August 25, 2015 Issue of JAMA

August 25, 2015, Vol 314, No. 8, Pages 747-850

This Week in JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2015;314(8):747-749. doi:10.1001/jama.2014.11935

Podcast: Effects of exercise and supplements on cognition in older adults, mutation clearance and AML outcomes, and more.

Original Investigation

Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial

Kaycee M. Sink, MD, MAS; Mark A. Espeland, PhD; Cynthia M. Castro, PhD; et al.

Abstract Full Text

free access has multimedia has audio

JAMA. 2015;314(8):781-790. doi:10.1001/jama.2015.9617

This randomized trial assessed the effects of a 24-month physical activity program on cognitive function, mild cognitive impairment, and dementia compared with a health education program in sedentary adults aged 70 to 89 years.

Podcast: Activity Intervention vs Health Education in Sedentary Older Adults

Editorial
Lifestyles and Cognitive Health: What Older Individuals Can Do to Optimize Cognitive Outcomes
Sudeep S. Gill, MD, MSc; Dallas P. Seitz, MD, PhD

JAMA

Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial

Emily Y. Chew, MD; Traci E. Clemons, PhD; Elvira Agrón, MA; et al.

Abstract Full Text

free access

JAMA. 2015;314(8):791-801. doi:10.1001/jama.2015.9677

This randomized trial reports that among older individuals with age-related macular degeneration supplements containing long-chain fatty acids and/or lutein and zeaxanthin had no effect on cognitive function.

Editorial
Lifestyles and Cognitive Health: What Older Individuals Can Do to Optimize Cognitive Outcomes
Sudeep S. Gill, MD, MSc; Dallas P. Seitz, MD, PhD

JAMA

Caring for the Critically Ill Patient

Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest

Lars W. Andersen, MD; Katherine M. Berg, MD; Brian Z. Saindon, BS; et al.

Abstract Full Text

free access

JAMA. 2015;314(8):802-810. doi:10.1001/jama.2015.9678

This study uses data for pediatric patients from the Get With the Guidelines鈥揜esuscitation registry to report associations between delay in epinephrine and survival and neurological outcome after pediatric in-hospital cardiac arrest.

Editorial
Pediatric Pulseless Arrest With 鈥淣onshockable鈥� Rhythm: Does Faster Time to Epinephrine Improve Outcome?
Robert C. Tasker, MBBS, MD; Adrienne G. Randolph, MD, MSc

JAMA

Preliminary Communication

Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

Jeffery M. Klco, MD, PhD; Christopher A. Miller, PhD; Malachi Griffith, PhD; et al.

Abstract Full Text

free access has audio

JAMA. 2015;314(8):811-822. doi:10.1001/jama.2015.9643

This cohort study investigates clearance patterns of somatic mutations in acute myeloid leukemia patients given induction chemotherapy, and associations between those patterns and clinical outcomes.

Podcast: Mutation Clearance After Chemotherapy and Outcomes in AML

Editorial
Next-Generation Sequencing and Detection of Minimal Residual Disease in Acute Myeloid Leukemia: Ready for Clinical Practice?
Friederike Pastore, MD; Ross L. Levine, MD

JAMA

Research Letter

Military Misconduct and Homelessness Among US Veterans Separated From Active Duty, 2001-2012

Adi V. Gundlapalli, MD, PhD, MS; Jamison D. Fargo, PhD, MS; Stephen Metraux, PhD; et al.

Abstract Full Text

free access

JAMA. 2015;314(8):832-834. doi:10.1001/jama.2015.8207

This study used Veterans Health Administration data to investigate the association between misconduct-related separations and homelessness among recently returned active-duty US military service members.

Viewpoint

Sexual Health in America: Improving Patient Care and Public Health

David Satcher, MD, PhD; Edward W. Hook III, MD; Eli Coleman, PhD

Abstract Full Text

JAMA. 2015;314(8):765-766. doi:10.1001/jama.2015.6831

This Viewpoint discusses a framework for improving patient care and public sexual health.

Fusing Randomized Trials With Big Data: The Key to Self-learning Health Care Systems?

Derek C. Angus, MD, MPH

Abstract Full Text

JAMA. 2015;314(8):767-768. doi:10.1001/jama.2015.7762

This Viewpoint proposes ways that electronic health records and other 鈥渂ig data鈥� can be integrated with randomized trial designs to leverage the strengths of both for research inferences.

Quality Indicators for Physical and Behavioral Health Care Integration

Matthew L. Goldman, MD, MS; Brigitta Spaeth-Rublee, MA; Harold Alan Pincus, MD

Abstract Full Text

JAMA. 2015;314(8):769-770. doi:10.1001/jama.2015.6447

This Viewpoint discusses developing quality metrics in behavioral and general health care to encourage more cost-effective care and improve the status quo.

Middle East Respiratory Syndrome: A Global Health Challenge

Lawrence O. Gostin, JD; Daniel Lucey, MD, MPH

Abstract Full Text

free access

JAMA. 2015;314(8):771-772. doi:10.1001/jama.2015.7646

This Viewpoint discusses the importance of a well-trained and well-prepared health workforce in controlling outbreaks such as Middle East respiratory syndrome.

A Piece of My Mind

The 鈥淕ood Person鈥� Sign

Timothy M. Dempsey, MD, MPH

Abstract Full Text

JAMA. 2015;314(8):773. doi:10.1001/jama.2015.4890

Editorial

Lifestyles and Cognitive Health: What Older Individuals Can Do to Optimize Cognitive Outcomes

Sudeep S. Gill, MD, MSc; Dallas P. Seitz, MD, PhD

Abstract Full Text

JAMA. 2015;314(8):774-775. doi:10.1001/jama.2015.9526

Pediatric Pulseless Arrest With 鈥淣onshockable鈥� Rhythm: Does Faster Time to Epinephrine Improve Outcome?

Robert C. Tasker, MBBS, MD; Adrienne G. Randolph, MD, MSc

Abstract Full Text

JAMA. 2015;314(8):776-777. doi:10.1001/jama.2015.9527

Next-Generation Sequencing and Detection of Minimal Residual Disease in Acute Myeloid Leukemia: Ready for Clinical Practice?

Friederike Pastore, MD; Ross L. Levine, MD

Abstract Full Text

JAMA. 2015;314(8):778-780. doi:10.1001/jama.2015.9452

From the 糖心vlog

Engaging Primary Care Clinicians in Early Obesity Prevention Research

Myles S. Faith, PhD; Nicolas Stettler, MD, MSCE; Angelo Pietrobelli, MD

Abstract Full Text

JAMA. 2015;314(8):823-824. doi:10.1001/jama.2015.6262

This commentary describes a report published in JAMA Pediatrics summarizing a National Institutes of Health workshop about primary care clinician involvement in preventing early childhood obesity.

JAMA Clinical Guidelines Synopsis

Prostate Cancer Screening

Scott E. Eggener, MD; Adam S. Cifu, MD; Chadi Nabhan, MD

Abstract Full Text

JAMA. 2015;314(8):825-826. doi:10.1001/jama.2015.8033

This JAMA Clinical Guidelines Synopsis summarizes the US Preventive Services Task Force鈥檚 (2012) and American Urological Association鈥檚 (2013) clinical practice guidelines for prostate cancer screening.

JAMA Diagnostic Test Interpretation

Clinical Significance of a Positive Antinuclear Antibody Test

Gita Fatemi, MD; Tanaz A. Kermani, MD, MS

Abstract Full Text

JAMA. 2015;314(8):827-828. doi:10.1001/jama.2015.7649

A 30-year-old woman with polyarthralgias responsive to celecoxib has an ANA titer of 1:80. How do you interpret this test result?

Medical News & Perspectives

Questions of Safety and Fairness Raised as Right-to-Try Movement Gains Steam

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2015;314(8):758-760. doi:10.1001/jama.2015.7691

This Medical News and Perspectives article discusses issues surrounding Right-to-Try laws that allow patients with terminal illness to petition for access to investigational drugs and therapies.

News From the Centers for Disease Control and Prevention