October 20, 2015 Issue of JAMA

October 20, 2015, Vol 314, No. 15, Pages 1539-1658

This Week in JAMA

Highlights

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JAMA. 2015;314(15):1539-1541. doi:10.1001/jama.2014.12033

Podcast: The American Cancer Society's 2015 Breast Cancer Screening guideline update, flexeril vs percocet for low back pain in the ED, safety of Tdap vaccination in pregnant women, and more.

Original Investigation

Naproxen With Cyclobenzaprine, Oxycodone/Acetaminophen, or Placebo for Treating Acute Low Back Pain: A Randomized Clinical Trial

Benjamin W. Friedman, MD, MS; Andrew A. Dym, BS; Michelle Davitt, MD; et al.

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JAMA. 2015;314(15):1572-1580. doi:10.1001/jama.2015.13043

This randomized trial compared improvement in functional outcomes among patients with low back pain discharged from the emergency department and receiving naproxen with either placebo, cyclobenzaprine, or oxycodone/acetaminophen.

Association of Tdap Vaccination With Acute Events and Adverse Birth Outcomes Among Pregnant Women With Prior Tetanus-Containing Immunizations

Lakshmi Sukumaran, MD, MPH; Natalie L. McCarthy, MPH; Elyse O. Kharbanda, MD, MPH; et al.

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JAMA. 2015;314(15):1581-1587. doi:10.1001/jama.2015.12790

This cohort study of women given Tdap vaccine during pregnancy evaluates associations between time since prior tetanus-containing vaccinations and acute adverse events in mothers and adverse birth outcomes.

Association Between Preeclampsia and Congenital Heart Defects

Nathalie Auger, MD, MSc, FRCPC; William D. Fraser, MD, MSc, FRCSC; Jessica Healy-Profitós, MPH; et al.

Abstract Full Text

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JAMA. 2015;314(15):1588-1598. doi:10.1001/jama.2015.12505

This population study used Quebec hospital data to assess the association between preeclampsia and critical and noncritical heart defects in offspring.

Research Letter

Red Blood Cell Concentrate Storage and Survival After Cardiac Surgery

Ulrik Sartipy, MD, PhD; Martin J. Holzmann, MD, PhD; Henrik Hjalgrim, MD, DrMedSci; et al.

Abstract Full Text

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JAMA. 2015;314(15):1641-1643. doi:10.1001/jama.2015.8690

This cohort study uses Swedish national registry data to investigate the association between duration of storage of transfused red blood cells and mortality among patients undergoing cardiac surgery.

Special Communication

Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society

Kevin C. Oeffinger, MD; Elizabeth T. H. Fontham, MPH, DrPH; Ruth Etzioni, PhD; et al.

Abstract Full Text

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JAMA. 2015;314(15):1599-1614. doi:10.1001/jama.2015.12783

This guideline updates the American Cancer Society breast cancer screening recommendations for women at average risk for breast cancer.

Video: 2015 Breast Cancer Screening Recommendations for Women at Average Risk

Podcast: 2015 Breast Cancer Screening Recommendations for Women at Average Risk
Podcast: Breast Cancer Screening Guidelines
Podcast: Testing for Breast Cancer Susceptibility Genes

Editorial
New Guidelines for Breast Cancer Screening in US Women
Nancy L. Keating, MD, MPH; Lydia E. Pace, MD, MPH

JAMA
- Podcast: Breast Cancer Screening Guidelines

Viewpoint

Red Blood Cell Transfusion: Precision vs Imprecision Medicine

Harvey G. Klein, MD; Willy A. Flegel, MD; Charles Natanson, MD

Abstract Full Text

JAMA. 2015;314(15):1557-1558. doi:10.1001/jama.2015.10890

This Viewpoint discusses how new technologies could be developed and applied to the decision to transfuse.

Modernizing Medicaid Managed Care: Can States Meet the Data Challenges?

Philip Rocco, PhD; Walid F. Gellad, MD, MPH; Julie M. Donohue, PhD

Abstract Full Text

JAMA. 2015;314(15):1559-1560. doi:10.1001/jama.2015.10979

This Viewpoint discusses CMS鈥� proposed overhaul of Medicaid鈥檚 managed care programs.

Pilot Studies: A Critical but Potentially Misused Component of Interventional Research

Caroline Kistin, MD, MSc; Michael Silverstein, MD, MPH

Abstract Full Text

JAMA. 2015;314(15):1561-1562. doi:10.1001/jama.2015.10962

This Viewpoint discusses the goals of pilot studies as precursors to large-scale trials as well as the need for formal guidelines for the conduct and reporting of pilot trials.

The Trans-Pacific Partnership Agreement and Implications for Access to Essential Medicines

Jing Luo, MD; Aaron S. Kesselheim, MD, JD, MPH

Abstract Full Text

JAMA. 2015;314(15):1563-1564. doi:10.1001/jama.2015.10872

This Viewpoint discusses the importance of patent protection and its role in the Trans-Pacific Partnership (TPP) Agreement.

The Next Era of Palliative Care

Yael Schenker, MD, MAS; Robert Arnold, MD

Abstract Full Text

JAMA. 2015;314(15):1565-1566. doi:10.1001/jama.2015.11217

This Viewpoint urges the development of systems to help patients with serious illness and their families understand palliative care options.

A Piece of My Mind

When Accommodation Gets Complicated

Nicole M. Glenn, PhD; Marianne Clark, PhD

Abstract Full Text

JAMA. 2015;314(15):1567-1568. doi:10.1001/jama.2015.5978

Editorial

New Guidelines for Breast Cancer Screening in US Women

Nancy L. Keating, MD, MPH; Lydia E. Pace, MD, MPH

Abstract Full Text

has audio

JAMA. 2015;314(15):1569-1571. doi:10.1001/jama.2015.13086

Podcast: Breast Cancer Screening Guidelines

Review

Benefits and Harms of Breast Cancer Screening: A Systematic Review

Evan R. Myers, MD, MPH; Patricia Moorman, PhD; Jennifer M. Gierisch, PhD, MPH; et al.

Abstract Full Text

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JAMA. 2015;314(15):1615-1634. doi:10.1001/jama.2015.13183

This systematic review reports that among US women at average risk for breast cancer, mammographic screening is associated with reduction in breast cancer mortality, but the magnitude of the benefits and harms of different screening strategies remains uncertain.

Podcast: Breast Cancer Screening Guidelines

Editorial
New Guidelines for Breast Cancer Screening in US Women
Nancy L. Keating, MD, MPH; Lydia E. Pace, MD, MPH

JAMA
- Podcast: Breast Cancer Screening Guidelines

JAMA Guide to Statistics and Methods

The Propensity Score

Jason S. Haukoos, MD, MSc; Roger J. Lewis, MD, PhD

Abstract Full Text

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JAMA. 2015;314(15):1637-1638. doi:10.1001/jama.2015.13480

This JAMA Guide to Statistics and Methods article discusses the use of propensity scores as a way to reduce bias in estimates of treatment effect when randomized trials are not feasible.

Podcast: JAMA Guide to Statistics and Methods

From the 糖心vlog

Optimizing Mammography Screening Intervals

Min Yi, MD, PhD; Kelly K. Hunt, MD

Abstract Full Text

JAMA. 2015;314(15):1635-1636. doi:10.1001/jama.2015.13149

This commentary discusses a cohort study by the Breast Cancer Surveillance Consortium published in JAMA Oncology reporting an association between longer mammography screening intervals and unfavorable prognostic characteristics

Medical News & Perspectives

Another Frontier in Microbiome Research: Preterm Birth

Julie A. Jacob, MA

Abstract Full Text

JAMA. 2015;314(15):1550-1551. doi:10.1001/jama.2015.11563

This Medical News & Perspectives article takes a look at a recent study that found an association between a Lactobacillus-poor vaginal microbiome and the risk of preterm birth.

News From the Food and Drug Administration