ÌÇÐÄvlog

Key Points

QuestionÌý What symptoms are differentially present in SARS-CoV-2–infected individuals 6 months or more after infection compared with uninfected individuals, and what symptom-based criteria can be used to identify postacute sequelae of SARS-CoV-2 infection (PASC) cases?

FindingsÌý In this analysis of data from 9764 participants in the RECOVER adult cohort, a prospective longitudinal cohort study, 37 symptoms across multiple pathophysiological domains were identified as present more often in SARS-CoV-2–infected participants at 6 months or more after infection compared with uninfected participants. A preliminary rule for identifying PASC was derived based on a composite symptom score.

MeaningÌý A framework for identifying PASC cases based on symptoms is a first step to defining PASC as a new condition. These findings require iterative refinement that further incorporates clinical features to arrive at actionable definitions of PASC.

ImportanceÌý SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals.

ObjectiveÌý To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections.

Design, Setting, and ParticipantsÌý Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling.

ExposureÌý SARS-CoV-2 infection.

Main Outcomes and MeasuresÌý PASC and 44 participant-reported symptoms (with severity thresholds).

ResultsÌý A total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%]) were PASC positive at 6 months.

Conclusions and RelevanceÌý A definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC.

More than 658 million people worldwide have been infected with SARS-CoV-2.¹ Postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID and defined as ongoing, relapsing, or new symptoms or conditions present 30 or more days after infection, is a major clinical and public health concern.^2-6 Short- and long-term effects of PASC have substantial impacts on health-related quality of life, earnings, and health care costs.^7,8 Most existing PASC studies have focused on individual symptom frequency and have generated widely divergent estimates of prevalence due to their retrospective design and lack of an uninfected comparison group. Moreover, defining PASC precisely is difficult because it is heterogeneous, composed of conditions with variable and potentially overlapping etiologies (eg, organ injury, viral persistence, immune dysregulation, autoimmunity, and gut dysbiosis).^9,10

It is of significant public health and scientific importance to better research the underlying mechanisms of PASC and potential preventive and therapeutic interventions. This effort requires data collection on SARS-CoV-2–infected and –uninfected individuals in a large prospective cohort study designed specifically to characterize PASC. Additionally, simultaneous consideration of multiple symptoms that persist over time and application of appropriate analytical techniques are essential. Further consideration of changes in PASC frequency and its manifestations over the course of the COVID-19 pandemic, due to variable SARS-CoV-2 strains, new treatment and prevention strategies, and repeat infections, is important.

This study is part of the National Institutes of Health’s Researching COVID to Enhance Recovery (RECOVER) Initiative, which seeks to understand, treat, and prevent PASC (). In this first analysis of data from the RECOVER adult cohort, criteria for identifying PASC based on self-reported symptoms are delineated and several distinctive PASC subphenotypes with varying impacts on well-being and physical health are described. This study was enriched with self-referred participants to promote inclusive participation. Estimates were expected to be more accurate in the subcohort of participants enrolled within 30 days of acute infection, for whom selection bias based on PASC would be minimal.

Unlike electronic health records and most existing cohort studies, data from this study captured PASC-specific self-reported symptoms based on standardized questionnaires developed with input from patient representatives. This report is an adequately powered, prospective study of PASC based on participant-reported symptoms that included both infected and uninfected individuals over the course of the pandemic. Notably, unlike prior reports, the paradigm presented here does not rely on predefined clinical symptoms; instead, a definition of PASC as a new condition specific to SARS-CoV-2 infection is proposed.

Institutional review boards at NYU Grossman School of Medicine, serving as a single institutional review board, and other participating institutions reviewed and approved the protocol. All participants provided written informed consent to participate in research.

The RECOVER adult cohort study included SARS-CoV-2–infected and –uninfected participants (the trial protocol is in Supplement 1 and the statistical analysis plan in Supplement 2). All infected participants met World Health Organization suspected, probable, or confirmed criteria.¹¹ Index for infected participants was defined as date of first positive SARS-CoV-2 test result or COVID-19 symptom onset. Uninfected participants had no known history of SARS-CoV-2 infection and index was defined as a past negative SARS-CoV-2 test result date. Participants belonged to either the acute cohort (enrolled ≤30 days since index) or the postacute cohort (enrolled >30 days to 3 years after index). Participants were recruited from 85 sites across the United States and completed office visits and remote surveys developed with early engagement of patients, support group stakeholders, and multidisciplinary clinical experts.¹²

Adult participants enrolled prior to April 10, 2023 (N = 13 754) were considered (Figure 1). Enrollment is ongoing, and not all enrolled participants have reached eligibility for inclusion. The analysis cohort included participants with a study visit completed 6 months or more after the index date (Table 1). Uninfected participants with a reported on-study infection and participants who had no symptom survey data were excluded. A subgroup of participants also belonged to the RECOVER pregnancy cohort. Race and ethnicity were captured via participant self-report using fixed categories to better understand racial and ethnic differences in sequelae due to SARS-CoV-2 infection (eMethods in Supplement 3).

The analysis used the first study visit at 6 months or more after the index date. The exposure was SARS-CoV-2 infection prior to study enrollment. Uninfected participants with antibody results at enrollment indicating prior infection were reclassified as infected and assigned an index date 90 days prior. The primary outcome was the presence of each of 44 symptoms (eTable 1 in Supplement 3). Using these symptoms, a PASC definition was developed. The primary analysis used symptom presence for inclusivity; sensitivity analysis considered new-onset symptoms. Results were reported for 3 additional age- and sex-dependent symptoms (eTable 1 in Supplement 3).

Results were reported overall and within 3 subcohorts: acute Omicron (n = 2231 infected, n = 388 uninfected; index date on or after December 1, 2021); postacute pre-Omicron (n = 3732 infected, n = 290 uninfected; index date before December 1, 2021); and postacute Omicron (n = 2666 infected, n = 438 uninfected; index date on or after December 1, 2021). Acute cohort participants with a pre-Omicron index date (17 infected, 2 uninfected) were included in overall analyses.

Balancing weights were used to account for differences in the age, sex, and race and ethnicity distributions between infected and uninfected participants (eMethods in Supplement 3). Symptom frequency was defined as the proportion reporting a symptom and exceeding corresponding moderate to severe symptom severity threshold (eTables 1 and 2 in Supplement 3). Symptoms with frequency of 2.5% or greater were considered. Symptom frequencies by infection status were reported and adjusted odds ratios (aORs) were calculated using weighted logistic regression. In sensitivity analysis, new-onset symptom frequency was defined as the proportion of participants with the symptom at study visit among those without the symptom in the year prior to the index date. Symptom frequencies characterized the study cohort and were not unbiased estimators of population-level prevalence due to the cohort sampling strategies. Symptom frequency estimates within the acute Omicron subcohort were expected to be more aligned with the corresponding population frequencies.

A rule for identifying PASC was derived. Symptoms differentiating infected and uninfected participants were identified using least absolute shrinkage and selection operator (LASSO) with balancing weights.¹³ Each symptom was assigned a score based on the estimated coefficients and participants were assigned a total score by summing the symptom scores for each reported symptom. Using 10-fold cross-validation, an optimal score threshold for PASC was selected (eMethods in Supplement 3). Participants meeting the PASC score threshold were classified as PASC positive; others were classified as PASC unspecified. The proportions were reported.

Participants classified as PASC positive were clustered into subgroups using unsupervised learning (K-means consensus clustering¹⁴ followed by hierarchical clustering¹⁵) including symptoms identified with LASSO. Symptoms highly correlated with those identified by LASSO were reported. The distribution of PASC score and Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health 10 general quality of life (Q2), general physical health (Q3), and ability to carry out everyday physical activities (Q6) (eTable 3 in Supplement 3) were reported.

Rates of PASC were assessed by infection status, sex, age, and vaccination status at the index date (eTable 4 in Supplement 3), reinfection (between index and analysis visit), and visit month. The proportion of participants meeting criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS, defined based on RECOVER survey; eMethods in Supplement 3) who were PASC positive at the same visit was reported. Sensitivity analyses removed the symptom severity thresholds and separately added well-being and physical health requirements for PASC (Q2 or Q3: fair or poor; Q6: moderate or worse). Inverse probability weighting was applied to account for loss to follow-up in the acute Omicron subcohort (eMethods in Supplement 3).

A total of 9764 participants (8646 infected; 1118 uninfected) met study criteria (Figure 1, 71% female [6932/9712]; 16% Hispanic/Latino [1592/9664]; 15% non-Hispanic Black [1417/9664]; 58% fully vaccinated at the index date [5585/9633]; median age, 47 years [IQR, 35-60]). After application of balancing weights, the distributions of age, sex, and race and ethnicity were the same in infected and uninfected participants (Table 1). In the weighted cohort, uninfected participants were more likely to be fully vaccinated (77% vs 55%). Comorbidity frequencies were similar between infected and uninfected participants (eTable 5 in Supplement 3). Uninfected participants were more likely to be self-referrals or recruited via community outreach (eTable 5 in Supplement 3). A total of 1260 of 6932 female participants (18%) were in the pregnancy cohort.

In the full cohort, 37 symptoms had frequency of 2.5% or greater and aORs were 1.5 or greater (infected vs uninfected participants) for all 37 (eFigure 1 in Supplement 3). Symptoms (using severity thresholds) with more than 15% absolute difference in frequencies (infected vs uninfected) included postexertional malaise (PEM) (28% vs 7%; aOR, 5.2 [95% CI, 3.9-6.8]), fatigue (38% vs 17%; aOR, 2.9 [95% CI, 2.4-3.4]), dizziness (23% vs 7%; aOR, 3.4 [95% CI, 2.6-4.4]), brain fog (20% vs 4%; aOR, 4.5 [95% CI, 3.2-6.2]), and gastrointestinal (GI) symptoms (25% vs 10%; aOR, 2.7 [95% CI, 2.2-3.4]).

In infected participants, the frequencies of new-onset symptoms (with severity thresholds) were similar, including PEM (28%), fatigue (37%), dizziness (21%), brain fog (20%), and GI symptoms (20%) (eFigure 2 in Supplement 3). The corresponding observed symptom frequencies without severity thresholds were higher (eg, fatigue, 47%; brain fog, 40%) (eFigure 3 in Supplement 3).

The distributions of demographics and comorbidities were comparable across the acute Omicron, postacute pre-Omicron, and postacute Omicron subcohorts, though there was a higher proportion unvaccinated in the postacute pre-Omicron subcohort (eTable 6 in Supplement 3). Time from the index date to analysis visit ranged from 6 to 15 months in the acute Omicron and postacute Omicron subcohorts and 6 to 39 months in the postacute pre-Omicron subcohort (eFigure 4 in Supplement 3). Generally, symptom frequencies and the differences between infected and uninfected participants were lower in the acute Omicron subcohort, higher in the postacute Omicron subcohort, and highest in the postacute pre-Omicron subcohort (eFigures 5-7 in Supplement 3). Symptom frequencies in acute Omicron participants who were also fully vaccinated were the lowest (eFigure 8 in Supplement 3).

Using the full cohort, LASSO identified 12 symptoms with corresponding scores ranging from 1 to 8 (Table 2). The optimal PASC score threshold used was 12 or greater (Figure 2A). The symptoms (ordered by decreasing frequencies among participants with a qualifying PASC score) were PEM, fatigue, brain fog, dizziness, GI symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Symptoms correlated with the selected symptoms included dry mouth, weakness, headaches, tremor, muscle and abdominal pain, fever/sweats/chills, and sleep disturbance (eTable 7 in Supplement 3).

The proportion with a qualifying PASC score in the full cohort (subject to selection bias) was 1990 of 8646 infected participants (23%) and 41 of 1118 of uninfected participants (3.7%) (overall: 2031/9764 [21%]). Among participants with PASC, the most common symptoms were PEM (87%), fatigue (85%), brain fog (64%), dizziness (62%), GI (59%), and palpitations (57%) (Figure 2B; eTable 8 in Supplement 3). Higher PASC scores were associated with worse PROMIS Global 10 scores (Figure 2C).

The proportion of infected participants with PASC in the acute Omicron subcohort was 10% (95% CI, 8.8%-11%; 224/2231). After adjustment for missing data, the estimated rate was 9.8% (95% CI, 8.6%-11%). It was greater in the postacute pre-Omicron (1320/3732 [35%; 95% CI, 34%-37%]) and postacute Omicron (442/2666 [17%; 95% CI, 15%-18%]) subcohorts (Table 3). Symptom frequencies among PASC-infected participants were similar across subcohorts, with a few notable exceptions, including brain fog, GI symptoms, and palpitations (eTable 8 in Supplement 3). The proportion of PASC positivity was lower among fully vaccinated than unvaccinated participants (acute Omicron: 9.7% vs 17%; postacute pre-Omicron: 31% vs 37%; postacute Omicron: 16% vs 22%) (Table 3). In the Omicron cohorts, the estimated proportion of PASC positivity was greater among reinfected participants compared with participants with 1 reported infection (acute Omicron: 20% vs 9.7%; postacute Omicron: 21% vs 16%) (Table 3).

Among infected participants in the full cohort, the proportions of PASC positivity were 39% (299/757) among hospitalized participants and 22% (1636/7387) among not hospitalized participants during acute infection; 19% (442/2377) among males and 25% (1540/6221) among females; and 20% (885/4389) among those aged 18 to 45 years and 28% (904/3175) (28%) among those aged 46 to 65 years. In cross-sectional analysis, the proportion of PASC-positive participants was consistent over the visit month used in analysis (eTable 9 in Supplement 3). In subgroups with repeated visits at 6 and 9 months after the index date, PASC positivity varied over study visit, though 68% of PASC-positive participants remained positive at the subsequent visit (eTable 10 in Supplement 3). Among infected participants meeting criteria for ME/CFS, 98% met the criteria for PASC.

The proportions of PASC increased to 27% (2300/8646) among infected participants and 4.7% (52/1118) among uninfected participants when severity scores were not included in the PASC score determination. After applying additional PROMIS Global 10 criteria to qualify as PASC positive, 17% (1434/8646) were PASC positive among infected participants and 3.0% (34/1118) among uninfected participants.

Four PASC subgroups were identified (Figure 3A). Features of PASC subgroups included loss of or change in smell or taste (100%) in cluster 1 (n = 477); PEM (99%) and fatigue (84%) in cluster 2 (n = 405); brain fog (100%), PEM (99%), and fatigue (94%) in cluster 3 (n = 587); and fatigue (94%), PEM (94%), dizziness (94%), brain fog (94%), GI (88%), and palpitations (86%) in cluster 4 (n = 562) (Figure 3B). Twenty-six percent of the PASC-unspecified group also met PROMIS Global 10 criteria compared with 53% of participants in cluster 1, 69% in cluster 2, 77% in cluster 3, and 86% in cluster 4. Among infected participants, 456 of 1540 females (30%) and 102 of 442 males (23%) with PASC were in cluster 4. A total of 277 of 885 participants aged 18 to 45 years (31%), 254 of 904 participants aged 46 to 65 years (28%), and 29 of 198 participants aged older than 65 years (15%) with PASC were in cluster 4.

The proportion of PASC-positive infected participants in cluster 4 was higher within the postacute pre-Omicron (31%) than postacute Omicron (23%) and acute Omicron (23%) subcohorts (eTable 11A in Supplement 3). Overall, among PASC-positive infected participants, the proportion in cluster 4 among fully vaccinated compared with unvaccinated participants was 23% vs 32% (eTable 11B in Supplement 3). The distribution of clusters was similar for participants with a single reported infection compared with those with more than 1 infection, though the results varied by prevalent SARS-CoV-2 strain (eTable 11C in Supplement 3).

This study reported early results from a prospective, survey-based cohort of adult SARS-CoV-2–infected and –uninfected individuals with ascertainment of patient-reported symptoms. A data-driven scoring framework was developed to classify PASC as a condition specific to SARS-CoV-2 infection. Based on this PASC score, 10% of participants first infected on or after December 1, 2021, and enrolled within 30 days of infection were classified as PASC positive at 6 months after infection. Increasing levels of the PASC score were associated with progressively worse measures of well-being and functioning. Although only 12 symptoms contributed to the PASC score, other symptoms correlated with this subgroup are individually important, considering their potential adverse impact on health-related quality of life.

PASC positivity was more common and associated with more severe manifestation in participants infected in the pre-Omicron era. Though participants with earlier infection may have been more likely to enroll in the RECOVER adult cohort because of known PASC, multiple studies reported an association between PASC and early pandemic variants.¹⁶ Among participants with a first infection during the Omicron era, PASC frequency was higher among those with recurrent infections, corroborating electronic health record–based studies.^4,17-23 Though studies on the effect of vaccination are conflicting, these findings of modest reduction in PASC frequency among fully vaccinated participants align with recent systematic reviews.^24,25

This study found that long-term symptoms associated with SARS-CoV-2 infection spanned multiple organ systems. The diversity of symptoms may be related to persistent viral reservoirs, autoimmunity, or direct differential organ injury. The symptoms identified are consistent with those reported in studies that assessed PASC manifestations (eMethods in Supplement 3). However, by simultaneously considering the contributions of multiple self-reported symptoms, a PASC-scoring algorithm that provides a framework for diagnosing PASC was developed.

Given the heterogeneity of PASC symptoms, determining whether PASC represents one unified condition or reflects a group of unique phenotypes is important. Recent evidence supports the presence of PASC phenotypes, although characterization of these phenotypes is inconsistent and largely dependent on available data.^2,6,22,23 Accurate phenotypic stratification has important implications for investigations into the pathophysiological processes underlying PASC and clinical trial design. PASC subgroups that demonstrate overlap with conditions previously described in clinical practice are detailed here, including olfactory dysfunction, cardiopulmonary sequelae, neurocognitive impairment, ME/CFS, and dysautonomia^26-30 and overlap with those reported by the National COVID Cohort Collaborative.⁶ Biological samples from these participants may enable the development of biomarkers of PASC and reveal insights into the mechanistic underpinnings of PASC that inform choice of therapeutic interventions and case selection in upcoming clinical trials for PASC.

First, the proposed paradigm and accompanying decision rule require iterative refinement as additional data become available. The PASC score provides an operational definition of PASC and requires further refinement and validation. RECOVER recruitment is ongoing, and not all participants have reached the analysis stage. Evolution and refinement of the phenotypes are anticipated as additional data become available.

Second, selection bias was likely among postacute cohort participants that may have affected frequency estimates including distribution of subphenotypes because PASC severity may impact study participation. Differential attrition of symptomatic and asymptomatic participants at follow-up visits could also have biased frequency estimates though use of inverse probability weighting in the acute cohorts mitigated this bias.

Third, uninfected participants may have had prior asymptomatic SARS-CoV-2 infections not detected due to variations in antibody production and persistence, weakening the discriminant characteristics of this PASC score threshold.

Fourth, symptoms were self-reported and only some symptoms integrate severity scales. Participants could report other symptoms as free text; these were not included in this analysis.

Fifth, confounding may have impacted effect sizes, eg, vaccination status may have been higher in participants at higher risk of PASC, attenuating a vaccination effect. Additionally, PASC status can change over time, perhaps due to underlying mechanistic changes.

Sixth, more than 200 symptoms of PASC have been reported, each with the potential of being life-altering and debilitating, and the symptoms highlighted herein may not reflect the severity or impact of other symptoms.

This symptom-based PASC definition represents a first step for identifying PASC cases and serves as a launching point for further investigations. Definition of a classification rule for PASC requires an updated algorithm that incorporates symptoms as well as biological features. Future analyses must consider the relationships among age, sex, race and ethnicity, social determinants of health, vaccination status after index date, comorbidities, and pregnancy status during infection on the risk of PASC and the distribution of PASC subgroups.

Accepted for Publication: May 1, 2023.

Published Online: May 25, 2023. doi:10.1001/jama.2023.8823

Correction: This article was corrected on April 10, 2024, to add RECOVER Consortium authors and nonauthor collaborators.

Corresponding Author: Andrea S. Foulkes, ScD, Massachusetts General Hospital Biostatistics, 50 Staniford St, Ste 560, Boston, MA 02114 (afoulkes@mgh.harvard.edu).

RECOVER Consortium Authors: George A. Alba, MD; Radica Alicic, MD; Natasha Altman, MD; Khamal Anglin, MD, MPH; Urania Argueta, BS; Hassan Ashktorab, PhD; Gaston Baslet, MD; Ingrid V. Bassett, MD, MPH; Lucinda Bateman, MD; Brahmchetna Bedi, PhD; Shamik Bhattacharyya, MD, MS; Marie-Abele Bind, PhD; Andra L. Blomkalns, MD, MBA; Hector Bonilla, MD; Hassan Brim, PhD; Patricia A. Bush, MS, EdD; Mario Castro, MD, MPH; James Chan, MA; Alexander W. Charney, MD, PhD; Peter Chen, MD; Lori B. Chibnik, PhD, MPH; Helen Y. Chu, MD, MPH; Rebecca G. Clifton, PhD; Maged M. Costantine, MD; Sushma K. Cribbs, MD, MSc; Sylvia I. Davila Nieves, MS; Steven G. Deeks, MD; Alexandria Duven, RN; Ivette F. Emery, PhD; Nathan Erdmann, MD, PhD; Kristine M. Erlandson, MD, MS; Kacey C. Ernst, PhD, MPH; Rachael Farah-Abraham, PhD; Cheryl E. Farner, MSN; Elen M. Feuerriegel, PhD; Judes Fleurimont, MPH; Vivian Fonseca, MD; Nicholas Franko, BS; Vivian Gainer, MS; Jennifer C. Gander, PhD; Edward M. Gardner, MD; Linda N. Geng, MD, PhD; Kelly S. Gibson, MD; Minjoung Go, MD, MPH; Jason D. Goldman, MD, MPH; Halle Grebe, BS; Frank L. Greenway, MD; Mounira Habli, MD; John Hafner, MD, MPH; Jenny E. Han, MD, MS; Keith A. Hanson, MD, PhD; James Heath, PhD; Carla Hernandez, RN; Rachel Hess, MD, MS; Sally L. Hodder, MD; Matthew K. Hoffman, MD, MPH; Susan E. Hoover, MD, PhD; Beatrice Huang, BA; Brenna L. Hughes, MD; Prasanna Jagannathan, MD; Janice John, MS, MHCDS; Michael R. Jordan, MD; Stuart D. Katz, MD, MS; Elizabeth S. Kaufman, MD; John D. Kelly, MD; Sara W. Kelly, PhD, MPH; Megan M. Kemp, BA; John P. Kirwan, PhD; Jonathan D. Klein, MD, MPH; Kenneth S. Knox, MD; Jerry A. Krishnan, MD, PhD; Andre Kumar, MD; Adeyinka O. Laiyemo, MD; Allison A. Lambert, MD; Margaret Lanca, PhD; Joyce K. Lee-Iannotti, MD; Brian P. Logarbo, MD, MS; Michele T. Longo, MD; Carlos A. Luciano, MD; Karen Lutrick, PhD; Jason H. Maley, MD, MS; Gail Mallett, MS; Jai G. Marathe, MD, MBBS; Vincent Marconi, MD; Gailen D. Marshall, MD, PhD, MS; Christopher F. Martin, MBA; Yuri Matusov, MD; Alem Mehari, MD; Hector Mendez-Figueroa, MD; Robin Mermelstein, PhD; Torri D. Metz, MD, MS; Richard Morse, BA; Jarrod Mosier, MD; Christian Mouchati, MD; Janet Mullington, PhD; Shawn N. Murphy, MD, PhD; Robert B. Neuman, MD; Janko Z. Nikolich, MD, PhD; Ighovwerha Ofotokun, MD; Elizabeth Ojemakinde, MD, MPH; Anna Palatnik, MD; Kristy Palomares, MD, PhD; Tanyalak Parimon, MD; Samuel Parry, MD; Jan E. Patterson, MD; Thomas F. Patterson, MD; Rachel E. Patzer, PhD, MPH; Michael J. Peluso, MD; Priscilla Pemu, MD, MS; Christian M. Pettker, MD; Beth A. Plunkett, MD, MPH; Kristen Pogreba-Brown, PhD; Athena Poppas, MD; John G. Quigley, MD; Uma Reddy, MD; Rebecca Reece, MD; Harrison Reeder, PhD; W. B. Reeves, MD; Eric M. Reiman, MD; Franz Rischard, DO, MSc; Jonathan Rosand, MD, MS; Dwight J. Rouse, MD; Adam Ruff, BS; George Saade, MD; Grecio J. Sandoval, PhD; Jorge L. Santana, MD; Shannon M. Schlater, MS; Frank C. Sciurba, MD; Fitzgerald Shepherd, MD; Zaki A. Sherif, PhD; Hyagriv Simhan, MD; Nora G. Singer, MD; Daniel W. Skupski, MD; Amber Sowles, RN, BSN; Jeffrey A. Sparks, MD, MMSc; Fatima I. Sukhera, MD; Barbara S. Taylor, MD; Larissa Teunis, MPA; Robert J. Thomas, MD; John M. Thorp, MD, MS; Paul Thuluvath, MD; Amberly Ticotsky, MPH, RN; Alan T. Tita, MD, PhD; Katherine R. Tuttle, MD; Alfredo E. Urdaneta, MD; Daisy Valdivieso, BS; Timothy M. VanWagoner, PhD; Andrew Vasey, MD; Monica Verduzco-Gutierrez, MD; Zachary S. Wallace, MD; Honorine D. Ward, MD; David E. Warren, PhD; Steven J. Weiner, MS; Shelley Welch, MS; Sidney W. Whiteheart, PhD; Zanthia Wiley, MD; Juan P. Wisnivesky, MD, DrPH; Lynn M. Yee, MD; Sokratis Zisis, MD.

Affiliations of RECOVER Consortium Authors: Massachusetts General Hospital, Boston (Alba, Bassett, Bind, Chan, Chibnik, Morse, Murphy, Reeder, Rosand, Wallace); Harvard Medical School, Boston, Massachusetts (Lanca, Mullington, Plunkett); University of Colorado Anschutz Medical Campus, Aurora (Altman, Erlandson, Feuerriegel); Brigham and Women’s Hospital, Boston, Massachusetts (Baslet, Bhattacharyya, Sparks); University of Alabama at Birmingham (Erdmann); Case Western Reserve University, Cleveland, Ohio (Zisis); Icahn School of Medicine at Mount Sinai, New York, New York (Charney, Wisnivesky); Stanford University School of Medicine, Stanford, California (Go, Kumar, Urdaneta); Emory University School of Medicine, Atlanta, Georgia (Bedi, Cribbs, Han, Ofotokun); New York University Grossman School of Medicine, New York (Katz); University of Washington, Seattle (Alicic, Franko, Kemp, Lambert, Tuttle); University of California, San Francisco (Anglin, Argueta, Deeks, Grebe, Huang, Peluso, Valdivieso); Howard University, Washington, DC (Ashktorab); Bateman Horne Center, Salt Lake City, Utah (Bateman); Stanford University, Stanford, California (Blomkalns, Bonilla, Geng, Jagannathan); Pathology Department, Howard University, Washington, DC (Brim); Kaiser Foundation Health Plan of Georgia Inc, Atlanta (Bush, Neuman); University of Kansas Medical Center, Kansas City (Castro); Cedars-Sinai Medical Center, Los Angeles, California (Chen, Matusov); University of Washington School of Medicine, Seattle (Chu); George Washington University, Washington, DC (Clifton); The Ohio State University, Columbus (Costantine); Universidad de Puerto Rico Recinto de Ciencias Medicas, San Juan, Puerto Rico (Davila Nieves); Swedish Medical Center, Seattle, Washington (Duven, Goldman); MaineHealth, Portland (Emery); The University of Arizona, Tucson (Ernst, Lutrick, Nikolich, Pogreba-Brown); Emory University, Atlanta, Georgia (Farah-Abraham, Marconi, Martin, Patzer, Teunis, Wiley); The University of Texas Health Science Center at San Antonio (Farner, J. E. Patterson, T. F. Patterson, Taylor, Verduzco-Gutierrez); University of Illinois Chicago (Fleurimont, Mermelstein); Tulane University Health Sciences Center, New Orleans, Louisiana (Fonseca); Partners HealthCare Systems, Boston, Massachusetts (Gainer); Kaiser Permanente Georgia, Atlanta (Gander); Denver Health, Denver, Colorado (Gardner); MetroHealth Medical Center, Cleveland, Ohio (Gibson, Singer); Pennington Biomedical Research Center, Baton Rouge, Louisiana (Greenway, Kirwan); TriHealth, Cincinnati, Ohio (Habli); University of Illinois Chicago College of Medicine (Hafner); University of Illinois College of Medicine at Peoria (Hanson, S. W. Kelly); Institute for Systems Biology, Seattle, Washington (Heath); UH Cleveland Medical Center, Cleveland, Ohio (Hernandez); University of Utah Schools of the Health Sciences, Salt Lake City (Hess); West Virginia Clinical and Translational Science Institute, Morgantown (Hodder); Christiana Care Health Services Inc, Newark, Delaware (Hoffman); Sanford Health, Sioux Falls, South Dakota (Hoover); Duke University, Durham, North Carolina (Hughes); Cambridge Health Alliance, Cambridge, Massachusetts (John, Ticotsky); Tufts Medical Center, Boston, Massachusetts (Jordan, Ward); MetroHealth Campus of Case Western Reserve University, Cleveland, Ohio (Kaufman); University of California, San Francisco (J. D. Kelly); University of Illinois Chicago (Klein, Quigley); The University of Arizona College of Medicine, Phoenix (Knox, Lee-Iannotti); University of Illinois Hospital and Health Sciences System, Chicago (Krishnan); Howard University College of Medicine, Washington, DC (Laiyemo, Mehari, Sherif); Tulane University, New Orleans, Louisiana (Logarbo); Tulane School of Medicine, New Orleans, Louisiana (Longo); Universidad de Puerto Rico, San Juan, Puerto Rico (Luciano); Beth Israel Deaconess Medical Center, Boston, Massachusetts (Maley, Thomas); Department of ObGyn/Maternal Fetal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (Mallett); Boston University, Boston, Massachusetts (Marathe); University of Mississippi, Oxford (Marshall); McGovern Medical School at The University of Texas Health Science Center at Houston (Mendez-Figueroa); University of Utah Health, Salt Lake City (Metz, Schlater, Sowles); University of Arizona, Tucson (Mosier); Case Western Reserve University School of Medicine, Cleveland, Ohio (Mouchati); Morehouse School of Medicine, Atlanta, Georgia (Ojemakinde, Pemu); Medical College of Wisconsin, Milwaukee (Palatnik); Saint Peter’s University Hospital, Brunswick, New Jersey (Palomares); Cedars-Sinai Health System, Los Angeles, California (Parimon); University of Pennsylvania, Philadelphia (Parry); Yale School of Medicine, New Haven, Connecticut (Pettker); NorthShore University Health System, Evanston, Illinois (Plunkett); Warren Alpert Medical School, Brown University, Providence, Rhode Island (Poppas); Columbia University Irving Medical Center, New York, New York (Reddy); West Virginia University School of Medicine, Morgantown (Reece); Department of Medicine, The University of Texas Health Science Center at San Antonio (Reeves); Banner Alzheimer’s Institute, Phoenix, Arizona (Reiman); Banner University Medical Center Tucson, Arizona (Rischard); Brown University, Providence, Rhode Island (Rouse); The University of Kansas Medical Center, Kansas City (Ruff); Eastern Virginia Medical School, Norfolk (Saade); Milken Institute of Public Health, The George Washington University, Washington, DC (Sandoval); School of Medicine, University of Puerto Rico, San Juan, Puerto Rico (Santana); Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania (Sciurba); Boston University School of Medicine, Boston, Massachusetts (Shepherd); University of Pittsburgh, Pittsburgh, Pennsylvania (Simhan); Weill Cornell Medicine, New York, New York (Skupski); The University of Oklahoma, Norman (Sukhera); The University of North Carolina at Chapel Hill (Thorp); Mercy Medical Center, Baltimore, Maryland (Thuluvath); University of Alabama, Birmingham (Tita); University of Oklahoma Health Sciences Center, Oklahoma City (VanWagoner); University of Nebraska Medical Center, Omaha (Vasey, Warren); The George Washington University Biostatistics Center, Rockville, Maryland (Weiner); West Virginia University, Morgantown (Welch); University of Kentucky, Lexington (Whiteheart); Feinberg School of Medicine, Northwestern University, Chicago, Illinois (Yee).

Author Contributions: Drs Thaweethai and Foulkes had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Thaweethai, Jolley, Karlson, Levy, McComsey, Parthasarathy, Singh, Shinnick, Altman, Bassett, Brim, Chan, Charney, Chibnik, Clifton, Deeks, Erdmann, Ernst, Fonseca, Gander, Gibson, Heath, Hodder, Hughes, Jagannathan, Jordan, Katz, J. Kelly, Kirwan, Knox, Krishnan, Kumar, Laiyemo, Lee-Iannotti, Maley, Marshall, Mehari, Mendez-Figueroa, Mermelstein, Metz, Mosier, Mullington, Murphy, Nikolich, Ofotokun, J. Patterson, Patzer, Peluso, Pemu, Pettker, Poppas, Reeves, Reiman, Sherif, Teunis, Thomas, Tita, Verduzco-Gutierrez, Wisnivesky, Yee, Zisis, Horwitz, Foulkes.

Acquisition, analysis, or interpretation of data: Thaweethai, Jolley, Karlson, Levitan, Levy, McComsey, McCorkell, Nadkarni, Parthasarathy, Singh, Walker, Selvaggi, Shinnick, Schulte, Atchley-Challenner, Alba, Alicic, Anglin, Ashktorab, Argueta, Baslet, Bassett, Bateman, Bedi, Bhattacharyya, Bind, Blomkalns, Bonilla, Brim, Bush, Castro, Chan, Charney, Chen, Chibnik, Chu, Clifton, Costantine, Cribbs, Davila Nieves, Deeks, Duven, Emery, Erdmann, Erlandson, Farah-Abraham, Farner, Feuerriegel, Fleurimont, Fonseca, Franko, Gainer, Gander, Gardner, Geng, Go, Goldman, Grebe, Greenway, Habli, Hafner, Han, Hanson, Heath, Hernandez, Hess, Hodder, Hoffman, Hoover, Huang, John, Katz, Kaufman, J. Kelly, S. Kelly, Kemp, Kirwan, Klein, Laiyemo, Lambert, Lanca, Lee-Iannotti, Logarbo, Longo, Luciano, Lutrick, Maley, Mallett, Marathe, Marconi, Martin, Matusov, Metz, Morse, Mosier, Mouchati, Mullington, Murphy, Neuman, Ofotokun, Ojemakinde, Palatnik, Palomares, Parimon, Parry, T. Patterson, Patzer, Peluso, Pemu, Plunkett, Pogreba-Brown, Quigley, Reddy, Reece, Reeder, Rischard, Rosand, Rouse, Ruff, Saade, Sandoval, Santana, Schlater, Sciurba, Shepherd, Sherif, Simhan, Singer, Skupski, Sowles, Sparks, Sukhera, Taylor, Teunis, Thomas, Thorp, Thuluvath, Ticotsky, Tita, Tuttle, Urdaneta, Valdivieso, VanWagoner, Vasey, Verduzco-Gutierrez, Wallace, Ward, Warren, Weiner, Welch, Whiteheart, Wiley, Wisnivesky, Yee, Zisis, Horwitz, Foulkes.

Drafting of the manuscript: Thaweethai, Jolley, Karlson, McComsey, McCorkell, Parthasarathy, Singh, Walker, Selvaggi, Bedi, Farner, Fleurimont, Gander, Jordan, J. Kelly, Kirwan, Kumar, Taylor, Teunis, Zisis, Foulkes, Sciurba.

Critical revision of the manuscript for important intellectual content: Thaweethai, Jolley, Karlson, Levitan, Levy, McComsey, McCorkell, Nadkarni, Parthasarathy, Walker, Selvaggi, Shinnick, Schulte, Atchley-Challenner, Alba, Alicic, Altman, Anglin, Ashktorab, Argueta, Baslet, Bassett, Bateman, Bhattacharyya, Bind, Blomkalns, Bonilla, Brim, Bush, Castro, Chan, Charney, Chen, Chibnik, Chu, Clifton, Costantine, Cribbs, Davila Nieves, Deeks, Duven, Emery, Erdmann, Erlandson, Ernst, Farah-Abraham, Feuerriegel, Fonseca, Franko, Gainer, Gander, Gardner, Geng, Gibson, Go, Goldman, Grebe, Greenway, Habli, Hafner, Han, Hanson, Heath, Hernandez, Hess, Hodder, Hoffman, Hoover, Huang, Hughes, Jagannathan, John, Jordan, Katz, Kaufman, J. Kelly, S. Kelly, Kemp, Kirwan, Klein, Knox, Krishnan, Laiyemo, Lambert, Lanca, Lee-Iannotti, Logarbo, Longo, Luciano, Lutrick, Maley, Mallett, Marathe, Marconi, Marshall, Martin, Matusov, Mehari, Mendez-Figueroa, Mermelstein, Metz, Morse, Mosier, Mouchati, Mullington, Murphy, Neuman, Nikolich, Ofotokun, Ojemakinde, Palatnik, Palomares, Parimon, Parry, J. Patterson, T. Patterson, Patzer, Peluso, Pemu, Pettker, Plunkett, Pogreba-Brown, Poppas, Quigley, Reddy, Reece, Reeder, Reeves, Reiman, Rischard, Rosand, Rouse, Ruff, Saade, Sandoval, Santana, Schlater, Sciurba, Shepherd, Sherif, Simhan, Singer, Skupski, Sowles, Sparks, Sukhera, Thomas, Thorp, Thuluvath, Ticotsky, Tita, Tuttle, Urdaneta, Valdivieso, VanWagoner, Vasey, Verduzco-Gutierrez, Wallace, Ward, Warren, Weiner, Welch, Whiteheart, Wiley, Wisnivesky, Yee, Zisis, Horwitz, Foulkes.

Statistical analysis: Thaweethai, Selvaggi, Shinnick, Schulte, Bind, Chan, Chibnik, Reeder, Taylor, Foulkes, Santana, Sciurba.

Obtained funding: Thaweethai, Karlson, Levy, McComsey, Parthasarathy, Bassett, Charney, Chu, Cribbs, Deeks, Erlandson, Ernst, Heath, Hess, Katz, J. Kelly, Kirwan, Knox, Krishnan, Maley, Martin, Metz, Murphy, Nikolich, Parry, T. Patterson, Patzer, Peluso, Pemu, Quigley, Reeves, Reiman, Saade, Sherif, Simhan, Taylor, Teunis, Tita, Tuttle, Warren, Wisnivesky, Horwitz, Foulkes.

Administrative, technical, or material support: Levy, McComsey, Nadkarni, Singh, Anglin, Ashktorab, Argueta, Bassett, Bedi, Bhattacharyya, Bush, Chan, Charney, Clifton, Costantine, Cribbs, Davila Nieves, Emery, Farah-Abraham, Farner, Feuerriegel, Fleurimont, Franko, Gainer, Gander, Gardner, Geng, Go, Grebe, Habli, Hafner, Han, Hanson, Heath, Hernandez, Hess, Hodder, Hoffman, Huang, Jagannathan, John, Katz, J. Kelly, S. Kelly, Kirwan, Klein, Krishnan, Kumar, Laiyemo, Lambert, Lanca, Lee-Iannotti, Luciano, Lutrick, Maley, Marshall, Martin, Mehari, Mendez-Figueroa, Metz, Morse, Mosier, Mouchati, Mullington, Murphy, Neuman, Ojemakinde, Palomares, Parimon, J. Patterson, Patzer, Peluso, Pettker, Pogreba-Brown, Poppas, Reiman, Rouse, Saade, Schlater, Sciurba, Shepherd, Simhan, Sowles, Sparks, Sukhera, Taylor, Teunis, Thuluvath, Tita, Urdaneta, Valdivieso, Wallace, Ward, Weiner, Yee, Horwitz, Foulkes.

Supervision: Thaweethai, Jolley, Karlson, Levy, McComsey, Parthasarathy, Singh, Walker, Alba, Bassett, Bateman, Bedi, Blomkalns, Bonilla, Brim, Castro, Chan, Charney, Chen, Chu, Costantine, Emery, Erlandson, Farah-Abraham, Gander, Goldman, Greenway, Hafner, Han, Heath, Hernandez, Hodder, Hoffman, Huang, Jagannathan, Jordan, Katz, J. Kelly, Kirwan, Knox, Krishnan, Lee-Iannotti, Longo, Mallett, Martin, Mendez-Figueroa, Metz, Mullington, Murphy, Neuman, Nikolich, Ofotokun, Patzer, Peluso, Plunkett, Poppas, Reiman, Rosand, Saade, Santana, Shepherd, Simhan, Skupski, Sukhera, Thorp, Thuluvath, Tita, Ward, Warren, Whiteheart, Yee, Horwitz, Foulkes.

Other - gave feedback based on study design: Singer.

Other - cohort recruitment and study supervision: Alba.

Other - was one of the original Boston Hub investigators involved in application for funding: Mullington.

Other - operationalization: Farah-Abraham.

Other - literature review: Atchley-Challenner.

Other - site PI team management: Marconi.

Other - data procurement: Kumar.

Conflict of Interest Disclosures: Dr Thaweethai reported receiving grants from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) and serving as co-investigator of the RECOVER Data Resource Core. Dr Jolley reported receiving grants from the NIH/NHLBI. Dr Karlson reported receiving grants from the NIH. Dr Levitan reported receiving grants from the NIH and Amgen. Dr Levy reported receiving grants from the NHLBI and personal fees or research support from Entrinsic Bioscience, Nocion Therapeutics, Gossamer Bio, AstraZeneca, Novartis, Sanofi, Amgen, Genentech, Pieris Pharmaceuticals, and SRA. Dr McComsey reported serving as a consultant for Gilead, Merck, Janssen, and GlaxoSmithKline and receiving research support from Pfizer, Genentech, and Roche. Ms McCorkell reported receiving personal fees from NIH RECOVER and research funding as a subcontractor from the NIH and the Patient-Centered Outcomes Research Institute (PCORI). Dr Parthasarathy reported receiving grants from the NIH, NHLBI, Sergey-Brin Foundation, and Regeneron and personal fees from Jazz Pharmaceuticals. Dr Singh reported receiving grants from Pfizer and serving as an advisor to Regeneron and Gilead. Dr Walker reported receiving grants from the NHLBI. Mr Shinnick reported receiving grants from the NIH/NHLBI. Dr Horwitz reported receiving grants from the NIH and serving on an ad hoc committee for the National Academy of Medicine. Dr Foulkes reported receiving grants from the NIH/NHLBI and personal fees from the Round Table Group and serving as principal investigator of the RECOVER Data Resource Core. Dr Alba reported receiving personal fees from Minerva Biotechnologies. Dr Alicic reported receiving grants from the NIH, the Centers for Disease Control and Prevention, and Travere Therapeutics and personal fees from Boehringer Ingelheim. Dr Ashktorab reported receiving grants from the NIH. Dr Bhattacharyya reported receiving grants from NIH RECOVER, Alexion Pharmaceuticals, UCB, and Massachusetts Consortium on Pathogen Readiness and personal fees from American Academy of Neurology and UpToDate. Dr Castro reported receiving grants from the NIH, American Lung Association, PCORI, AstraZeneca, Gala Therapeutics, Genentech, GlaxoSmithKline, Novartis, Pulmatrix, Sanofi, Shionogi, and Theravance Biopharma; personal fees from Allakos, Amgen, OM Pharma, Pfizer, Pioneering Medicines, AstraZeneca, GlaxoSmithKline, Genentech, Teva Pharmaceutical Industries, Sanofi, Merck, Novartis, Arrowhead Pharmaceuticals, and Regeneron; stock options from Aer Therapeutics; and royalties from Elsevier. Dr Chu reported receiving grants from the NIH and personal fees from Merck, Vir Biotechnology, AbbVie, Ellume, Pfizer, and the Bill and Melinda Gates Foundation; serving on advisory boards for Merck and AbbVie; conducting CME teaching with Medscape, Vindico, and Clinical Care Options; and receiving research funding from Gates Ventures and support and reagents from Ellume and Cepheid. Dr Clifton reported receiving grants from the NIH. Dr Costantine reported receiving grants from the NIH, Baxter International, and Siemens Healthcare and personal fees from Quidel, Progenity, and Siemens Healthcare. Dr Davila Nieves reported receiving grants from the NIH. Dr Deeks reported receiving grants from the NIH. Dr Emery reported receiving grants from the NIH. Dr Erdmann reported receiving grants from the NIH and personal fees from Perspectum and having a patent for Plantform. Dr Erlandson reported receiving grant funding and advisory fee payments from Gilead Sciences (paid to the University of Colorado) and advisory fee payments from Merck and ViiV (paid to the University of Colorado) in the last 3 years. Ms Gainer reported receiving grants from NIH RECOVER. Dr Geng reported receiving grants from Pfizer and personal fees from UnitedHealthcare. Dr Gibson reported receiving grants from the NIH. Dr Go reported receiving grants from the NIH. Dr Goldman reported receiving grants from Gilead Sciences and Merck; personal fees from Gilead Sciences and Eli Lilly; contracted research from Gilead Sciences, Eli Lilly, and Regeneron Pharmaceuticals; and nonfinancial support from Adaptive Biotechnologies, Labcorp, and Monogram Biosciences. Dr Greenway reported receiving grants from the NIH. Dr Heath reported receiving grants from Merck and Gilead Sciences, personal fees from Regeneron Pharmaceuticals, and being a board member for IsoPlexis. Dr Hess reported receiving grants from the NIH and being a member of a data and safety monitoring board for Astellas Pharmaceuticals. Dr Hodder reported receiving grants from the NHLBI. Dr Hoffman reported receiving grants from the NHLBI. Dr Hughes reported receiving honorarium from UpToDate and personal fees from AMAG Pharmaceuticals. Ms John reported receiving grants from the NIH. Dr Katz reported receiving grants from the NIH. Dr Klein reported receiving grants from NIH RECOVER and consulting fees from Gilead Sciences. Dr Knox reported receiving grants from the NIH. Dr Krishnan reported receiving grants from the NIH/NHLBI; personal fees from GlaxoSmithKline, AstraZeneca, CereVu Medical, BData, Propeller, ResMed, American Board of Internal Medicine, American Academy of Allergy, Asthma, and Immunology; and research funding from the NIH, PCORI, American Lung Association, COPD Foundation, and the Sergey Brin Family Foundation. Dr Laiyemo reported receiving grants from the NIH. Dr Lambert reported receiving grants from the NIH and the PCORI and serving as a site principal investigator for trials funded by Vertex and Aceragan. Dr Luciano reported receiving grants from the NIH and speaker fees from Sanofi-Genzyme. Ms Mallett reported receiving grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Dr Marathe reported receiving grants from NIH RECOVER and funding from Boston Medical Center. Dr Marconi reported receiving grants from the Centers for Disease Control and Prevention, Veteran Affairs, and the NIH; grants, personal fees, nonfinancial support, and other from Eli Lilly and Gilead; grants and personal fees from ViiV; and nonfinancial support from Bayer. Dr Marshall reported receiving grants from the NIH. Mr Martin reported receiving grants from the NIH. Dr Metz reported receiving grants from the NIH and Pfizer and personal fees from Pfizer. Mr Morse reported receiving grants from the NIH/NHLBI. Dr Mullington reported receiving grants from the NIH and Open Medicine Foundation and speaker and book chapter contribution for Idorsia Pharmaceuticals. Dr Murphy reported receiving grants from the NIH/NHLBI. Dr Nikolich reported receiving grants from the NIH/NHLBI. Dr Ojemakinde reported receiving grants from the NIH. Dr Parry reported receiving grants from NIH RECOVER paid to Penn and funding from the Sergey Brin Family Foundation. Dr Peluso reported receiving personal fees from Gilead Sciences and AstraZeneca. Dr Pogreba-Brown reported receiving grants from NIH RECOVER. Dr Poppas reported owning stock in GE and serving as an UpToDate contributor and co-editor of Hurst and Fuster’s The Heart. Dr Quigley reported receiving grants from the NIH, Pfizer, AbbVie, and Teva Pharmaceutical Industries and personal fees from Alexion Pharmaceuticals, Servier Laboratories, Agios Pharmaceuticals, and Rigel Pharmaceuticals. Dr Reiman reported receiving grants from the NIH. Dr Rischard reported receiving grants from the NIH/NHLBI, Bayer, Janssen, Merck, Aerovate Therapeutics, and Respira Therapeutics and consulting relationships with Acceleron Pharma and United Therapeutics. Dr Rosand reported receiving grants from the NIH and the American Heart Association and personal fees from the National Football League and Takeda Pharmaceutical Co. Dr Shepherd reported receiving grants from NIH RECOVER. Dr Simhan reported receiving grants from the NIH. Dr Singer reported receiving grants from Case Western Reserve University and MetroHealth. Dr Sparks reported receiving grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the R. Bruce and Joan M. Mickey Research Scholar Fund, the Llura Gund Award for Rheumatoid Arthritis Research and Care, Brigham and Women’s Hospital, and Bristol Myers Squibb and personal fees from Bristol Myers Squibb, AbbVie, Amgen, Boehringer Ingelheim, Gilead Sciences, Inova Diagnostics, Janssen, Optum, and Pfizer. Dr Thomas reported receiving personal fees from Guidepoint Global and GLG Councils and having a patent for ECG-spectrogram with royalties paid from MyCardio LLC through Beth Israel Deaconess Medical Center. Dr Thuluvath reported receiving grants from Mercy Medical Center. Dr Tita reported receiving grants from Pfizer. Dr VanWagoner reported receiving grants from the NIH. Dr Vasey reported receiving grants from NIH RECOVER. Dr Wallace reported receiving grants from Bristol Myers Squibb, Sanofi, and Horizon Therapeutics and personal fees from Sanofi, Novartis, Shionogi, Visterra, Horizon Therapeutics, PPD Inc, Zenas BioPharma, and Medpace. Dr Warren reported receiving grants from the NIH. Mr Weiner reported receiving grants from the NIH. Ms Welch reported receiving grants from the NIH. Dr Wisnivesky reported receiving personal fees from PPD Inc, Banook, Sanofi, Atea Pharmaceuticals, and Prospero and grants from Regeneron Pharmaceuticals, Axella, Sanofi, and Arnold. Dr Yee reported receiving grants from the NIH. No other disclosures were reported.

Funding/Support: This research was funded by the NIH (OTA OT2HL161841, OT2HL161847, and OT2HL156812) as part of the Researching COVID to Enhance Recovery (RECOVER) research program. Additional support for Drs Foulkes, Thaweethai, and Schulte was provided by R01 HL162373.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Group Information: The RECOVER Consortium nonauthor collaborators are listed in Supplement 4.

Disclaimer: This content is solely the responsibility of the authors and does not necessarily represent the official views of the RECOVER Initiative, the NIH, or other funders.

Data Sharing Statement: See Supplement 5.

Additional Information: This study is part of the RECOVER initiative, which seeks to understand, treat, and prevent the postacute sequelae of SARS-CoV-2 infection. For more information on RECOVER, visit . We thank all the participants enrolled in the RECOVER Initiative, the National Community Engagement Group (NCEG), and all patient, caregiver and community representatives.