December 15, 2015 Issue of JAMA

December 15, 2015, Vol 314, No. 23, Pages 2469-2580

This Week in JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2015;314(23):2469-2471. doi:10.1001/jama.2014.12145

Podcast: RBC storage duration, stem cell transplantation for Crohn disease, management of Graves disease, and more.

Original Investigation

Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia: The TOTAL Randomized Clinical Trial

Aggrey Dhabangi, MD; Brenda Ainomugisha, MD; Christine Cserti-Gazdewich, MD; et al.

Abstract Full Text

free access

JAMA. 2015;314(23):2514-2523. doi:10.1001/jama.2015.13977

This randomized trial determines if longer-storage RBCs are inferior to shorter-storage RBCs for tissue oxygenation as measured by reduction in blood lactate levels and cerebral tissue oxygen saturation among children with severe anemia.

Editorial
Storage Duration and Other Measures of Quality of Red Blood Cells for Transfusion
Philip C. Spinella, MD, FCCM; Jason Acker, MBA, PhD

JAMA

Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial

Christopher J. Hawkey, FMedSci; Matthieu Allez, PhD; Miranda M. Clark, BSc(Hons); et al.

Abstract Full Text

free access

JAMA. 2015;314(23):2524-2534. doi:10.1001/jama.2015.16700

This randomized clinical trial evaluates the effect of autologous hematopoietic stem cell transplantation on sustained disease remission among patients with refractory Crohn disease.

Preliminary Communication

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial

Roger Stupp, MD; Sophie Taillibert, MD; Andrew A. Kanner, MD; et al.

Abstract Full Text

free access has multimedia has audio

JAMA. 2015;314(23):2535-2543. doi:10.1001/jama.2015.16669

This randomized trial evaluates the safety and effectiveness of adding treatment with tumor-treating fields to maintenance temozolomide in patients with glioblastoma after chemoradiation.

Video: TTFields Plus Temozolomide vs Temozolomide on Glioblastoma

Podcast: Maintenance Therapy After Chemoradiation in Patients With Glioblastoma

Editorial
Alternating Electric Fields for the Treatment of Glioblastoma
John H. Sampson, MD, PhD, MHSc, MBA

JAMA
- Podcast: Alternating Electric Fields for the Treatment of Glioblastoma

Research Letter

Trends in National Institutes of Health Funding for Clinical Trials Registered in ClinicalTrials.gov

Stephan Ehrhardt, MD, MPH; Lawrence J. Appel, MD, MPH; Curtis L. Meinert, PhD

Abstract Full Text

free access

JAMA. 2015;314(23):2566-2567. doi:10.1001/jama.2015.12206

This study characterizes trends in the total number of clinical trials and in the proportion of trials funded by the National Institutes of Health and registered at ClinicalTrials.gov between 2006 and 2014.

Viewpoint

Engaging Patients Across the Spectrum of Medical Product Development: View From the US Food and Drug Administration

Nina L. Hunter, PhD; Kathryn M. O鈥機allaghan, BSE; Robert M. Califf, MD

Abstract Full Text

JAMA. 2015;314(23):2499-2500. doi:10.1001/jama.2015.15818

This Viewpoint discusses the conceptual framework of the Precision Medicine Initiative that could lead to improved health by more effectively matching medical products to the needs and preferences of patients and care partners.

Measurement Is Essential for Improving Diagnosis and Reducing Diagnostic Error: A Report From the Institute of Medicine

Elizabeth A. McGlynn, PhD; Kathryn M. McDonald, MM; Christine K. Cassel, MD

Abstract Full Text

JAMA. 2015;314(23):2501-2502. doi:10.1001/jama.2015.13453

This Viewpoint discusses the newly released Institute of Medicine report about diagnostic error and the most effective strategies for improving the diagnostic process.

Payer and Policy Maker Steps to Support Value-Based Pricing for Drugs

Peter B. Bach, MD; Steven D. Pearson, MD, MSc

Abstract Full Text

JAMA. 2015;314(23):2503-2504. doi:10.1001/jama.2015.16843

This Viewpoint proposes policy options for payers and the federal government to incentivize pharmaceutical manufacturers to adopt value-based pricing of prescription drugs commensurate with the value they bring to patients.

Choosing a Health Insurance Plan: Complexity and Consequences

Saurabh Bhargava, PhD; George Loewenstein, PhD

Abstract Full Text

JAMA. 2015;314(23):2505-2506. doi:10.1001/jama.2015.15176

This Viewpoint discusses the challenges facing consumers in choosing a health insurance plan and proposes approaches that might facilitate or simplify the process.

A Piece of My Mind

From Shame to Guilt to Love

Peter J. Pronovost, MD, PhD; O. Joseph Bienvenu, MD, PhD

Abstract Full Text

JAMA. 2015;314(23):2507-2508. doi:10.1001/jama.2015.11521

Editorial

Storage Duration and Other Measures of Quality of Red Blood Cells for Transfusion

Philip C. Spinella, MD, FCCM; Jason Acker, MBA, PhD

Abstract Full Text

JAMA. 2015;314(23):2509-2510. doi:10.1001/jama.2015.14714

Alternating Electric Fields for the Treatment of Glioblastoma

John H. Sampson, MD, PhD, MHSc, MBA

Abstract Full Text

has audio

JAMA. 2015;314(23):2511-2513. doi:10.1001/jama.2015.16701

Podcast: Alternating Electric Fields for the Treatment of Glioblastoma

Review

Management of Graves Disease: A Review

Henry B. Burch, MD; David S. Cooper, MD

Abstract Full Text

has audio

JAMA. 2015;314(23):2544-2554. doi:10.1001/jama.2015.16535

This review summarizes use of antithyroid drugs, radioactive iodine, or thyroidectomy in treating Graves disease.

Podcast: Graves Disease
Podcast: Diagnosis and Management of Graves Disease

JAMA Clinical Challenge

What Does This Retina Examination Show?

Wenyu Huang, MD, PhD; Rukhsana G. Mirza, MD; Mark E. Molitch, MD

Abstract Full Text

JAMA. 2015;314(23):2555-2556. doi:10.1001/jama.2015.9162

A 50-year-old man reported experiencing blurry vision for 5 months. He has a BMI of 30.6 and blood pressure of 160/102 mm Hg. Dilated retinal examination showed arteriolar narrowing, microaneurysms, intraretinal hemorrhaging, and cotton-wool spots. What would you do next?

JAMA Diagnostic Test Interpretation

Hormonal Evaluation of Hyperandrogenism in Women

Susan Sam, MD, MSc; David A. Ehrmann, MD

Abstract Full Text

JAMA. 2015;314(23):2557-2558. doi:10.1001/jama.2015.11612

A 19-year-old woman who has had fewer than 6 menstrual cycles per year since menarche and normal luteinizing hormone-to-follicle-stimulating hormone ratio is tested for polycystic ovary syndrome and referred by her gynecologist to an endocrinologist for further testing. How do you interpret these test results?

Medical News & Perspectives

The Brain Fights Back: New Approaches to Mitigating Cognitive Decline

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2015;314(23):2492-2494. doi:10.1001/jama.2015.15390

This Medical News and Perspectives article explores the biological mechanisms underlying brain resilience that could help inform therapeutic strategies to mitigate cognitive decline.

News From the Food and Drug Administration