March 13, 2018 Issue of JAMA

March 13, 2018, Vol 319, No. 10, Pages 957-1058

This Week in JAMA

Highlights

Abstract Full Text

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JAMA. 2018;319(10):957-959. doi:10.1001/jama.2017.12273

Podcast: Trends in US Opioid and Injury Mortality, International Comparisons of Health Care Spending, Weaving Indigenous Art in Cardiac Devices, and more

Original Investigation

Caring for the Critically Ill Patient

Effect of On-Demand vs Routine Nebulization of Acetylcysteine With Salbutamol on Ventilator-Free Days in Intensive Care Unit Patients Receiving Invasive Ventilation: A Randomized Clinical Trial

David M. P. van Meenen, MD; Sophia M. van der Hoeven, MD; Jan M. Binnekade, PhD; et al.

Abstract Full Text

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JAMA. 2018;319(10):993-1001. doi:10.1001/jama.2018.0949

This noninferiority randomized trial compares the effects of on-demand nebulization of acetylcysteine or salbutamol vs routine nebulization of acetylcysteine and salbutamol on duration of invasive ventilation and mortality in adult intensive care unit (ICU) patients.

Caring for the Critically Ill Patient

Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial

Christopher S. Parshuram, MBChB, DPhil; Karen Dryden-Palmer, MScN; Catherine Farrell, MD; et al.

Abstract Full Text

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JAMA. 2018;319(10):1002-1012. doi:10.1001/jama.2018.0948

This cluster randomized trial evaluates the effect of the Bedside Paediatric Early Warning System, a system of care that guides escalation and de-escalation of care for hospitalized children, on all-cause hospital mortality.

Editorial
Early Warning Systems for Hospitalized Pediatric Patients
Neil A. Halpern, MD, MCCM

JAMA

Trends and Patterns of Geographic Variation in Mortality From Substance Use Disorders and Intentional Injuries Among US Counties, 1980-2014

Laura Dwyer-Lindgren, PhD; Amelia Bertozzi-Villa, MPH; Rebecca W. Stubbs, MA; et al.

Abstract Full Text

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JAMA. 2018;319(10):1013-1023. doi:10.1001/jama.2018.0900

This population epidemiology study estimates county-level mortality rates for alcohol use disorders, drug use disorders, self-harm, and interpersonal violence in the United States between 1980 and 2014.

Research Letter

Frequency and Magnitude of Co-payments Exceeding Prescription Drug Costs

Karen Van Nuys, PhD; Geoffrey Joyce, PhD; Rocio Ribero, PhD; et al.

Abstract Full Text

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JAMA. 2018;319(10):1045-1047. doi:10.1001/jama.2018.0102

This study uses Centers for Medicare & Medicaid Services data to assess the proportion of pharmacy claims with patient co-pay overpayment and the mean dollar amount of overpayment in 2013.

Special Communication

Health Care Spending in the United States and Other High-Income Countries

Irene Papanicolas, PhD; Liana R. Woskie, MSc; Ashish K. Jha, MD, MPH

Abstract Full Text

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JAMA. 2018;319(10):1024-1039. doi:10.1001/jama.2018.1150

This Special Communication analyzes data primarily from 2013-2016 to compare potential drivers of health care spending in the United States with those of 10 other high-income countries.

Video: Health Care Spending in the United States and Other High-Income Countries

Podcast: Health Care Spending in the United States and Other High-Income Countries

Editorial
Factors Contributing to Higher Health Care Spending in the United States Compared With Other High-Income Countries
Stephen T. Parente, PhD

JAMA
The Real Cost of the US Health Care System
Ezekiel J. Emanuel, MD, PhD

JAMA
Challenges in Understanding Differences in Health Care Spending Between the United States and Other High-Income Countries
Katherine Baicker, PhD; Amitabh Chandra, PhD

JAMA
Health Care Spending in the United States Compared With 10 Other High-Income Countries: What Uwe Reinhardt Might Have Said
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA

JAMA

Viewpoint

Time to Release Medicare Advantage Claims Data

Niall Brennan, MPP; Charles Ornstein, BA; Austin B. Frakt, PhD

Abstract Full Text

JAMA. 2018;319(10):975-976. doi:10.1001/jama.2017.21519

This Viewpoint argues for Medicare Advantage claims data to be made publicly available for research and analysis purposes.

Hip and Knee Replacements: A Neglected Potential Savings Opportunity

Vanessa Lam, BA; Steven Teutsch, MD, MPH; Jonathan Fielding, MD, MPH, MA, MBA

Abstract Full Text

JAMA. 2018;319(10):977-978. doi:10.1001/jama.2018.2310

This Viewpoint discusses the factors contributing to the estimated $20 billion annual cost of joint replacements in the United States, and proposes ways to realize cost savings without harming care quality or patient outcomes, including reduction of inappropriate procedures, limits to payment variation and device pricing, and use of outpatient rather than surgical center settings.

A Piece of My Mind

The Cicada Season

Anne Jacobson, MD, MPH

Abstract Full Text

JAMA. 2018;319(10):979-980. doi:10.1001/jama.2018.1338

In this essay, the author celebrates the mystery and beauty of the 17-year cicadas鈥� long dormancy and short rebirths and reads the same cycles into her own infertility, her children鈥檚 adoption process, and her children鈥檚 development into young adults.

Editorial

Early Warning Systems for Hospitalized Pediatric Patients

Neil A. Halpern, MD, MCCM

Abstract Full Text

JAMA. 2018;319(10):981-982. doi:10.1001/jama.2018.1524

The Real Cost of the US Health Care System

Ezekiel J. Emanuel, MD, PhD

Abstract Full Text

JAMA. 2018;319(10):983-985. doi:10.1001/jama.2018.1151

Editorial
Factors Contributing to Higher Health Care Spending in the United States Compared With Other High-Income Countries
Stephen T. Parente, PhD

JAMA
Challenges in Understanding Differences in Health Care Spending Between the United States and Other High-Income Countries
Katherine Baicker, PhD; Amitabh Chandra, PhD

JAMA
Health Care Spending in the United States Compared With 10 Other High-Income Countries: What Uwe Reinhardt Might Have Said
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA

JAMA

Challenges in Understanding Differences in Health Care Spending Between the United States and Other High-Income Countries

Katherine Baicker, PhD; Amitabh Chandra, PhD

Abstract Full Text

JAMA. 2018;319(10):986-987. doi:10.1001/jama.2018.1152

Editorial
Factors Contributing to Higher Health Care Spending in the United States Compared With Other High-Income Countries
Stephen T. Parente, PhD

JAMA
The Real Cost of the US Health Care System
Ezekiel J. Emanuel, MD, PhD

JAMA
Health Care Spending in the United States Compared With 10 Other High-Income Countries: What Uwe Reinhardt Might Have Said
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA

JAMA

Factors Contributing to Higher Health Care Spending in the United States Compared With Other High-Income Countries

Stephen T. Parente, PhD

Abstract Full Text

JAMA. 2018;319(10):988-990. doi:10.1001/jama.2018.1149

Editorial
The Real Cost of the US Health Care System
Ezekiel J. Emanuel, MD, PhD

JAMA
Challenges in Understanding Differences in Health Care Spending Between the United States and Other High-Income Countries
Katherine Baicker, PhD; Amitabh Chandra, PhD

JAMA
Health Care Spending in the United States Compared With 10 Other High-Income Countries: What Uwe Reinhardt Might Have Said
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA

JAMA

Health Care Spending in the United States Compared With 10 Other High-Income Countries: What Uwe Reinhardt Might Have Said

Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA

Abstract Full Text

JAMA. 2018;319(10):990-992. doi:10.1001/jama.2018.1879

Editorial
Factors Contributing to Higher Health Care Spending in the United States Compared With Other High-Income Countries
Stephen T. Parente, PhD

JAMA
The Real Cost of the US Health Care System
Ezekiel J. Emanuel, MD, PhD

JAMA
Challenges in Understanding Differences in Health Care Spending Between the United States and Other High-Income Countries
Katherine Baicker, PhD; Amitabh Chandra, PhD

JAMA

JAMA Clinical Guidelines Synopsis

Treatment of Osteoporosis

Kamala Gullapalli Cotts, MD; Adam S. Cifu, MD

Abstract Full Text

JAMA. 2018;319(10):1040-1041. doi:10.1001/jama.2017.21995

This JAMA Clinical Guidelines Synopsis summarizes the 2017 American College of Physicians鈥� guideline on treatment of osteoporosis.

From The Medical Letter on Drugs and Therapeutics

Prescription Drug Prices in the US

Abstract Full Text

JAMA. 2018;319(10):1042-1043. doi:10.1001/jama.2018.1844

This Medical Letter review summarizes the multiple factors that increase the cost of prescription drugs in the United States compared with Canada and other countries.

Medical News & Perspectives

How Value-Based Medicare Payments Exacerbate Health Care Disparities

Rita Rubin, MA

Abstract Full Text

JAMA. 2018;319(10):968-970. doi:10.1001/jama.2018.0240

This Medical News article discusses how current value-based Medicare payment schemes can exacerbate health care disparities and explores possible policy solutions.

The JAMA Forum

Don鈥檛 Let Budget Cuts Wreck Medicare Reform

Stuart M. Butler, PhD

Abstract Full Text

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JAMA. 2018;319(10):970-971. doi:10.1001/jama.2018.1439

News From the Centers for Disease Control and Prevention

Zika-Associated Birth Defects Increasing

Bridget Kuehn, MSJ

Abstract Full Text

JAMA. 2018;319(10):973. doi:10.1001/jama.2018.1611

Suicide: The Leading Cause of Violent Death

Bridget Kuehn, MSJ

Abstract Full Text

JAMA. 2018;319(10):973. doi:10.1001/jama.2018.1699

Biotech Innovations

Ingestible Electronic Capsule Measures Gases in the Gut

Jennifer Abbasi

Abstract Full Text

JAMA. 2018;319(10):972. doi:10.1001/jama.2018.1629

Plasma Biomarkers Predict Brain Amyloid-尾 Burden

Jennifer Abbasi

Abstract Full Text

JAMA. 2018;319(10):972. doi:10.1001/jama.2018.2024

Accurate HIV Spit Test on the Horizon

Jennifer Abbasi

Abstract Full Text

JAMA. 2018;319(10):972. doi:10.1001/jama.2018.2026

The Arts and Medicine

Weaving Indigenous Textile Art Into Cardiac Devices

Alexandra Heath, MD, PhD; Alexander Javois, MD; Franz Freudenthal, MD

Abstract Full Text

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JAMA. 2018;319(10):966-967. doi:10.1001/jama.2018.0387

This Arts and Medicine essay describes how indigenous Aymara women in La Paz, Bolivia, are using traditional weaving techniques and patterns to create cardiac devices for occlusion of large congenital heart defects in children.