February 17, 2015 Issue of JAMA

February 17, 2015, Vol 313, No. 7, Pages 643-758

This Week in JAMA

Highlights

Abstract Full Text

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JAMA. 2015;313(7):643-645. doi:10.1001/jama.2014.11581

Podcast: Corticosteroids for pneumonia, varenicline for smoking cessation, eliglustat for splenomegaly in Gaucher disease, and more.

Original Investigation

Caring for the Critically Ill Patient

Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response: A Randomized Clinical Trial

Antoni Torres, MD, PhD; Oriol Sibila, MD, PhD; Miquel Ferrer, MD, PhD; et al.

Abstract Full Text

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JAMA. 2015;313(7):677-686. doi:10.1001/jama.2015.88

This randomized clinical trial reports that among patients with severe community-acquired pneumonia and high initial inflammatory response, the acute use of methylprednisolone compared with placebo decreased treatment failure.

Podcast: Corticosteroids for Severe Community-Acquired Pneumonia

Editorial
Corticosteroids for Severe Community-Acquired Pneumonia: Not for Everyone
Richard G. Wunderink, MD

JAMA

Effect of Varenicline on Smoking Cessation Through Smoking Reduction: A Randomized Clinical Trial

Jon O. Ebbert, MD, MSc; John R. Hughes, MD; Robert J. West, PhD; et al.

Abstract Full Text

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JAMA. 2015;313(7):687-694. doi:10.1001/jama.2015.280

Ebbert and coauthors determine efficacy and safety of varenicline among 1510 cigarette smokers for increasing smoking abstinence rates through smoking reduction.

Podcast: Varenicline for Smoking Cessation Through Smoking Reduction

Effect of Oral Eliglustat on Splenomegaly in Patients With Gaucher Disease Type 1: The ENGAGE Randomized Clinical Trial

Pramod K. Mistry, MD, PhD, FRCP; Elena Lukina, MD; Hadhami Ben Turkia, MD; et al.

Abstract Full Text

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JAMA. 2015;313(7):695-706. doi:10.1001/jama.2015.459

This international randomized clinical trial found that among adults with Gaucher disease type 1, treatment with eliglustat for 9 months resulted in significant improvements in spleen volume, hemoglobin level, liver volume, and platelet count compared with placebo.

Association Between the Use of Fondaparinux vs Low-Molecular-Weight Heparin and Clinical Outcomes in Patients With Non鈥揝T-Segment Elevation Myocardial Infarction

Karolina Szummer, MD, PhD; Jonas Oldgren, MD, PhD; Lars Lindhagen, PhD; et al.

Abstract Full Text

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JAMA. 2015;313(7):707-716. doi:10.1001/jama.2015.517

This cohort study showed that in routine care, fondaparinux was associated with lower rates of death and major bleeding among Swedish patients with non鈥揝T-segment myocardial infarction.

Research Letter

Heart Rate and Body Temperature Responses to Extreme Heat and Humidity With and Without Electric Fans

Nicholas M. Ravanelli, BSc; Simon G. Hodder, PhD; George Havenith, PhD; et al.

Abstract Full Text

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JAMA. 2015;313(7):724-725. doi:10.1001/jama.2015.153

Viewpoint

Stealth Research: Is Biomedical Innovation Happening Outside the Peer-Reviewed Literature?

John P. A. Ioannidis, MD, DSc

Abstract Full Text

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JAMA. 2015;313(7):663-664. doi:10.1001/jama.2014.17662

This Viewpoint discusses the need for scientific transparency when biomedical innovation takes place outside of the peer-reviewed literature.

Podcast: Biomedical Innovation and Peer-Reviewed Literature

In Defense of the Employer Mandate: Hedging Against Uninsurance

John E. McDonough, DrPH, MPA; Eli Y. Adashi, MD, MS

Abstract Full Text

JAMA. 2015;313(7):665-666. doi:10.1001/jama.2014.17658

This Viewpoint traces the origins of the Affordable Care Act鈥檚 employer mandate provision, delineates its all-important rationale, and discusses the likelihood and consequences of its potential repeal.

FDA Regulation of Laboratory-Developed Diagnostic Tests: Protect the Public, Advance the Science

Joshua Sharfstein, MD

Abstract Full Text

JAMA. 2015;313(7):667-668. doi:10.1001/jama.2014.18135

This Viewpoint discusses the need for regulation meant to ensure the quality, safety, and validity of laboratory-developed diagnostic tests.

Genetic Testing and FDA Regulation: Overregulation Threatens the Emergence of Genomic Medicine

James P. Evans, MD, PhD; Michael S. Watson, PhD

Abstract Full Text

JAMA. 2015;313(7):669-670. doi:10.1001/jama.2014.18145

This Viewpoint discusses potential drawbacks of regulation meant to to ensure the quality, safety, and validity of laboratory-developed diagnostic tests.

A Piece of My Mind

The Other AMA

Daniel F. Chen, MD

Abstract Full Text

JAMA. 2015;313(7):671-672. doi:10.1001/jama.2014.13626

Editorial

Corticosteroids for Severe Community-Acquired Pneumonia: Not for Everyone

Richard G. Wunderink, MD

Abstract Full Text

JAMA. 2015;313(7):673-674. doi:10.1001/jama.2015.115

To JAMA Authors, Peer Reviewers, and Readers鈥擳hank You

Howard Bauchner, MD; Phil B. Fontanarosa, MD; Robert M. Golub, MD

Abstract Full Text

JAMA. 2015;313(7):675-676. doi:10.1001/jama.2015.0825

From the 糖心vlog

Starting a New Discussion About Screening for Lung Cancer

Russell P. Harris, MD, MPH

Abstract Full Text

JAMA. 2015;313(7):717-718. doi:10.1001/jama.2014.14769

JAMA Clinical Guidelines Synopsis

Use of Pneumococcal Vaccine in Adults

Jennifer Pisano, MD; Adam S. Cifu, MD

Abstract Full Text

JAMA. 2015;313(7):719-720. doi:10.1001/jama.2015.63

This JAMA Clinical Guidelines Synopsis article evaluates the most recent Advisory Committee for Immunization Practices guideline on use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged 65 years or older.

JAMA Clinical Challenge

Shortness of Breath After a Choking Incident

Mourad H. Senussi, MD; Hemantha Surath, MD; Eduardo Mireles-Cabodevila, MD

Abstract Full Text

JAMA. 2015;313(7):721-722. doi:10.1001/jama.2014.17182

Medical News & Perspectives

Researchers Look to MRI and Biomarkers to Help Improve Detection of Aggressive Prostate Cancers

Rita Rubin, MA

Abstract Full Text

JAMA. 2015;313(7):654-656. doi:10.1001/jama.2015.169

The JAMA Forum

Choosing Wisely: Changing Clinicians, Patients, or Policies?

Diana J. Mason, PhD, RN

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JAMA. 2015;313(7):657-658. doi:10.1001/jama.2014.17422

News From the Centers for Disease Control and Prevention

Sickle Cell Disease Screening Offers Educational Opportunity for Parents

Abstract Full Text

JAMA. 2015;313(7):660. doi:10.1001/jama.2015.237

Knowing HIV Status Crucial in Cancer Treatment

Abstract Full Text

JAMA. 2015;313(7):660. doi:10.1001/jama.2015.238

Global Health

Preventing Interpersonal Violence

M.J. Friedrich

Abstract Full Text

JAMA. 2015;313(7):659. doi:10.1001/jama.2015.0573

Neonatal HBV Vaccine Protects Against Liver Disease

M.J. Friedrich

Abstract Full Text

JAMA. 2015;313(7):659. doi:10.1001/jama.2015.0575

Closer to an Effective Ebola Vaccine

M.J. Friedrich

Abstract Full Text

JAMA. 2015;313(7):659. doi:10.1001/jama.2015.0577

African Genome Variation Project Will Facilitate Genetic Studies in Africa

M.J. Friedrich

Abstract Full Text

JAMA. 2015;313(7):659. doi:10.1001/jama.2015.170

The Art of JAMA

House and Street: Stuart Davis

Thomas B. Cole, MD, MPH

Abstract Full Text

JAMA. 2015;313(7):650-651. doi:10.1001/jama.2014.11583

Poetry and Medicine

Myeloma Solstice

Ronald Pies, MD

Abstract Full Text

JAMA. 2015;313(7):731. doi:10.1001/jama.2014.14208

JAMA Revisited

The Treatment of Asthma: Portion of a Lecture delivered in the Regular Course of 1888-89

N. S. Davis Jr, A.M., M.D.

Abstract Full Text

JAMA. 2015;313(7):733. doi:10.1001/jama.2014.11590

Peer Reviewers List

JAMA Peer Reviewers in 2014

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JAMA. 2015;313(7):736-752. doi:10.1001/jama.2015.268

Editorial
To JAMA Authors, Peer Reviewers, and Readers鈥擳hank You
Howard Bauchner, MD; Phil B. Fontanarosa, MD; Robert M. Golub, MD

JAMA

JAMA Patient Page

Pneumococcal Vaccination

Jill Jin, MD, MPH

Abstract Full Text

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JAMA. 2015;313(7):758. doi:10.1001/jama.2015.64

Comment & Response

Fecal Microbiota Transplantation for Clostridium difficile Infection

Matthew J. Armstrong, MRCP, PhD; Shrikanth Pathmakanthan, FRCP, PhD; Tariq H. Iqbal, FRCP, PhD

Abstract Full Text

JAMA. 2015;313(7):725-726. doi:10.1001/jama.2014.18617

Fecal Microbiota Transplantation for Clostridium difficile 滨苍蹿别肠迟颈辞苍鈥搁别辫濒测

Ilan Youngster, MD, MMSc; Elizabeth L. Hohmann, MD

Abstract Full Text

JAMA. 2015;313(7):726. doi:10.1001/jama.2014.18619

Adapting to Climate Change

Cunrui Huang, MD, PhD; Roger Street, MS; Cordia Chu, PhD

Abstract Full Text

JAMA. 2015;313(7):727. doi:10.1001/jama.2014.18502

Adapting to Climate Change鈥擱eply

Jonathan A. Patz, MD, MPH; Howard Frumkin, MD, DrPH; Andrew Haines, MBBS, MD

Abstract Full Text

JAMA. 2015;313(7):727-728. doi:10.1001/jama.2014.18525

Goals of Displaying Health Care Prices to Physicians

Eric K. Hoffer, MD

Abstract Full Text

JAMA. 2015;313(7):728. doi:10.1001/jama.2014.17445

Goals of Displaying Health Care Prices to Physicians鈥擱eply

Kevin R. Riggs, MD, MPH; Matthew DeCamp, MD, PhD

Abstract Full Text

JAMA. 2015;313(7):728-729. doi:10.1001/jama.2014.17451

Correction

Incorrect Wording and Figure Numbering

Abstract Full Text

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JAMA. 2015;313(7):729. doi:10.1001/jama.2014.18379

Incorrect Text

Abstract Full Text

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JAMA. 2015;313(7):729. doi:10.1001/jama.2015.200

Clarification of 2 Sentences

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JAMA. 2015;313(7):729. doi:10.1001/jama.2015.211

Editorial
Patient-Centered Medical Home for High-Risk Children With Chronic Illness
James M. Perrin, MD

JAMA

Corrected Data and Wording in Related Editorial

Abstract Full Text

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JAMA. 2015;313(7):729. doi:10.1001/jama.2015.221

Editorial
Race, Ethnicity, and the Diagnosis of Breast Cancer
Bobby Daly, MD, MBA; Olufunmilayo I. Olopade, MBBS, FACP

JAMA

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February 17, 2015, Vol 313, No. 7, Pages 643-758

Caring for the Critically Ill Patient

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