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November 2024 - July 1883

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November 9, 2021, Vol 326, No. 18, Pages 1771-1880

This Week in JAMA

Audio Highlights

Abstract Full Text
free access online only has audio
JAMA. 2021;326(18):e2018217. doi:10.1001/jama.2020.18217
  • Podcast: Dexamethasone Dose in Adults With Severe COVID-19, Mental Stress-Induced Myocardial Ischemia and Cardiovascular Events, Medicare Outcomes From the Oncology Care Model, and more
Original Investigation

Caring for the Critically Ill Patient

Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial

The COVID STEROID 2 Trial Group
Abstract Full Text
free access has multimedia
JAMA. 2021;326(18):1807-1817. doi:10.1001/jama.2021.18295

This multicenter randomized clinical trial compares the effects of 12 mg/d vs 6 mg/d of dexamethasone in patients with COVID-19 and severe hypoxemia.

  • Video: Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia

Association of Mental Stress鈥揑nduced Myocardial Ischemia With Cardiovascular Events in Patients With Coronary Heart Disease

Viola Vaccarino, MD, PhD; Zakaria Almuwaqqat, MD; Jeong Hwan Kim, MD; et al.
Abstract Full Text
free access
JAMA. 2021;326(18):1818-1828. doi:10.1001/jama.2021.17649

This study examines whether mental stress鈥搃nduced ischemia is related to adverse cardiovascular events in 2 parallel modern cohorts of patients with stable coronary heart disease.

Association of Participation in the Oncology Care Model With Medicare Payments, Utilization, Care Delivery, and Quality Outcomes

Nancy L. Keating, MD, MPH; Shalini Jhatakia, MA; Gabriel A. Brooks, MD, MPH; et al.
Abstract Full Text
free access
JAMA. 2021;326(18):1829-1839. doi:10.1001/jama.2021.17642

This study assesses the association of the US Centers for Medicare & Medicaid Services Oncology Care Model (OCM), an alternative payment model for cancer patients undergoing chemotherapy, with changes in Medicare spending, utilization, quality, and patient experience during the OCM鈥檚 first 3 years (2016-2018).

Research Letter

Characteristics and Outcomes of Products Seeking Competitive Generic Therapy Designation and Exclusivity

Harinder Singh Chahal, PharmD, MSc; Annabelle C. Fowler, PhD; Rinku Patel, PharmD; et al.
Abstract Full Text
free access
JAMA. 2021;326(18):1863-1865. doi:10.1001/jama.2021.14595

This study describes the process used by the US Food and Drug Administration to review potential generic drugs for Competitive Generic Therapy (CGT) designation and marketing exclusivity as well as the characteristics and outcomes of products that have sought CGT designation and exclusivity from 2017-2020.

COVID-19 Incidence and Mortality in Federal and State Prisons Compared With the US Population, April 5, 2020, to April 3, 2021

Neal Marquez, MPH; Julie A. Ward, MN, RN; Kalind Parish, MA; et al.
Abstract Full Text
free access
JAMA. 2021;326(18):1865-1867. doi:10.1001/jama.2021.17575

This study examines COVID-19 cases and deaths among US federal and state prisoners from April 5, 2020, to April 3, 2021, compared with cases and deaths in the overall US population.

Medical Specialty Board Parental, Caregiver, and Medical Leave Policy Updates After 2021 American Board of Medical Specialties Mandate

Kirti Magudia, MD, PhD; Shauna R. Campbell, DO; Erika L. Rangel, MD, MS; et al.
Abstract Full Text
free access
JAMA. 2021;326(18):1867-1870. doi:10.1001/jama.2021.15871

This study assesses how member boards of the American Board of Medical Specialties (ABMS) have adhered to a 2021 ABMS policy change allowing residents a minimum of 6 weeks of parental, caregiver, and medical leave.

Viewpoint

A Policy Prescription for Reducing Health Disparities鈥擜chieving Pharmacoequity

Utibe R. Essien, MD, MPH; Stacie B. Dusetzina, PhD; Walid F. Gellad, MD, MPH
Abstract Full Text
has audio
JAMA. 2021;326(18):1793-1794. doi:10.1001/jama.2021.17764

This Viewpoint discusses pharmacoequity, which is the goal of ensuring that all individuals have access to the highest-quality medications required to manage their health needs, and ways in which this can be achieved.

  • Podcast: A Continued Focus on Equity Through Pharmacoequity and Digital Health Equity: Two Current Viewpoints

Focusing on Digital Health Equity

Courtney R. Lyles, PhD; Robert M. Wachter, MD; Urmimala Sarkar, MD, MPH
Abstract Full Text
has audio
JAMA. 2021;326(18):1795-1796. doi:10.1001/jama.2021.18459

This Viewpoint describes ways in which health care digital tools and platforms can be designed and implemented to address long-standing health equity disparities.

  • Podcast: A Continued Focus on Equity Through Pharmacoequity and Digital Health Equity: Two Current Viewpoints

The Affordable Care Act Resurrected: Curtailing the Ranks of the Uninsured

Eli Y. Adashi, MD, MS; Daniel P. O鈥橫ahony, MSLS; I. Glenn Cohen, JD
Abstract Full Text
JAMA. 2021;326(18):1797-1798. doi:10.1001/jama.2021.17531

This Viewpoint examines the coverage gap in health insurance in the US and its potential redress by enhancing federal outreach to the uninsured, rendering permanent the health insurance benefits of the American Rescue Plan Act, and establishing a federal health insurance program for low-income adults in states that did not expand their Medicaid programs.

A Piece of My Mind

Little Acts and Big Differences: Perspectives on Civility in Medicine

Danielle Dougherty, MD; Erin E. Perrone, MD
Abstract Full Text
JAMA. 2021;326(18):1799-1800. doi:10.1001/jama.2021.19289

In this narrative medicine essay, a fetal surgery research fellow and a pediatric surgeon consider how the small moments of recognition and kindness offered by and to health care workers bring joy and civility to a stressful environment.

Editorial

Glucocorticoid Dose in COVID-19: Lessons for Clinical Trials During a Pandemic

Steven A. Webb, MD, PhD; Alisa M. Higgins, PhD; Colin J. McArthur, MBChB
Abstract Full Text
free access has multimedia
JAMA. 2021;326(18):1801-1802. doi:10.1001/jama.2021.16438
  • Video: Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia

Mental Stress鈥揑nduced Myocardial Ischemia: When the Mind Controls the Fate of the Heart

Paco E. Bravo, MD; Thomas P. Cappola, MD, ScM
Abstract Full Text
JAMA. 2021;326(18):1803-1804. doi:10.1001/jama.2021.18766

Medicare Spending, Utilization, and Quality in the Oncology Care Model

Raymond U. Osarogiagbon, MBBS; Samyukta Mullangi, MD; Deborah Schrag, MD, MPH
Abstract Full Text
JAMA. 2021;326(18):1805-1806. doi:10.1001/jama.2021.18765
Review

Cardiogenic Shock After Acute Myocardial Infarction: A Review

Marc D. Samsky, MD; David A. Morrow, MD, MPH; Alastair G. Proudfoot, MBChB, PhD; et al.
Abstract Full Text
JAMA. 2021;326(18):1840-1850. doi:10.1001/jama.2021.18323

This review discusses the pathophysiology, diagnosis, and management of cardiogenic shock associated with acute myocardial infarction.

JAMA Clinical Challenge

Blue Pigmentation of the Skin, Sclera, and Teeth

Nina A. Ran, MD; Matthew L. Hedberg, MD, PhD; Misha Rosenbach, MD
Abstract Full Text
JAMA. 2021;326(18):1851-1852. doi:10.1001/jama.2021.16176

A 69-year-old patient presented with progressive blue skin pigmentation. He had recurrent staphylococcus bacteremia due to infection of an ICD lead and was being treated with minocycline, 100 mg twice daily. He reported no discoloration of his sweat or urine. Laboratory tests revealed elevated creatinine and total bilirubin. What is the diagnosis and what would you do next?

From The Medical Letter on Drugs and Therapeutics

Higher-Dose Naloxone Nasal Spray (Kloxxado) for Opioid Overdose

Abstract Full Text
JAMA. 2021;326(18):1853-1854. doi:10.1001/jama.2021.15948

This Medical Letter review summarizes the use of Kloxxado, a higher-dose intranasal naloxone formulation, for emergency treatment of opioid overdose.

Medical News & Perspectives

The Flawed Science of Antibody Testing for SARS-CoV-2 Immunity

Jennifer Abbasi
Abstract Full Text
free access has audio
JAMA. 2021;326(18):1781-1782. doi:10.1001/jama.2021.18919

This Medical News article discusses why experts recommend against patients getting antibody testing to assess their protection from SARS-CoV-2 after vaccination or infection.

  • Podcast: November 2021 Medical News Summary

Quick Uptakes

Survey Describes How Patients With Arthritis Get Moving

Rebecca Voelker, MSJ
Abstract Full Text
JAMA. 2021;326(18):1783. doi:10.1001/jama.2021.19532

This Medical News article describes the physical activities that adults with arthritis engage in most frequently.

News From the Centers for Disease Control and Prevention

Targeted Efforts Needed to Curb Arthritis-Related Disability

Bridget M. Kuehn, MSJ
Abstract Full Text
JAMA. 2021;326(18):1786. doi:10.1001/jama.2021.19393

Low PrEP Awareness, Referrals for Black, Hispanic, and Latino People

Bridget M. Kuehn, MSJ
Abstract Full Text
JAMA. 2021;326(18):1786. doi:10.1001/jama.2021.19238
Biotech Innovations

Pfizer Launches Phase 1 mRNA Flu Vaccine Trial

Jennifer Abbasi
Abstract Full Text
JAMA. 2021;326(18):1784. doi:10.1001/jama.2021.19634

Flu Vaccine Candidate Elicits Enhanced Immune Response

Jennifer Abbasi
Abstract Full Text
JAMA. 2021;326(18):1784. doi:10.1001/jama.2021.19385

鈥淧olymutant鈥� Spike Points Way Toward More Durable COVID-19 Vaccine

Jennifer Abbasi
Abstract Full Text
free access
JAMA. 2021;326(18):1784. doi:10.1001/jama.2021.19635

Closed Loop Device May Alleviate Treatment-Resistant Depression

Jennifer Abbasi
Abstract Full Text
JAMA. 2021;326(18):1785. doi:10.1001/jama.2021.19636

Guided Ultrasound Opens Blood-Brain Barrier to Cancer Drugs

Jennifer Abbasi
Abstract Full Text
JAMA. 2021;326(18):1785. doi:10.1001/jama.2021.19638

Augmented Cane Could Help People With Visual Impairments

Jennifer Abbasi
Abstract Full Text
JAMA. 2021;326(18):1785. doi:10.1001/jama.2021.19637
The Arts and Medicine

Gustav Klimt鈥檚 The Kiss鈥�Art and the Biology of Early Human Development

Dai Hyun Kim, MD, PhD; Hyunmi Park, MBChB, PhD, Med Ed; Im Joo Rhyu, MD, PhD
Abstract Full Text
JAMA. 2021;326(18):1778-1780. doi:10.1001/jama.2021.14307

This Arts and Medicine feature identifies biological illustrations that may have influenced ornamental forms in The Kiss and other paintings by Gustav Klimt, emerging from the artist鈥檚 close interactions with scientists and embryologists and their writings in turn-of-the-century Vienna society.

Poetry and Medicine

Poem by a Woman With Glaucoma

Terri Kirby Erickson, BA
Abstract Full Text
JAMA. 2021;326(18):1875. doi:10.1001/jama.2021.12950
JAMA Revisited

Routine Smallpox Vaccination

Abstract Full Text
JAMA. 2021;326(18):1876. doi:10.1001/jama.2020.18218
JAMA Patient Page

Separation Anxiety Disorder

Avani K. Patel, MD, MHA; Beverly Bryant, MD
Abstract Full Text
free access
JAMA. 2021;326(18):1880. doi:10.1001/jama.2021.17269

This JAMA Patient Page describes separation anxiety disorder and its risk factors, diagnosis, and treatment.

Comment & Response

Iatrogenic Delivery for Suspected Fetal Growth Restriction and Childhood School Outcomes

Gordon C. S. Smith, MD, PhD, DSc
Abstract Full Text
JAMA. 2021;326(18):1870-1871. doi:10.1001/jama.2021.15516

Iatrogenic Delivery for Suspected Fetal Growth Restriction and Childhood School Outcomes

Niel F. Miele, MD
Abstract Full Text
JAMA. 2021;326(18):1871. doi:10.1001/jama.2021.15519

Iatrogenic Delivery for Suspected Fetal Growth Restriction and Childhood School Outcomes鈥擱eply

Roshan John Selvaratnam, BMedSc(Hons); Euan Morrison Wallace, MD; Mary-Ann Davey, DPH
Abstract Full Text
JAMA. 2021;326(18):1871-1872. doi:10.1001/jama.2021.15522

The Effect of Cytisine vs Varenicline on Smoking Cessation

Adam Edward Lang, PharmD
Abstract Full Text
JAMA. 2021;326(18):1872. doi:10.1001/jama.2021.16046

The Effect of Cytisine vs Varenicline on Smoking Cessation鈥擱eply

Ryan J. Courtney, PhD; Piotr Tutka, MD; Michael Farrell, PhD
Abstract Full Text
JAMA. 2021;326(18):1872-1873. doi:10.1001/jama.2021.16064

Medical Debt in the US From 2009 to 2020

Nishant Uppal, BS; Carrie Lubitz, MD, MPH; Benjamin James, MD, MS
Abstract Full Text
JAMA. 2021;326(18):1873. doi:10.1001/jama.2021.16061

Medical Debt in the US From 2009 to 2020鈥擱eply

Neale Mahoney, PhD; Francis Wong, PhD; Wesley Yin, PhD
Abstract Full Text
JAMA. 2021;326(18):1873-1874. doi:10.1001/jama.2021.16073
Correction

Addition of Nonauthor Collaborator Names of the COMEBAC Study

Abstract Full Text
free access
JAMA. 2021;326(18):1874. doi:10.1001/jama.2021.19113

Incorrect Patient Data Reported

Abstract Full Text
free access
JAMA. 2021;326(18):1874. doi:10.1001/jama.2021.18721
  • Editorial
    Vasopressin and Steroids as Adjunctive Treatment for In-Hospital Cardiac Arrest
    Jason Haukoos, MD, MSc; Ivor S. Douglas, MD; Comilla Sasson, MD, PhD
    JAMA
    • Video: Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
    • Video: Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest
JAMA Masthead

JAMA

Abstract Full Text
free access
JAMA. 2021;326(18):1771-1772. doi:10.1001/jama.2020.18215

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