September 7, 2021 Issue of JAMA

September 7, 2021, Vol 326, No. 9, Pages 793-880

This Week in JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2021;326(9):e2018109. doi:10.1001/jama.2020.18109

Podcast: Effect of IV Fluid Type and Rate on Mortality in Critical Illness, Environmental Remediation for Asthma Prevention in Urban Schoolchildren, Review of Pancreatic Cancer, and more

Original Investigation

Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial

Fernando G. Zampieri, MD, PhD; Flávia R. Machado, MD, PhD; Rodrigo S. Biondi, MD; et al.

Abstract Full Text

free access has multimedia has audio

JAMA. 2021;326(9):818-829. doi:10.1001/jama.2021.11684

This randomized clinical trial compares the effect of a balanced solution vs saline solution on 90-day survival in critically ill patients.

Video: Effect of Intravenous Fluid Treatment With a Balanced vs Normal Saline Solution at a High vs Low Infusion Rate on Mortality in Critically Ill Patients

Podcast: Managing Fluids in Critically Ill Patients

Editorial
Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU?
Michael J. Connor Jr, MD; Craig M. Coopersmith, MD

JAMA
- Podcast: Managing Fluids in Critically Ill Patients

Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial

Fernando G. Zampieri, MD, PhD; Flávia R. Machado, MD, PhD; Rodrigo S. Biondi, MD; et al.

Abstract Full Text

free access has multimedia has audio

JAMA. 2021;326(9):830-838. doi:10.1001/jama.2021.11444

This factorial clinical trial examined whether infusing critically ill patients in the intensive care unit requiring fluid challenges at a slower rate than a faster rate would reduce 90-day mortality.

Video: Effect of Intravenous Fluid Treatment With a Balanced vs Normal Saline Solution at a High vs Low Infusion Rate on Mortality in Critically Ill Patients

Podcast: Managing Fluids in Critically Ill Patients

Editorial
Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU?
Michael J. Connor Jr, MD; Craig M. Coopersmith, MD

JAMA
- Podcast: Managing Fluids in Critically Ill Patients

Effect of School Integrated Pest Management or Classroom Air Filter Purifiers on Asthma Symptoms in Students With Active Asthma: A Randomized Clinical Trial

Wanda Phipatanakul, MD, MS; Petros Koutrakis, PhD; Brent A. Coull, MD, PhD; et al.

Abstract Full Text

free access

JAMA. 2021;326(9):839-850. doi:10.1001/jama.2021.11559

This randomized clinical trial compares use of a school-wide integrated pest management (IPM) program vs use of high-efficiency particulate air (HEPA) filter purifiers in the classrooms for students with active asthma attending urban elementary schools who were randomized to IPM by school and HEPA filter purifiers by classroom.

Editorial
School Classrooms as Targets to Reduce Allergens and Improve Asthma
William W. Busse, MD; Daniel J. Jackson, MD

JAMA

Research Letter

Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples

Timothy A. Bates, BSc; Hans C. Leier, BA; Zoe L. Lyski, MS; et al.

Abstract Full Text

free access

JAMA. 2021;326(9):868-869. doi:10.1001/jama.2021.11656

This study examines the relationship between age and neutralizing antibody titers against the SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant after 2 doses of the BNT162b2 vaccine.

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents

Thomas Radtke, PhD; Agne Ulyte, MD, PhD; Milo A. Puhan, MD, PhD; et al.

Abstract Full Text

free access

JAMA. 2021;326(9):869-871. doi:10.1001/jama.2021.11880

This cohort study reports the prevalence of long-term symptoms in children and adolescents who had recovered from acute SARS-CoV-2 infection.

Viewpoint

Aligning Payments, Services, and Quality in Primary Care

John H. Wasson, MD; Harold C. Sox, MD; Harold D. Miller

Abstract Full Text

JAMA. 2021;326(9):805-806. doi:10.1001/jama.2021.12775

This Viewpoint suggests a hybrid reimbursement model for primary care practices that could help align payments and practice structure with the types and intensity of services that patients need.

Enforcement of the Physician Payments Sunshine Act: Trust and Verify

Eli Y. Adashi, MD, MS; I. Glenn Cohen, JD

Abstract Full Text

JAMA. 2021;326(9):807-808. doi:10.1001/jama.2021.13156

This Viewpoint revisits the Open Payments Program, mandated by the Sunshine Act, and discusses alleged violations by device and pharmaceutical manufacturers and the future enforcement of the program.

Cancer as a Global Health Priority

Satish Gopal, MD; Norman E. Sharpless, MD

Abstract Full Text

JAMA. 2021;326(9):809-810. doi:10.1001/jama.2021.12778

This Viewpoint discusses the mission, vision, and goals of the US National Cancer Institute Center for Global Health on the 10th anniversary of creation of the Center, which was established to incorporate cancer control into broader global health programs, foster relevant research, and cultivate collaborations among researchers with shared global health objectives.

A Piece of My Mind

Drifting Over the Horizon: Navigating the End-of-Life Journey

David Allan Gruenewald, MD

Abstract Full Text

JAMA. 2021;326(9):811-812. doi:10.1001/jama.2021.14031

In this narrative medicine essay, a geriatrician describes how his mother and he navigate the last months and days of her life while basking in their mutual love, trust, and respect.

Editorial

Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU?

Michael J. Connor Jr, MD; Craig M. Coopersmith, MD

Abstract Full Text

has audio

JAMA. 2021;326(9):813-815. doi:10.1001/jama.2021.11119

Podcast: Managing Fluids in Critically Ill Patients

School Classrooms as Targets to Reduce Allergens and Improve Asthma

William W. Busse, MD; Daniel J. Jackson, MD

Abstract Full Text

JAMA. 2021;326(9):816-817. doi:10.1001/jama.2021.12322

Review

Pancreatic Cancer: A Review

Wungki Park, MD; Akhil Chawla, MD; Eileen M. O鈥橰eilly, MD

Abstract Full Text

JAMA. 2021;326(9):851-862. doi:10.1001/jama.2021.13027

This review summarizes current evidence regarding pathobiology, diagnosis, and management of pancreatic ductal adenocarcinoma.

JAMA Insights

Cognitive Decline Associated With Anesthesia and Surgery in Older Patients

Susana Vacas, MD, PhD; Daniel J. Cole, MD; Maxime Cannesson, MD, PhD

Abstract Full Text

free access

JAMA. 2021;326(9):863-864. doi:10.1001/jama.2021.4773

This JAMA Insights article reviews how changes in the brain related to aging may contribute to decreased cognitive reserve, susceptibility to the stresses of surgery and anesthesia, and increased risk of neurologic injury from anesthesia and surgery in older patients.

JAMA Clinical Challenge

Inflammatory Myositis in a Patient With Melanoma

Mithu Maheswaranathan, MD; Michel G. Khouri, MD; Sophia C. Weinmann, MD

Abstract Full Text

JAMA. 2021;326(9):865-866. doi:10.1001/jama.2021.9025

A 47-year-old man with melanoma presented with 1 week of low-grade fevers, myalgias, elevated creatine kinase levels, and proximal muscle weakness. He previously underwent amputation of a finger and began adjuvant nivolumab for stage IIIC melanoma. One week later, he developed fevers, myalgias, dark urine, weakness, and difficulty walking. What is the diagnosis and what would you do next?

Medical News & Perspectives

Detecting Kids鈥� Broken Hearts鈥擟ardiac Screening Advised During Well-Child Visits

Anita Slomski

Abstract Full Text

has audio

JAMA. 2021;326(9):797-799. doi:10.1001/jama.2021.13323

This Medical News article discusses new American Academy of Pediatrics policy that advises universal cardiac screening for children and adolescents.

Podcast: August 2021 Medical News Summary

News From the 糖心vlog

Most Fully Vaccinated Patients With Cancer Have SARS-CoV-2 Antibodies

Anita Slomski

Abstract Full Text

free access

JAMA. 2021;326(9):800. doi:10.1001/jama.2021.14707

Covering Tracheostomies Reduces Viral Spread to Health Care Staff

Anita Slomski

Abstract Full Text

free access

JAMA. 2021;326(9):800. doi:10.1001/jama.2021.13454

Novel Oral Drug Rapidly Treats Postpartum Depression

Anita Slomski

Abstract Full Text

JAMA. 2021;326(9):800. doi:10.1001/jama.2021.14708

Guidelines for Lipid-Lowering Therapy Intensification Rarely Followed

Anita Slomski

Abstract Full Text

JAMA. 2021;326(9):800. doi:10.1001/jama.2021.14709

News From the Food and Drug Administration

First Interchangeable Biosimilar Insulin Drug Is Approved

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2021;326(9):801. doi:10.1001/jama.2021.14729

Testing Monoclonal Antibodies for Rabies Prophylaxis

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2021;326(9):801. doi:10.1001/jama.2021.13757

Developing Partnerships to Streamline Global Food Safety

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2021;326(9):801. doi:10.1001/jama.2021.14730

The Arts and Medicine

Emoji for the Medical Community鈥擟hallenges and Opportunities

Debbie Lai, BA; Jennifer 8. Lee, BA; Shuhan He, MD

Abstract Full Text

JAMA. 2021;326(9):795-796. doi:10.1001/jama.2021.8409

This Arts and Medicine feature reviews currently available medical emoji and proposes that an expanded set of images could improve medical communication, clinical care, and public health.

Poetry and Medicine

Sequelae

Nancy Naomi Carlson, PhD

Abstract Full Text

JAMA. 2021;326(9):874. doi:10.1001/jama.2021.9462

JAMA Revisited

Public Health and Private Practice

Abstract Full Text

JAMA. 2021;326(9):875. doi:10.1001/jama.2020.18110

JAMA Patient Page

Variants of SARS-CoV-2

Adam S. Lauring, MD, PhD; Preeti N. Malani, MD, MSJ

Abstract Full Text

free access

JAMA. 2021;326(9):880. doi:10.1001/jama.2021.14181

This JAMA Patient Page explains what virus variants are and describes several recent variants of the SARS-CoV-2 virus and the public health concerns relating to these variants.

Comment & Response