February 9, 2021 Issue of JAMA

February 9, 2021, Vol 325, No. 6, Pages 507-596

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2021;325(6):e2017785. doi:10.1001/jama.2020.17785

Podcast: Exercise Training for HFpEF, Blood Transfusion for AMI and Anemia, Review of Hip and Knee OA, and more

Original Investigation

Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial

Stephan Mueller, MA; Ephraim B. Winzer, MD; André Duvinage, MD; et al.

Abstract Full Text

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JAMA. 2021;325(6):542-551. doi:10.1001/jama.2020.26812

This randomized trial compares the effects of high-intensity interval training, moderate continuous training, and guideline-based physical activity on change in peak oxygen consumption (V虈o2) in patients with heart failure with preserved ejection fraction (HFpEF).

Editorial
Searching for the Optimal Exercise Training Regimen in Heart Failure With Preserved Ejection Fraction
Ambarish Pandey, MD, MSCS; Dalane W. Kitzman, MD

JAMA

Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial

Gregory Ducrocq, MD, PhD; Jose R. Gonzalez-Juanatey, MD; Etienne Puymirat, MD; et al.

Abstract Full Text

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JAMA. 2021;325(6):552-560. doi:10.1001/jama.2021.0135

This noninferiority trial compares the effects of a restrictive (hemoglobin 鈮�8 g/dL) vs liberal (hemoglobin 鈮�10 g/dL) transfusion strategy on 30-day cardiovascular events among adults with acute myocardial infarction (AMI) and anemia (hemoglobin 7-10 g/dL).

Prevalence of Bicuspid Aortic Valve and Associated Aortopathy in Newborns in Copenhagen, Denmark

Anne-Sophie Sillesen, MD, PhD; Ottilia Vøgg, MD; Christian Pihl, MD; et al.

Abstract Full Text

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JAMA. 2021;325(6):561-567. doi:10.1001/jama.2020.27205

This population epidemiology study describes the prevalence of bicuspid aortic valve (BAV) and BAV subtypes, and of accompanying enlarged aortic diameter or coarctation, in Danish newborns born in Copenhagen 2016-2018.

Editorial
Bicuspid Aortic Valve鈥擜 Common Form of Structural Heart Disease
Gregory Curfman, MD

JAMA

Research Letter

Prevalence and Outcomes of SARS-CoV-2 Infection Among Migrant Workers in Singapore

Iain Beehuat Tan, MBBS, PhD; Clive Tan, MBBS, MPH; Li Yang Hsu, MBBS, MPH; et al.

Abstract Full Text

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JAMA. 2021;325(6):584-585. doi:10.1001/jama.2020.24071

This study examines the prevalence and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among migrant workers in Singapore.

Viewpoint

Health Policy

The COVID-19 Pandemic as an Opportunity to Ensure a More Successful Future for Science and Public Health

K. M. Venkat Narayan, MD, MSc; James W. Curran, MD, MPH; William H. Foege, MD, MPH

Abstract Full Text

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JAMA. 2021;325(6):525-526. doi:10.1001/jama.2020.23479

This Viewpoint suggests that the COVID-19 pandemic provides an opportunity to build trust in science and update federal agencies to improve public health and poses questions and offers recommendations for consideration.

Editorial
Health Care Is a Right, Not a Privilege: A New Series on US Health Care and Health Policy
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Karen Joynt Maddox, MD, MPH

JAMA
- Video: Health Care Reform in the Biden Era
- Conversations with Dr Bauchner: Health Care Reform in the Biden Era

Health Policy

Cancer Care Under the Biden Administration

Stacie B. Dusetzina, PhD

Abstract Full Text

JAMA. 2021;325(6):527-528. doi:10.1001/jama.2020.25424

This Viewpoint evaluates Biden鈥檚 health care proposals to help reduce the cost burden on patients with cancer should they be enacted legislatively.

Editorial
Health Care Is a Right, Not a Privilege: A New Series on US Health Care and Health Policy
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Karen Joynt Maddox, MD, MPH

JAMA
- Video: Health Care Reform in the Biden Era
- Conversations with Dr Bauchner: Health Care Reform in the Biden Era

Genetic Variants of SARS-CoV-2鈥擶hat Do They Mean?

Adam S. Lauring, MD, PhD; Emma B. Hodcroft, PhD

Abstract Full Text

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JAMA. 2021;325(6):529-531. doi:10.1001/jama.2020.27124

This Viewpoint discusses emerging genetic variants of SARS-CoV-2, including new 鈥淯K鈥� and 鈥渕ink鈥� variants and the significance of the new variants to coronavirus transmissibility, spread, virulence, and efforts to vaccinate the population against COVID-19.

Video: Coronavirus Variants and Vaccines
Video: Coronavirus Vaccine Update From the CDC With Nancy E. Messonnier, MD
Video: Coronavirus Variants - What They Mean

Podcast: Understanding SARS-CoV-2 Genetic Variants
Podcast: Understanding the New SARS-CoV-2 Mutation Found in England
Conversations with Dr Bauchner: Coronavirus Variants - What They Mean
Conversations with Dr Bauchner: Coronavirus Vaccine Update From the CDC With Nancy E. Messonnier, MD

Mandating COVID-19 Vaccines

Lawrence O. Gostin, JD; Daniel A. Salmon, MPH, PhD; Heidi J. Larson, PhD

Abstract Full Text

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JAMA. 2021;325(6):532-533. doi:10.1001/jama.2020.26553

This Viewpoint discusses whether US states, businesses, health care facilities, and schools and universities can mandate vaccination against coronavirus as a condition of employment or service.

Conversations with Dr Bauchner: Mandating COVID-19 Vaccines鈥擡thical and Legal Considerations

Editorial
Reassuring the Public and Clinical Community About the Scientific Review and Approval of a COVID-19 Vaccine
Howard Bauchner, MD; Preeti N. Malani, MD, MSJ; Joshua Sharfstein, MD

JAMA
- Video: Coronavirus Vaccine Update With Anthony Fauci
- Video: Coronavirus Update With Anthony Fauci - October 28, 2020
- Video: Coronavirus Q&A With Anthony Fauci, MD 鈥� September 25, 2020
- Video: Coronavirus Update With Michael T. Osterholm, PhD, MPH
- Video: COVID-19 Vaccine Approval and the FDA
- Conversations with Dr Bauchner: COVID-19 Vaccine Approval and the FDA
- Conversations with Dr Bauchner: Coronavirus Update With Michael T. Osterholm, PhD, MPH
- Conversations with Dr Bauchner: Coronavirus Q&A With Anthony Fauci, MD 鈥� September 25, 2020
- Conversations with Dr Bauchner: Coronavirus Update With Anthony Fauci - October 28, 2020
- Conversations with Dr Bauchner: Coronavirus Vaccine Update With Anthony Fauci

Problems With Paying People to Be Vaccinated Against COVID-19

Emily A. Largent, JD, PhD, RN; Franklin G. Miller, PhD

Abstract Full Text

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JAMA. 2021;325(6):534-535. doi:10.1001/jama.2020.27121

This Viewpoint describes features of 2 proposals to pay US residents to be vaccinated against COVID-19 and proposes ethical and practical complications of the plans, arguing that they are morally suspect, likely unnecessary, and may be counterproductive.

Editorial
Vaccine Distribution鈥擡quity Left Behind?
Muriel Jean-Jacques, MD, MAPP; Howard Bauchner, MD

JAMA
- Video: Coronavirus Vaccine Update From the CDC With Nancy E. Messonnier, MD
- Video: Prioritizing Minorities for Coronavirus Vaccination
- Video: Who Gets Coronavirus Vaccine First?
- Conversations with Dr Bauchner: Who Gets Coronavirus Vaccine First?
- Conversations with Dr Bauchner: Prioritizing Racial and Ethnic Minority Populations for Coronavirus Vaccination
- Conversations with Dr Bauchner: Coronavirus Vaccine Update From the CDC With Nancy E. Messonnier, MD

A Piece of My Mind

Donning and Doffing

Michelle S. Mourad, MD

Abstract Full Text

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JAMA. 2021;325(6):536. doi:10.1001/jama.2020.26468

In this narrative medicine essay an internal medicine hospitalist explores what the new diagnosis of breast cancer means for her professional identity and considers how the COVID-19 pandemic facilitates the hiding of serious illness but also complicates disclosing the news to colleagues and friends.

Editorial

Searching for the Optimal Exercise Training Regimen in Heart Failure With Preserved Ejection Fraction

Ambarish Pandey, MD, MSCS; Dalane W. Kitzman, MD

Abstract Full Text

JAMA. 2021;325(6):537-539. doi:10.1001/jama.2020.26347

Bicuspid Aortic Valve鈥擜 Common Form of Structural Heart Disease

Gregory Curfman, MD

Abstract Full Text

JAMA. 2021;325(6):540-541. doi:10.1001/jama.2021.0109

Review

Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review

Jeffrey N. Katz, MD, MSc; Kaetlyn R. Arant, BA; Richard F. Loeser, MD

Abstract Full Text

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JAMA. 2021;325(6):568-578. doi:10.1001/jama.2020.22171

This narrative review summarizes the pathophysiology, diagnosis, and treatment of osteoarthritis (OA) of the hip and knee, including use of structured exercise, acetaminophen and NSAIDs, corticosteroid injections, and surgery to manage symptoms.

Podcast: Osteoarthritis鈥擠iagnosis and Treatment

JAMA Clinical Challenge

An 18-Month History of Dorsal Foot Lesions

Gordon T. Moffat, MD; Zhe Ren, BSc; Andrew A. Simone, MD

Abstract Full Text

JAMA. 2021;325(6):579-580. doi:10.1001/jama.2020.16053

A 32-year-old Nigerian woman with a childhood transfusion history developed scaly plaques with cobblestone surfaces on the dorsum of the forefoot and midfoot bilaterally; serologic testing was negative for HIV and positive for hepatitis C virus. What is the diagnosis and what would you do next?

From The Medical Letter on Drugs and Therapeutics

Drugs for Osteoarthritis

Abstract Full Text

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JAMA. 2021;325(6):581-582. doi:10.1001/jama.2020.8395

This Medical Letter review reproduces a Table summarizing key information about drugs for osteoarthritis published as part of a comprehensive review on the topic.

Podcast: Osteoarthritis鈥擠iagnosis and Treatment

Medical News & Perspectives

Helping People Who Are Homeless Stay Healthy During the Pandemic

Rita Rubin, MA

Abstract Full Text

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JAMA. 2021;325(6):517-519. doi:10.1001/jama.2020.23436

This Medical News story profiles Harvard dermatologist Jennifer Tan, MD, who helps care for people experiencing homelessness.

Podcast: Dermatologist Cares for People Experiencing Homelessness

The JAMA Forum

Social Isolation and Loneliness: Imperatives for Health Care in a Post-COVID World

Eve Escalante, MSW, LCSW; Robyn L. Golden, MA, LCSW; Diana J. Mason, PhD, RN

Abstract Full Text

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JAMA. 2021;325(6):520-521. doi:10.1001/jama.2021.0100

News From the Centers for Disease Control and Prevention

Updated Recommendations for Gonorrhea Treatment

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2021;325(6):523. doi:10.1001/jama.2021.0241

Accelerated Overdose Deaths Linked With COVID-19

Bridget M. Kuehn, MSJ

Abstract Full Text

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JAMA. 2021;325(6):523. doi:10.1001/jama.2021.0074

Biotech Innovations

CRISPR-Based COVID-19 Smartphone Test in Development

Jennifer Abbasi

Abstract Full Text

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JAMA. 2021;325(6):522. doi:10.1001/jama.2021.0493

Predicting COVID-19 Outcomes in Emergency Department Patients

Jennifer Abbasi

Abstract Full Text

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JAMA. 2021;325(6):522. doi:10.1001/jama.2021.0227

Phone Apps and Wearable Trackers Modestly Improve Activity

Jennifer Abbasi

Abstract Full Text

JAMA. 2021;325(6):522. doi:10.1001/jama.2021.0495

The Arts and Medicine

Death by Massive Hemorrhage in Robert Frost鈥檚鈥淥ut, Out鈥撯€�: A Plea to the Immediate Responder

Rosalyn Buckland, PhD; Michael K. Abernethy, MD

Abstract Full Text

JAMA. 2021;325(6):515-516. doi:10.1001/jama.2020.24787

This Arts and Medicine feature uses poet Robert Frost鈥檚 poem 鈥淥ut, Out鈥撯€�, about the tragic death of a boy in the premodern era from a work injury and hemorrhagic shock, to discuss the stakes of developing a more effective public health response to traumatic injury.

Poetry and Medicine

To a Firstborn Son

Scott Hendrik Van Hoeven, BSc

Abstract Full Text

JAMA. 2021;325(6):590. doi:10.1001/jama.2020.23816

JAMA Revisited

Income Tax Credit for Charity Practice of Physicians

Abstract Full Text

JAMA. 2021;325(6):591. doi:10.1001/jama.2020.17786

JAMA Patient Page

Treatment of Alcohol Use Disorder

Avani K. Patel, MD, MHA; Alëna A. Balasanova, MD

Abstract Full Text

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JAMA. 2021;325(6):596. doi:10.1001/jama.2020.2012

This JAMA Patient Page explains the medications (naltrexone, acamprosate, disulfiram) and behavioral treatments (cognitive behavior therapy [CBT]) used to manage alcohol use disorder.

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