September 22, 2015 Issue of JAMA

September 22/29, 2015, Vol 314, No. 12, Pages 1197-1312

This Week in JAMA

Highlights

Abstract Full Text

free access has audio

JAMA. 2015;314(12):1197-1199. doi:10.1001/jama.2014.11991

Podcast: Treatment of agitation in Alzheimer disease, text messaging for CV risk modification, a newly approved PCSK9 inhibitor for dyslipidemia, and more.

Original Investigation

Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial

Jeffrey L. Cummings, MD, ScD; Constantine G. Lyketsos, MD, MHS; Elaine R. Peskind, MD; et al.

Abstract Full Text

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JAMA. 2015;314(12):1242-1254. doi:10.1001/jama.2015.10214

This randomized trial assessed the efficacy and safety of combination dextromethorphan-quinidine to manage agitation among patients with probable Alzheimer disease.

Podcast: Dextromethorphan-Quinidine for Agitation in Patients With Alzheimer Disease

Editorial
Dextromethorphan and Quinidine for Treating Agitation in Patients With Alzheimer Disease Dementia
Clive Ballard, MD; Samantha Sharp, BSc; Anne Corbett, PhD

JAMA

Effect of Lifestyle-Focused Text Messaging on Risk Factor Modification in Patients With Coronary Heart Disease: A Randomized Clinical Trial

Clara K. Chow, MBBS, PhD; Julie Redfern, PhD; Graham S. Hillis, MBChB, PhD; et al.

Abstract Full Text

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JAMA. 2015;314(12):1255-1263. doi:10.1001/jama.2015.10945

This randomized trial reports that among men with coronary heart disease, use of a lifestyle-focused text messaging service vs usual care resulted in modest improvement in low-density lipoprotein cholesterol levels and greater improvement in other cardiovascular disease risk factors.

Editorial
Can Mobile Health Applications Facilitate Meaningful Behavior Change?Time for Answers
Zubin J. Eapen, MD, MHS; Eric D. Peterson, MD, MPH

JAMA

Caring for the Critically Ill Patient

Alignment of Do-Not-Resuscitate Status With Patients鈥� Likelihood of Favorable Neurological Survival After In-Hospital Cardiac Arrest

Timothy J. Fendler, MD, MS; John A. Spertus, MD, MPH; Kevin F. Kennedy, MS; et al.

Abstract Full Text

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JAMA. 2015;314(12):1264-1271. doi:10.1001/jama.2015.11069

This study of patients successfully resuscitated after an inpatient cardiac arrest assessed whether their postevent do-not-resuscitate staus was appropriate given their neurological prognosis.

Podcast: DNR Status and Neurological Prognosis After In-Hospital Cardiac Arrest

Editorial
Successful Resuscitation From In-Hospital Cardiac Arrest鈥擶hat Happens Next?
Derek C. Angus, MD, MPH

JAMA

Caring for the Critically Ill Patient

Association of Intensive Care Unit Admission With Mortality Among Older Patients With Pneumonia

Thomas S. Valley, MD; Michael W. Sjoding, MD; Andrew M. Ryan, PhD; et al.

Abstract Full Text

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JAMA. 2015;314(12):1272-1279. doi:10.1001/jama.2015.11068

This cohort study investigates the association between intensive care unit admission and 30-day mortality for Medicare patients with pneumonia.

Editorial
Assessing the Value of Intensive Care
Ian J. Barbash, MD; Jeremy M. Kahn, MD, MS

JAMA

Research Letter

Long-term Follow-up of a Randomized Trial of Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer

Anthony V. D鈥橝mico, MD, PhD; Ming-Hui Chen, PhD; Andrew Renshaw, MD; et al.

Abstract Full Text

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JAMA. 2015;314(12):1291-1293. doi:10.1001/jama.2015.8577

This study uses long-term follow-up data from a randomized trial comparing radiation therapy with vs without androgen deprivation therapy for unfavorable-risk prostate cancer to compare survival and cause-specific mortality by severity of comorbidity.

Viewpoint

The Arc of Health Literacy

Howard K. Koh, MD, MPH; Rima E. Rudd, ScD, MSPH

Abstract Full Text

JAMA. 2015;314(12):1225-1226. doi:10.1001/jama.2015.9978

This Viewpoint discusses potential roles for clinicians, institutions, and systems in increasing health literacy at both the individual patient and population level.

Improving the Quality of Psychosocial Interventions for Mental and Substance Use Disorders: A Report From the IOM

Harold Alan Pincus, MD; Mary Jane England, MD

Abstract Full Text

JAMA. 2015;314(12):1227-1228. doi:10.1001/jama.2015.9212

This Viewpoint discusses an Institute of Medicine framework for improving the quality of psychosocial interventions delivered to persons with mental health and substance use disorders.

Measles Outbreak as a Catalyst for Stricter Vaccine Exemption Legislation

Y. Tony Yang, ScD, LLM, MPH; Leila Barraza, JD, MPH; Kim Weidenaar, JD

Abstract Full Text

JAMA. 2015;314(12):1229-1230. doi:10.1001/jama.2015.9579

This Viewpoint discusses how a recent measles outbreak may lead to tightening of US school immunization laws and describes the recent passage of such a law in California as an example other states might follow.

A Piece of My Mind

Mercy

Elizabeth B. Fortescue, MD, MPH

Abstract Full Text

JAMA. 2015;314(12):1231-1232. doi:10.1001/jama.2015.7653

Editorial

Dextromethorphan and Quinidine for Treating Agitation in Patients With Alzheimer Disease Dementia

Clive Ballard, MD; Samantha Sharp, BSc; Anne Corbett, PhD

Abstract Full Text

JAMA. 2015;314(12):1233-1235. doi:10.1001/jama.2015.10215

Can Mobile Health Applications Facilitate Meaningful Behavior Change?Time for Answers

Zubin J. Eapen, MD, MHS; Eric D. Peterson, MD, MPH

Abstract Full Text

JAMA. 2015;314(12):1236-1237. doi:10.1001/jama.2015.11067

Successful Resuscitation From In-Hospital Cardiac Arrest鈥擶hat Happens Next?

Derek C. Angus, MD, MPH

Abstract Full Text

JAMA. 2015;314(12):1238-1239. doi:10.1001/jama.2015.11735

Assessing the Value of Intensive Care

Ian J. Barbash, MD; Jeremy M. Kahn, MD, MS

Abstract Full Text

JAMA. 2015;314(12):1240-1241. doi:10.1001/jama.2015.11171

From the 糖心vlog

Potential Overtreatment of Older, Complex Adults With Diabetes

Elbert S. Huang, MD, MPH

Abstract Full Text

JAMA. 2015;314(12):1280-1281. doi:10.1001/jama.2015.9757

This commentary discusses a cross-sectional analysis of National Health and Nutrition Examination Survey data published in JAMA Internal Medicine suggesting substantial overtreatment of older adults with diabetes.

JAMA Clinical Evidence Synopsis

Oxycodone for Cancer Pain in Adult Patients

Mia Schmidt-Hansen, BSc, PhD; Michael I. Bennett, MB, ChB, MD, FRCP; Jennifer Hilgart, BSc, MSc

Abstract Full Text

JAMA. 2015;314(12):1282-1283. doi:10.1001/jama.2015.8556

This Clinical Evidence Synopsis summarizes a Cochrane review of trials comparing oxycodone with placebo and other opioids for treating cancer pain in adults.

From The Medical Letter on Drugs and Therapeutics

Alirocumab (Praluent) to Lower LDL-Cholesterol

Abstract Full Text

JAMA. 2015;314(12):1284-1285. doi:10.1001/jama.2015.11372

This Medical Letter on Drugs and Therapeutics review summarizes information about alirocumab, a subcutaneously injected PCSK9 inhibitor, approved for use as an adjunct to statin therapy in patients with clinical atherosclerotic disease requiring further lowering of LDL levels.

Medical News & Perspectives