This clinical trial compares the efficacy of canakinumab vs placebo on survival without invasive mechanical ventilation (IMV) in patients hospitalized with severe COVID-19.
This phase 1 randomized crossover clinical trial evaluates the 24-hour urinary excretion of N-nitrosodimethylamine (NDMA) after oral administration of ranitidine compared with placebo.
This retrospective cohort analysis of credit reports for a nationally representative 10% panel of individuals estimates the amount of medical debt nationally and by geographic region and income group and its association with Medicaid expansion under the Affordable Care Act.
To address vaccine hesitancy based on concerns about fertility, this study assesses sperm parameters before and after mRNA vaccine administration.
This study examines the association between prescription drug monitoring program mandates and changes in opioids dispensed to patients with sickle cell disease or cancer with bone metastasis who presented to the emergency department in 29 US states.
This Special Communication describes CONSERVE, a guideline developed to improve the transparency, quality, and completeness of reporting of trials and trial protocols that undergo important modifications in response to extenuating circumstances such as the COVID-19 pandemic.
This Viewpoint examines the potential of using newer strategies to prevent ischemic stroke due to large and small artery atherothrombosis, including agents to lower LDL cholesterol, as well as increase eicosapentaenoic acid levels, insulin sensitivity and synthesis, and folic acid levels.
This Viewpoint offers 3 strategies to address inequity in pandemic vaccine response: surge funding, increased funding, and an agreement to share technology and allow countries to waive intellectual property rights in global public health emergencies.
This Viewpoint discusses why offering incentives for COVID-19 vaccination is not only ethical, but an important tool in increasing vaccine uptake, which benefits society as a whole.
In this narrative medicine essay, an internist asks the doctors who for 5 months could not diagnose her son鈥檚 agonizing illness to apologize and, when most could not, asks that the medical community shift focus from promoting a false sense of perfection to one that embraces humility enough to apologize as essential to the healing process.
This JAMA Insights Clinical Update reviews lipid-lowering therapies prescribed to reduce cardiovascular risk, including statins and ezetimibe, as well as novel therapies such as PCSK-9 inhibitors, bempedoic acid, icosapent ethyl, and inclisiran.
This Genomics and Precision Health article explains how genetic testing has evolved from detection of prespecified and unknown variants to assessing entire genomes to establish diagnoses using high-throughput sequencing.
This Medical Letter review summarizes the use of Gimoti, a nasal spray formulation of the dopamine-2 receptor antagonist metoclopramide, for relief of symptoms in adults with acute and recurrent diabetic gastroparesis.
This Medical News feature examines the association between changes in alcohol use patterns during the pandemic and increases in alcohol-associated diseases.
This Medical News article discusses parents鈥� decisions to permit their teenage children to drink alcohol during COVID-19 shutdowns and the effect alcohol has on brain development during adolescence.
This JAMA Patient Page describes low back pain and its diagnosis and treatment options.