September 1, 2015 Issue of JAMA

September 1, 2015, Vol 314, No. 9, Pages 853-964

This Week in JAMA

Highlights

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JAMA. 2015;314(9):853-855. doi:10.1001/jama.2014.11949

Podcast: Aldosterone antagonism for diabetic nephropathy, genomic testing of children with autism and cancer, treatment of chronic sinusitis, and more.

Original Investigation

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial

George L. Bakris, MD; Rajiv Agarwal, MD; Juliana C. Chan, MD; et al.

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JAMA. 2015;314(9):884-894. doi:10.1001/jama.2015.10081

This randomized trial compares the safety and effects of finerenone, a nonsteroidal mineralocorticoid receptor antagonist, on albuminuria in patients with diabetic nephropathy already taking renin-angiotensin blockers.

Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder

Kristiina Tammimies, PhD; Christian R. Marshall, PhD; Susan Walker, PhD; et al.

Abstract Full Text

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JAMA. 2015;314(9):895-903. doi:10.1001/jama.2015.10078

This case series of children with autism spectrum disorder compares the diagnostic yield of chromosomal microarray analysis vs whole-exome sequencing.

Podcast: Molecular Diagnostic Tests in Children With Autism Spectrum Disorder

Editorial
Complex Autism Spectrum Disorders and Cutting-Edge Molecular Diagnostic Tests
Judith H. Miles, MD, PhD

JAMA

Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage

Alessandro Biffi, MD; Christopher D. Anderson, MD, MMSc; Thomas W. K. Battey, BS; et al.

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JAMA. 2015;314(9):904-912. doi:10.1001/jama.2015.10082

This cohort study reports that among patients with a first episode of intracranial hemorrhage (ICH), inadequate blood pressure control was associated with higher risk of recurrence of ICH.

Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth

Rajen J. Mody, MBBS, MS; Yi-Mi Wu, PhD; Robert J. Lonigro, MS; et al.

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JAMA. 2015;314(9):913-925. doi:10.1001/jama.2015.10080

This case series involving children and young adults with cancer whose genomic sequencing results were the basis for clinical case recommendations charaterizes the number of clinically actionable findings and resulting patient outcomes.

Editorial
Improving Patient Outcomes With Cancer Genomics: Unique Opportunities and Challenges in Pediatric Oncology
Robert W. Schnepp, MD, PhD; Kristopher R. Bosse, MD; John M. Maris, MD

JAMA

Research Letter

Bicycle Trauma Injuries and Hospital Admissions in the United States, 1998-2013

Thomas Sanford, MD; Charles E. McCulloch, PhD; Rachael A. Callcut; et al.

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JAMA. 2015;314(9):947-949. doi:10.1001/jama.2015.8295

This study uses National Electronic Injury Surveillance System data to describe trends in adult cycling injuries and related hospital admissions in the United States.

Viewpoint

Evaluation of Flibanserin: Science and Advocacy at the FDA

Walid F. Gellad, MD, MPH; Kathryn E. Flynn, PhD; G. Caleb Alexander, MD, MS

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JAMA. 2015;314(9):869-870. doi:10.1001/jama.2015.8405

This Viewpoint discusses the history of flibanserin and provides insight about the regulatory process.

Specialty Society Clinical Practice Guidelines: Time for Evolution or Revolution?

David C. Classen, MD, MS; Leonard A. Mermel, DO, ScM

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JAMA. 2015;314(9):871-872. doi:10.1001/jama.2015.7462

This Viewpoint discusses challenges of developing and implementing clinical practice guidelines.

Body-Fixed Sensors for Parkinson Disease

Anat Mirelman, PhD; Nir Giladi, MD; Jeffrey M. Hausdorff, PhD

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JAMA. 2015;314(9):873-874. doi:10.1001/jama.2015.8530

This Viewpoint discusses the use of body-fixed sensors to accurately track disease status and the effect of treatment in patients with Parkinson disease.

Learning From the Past to Measure the Future

Christine K. Cassel, MD; Richard Kronick, PhD

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JAMA. 2015;314(9):875-876. doi:10.1001/jama.2015.9186

This Viewpoint, from the current CEO of the National Quality Forum and the director of AHRQ, discusses the changes in health care quality measurement over the past 15 years and opportunities for future progress.

A Piece of My Mind

Beliefs

M. John Rowe III, MD

Abstract Full Text

JAMA. 2015;314(9):877-878. doi:10.1001/jama.2015.2146

Editorial

Complex Autism Spectrum Disorders and Cutting-Edge Molecular Diagnostic Tests

Judith H. Miles, MD, PhD

Abstract Full Text

JAMA. 2015;314(9):879-880. doi:10.1001/jama.2015.9577

Improving Patient Outcomes With Cancer Genomics: Unique Opportunities and Challenges in Pediatric Oncology

Robert W. Schnepp, MD, PhD; Kristopher R. Bosse, MD; John M. Maris, MD

Abstract Full Text

JAMA. 2015;314(9):881-883. doi:10.1001/jama.2015.9794

Review

Medical Therapies for Adult Chronic Sinusitis: A Systematic Review

Luke Rudmik, MD, MSc; Zachary M. Soler, MD, MSc

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JAMA. 2015;314(9):926-939. doi:10.1001/jama.2015.7544

This systematic review summarizes the evidence-based medical treatment of adult chronic sinusitis and propses a treatment algorithm.

Podcast: Treating Chronic Sinusitis in Adults

JAMA Guide to Statistics and Methods

Missing Data: How to Best Account for What Is Not Known

Craig D. Newgard, MD, MPH; Roger J. Lewis, MD, PhD

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JAMA. 2015;314(9):940-941. doi:10.1001/jama.2015.10516

This Guide to Statistics and Methods characterizes the strengths and limitations of different approaches for modeling missing data in clinical research using the example of a trial that applied several of these techniques.

Podcast: JAMA Guide to Statistics and Methods

JAMA Clinical Challenge

Diplopia and Ataxia in a Heavy Smoker

Yuanquan Yang, MD, PhD; Missak Haigentz Jr, MD; Mary Welch, MD

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JAMA. 2015;314(9):942-943. doi:10.1001/jama.2015.8617

A 64-year-old man with coronary artery disease and an 80 pack-year smoking habit presented with vertigo, diplopia, ataxia, cranial nerve palsy findings, and pulmonary nodules with mediastinal lymphadenopathy on CT. What would you do next?