May 4, 2021 Issue of JAMA

May 4, 2021, Vol 325, No. 17, Pages 1703-1804

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2021;325(17):e2017917. doi:10.1001/jama.2020.17917

Podcast: Helmet Ventilation for COVID-19, Rheumatoid Arthritis and Immune-Mediated Inflammatory Disease Treatment, Diagnosis and Management of Stable Angina, and more

Original Investigation

Caring for the Critically Ill Patient

Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial

Domenico Luca Grieco, MD; Luca S. Menga, MD; Melania Cesarano, MD; et al.

Abstract Full Text

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JAMA. 2021;325(17):1731-1743. doi:10.1001/jama.2021.4682

This randomized trial compares the effects of helmet noninvasive ventilation (鈮�48 hours) followed by high-flow nasal oxygen (HFNO) vs HFNO alone on the number of days free of respiratory support at 28 days among patients with COVID-19 and moderate to severe hypoxemia.

Video: Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19
Video: Noninvasive Ventilation of COVID-19 Patients

Conversations with Dr Bauchner: Noninvasive Ventilation of COVID-19 Patients

Editorial
Respiratory Support During the COVID-19 Pandemic: Is It Time to Consider Using a Helmet?
Laveena Munshi, MD; Jesse B. Hall, MD

JAMA
- Video: Noninvasive Ventilation of COVID-19 Patients
- Conversations with Dr Bauchner: Noninvasive Ventilation of COVID-19 Patients

Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial

Silje Watterdal Syversen, MD, PhD; Guro Løvik Goll, MD, PhD; Kristin Kaasen Jørgensen, MD, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(17):1744-1754. doi:10.1001/jama.2021.4172

This randomized trial assesses the effect of therapeutic drug monitoring vs standard therapy on clinical remission at 30 weeks among patients with immune-mediated inflammatory diseases (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, ulcerative colitis, Crohn disease, or psoriasis) initiating infliximab therapy.

Editorial
Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases
Jeffrey R. Curtis, MD, MS, MPH; Alexis Ogdie, MD, MSCE; Michael D. George, MD, MSCE

JAMA

Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial

Siri Lillegraven, MD, MPH, PhD; Nina Paulshus Sundlisæter, MD, PhD; Anna-Birgitte Aga, MD, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(17):1755-1764. doi:10.1001/jama.2021.4542

This randomized trial compares the effects of half-dose conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) vs stable-dose csDMARDs on the risk of flares in patients with rheumatoid arthritis in sustained remission.

Editorial
Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases
Jeffrey R. Curtis, MD, MS, MPH; Alexis Ogdie, MD, MSCE; Michael D. George, MD, MSCE

JAMA

Research Letter

Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients

Brian J. Boyarsky, MD; William A. Werbel, MD; Robin K. Avery, MD; et al.

Abstract Full Text

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JAMA. 2021;325(17):1784-1786. doi:10.1001/jama.2021.4385

This study quantifies antispike protein antibody responses to first-dose messenger RNA (mRNA) COVID-19 vaccines in solid organ transplant recipients to better understand the immunogenicity of the vaccines in immunocompromised individuals.

Excess Deaths From COVID-19 and Other Causes in the US, March 1, 2020, to January 2, 2021

Steven H. Woolf, MD, MPH; Derek A. Chapman, PhD; Roy T. Sabo, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(17):1786-1789. doi:10.1001/jama.2021.5199

This study updates an analysis of US mortality in 2020, including deaths due to COVID-19 as well as all other causes.

Editorial
Learning From Excess Pandemic Deaths
Alan M. Garber, MD, PhD

JAMA

Trends in the Prevalence of Concussion Reported by US Adolescents, 2016-2020

Phil Veliz, PhD; Sean Esteban McCabe, PhD; James T. Eckner, MD, MS; et al.

Abstract Full Text

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JAMA. 2021;325(17):1789-1791. doi:10.1001/jama.2021.1538

This study analyzes the increased incidence of concussion among US teens.

Viewpoint

Reducing Low-Value Care and Improving Health Care Value

Allison H. Oakes, PhD; Thomas R. Radomski, MD, MS

Abstract Full Text

JAMA. 2021;325(17):1715-1716. doi:10.1001/jama.2021.3308

This Viewpoint proposes ways health systems can sustainably reduce low-value care, including testing and implementing reliable measures, incorporating low-value care in performance and quality measurement, and emphasizing prevention of tangible harms rather than the financial savings that would result from its reduction or elimination.

Evaluation of Aducanumab for Alzheimer Disease: Scientific Evidence and Regulatory Review Involving Efficacy, Safety, and Futility

G. Caleb Alexander, MD, MS; Scott Emerson, MD, PhD; Aaron S. Kesselheim, MD, JD, MPH

Abstract Full Text

JAMA. 2021;325(17):1717-1718. doi:10.1001/jama.2021.3854

This Viewpoint details the development and regulatory path of aducanumab, a human IgG1 monoclonal antibody to treat Alzheimer disease, including termination of 2 clinical trials, identification of conflicting evidence of efficacy, and the FDA advisory committee vote against approval (final decision pending).

Revised UNAIDS/WHO Ethical Guidance for HIV Prevention Trials

Rieke van der Graaf, PhD; Andreas Reis, MD, MSc; Peter Godfrey-Faussett, MBBS

Abstract Full Text

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JAMA. 2021;325(17):1719-1720. doi:10.1001/jama.2021.0258

This Viewpoint summarizes updates to the UNAIDS/WHO document on ethical guidance for HIV prevention trials, emphasizing the importance of collaboration among trialists, sponsors, participants, and community members if the world is to reach a target of fewer than 200鈥�000 new infections per year by 2030.

A Piece of My Mind

The Silent Mutation

Margo A. Peyton, BA

Abstract Full Text

JAMA. 2021;325(17):1721-1722. doi:10.1001/jama.2021.5484

In this narrative medicine essay, a medical student learns of her inherited disease during a genetics class in which she sees an image of a foot that matches her own, a DNA missense stemming from her biological father who left her life when she was an infant.

Editorial

Respiratory Support During the COVID-19 Pandemic: Is It Time to Consider Using a Helmet?

Laveena Munshi, MD; Jesse B. Hall, MD

Abstract Full Text

free access has multimedia has audio

JAMA. 2021;325(17):1723-1725. doi:10.1001/jama.2021.4975

Video: Noninvasive Ventilation of COVID-19 Patients

Conversations with Dr Bauchner: Noninvasive Ventilation of COVID-19 Patients

Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases

Jeffrey R. Curtis, MD, MS, MPH; Alexis Ogdie, MD, MSCE; Michael D. George, MD, MSCE

Abstract Full Text

JAMA. 2021;325(17):1726-1728. doi:10.1001/jama.2021.2740

Learning From Excess Pandemic Deaths

Alan M. Garber, MD, PhD

Abstract Full Text

free access

JAMA. 2021;325(17):1729-1730. doi:10.1001/jama.2021.5120

Review

Diagnosis and Management of Stable Angina: A Review

Parag H. Joshi, MD, MHS; James A. de Lemos, MD

Abstract Full Text

has audio

JAMA. 2021;325(17):1765-1778. doi:10.1001/jama.2021.1527

This narrative review discusses diagnostic tests and medical therapies for stable angina that have evolved over the last decade with more clarity regarding the role for revascularization.

Podcast: Chronic Stable Angina鈥擠iagnosis and Treatment

JAMA Insights

The Importance of Delirium and Delirium Prevention in Older Adults During Lockdowns

Sharon K. Inouye, MD, MPH

Abstract Full Text

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JAMA. 2021;325(17):1779-1780. doi:10.1001/jama.2021.2211

This JAMA Insights Clinical Update discusses the underrecognition of delirium in older adults with COVID-19 and provides delirium prevention strategies for hospitalized patients, such as providing remote visits with family members and therapeutic activity kits to the bedside.

Women's Health

Risk-Reducing Mastectomy

Ismail Jatoi, MD, PhD; Zoe Kemp, MD, PhD

Abstract Full Text

JAMA. 2021;325(17):1781-1782. doi:10.1001/jama.2020.22414

This JAMA Insights Clinical Update discusses risk-reducing mastectomy, the surgical removal of the breasts to reduce breast cancer risk in the absence of malignancy, and other risk-reducing strategies based on breast cancer risk.

Invited Commentary
Mastectomy or Breast-Conserving Therapy for BRCA1/2 Variant Carriers
Marissa Howard-McNatt, MD

JAMA Netw Open

Medical News & Perspectives

Pandemic Boosts an Old Idea鈥擝ringing Acute Care to the Patient

Mary Chris Jaklevic, MSJ

Abstract Full Text

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JAMA. 2021;325(17):1706-1708. doi:10.1001/jama.2021.0127

This Medical News article describes how the need to free up inpatient beds during the COVID-19 pandemic has led to more hospitals providing acute care in patients鈥� homes.

Invited Commentary
Hospital-at-Home Care Programs鈥擨s the Hospital of the Future at Home?
Joshua M. Liao, MD, MSc; Amol Navathe, MD, PhD; Matthew J. Press, MD, MSc

JAMA Intern Med
- Podcast: Association of a Bundled Hospital-at-Home Program With Clinical Outcomes and Patient Experiences

A Partnership With the Cherokee Nation Advances Medical Education on Tribal Land

Mary Chris Jaklevic, MSJ

Abstract Full Text

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JAMA. 2021;325(17):1709-1710. doi:10.1001/jama.2021.1461

In this Medical News article, William Pettit, DO, dean of the new Oklahoma State University College of Osteopathic Medicine at the Cherokee Nation, discusses how the first US medical school on tribal land came into being.

Podcast: A Partnership With the Cherokee Nation Advances Medical Education on Tribal Land

JAMA Live Highlights

Experts Discuss COVID-19鈥擵ariants and Vaccine Efficacy, Immunosuppressed Patients, and More

Abstract Full Text

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JAMA. 2021;325(17):1711-1712. doi:10.1001/jama.2021.5938

JAMA Live Highlights features comments from livestream interviews with experts in clinical care, public health, and health policy on critical issues related to the COVID-19 pandemic. Comments have been edited for clarity.

Podcast: April 2021 Medical News Summary

News From the Food and Drug Administration

Cell-Based Gene Therapy Is New Option for Multiple Myeloma

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2021;325(17):1713. doi:10.1001/jama.2021.6401

Pioneering Heart Valve Approved for Patients With CHD

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2021;325(17):1713. doi:10.1001/jama.2021.6103

Electrical Stimulator Can Improve MS-Related Walking Problems

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2021;325(17):1713. doi:10.1001/jama.2021.6402

Poetry and Medicine

Lies Before Retirement

Michael Salcman, MD

Abstract Full Text

JAMA. 2021;325(17):1797. doi:10.1001/jama.2021.4701

JAMA Revisited

BOOK REVIEWS

Abstract Full Text

JAMA. 2021;325(17):1798. doi:10.1001/jama.2021.6857

JAMA Patient Page

Surgery for Breast Cancer Prevention

Ismail Jatoi, MD, PhD; Zoe Kemp, MD, PhD

Abstract Full Text

free access

JAMA. 2021;325(17):1804. doi:10.1001/jama.2021.1647

This JAMA Patient Page describes surgery for breast cancer prevention (the removal of healthy breasts to reduce risk of breast cancer), the patient population who should consider this surgery, and the alternatives to and risks of the surgery.

Comment & Response

Effect of Adjuvant Metronomic Capecitabine on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer

Feng Du, MD; Peng Yuan, MD

Abstract Full Text

JAMA. 2021;325(17):1791-1792. doi:10.1001/jama.2021.2780

Effect of Adjuvant Metronomic Capecitabine on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer

Deep Chakrabarti, MD; Naseem Akhtar, MCh; Vijay Kumar, MCh

Abstract Full Text

JAMA. 2021;325(17):1792-1793. doi:10.1001/jama.2021.2783

Effect of Adjuvant Metronomic Capecitabine on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer鈥擱eply

Xi-Wen Bi, MD; Xin Hua, MD; Zhong-Yu Yuan, MD

Abstract Full Text

JAMA. 2021;325(17):1793. doi:10.1001/jama.2021.2786

Management of Crohn Disease

Ahmed B. Bayoumy, BSc, BPharm; Nanne K. H. de Boer, MD, PhD; Chris J. J. Mulder, MD, PhD

Abstract Full Text

JAMA. 2021;325(17):1793-1794. doi:10.1001/jama.2021.2918

Management of Crohn Disease鈥擱eply

Kelly Cushing, MD, MSCI; Peter D. R. Higgins, MD, PhD, MSc

Abstract Full Text

JAMA. 2021;325(17):1794-1795. doi:10.1001/jama.2021.2921

Correction

Incorrect P Value and Figure Label Error

Abstract Full Text

free access

JAMA. 2021;325(17):1795. doi:10.1001/jama.2021.5454

November 2024 - July 1883

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May 4, 2021, Vol 325, No. 17, Pages 1703-1804

Caring for the Critically Ill Patient

Women's Health

JAMA Live Highlights

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