Fibrillation With Electrocardiography

Jill Jin, MD, MPH

Abstract Full Text

free access

JAMA. 2018;320(5):516. doi:10.1001/jama.2018.10598

This JAMA Patient Page describes the US Preventive Services Task Force鈥檚 recommendations on screening for atrial fibrillation using electrocardiography.

Comment & Response