April 21, 2015 Issue of JAMA

April 21, 2015, Vol 313, No. 15, Pages 1491-1584 | Child Health

This Week in JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2015;313(15):1491-1493. doi:10.1001/jama.2014.11693

Podcast: Child Health Theme Issue: Autism, diabetes prevention, gene therapy, and more.

Original Investigation

Effect of Parent Training vs Parent Education on Behavioral Problems in Children With Autism Spectrum Disorder: A Randomized Clinical Trial

Karen Bearss, PhD; Cynthia Johnson, PhD; Tristram Smith, PhD; et al.

Abstract Full Text

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JAMA. 2015;313(15):1524-1533. doi:10.1001/jama.2015.3150

This randomized trial reports that a 24-week parent training program was superior to parent education for reducing disruptive behavior among children with autism spectrum disorder.

Editorial
Promising Forecast for Autism Spectrum Disorders
Bryan H. King, MD, MBA

JAMA

Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism

Anjali Jain, MD; Jaclyn Marshall, MS; Ami Buikema, MPH; et al.

Abstract Full Text

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JAMA. 2015;313(15):1534-1540. doi:10.1001/jama.2015.3077

This observational cohort study reports no association between the MMR vaccine and autism spectrum disorder among US children with older siblings with autism.

Video: Autism Occurrence by MMR Vaccine Status Among US Children With Older Siblings With and Without Autism

Podcast: Autism Occurrence by MMR Vaccine Status Among US Children

Editorial
Promising Forecast for Autism Spectrum Disorders
Bryan H. King, MD, MBA

JAMA

Preliminary Communication

Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes: The Pre-POINT Randomized Clinical Trial

Ezio Bonifacio, PhD; Anette-G. Ziegler, MD; Georgeanna Klingensmith, MD; et al.

Abstract Full Text

free access has audio

JAMA. 2015;313(15):1541-1549. doi:10.1001/jama.2015.2928

This trial reports immune responses to insulin among children at risk for type 1 diabetes randomized to oral insulin vs placebo in an attempt to increase immune tolerance.

Podcast: Oral Insulin and Immune Responses in Children at Risk for Diabetes

Editorial
Toward Primary Prevention of Type 1 Diabetes
Jay S. Skyler, MD

JAMA

Outcomes Following Gene Therapy in Patients With Severe Wiskott-Aldrich Syndrome

Salima Hacein-Bey Abina, PharmD, PhD; H. Bobby Gaspar, MRCP, PhD; Johanna Blondeau, MS; et al.

Abstract Full Text

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JAMA. 2015;313(15):1550-1563. doi:10.1001/jama.2015.3253

This case series describes the clinical outcomes of 7 patients with severe Wiskott-Aldrich syndrome who were treated with gene-corrected autologous hematopoietic stem cell transplantation.

Editorial
An Emerging Era of Clinical Benefit From Gene Therapy
Harry L. Malech, MD; Hans D. Ochs, MD

JAMA

Research Letter

Incidence of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Colorado Youth, 1998-2012

Arleta Rewers, MD, PhD; Fran Dong, MS; Robert H. Slover, MD; et al.

Abstract Full Text

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JAMA. 2015;313(15):1570-1572. doi:10.1001/jama.2015.1414

Viewpoint

Improving Lifetime Health by Promoting Behavioral Health in Children

Thomas F. Boat, MD

Abstract Full Text

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JAMA. 2015;313(15):1509-1510. doi:10.1001/jama.2015.2977

This Viewpoint discusses the way that integration of behavioral health and care into early childhood primary care might improve general health outcomes for children.

Podcast: Improving Lifetime Health by Promoting Behavioral Health in Children

Newborn Screening: Evolving Challenges in an Era of Rapid Discovery

Donald B. Bailey Jr, PhD; Lisa Gehtland, MD

Abstract Full Text

JAMA. 2015;313(15):1511-1512. doi:10.1001/jama.2014.17488

This Viewpoint describes the current process by which illnesses are considered for newborn screening, and the technological and other processes that may force changes to the process.

Infant HIV-1 Vaccines: Supplementing Strategies to Reduce Maternal-Child Transmission

Genevieve G. Fouda, MD, PhD; Coleen K. Cunningham, MD; Sallie R. Permar, MD, PhD

Abstract Full Text

JAMA. 2015;313(15):1513-1514. doi:10.1001/jama.2015.1382

This Viewpoint proposes that development of an infant human immunodeficiency virus (HIV) type 1 vaccine is equally important as adult HIV-1 vaccine development to reduce maternal-child HIV transmission.

Neurotoxicity of Generic Anesthesia Agents in Infants and Children: An Orphan Research Question in Search of a Sponsor

Bruce M. Psaty, MD, PhD; Richard Platt, MD, MS; Russ B. Altman, MD, PhD

Abstract Full Text

JAMA. 2015;313(15):1515-1516. doi:10.1001/jama.2015.1149

This Viewpoint argues that more studies and trials are needed to address questions about the optimal dose, duration, and frequency of use of anesthetic agents and vulnerable periods of exposure in young children.

A Piece of My Mind

Addie鈥檚 Hope

Julie M. Cornfield

Abstract Full Text

JAMA. 2015;313(15):1517. doi:10.1001/jama.2014.7871

Editorial

Promising Forecast for Autism Spectrum Disorders

Bryan H. King, MD, MBA

Abstract Full Text

free access

JAMA. 2015;313(15):1518-1519. doi:10.1001/jama.2015.2628

This Editorial discusses recent studies of factors that contribute to autism risk and of information provided to families affected by autism.

Toward Primary Prevention of Type 1 Diabetes

Jay S. Skyler, MD

Abstract Full Text

JAMA. 2015;313(15):1520-1521. doi:10.1001/jama.2015.2054

This Editorial discusses the need for interventions for primary prevention of type 1 diabetes in children at genetically high risk.

An Emerging Era of Clinical Benefit From Gene Therapy

Harry L. Malech, MD; Hans D. Ochs, MD

Abstract Full Text

JAMA. 2015;313(15):1522-1523. doi:10.1001/jama.2015.2055

From the 糖心vlog

Fostering Early Brain Development

W. Thomas Boyce, MD

Abstract Full Text

JAMA. 2015;313(15):1564-1565. doi:10.1001/jama.2015.34

JAMA Clinical Challenge

An Adolescent With Right Shin Pain

Benjamin J. Davis, BS; A. Reed Estes, MD

Abstract Full Text

JAMA. 2015;313(15):1566-1567. doi:10.1001/jama.2014.17016

From The Medical Letter on Drugs and Therapeutics

MiniMed 530G: An Insulin Pump With Low-Glucose Suspend Automation

Abstract Full Text

JAMA. 2015;313(15):1568. doi:10.1001/jama.2015.2917

This Medical Letter review summarizes a sensor-augmented insulin pump that automatically stops delivery of insulin based on interstitial glucose levels in patients with type 1 diabetes.

Medical News & Perspectives