January 27, 2015 Issue of JAMA

January 27, 2015, Vol 313, No. 4, Pages 329-432

This Week in JAMA

Highlights

Abstract Full Text

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JAMA. 2015;313(4):329-331. doi:10.1001/jama.2014.11539

Podcast: Chlorhexidine bathing in the ICU, protocolized sedation for children with respiratory failure, MRI for prostate biopsies, C difficile review, and more.

Original Investigation

Caring for the Critically Ill Patient

Chlorhexidine Bathing and Health Care鈥揂ssociated Infections: A Randomized Clinical Trial

Michael J. Noto, MD, PhD; Henry J. Domenico, MS; Daniel W. Byrne, MS; et al.

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JAMA. 2015;313(4):369-378. doi:10.1001/jama.2014.18400

A cluster-randomized crossover trial found that daily bathing of patients in intensive care units with chlorhexidine did not reduce the incidence of health care鈥揳ssociated infections.

Editorial
Daily Chlorhexidine Bathing for Critically Ill Patients: A Note of Caution
Didier Pittet, MD, MS; Derek C. Angus, MD, MPH

JAMA

Caring for the Critically Ill Patient

Protocolized Sedation vs Usual Care in Pediatric Patients Mechanically Ventilated for Acute Respiratory Failure: A Randomized Clinical Trial

Martha A. Q. Curley, RN, PhD; David Wypij, PhD; R. Scott Watson, MD, MPH; et al.

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JAMA. 2015;313(4):379-389. doi:10.1001/jama.2014.18399

This cluster randomized trial found that among children undergoing mechanical ventilation for acute respiratory failure, use of a nurse-implemented, goal-directed sedation protocol did not reduce the duration of mechanical ventilation compared with usual care.

Editorial
Protocolized Sedation in Critically Ill Children
Sangeeta Mehta, MD, FRCPC

JAMA

Comparison of MR/Ultrasound Fusion鈥揋uided Biopsy With Ultrasound-Guided Biopsy for the Diagnosis of Prostate Cancer

M. Minhaj Siddiqui, MD; Soroush Rais-Bahrami, MD; Baris Turkbey, MD; et al.

Abstract Full Text

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JAMA. 2015;313(4):390-397. doi:10.1001/jama.2014.17942

This cohort study reports that targeted magnetic resonance/ultrasound fusion biopsy, compared with standard extended-sextant ultrasound-guided biopsy, was associated with increased detection of high-risk prostate cancer and decreased detection of low-risk prostate cancer among men undergoing biopsy for suspected prostate cancer.

Podcast: MR/Ultrasound Fusion Biopsy for Prostate Cancer

Editorial
MR/Ultrasound Fusion鈥揋uided Biopsy in Prostate Cancer: What Is the Evidentiary Standard?
Lawrence H. Schwartz, MD; Ethan Basch, MD

JAMA

Research Letter

Moral Concerns and the Willingness to Donate to a Research Biobank

Tom Tomlinson, PhD; Raymond De Vries, PhD; Kerry Ryan, MA; et al.

Abstract Full Text

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JAMA. 2015;313(4):417-419. doi:10.1001/jama.2014.16363

Viewpoint

Scientific Discovery and the Future of Medicine

Digital Medical Tools and Sensors

Eric J. Topol, MD; Steven R. Steinhubl, MD; Ali Torkamani, PhD

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JAMA. 2015;313(4):353-354. doi:10.1001/jama.2014.17125

In this Viewpoint, Eric Topol and colleagues discuss the effect that mobile devices as biomedical sensors could have on health care.

Podcast: Digital Medical Tools and Sensors

Sharing and Reporting the Results of Clinical Trials

Kathy L. Hudson, PhD; Francis S. Collins, MD, PhD

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JAMA. 2015;313(4):355-356. doi:10.1001/jama.2014.10716

This Viewpoint advocates initiating greater transparency in reporting results of clinical trials as a responsibility that will benefit the health of many.

Focusing to Achieve a World Without AIDS

Anthony S. Fauci, MD; Hilary D. Marston, MD, MPH

Abstract Full Text

JAMA. 2015;313(4):357-358. doi:10.1001/jama.2014.17454

This Viewpoint discusses essential steps to attaining a world without AIDS.

Maximizing Antiretroviral Therapy in Developing Countries: The Dual Challenge of Efficiency and Quality

Christopher J. L. Murray, MD, DPhil

Abstract Full Text

JAMA. 2015;313(4):359-360. doi:10.1001/jama.2014.16376

This Viewpoint discusses the need for improvement in both efficiency and quality of antiretroviral therapy programs in developing countries.

A Piece of My Mind

What I Learned About Adverse Events From Captain Sully: It鈥檚 Not What You Think

Marjorie Podraza Stiegler, MD

Abstract Full Text

JAMA. 2015;313(4):361-362. doi:10.1001/jama.2014.16025

Editorial

Protocolized Sedation in Critically Ill Children

Sangeeta Mehta, MD, FRCPC

Abstract Full Text

JAMA. 2015;313(4):363-364. doi:10.1001/jama.2015.1

Daily Chlorhexidine Bathing for Critically Ill Patients: A Note of Caution

Didier Pittet, MD, MS; Derek C. Angus, MD, MPH

Abstract Full Text

JAMA. 2015;313(4):365-366. doi:10.1001/jama.2014.18482

MR/Ultrasound Fusion鈥揋uided Biopsy in Prostate Cancer: What Is the Evidentiary Standard?

Lawrence H. Schwartz, MD; Ethan Basch, MD

Abstract Full Text

JAMA. 2015;313(4):367-368. doi:10.1001/jama.2014.17943

Review

Diagnosis and Treatment of Clostridium difficile in Adults: A Systematic Review

Natasha Bagdasarian, MD, MPH; Krishna Rao, MD; Preeti N. Malani, MD, MSJ

Abstract Full Text

JAMA. 2015;313(4):398-408. doi:10.1001/jama.2014.17103

This systematic review summarizes the diagnostic approaches for Clostridium difficile infection and evaluates which therapeutic approaches should be used.

JAMA Guide to Statistics and Methods

Decision Curve Analysis

Mark Fitzgerald, PhD; Benjamin R. Saville, PhD; Roger J. Lewis, MD, PhD

Abstract Full Text

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JAMA. 2015;313(4):409-410. doi:10.1001/jama.2015.37

This Guide to Statistics and Methods describes how a decision curve analysis can be used to evaluate the benefits of a diagnostic test, such as 3 prostate biopsy strategies.

Podcast: JAMA Guide to Statistics and Methods

From the 糖心vlog

Nonleg Venous Thrombosis in Critically Ill Adults

Lana A. Castellucci, MD, FRCPC; Philip S. Wells, MD, FRCPC, MSc; Lisa Duffett, MD, FRCPC

Abstract Full Text

JAMA. 2015;313(4):411-412. doi:10.1001/jama.2014.12496

From The Medical Letter on Drugs and Therapeutics

Antiviral Drugs for Seasonal Influenza 2014-2015

Abstract Full Text

JAMA. 2015;313(4):413-414. doi:10.1001/jama.2014.18380

This article reviews the antiviral drugs available to treat influenza this season鈥攊ncluding oseltamivir and zanamivir鈥攁s well as their indications and possible adverse effects.

Medical News & Perspectives

Mary L. (Nora) Disis, MD: Ready to Become Editor in Chief of the New JAMA Oncology

Tracy Hampton, PhD

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JAMA. 2015;313(4):343-344. doi:10.1001/jama.2014.17361

The JAMA Forum

Hospital Consolidation Isn鈥檛 the Key to Lowering Costs and Raising Quality

Austin B. Frakt, PhD

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JAMA. 2015;313(4):345. doi:10.1001/jama.2014.17412

News From the Centers for Disease Control and Prevention

Upswing in Skin Cancer Costs

Abstract Full Text

JAMA. 2015;313(4):348. doi:10.1001/jama.2014.17596

Avoiding Diabetes Self-management

Abstract Full Text

JAMA. 2015;313(4):348. doi:10.1001/jama.2014.17597

Clinical Trials Update

Short Therapy Reduces Depression in Family Caregivers of Patients With Dementia

Anita Slomski, MA

Abstract Full Text

JAMA. 2015;313(4):347. doi:10.1001/jama.2014.17991

Hyperkalemia Controlled With 2 Novel Medications

Anita Slomski, MA

Abstract Full Text

JAMA. 2015;313(4):347. doi:10.1001/jama.2014.18441

Health Agencies Update

New Kidney Allocation System

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2015;313(4):346. doi:10.1001/jama.2014.17574

New Modeling Software Evaluates Coronary Artery Blood Flow

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2015;313(4):346. doi:10.1001/jama.2014.18424

Proposal Seeks to Enhance Availability of Clinical Trial Results

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2015;313(4):346. doi:10.1001/jama.2014.18426

The Art of JAMA

Man in Armour Holding a Pike: Jan van Bijlert

Jeanette M. Smith, MD

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JAMA. 2015;313(4):336-337. doi:10.1001/jama.2014.11541

Poetry and Medicine

Lou Gehrig鈥檚 Disease

Michael Collins

Abstract Full Text

JAMA. 2015;313(4):425. doi:10.1001/jama.2014.8628

JAMA Revisited

The Architecture of Viruses

Abstract Full Text

JAMA. 2015;313(4):426. doi:10.1001/jama.2014.11548

JAMA Patient Page

Babies With Low Birth Weight

Jill Jin, MD, MPH

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JAMA. 2015;313(4):432. doi:10.1001/jama.2014.3698

Comment & Response

Heterogeneity in Meta-analysis of FDG-PET Studies to Diagnose Lung Cancer

Edward J. Mills, PhD, MSc, MSt; Jeroen P. Jansen, PhD; Steve Kanters, MSc

Abstract Full Text

JAMA. 2015;313(4):419. doi:10.1001/jama.2014.16482

Heterogeneity in Meta-analysis of FDG-PET Studies to Diagnose Lung Cancer鈥擱eply

Jeffrey D. Blume, PhD; Stephen A. Deppen, PhD; Eric L. Grogan, MD, MPH

Abstract Full Text

JAMA. 2015;313(4):419-420. doi:10.1001/jama.2014.16485

Diagnosing Endocarditis in Patients With Staphylococcus aureus Bacteremia

Matthew Schoenfeld, MD; Raj Machhar, MD; Anna Maw, MD

Abstract Full Text

JAMA. 2015;313(4):420. doi:10.1001/jama.2014.16951

Diagnosing Endocarditis in Patients With Staphylococcus aureus 叠补肠迟别谤别尘颈补鈥搁别辫濒测

Thomas L. Holland, MD; Vance G. Fowler Jr, MD, MHS

Abstract Full Text

JAMA. 2015;313(4):420-421. doi:10.1001/jama.2014.16954

Ethical Testing of Experimental Ebola Treatments

Morenike Oluwatoyin Folayan, MBChD, MBA, FWACS; Bridget Haire, PhD; Kristin Peterson, PhD

Abstract Full Text

JAMA. 2015;313(4):421. doi:10.1001/jama.2014.17256

Ethical Testing of Experimental Ebola Treatments

Steve Kanters, MSc; Kristian Thorlund, PhD; Edward J. Mills, PhD

Abstract Full Text

JAMA. 2015;313(4):421-422. doi:10.1001/jama.2014.17259

Ethical Testing of Experimental Ebola Treatments鈥擱eply

Steven Joffe, MD, MPH

Abstract Full Text

JAMA. 2015;313(4):422. doi:10.1001/jama.2014.17262

Correction

Incorrect Footnote Order

Abstract Full Text

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JAMA. 2015;313(4):422. doi:10.1001/jama.2014.17542

Revised Wording

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JAMA. 2015;313(4):422. doi:10.1001/jama.2014.18190

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January 27, 2015, Vol 313, No. 4, Pages 329-432

Caring for the Critically Ill Patient

Caring for the Critically Ill Patient

Scientific Discovery and the Future of Medicine

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