October 27, 2015 Issue of JAMA

October 27, 2015, Vol 314, No. 16, Pages 1669-1768

This Week in JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2015;314(16):1669-1671. doi:10.1001/jama.2014.12047

Podcast: Tiotropium vs LABAs for asthma, comparison of IV fluids and noninvasive ventilation in the ICU, trends in US mortality, and more.

Original Investigation

Caring for the Critically Ill Patient

Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial

Paul Young, FCICM; Michael Bailey, PhD; Richard Beasley, DSc; et al.

Abstract Full Text

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JAMA. 2015;314(16):1701-1710. doi:10.1001/jama.2015.12334

This randomized trial determines the effect of a buffered crystalloid compared with saline on renal complications among patients in the intensive care unit.

Editorial
Assessing Toxicity of Intravenous Crystalloids in Critically Ill Patients
John A. Kellum, MD; Andrew D. Shaw, MB, FRCA

JAMA

Caring for the Critically Ill Patient

Effect of Noninvasive Ventilation vs Oxygen Therapy on Mortality Among Immunocompromised Patients With Acute Respiratory Failure: A Randomized Clinical Trial

Virginie Lemiale, MD; Djamel Mokart, MD; Matthieu Resche-Rigon, MD, PhD; et al.

Abstract Full Text

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JAMA. 2015;314(16):1711-1719. doi:10.1001/jama.2015.12402

This randomized trial compares the effects of noninvasive ventilation vs oxygen alone on 28-day mortality among immunocompromised patients with acute hypoxemic respiratory failure.

Editorial
The Changing Landscape of Noninvasive Ventilation in the Intensive Care Unit
Bhakti K. Patel, MD; John P. Kress, MD

JAMA

Anticholinergic vs Long-Acting 尾-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial

Michael E. Wechsler, MD, MSc; Barbara P. Yawn, MD, MSc; Anne L. Fuhlbrigge, MD, MS; et al.

Abstract Full Text

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JAMA. 2015;314(16):1720-1730. doi:10.1001/jama.2015.13277

This randomized trial compares the effectiveness and safety of tiotropium vs long-acting 尾-agonists among black adults with asthma using inhaled corticosteroids, and determines whether polymorphisms at a locus of the 尾₂-adrenergic receptor gene affect treatment response.

Temporal Trends in Mortality in the United States, 1969-2013

Jiemin Ma, PhD, MHS; Elizabeth M. Ward, PhD; Rebecca L. Siegel, MPH; et al.

Abstract Full Text

free access has multimedia has audio

JAMA. 2015;314(16):1731-1739. doi:10.1001/jama.2015.12319

This population epidemiology study uses US National Vital Statistics System data to characterize trends in all-cause and cause-specific mortality between 1969-2013.

Podcast: Trends in US Mortality, 1969-2013
Podcast: Explaining the Improved Health of the US: Mortality Trends 1969-2013

Editorial
Mortality Trends and Signs of Health Progress in the United States: Improving Understanding and Action
J. Michael McGinnis, MD, MPP

JAMA
- Podcast: Explaining the Improved Health of the US: Mortality Trends 1969-2013

Research Letter

Adequacy of Outpatient Specialty Care Access in Marketplace Plans Under the Affordable Care Act

Stephen C. Dorner, MSc; Douglas B. Jacobs, ScB; Benjamin D. Sommers, MD, PhD

Abstract Full Text

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JAMA. 2015;314(16):1749-1750. doi:10.1001/jama.2015.9375

This study examines access to specialists in US physician networks participating in the Affordable Care Act鈥檚 insurance marketplaces in 2015.

Viewpoint

Experience With the Priority Review Voucher Program for Drug Development

Aaron S. Kesselheim, MD, JD, MPH; Lara R. Maggs, MBioethics; Ameet Sarpatwari, JD, PhD

Abstract Full Text

JAMA. 2015;314(16):1687-1688. doi:10.1001/jama.2015.11845

This Viewpoint assesses the US Food and Drug Administration鈥檚 priority review voucher program to encourage development of drugs to treat neglected tropical diseases or rare pediatric disease and recommends improvements to the program.

Time for a More Unified Approach to Pediatric Health Care Policy?The Case of Congenital Heart Care

Sara K. Pasquali, MD, MHS; Justin B. Dimick, MD, MPH; Richard G. Ohye, MD

Abstract Full Text

JAMA. 2015;314(16):1689-1690. doi:10.1001/jama.2015.10166

This Viewpoint argues for regionalization of care and accompanying payment reform to improve quality and reduce the costs of caring for children with complex health care needs.

Bridging Unmet Medical Device Ecosystem Needs With Strategically Coordinated Registries Networks

Mitchell W. Krucoff, MD; Art Sedrakyan, MD, PhD; Sharon-Lise T. Normand, PhD

Abstract Full Text

JAMA. 2015;314(16):1691-1692. doi:10.1001/jama.2015.11036

This Viewpoint proposes implementation of strategic coordinated registries networks as the foundation for a national surveillance system that inform decisions about medical device safety, effectiveness, and quality.

A Piece of My Mind

A Piece of My Mind鈥擜ctually

Herbert M. Adler, MD, PhD

Abstract Full Text

JAMA. 2015;314(16):1693-1694. doi:10.1001/jama.2015.8429

Editorial

Assessing Toxicity of Intravenous Crystalloids in Critically Ill Patients

John A. Kellum, MD; Andrew D. Shaw, MB, FRCA

Abstract Full Text

free access

JAMA. 2015;314(16):1695-1697. doi:10.1001/jama.2015.12390

The Changing Landscape of Noninvasive Ventilation in the Intensive Care Unit

Bhakti K. Patel, MD; John P. Kress, MD

Abstract Full Text

free access

JAMA. 2015;314(16):1697-1699. doi:10.1001/jama.2015.12401

Mortality Trends and Signs of Health Progress in the United States: Improving Understanding and Action

J. Michael McGinnis, MD, MPP

Abstract Full Text

has audio

JAMA. 2015;314(16):1699-1700. doi:10.1001/jama.2015.12391

Podcast: Explaining the Improved Health of the US: Mortality Trends 1969-2013

JAMA Clinical Challenge

Widespread Scaly Eruption in a Patient With Multiple Comorbidities

Elizabeth K. Jones, MD; Nina Mingioni, MD; Jason B. Lee, MD

Abstract Full Text

JAMA. 2015;314(16):1740-1741. doi:10.1001/jama.2015.9391

A 73-year-old woman presented with a widespread scaly pruritic rash lasting 2 months. She had an antinuclear antibody titer of 1:80, elevated SS-A antibodies, a creatinine level of 1.8 mg/dL, and an inflammatory pattern on skin biopsy. What would you do next?

JAMA Diagnostic Test Interpretation

Hyperprolactinemia

Nicholas A. Tritos, MD, DSc; Anne Klibanski, MD

Abstract Full Text

JAMA. 2015;314(16):1742-1743. doi:10.1001/jama.2015.7871

A 47-year-old man presents with bitemporal visual field defects, low libido, and an elevated prolactin level. How do you interpret the test results?

From The Medical Letter on Drugs and Therapeutics

Abuse-Deterrent Opioid Formulations

Abstract Full Text

JAMA. 2015;314(16):1744-1745. doi:10.1001/jama.2015.12869

This Medical Letter review summarizes several opioid formulations that claim to deter abuse.

Medical News & Perspectives

Working Late, Courting Stroke

Laura Buchholz

Abstract Full Text

JAMA. 2015;314(16):1679-1680. doi:10.1001/jama.2015.12245

This Medical News & Perspectives article describes the stroke risk associated with working too many hours and efforts to protect workers鈥� health as well as promote wellness.

The JAMA Forum