January 4, 2022 Issue of JAMA

January 4, 2022, Vol 327, No. 1, Pages 11-93

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2022;327(1):e2116792. doi:10.1001/jama.2021.16792

Podcast: Medical Oncology Depression Screening for Breast Cancer, Anesthesia Choice and Postoperative Delirium After Hip Fracture Surgery, Maternal Hormone Contraception and CNS Tumors in Children, and more

Original Investigation

Effect of a Community-Based Medical Oncology Depression Screening Program on Behavioral Health Referrals Among Patients With Breast Cancer: A Randomized Clinical Trial

Erin E. Hahn, PhD, MPH; Corrine E. Munoz-Plaza, MPH; Dana Pounds, MS; et al.

Abstract Full Text

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JAMA. 2022;327(1):41-49. doi:10.1001/jama.2021.22596

This randomized clinical trial evaluates whether a tailored depression screening program yielded more referrals among patients with breast cancer treated at community medical oncology practices to behavioral health or mental health services than did a clinician education-only strategy.

Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial

Ting Li, PhD; Jun Li, PhD; Liyong Yuan, MD; et al.

Abstract Full Text

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JAMA. 2022;327(1):50-58. doi:10.1001/jama.2021.22647

This randomized clinical trial compares the incidence of dementia and dementia-associated secondary outcomes among older patients in China undergoing hip fracture surgery with regional vs general anesthesia.

Editorial
General Anesthesia and Postoperative Neurocognitive Outcomes
Michael S. Avidan, MBBCh; Elizabeth L. Whitlock, MD, MS; George A. Mashour, MD, PhD

JAMA

Association Between Maternal Hormonal Contraception Use and Central Nervous System Tumors in Children

Marie Hargreave, PhD; Lina S. Mørch, PhD; Jeanette F. Winther, DMSc; et al.

Abstract Full Text

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JAMA. 2022;327(1):59-66. doi:10.1001/jama.2021.22482

This study examines the association between maternal hormonal contraception use and the risk of childhood central nervous system tumors in a nationwide cohort of all live-born children in Denmark from 1996 to 2014.

Editorial
Maternal Contraceptive Use and Central Nervous System Tumors in Offspring
Logan G. Spector, PhD; Christopher L. Moertel, MD; H. Irene Su, MD, MSCE

JAMA

Research Letter

Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine in People Aged 75 Years or Older

Marie Joelle Jabagi, PharmD, PhD; Jérémie Botton, PharmD, PhD; Marion Bertrand, MSc; et al.

Abstract Full Text

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JAMA. 2022;327(1):80-82. doi:10.1001/jama.2021.21699

This population-based study evaluates the short-term risk of severe cardiovascular events among French residents aged 75 years or older after receipt of the BNT162b2 mRNA COVID-19 vaccination.

Viewpoint

Medicare Advantage for All: A Potential Path to Universal Coverage

Greg J. Zahner, MD, MSc; Peter W. Croughan, MD; Daniel M. Blumenthal, MD, MBA

Abstract Full Text

JAMA. 2022;327(1):29-30. doi:10.1001/jama.2021.23329

This Viewpoint discusses implementation of a 鈥淢edicare Advantage for All鈥� structure as a possible path to universal health insurance in the US and describes its potential benefits, limitations, and risks.

Treating the Most Critically Ill Patients With COVID-19: The Evolving Role of Extracorporeal Membrane Oxygenation

Graeme MacLaren, MBBS, MSc; Dale Fisher, MBBS; Daniel Brodie, MD

Abstract Full Text

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JAMA. 2022;327(1):31-32. doi:10.1001/jama.2021.22580

This Viewpoint discusses the use of extracorporeal membrane oxygenation (ECMO) in treating patients with COVID-19 and how regional health care networks and governments should continue to monitor outcomes for patients with COVID-19 treated with ECMO to help manage ECMO resources for all critically ill patients.

Applying Syndemic Theory to Acute Illness

Kristina E. Rudd, MD, MPH; Christina F. Mair, PhD, MPH; Derek C. Angus, MD, MPH

Abstract Full Text

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JAMA. 2022;327(1):33-34. doi:10.1001/jama.2021.22583

This Viewpoint describes how syndemic theory, a way of analyzing harmful social conditions that contribute to chronic disease, could be applied to acute conditions of sepsis and COVID-19 that could guide the development of more precise strategies to clinical care, research, and health policies.

A Piece of My Mind

Scenes From a Mammogram

Lisa Michelle Sieczkowski, MD

Abstract Full Text

JAMA. 2022;327(1):35. doi:10.1001/jama.2021.23000

In this narrative medicine essay, a pediatrician describes her dreary routine visit to the local breast imaging center for her annual screening mammogram.

Editorial

General Anesthesia and Postoperative Neurocognitive Outcomes

Michael S. Avidan, MBBCh; Elizabeth L. Whitlock, MD, MS; George A. Mashour, MD, PhD

Abstract Full Text

JAMA. 2022;327(1):36-38. doi:10.1001/jama.2021.22465

Maternal Contraceptive Use and Central Nervous System Tumors in Offspring

Logan G. Spector, PhD; Christopher L. Moertel, MD; H. Irene Su, MD, MSCE

Abstract Full Text

JAMA. 2022;327(1):39-40. doi:10.1001/jama.2021.21809

Users' Guides to the Medical Literature

How to Use and Interpret the Results of a Platform Trial: Users鈥� Guide to the Medical Literature

Jay J. H. Park, PhD; Michelle A. Detry, PhD; Srinivas Murthy, MD, CM, MHSc; et al.

Abstract Full Text

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JAMA. 2022;327(1):67-74. doi:10.1001/jama.2021.22507

This Users鈥� Guide to the Medical Literature describes the fundamental concepts of platform trials and master protocols and reviews issues in the conduct and interpretation of these studies.

Podcast: Evaluating the Results of Platform Clinical Trials: A Guide for Clinicians

Editorial
Emerging Lessons From COVID-19 for the US Clinical Research Enterprise
Derek C. Angus, MD; Anthony C. Gordon, MD; Howard Bauchner, MD

JAMA

JAMA Insights

Genomics and Precision Health

Phenome-Wide Association Studies

Lisa Bastarache, MS; Joshua C. Denny, MD, MS; Dan M. Roden, MD

Abstract Full Text

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JAMA. 2022;327(1):75-76. doi:10.1001/jama.2021.20356

This Genomics and Precision Health article explores the concept of phenome-wide association studies, which use a data set to find phenotypic associations with genetic variations.

Podcast: Phenome-Wide Association Studies

JAMA Clinical Challenge

Severe Polyarthralgia After Kidney Transplant

Nur Azizah Allameen, MBBS, MMed; Jiacai Cho, MBBS, MMed

Abstract Full Text

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JAMA. 2022;327(1):77-78. doi:10.1001/jama.2021.18866

A 51-year-old woman had intense and worsening polyarthralgia and swelling of bilateral fingers and toes 1 year after kidney transplant complicated by Volvariella volvacea infection of the central nervous system. Her medications included tacrolimus, prednisolone, cinacalcet, and voriconazole. Alkaline phosphatase level was elevated, and radiography of the hands revealed periostitis. What is the diagnosis and what would you do next?

Medical News & Perspectives

Why Parents Still Hesitate to Vaccinate Their Children Against COVID-19

Melissa Suran, PhD, MSJ

Abstract Full Text

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JAMA. 2022;327(1):23-25. doi:10.1001/jama.2021.21625

This Medical News feature discusses concerns about giving children the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine despite federal recommendations.

Podcast: December 2021 Medical News Summary

News From the 糖心vlog

Some Men With Localized Prostate Cancer Regret Surgery

Anita Slomski

Abstract Full Text

JAMA. 2022;327(1):26. doi:10.1001/jama.2021.23317

An Increase in Adolescent Cannabis Vaping Is Reported

Anita Slomski

Abstract Full Text

JAMA. 2022;327(1):26. doi:10.1001/jama.2021.22982

Belief in Having Had COVID-19 Linked With Long COVID Symptoms

Anita Slomski

Abstract Full Text

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JAMA. 2022;327(1):26. doi:10.1001/jama.2021.23318

Novel Study Tests n-of-1 Trials for Atrial Fibrillation Triggers

Anita Slomski

Abstract Full Text

JAMA. 2022;327(1):26. doi:10.1001/jama.2021.23319

News From the Food and Drug Administration

Safer Water for Growing Produce

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2022;327(1):27. doi:10.1001/jama.2021.23422

Lighting the Way for Improved Detection of Ovarian Cancer

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2022;327(1):27. doi:10.1001/jama.2021.22960

A Treatment Advance for Patients With Posttransplant CMV

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2022;327(1):27. doi:10.1001/jama.2021.23423

The Arts and Medicine

The COVID-19 Pandemic in Serial Medical Dramas

Irene Cambra-Badii, PhD; Elena Guardiola, MD, PhD; Josep-E. Baños, MD, PhD

Abstract Full Text

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JAMA. 2022;327(1):20-22. doi:10.1001/jama.2021.19779

This Arts and Medicine feature summarizes representations of the coronavirus pandemic in the storylines of serial medical dramas that aired between November 2020 and May 2021.

Poetry and Medicine