January 5, 2021 Issue of JAMA

January 5, 2021, Vol 325, No. 1, Pages 9-96

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2021;325(1):e2017725. doi:10.1001/jama.2020.17725

Podcast: Effect of Tri- vs Quadrivalent Flu Vaccination on Mortality, COPD Exacerbation and VTE, Review of Crohn Disease, and more

Original Investigation

Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease: A Randomized Clinical Trial

Orly Vardeny, PharmD, MS; KyungMann Kim, PhD; Jacob A. Udell, MD, MPH; et al.

Abstract Full Text

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JAMA. 2021;325(1):39-49. doi:10.1001/jama.2020.23649

This randomized clinical trial compares the effect of high-dose vs standard-dose influenza vaccine on all-cause mortality and hospitalizations due to cardiovascular or pulmonary causes in patients with high-risk cardiovascular disease.

Editorial
Influenza Vaccine for Patients With High-risk Cardiovascular Disease
Manish M. Patel, MD, MS; Timothy M. Uyeki, MD, MPH, MPP

JAMA

Effect of Capecitabine Maintenance Therapy Using Lower Dosage and Higher Frequency vs Observation on Disease-Free Survival Among Patients With Early-Stage Triple-Negative Breast Cancer Who Had Received Standard Treatment: The SYSUCC-001 Randomized Clinical Trial

Xi Wang, MD; Shu-Sen Wang, MD; Heng Huang, MD; et al.

Abstract Full Text

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JAMA. 2021;325(1):50-58. doi:10.1001/jama.2020.23370

This randomized trial compares the effects of low-dose high-frequency capecitabine maintenance therapy vs observation after standard adjuvant chemotherapy on 5-year disease-free survival among women with early-stage triple-negative breast cancer.

Editorial
Adjuvant Capecitabine in Triple-Negative Breast Cancer: New Strategies for Tailoring Treatment Recommendations
Heather A. Parsons, MD, MPH; Harold J. Burstein, MD, PhD

JAMA

Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms

Francis Couturaud, MD, PhD; Laurent Bertoletti, MD, PhD; Jean Pastre, MD; et al.

Abstract Full Text

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JAMA. 2021;325(1):59-68. doi:10.1001/jama.2020.23567

This cross-sectional study characterizes the prevalence of pulmonary embolism defined by a uniform diagnostic algorithm in patients in France with COPD hospitalized with acutely worsening respiratory symptoms.

Research Letter

Stillbirths During the COVID-19 Pandemic in England, April-June 2020

Julia Stowe, PhD; Helen Smith, BSc(Hons); Kate Thurland, MPH; et al.

Abstract Full Text

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JAMA. 2021;325(1):86-87. doi:10.1001/jama.2020.21369

This study uses National Health Service data to compare the stillbirth rate overall and regionally during the initial April-June 2020 coronavirus lockdown vs the same period in 2019.

Changes in Preterm Birth Phenotypes and Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic, March-June 2020

Sara C. Handley, MD, MSCE; Anne M. Mullin, BS; Michal A. Elovitz, MD; et al.

Abstract Full Text

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JAMA. 2021;325(1):87-89. doi:10.1001/jama.2020.20991

This study uses data from the GeoBirth pregnancy cohort of all births in 2 hospitals in Philadelphia to examine whether rates of preterm birth, spontaneous preterm birth, medically indicated preterm birth, and stillbirth have changed during the SARS-CoV-2 pandemic compared with prepandemic rates.

Viewpoint

How to Leverage the Medicare Program for a COVID-19 Vaccination Campaign

Nicole Lurie, MD, MSPH; Bettina Experton, MD, MPH

Abstract Full Text

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JAMA. 2021;325(1):21-22. doi:10.1001/jama.2020.22720

This Viewpoint proposes that Medicare claims data could inform the rollout of a COVID-19 vaccination program in the US, including notifying beneficiaries of their risk and prioritization and supporting efforts to allocate the vaccine and monitor its uptake, immunogenicity, and safety.

Invited Commentary
Building Trust to Achieve Confidence in COVID-19 Vaccines
Douglas J. Opel, MD, MPH; Daniel A. Salmon, PhD, MPH; Edgar K. Marcuse, MD, MPH

JAMA Netw Open

Diversity in Medical Schools: A Much-Needed New Beginning

Valerie Montgomery Rice, MD

Abstract Full Text

has multimedia has audio

JAMA. 2021;325(1):23-24. doi:10.1001/jama.2020.21576

This Viewpoint reviews the many factors contributing to underrepresentation of Black physicians in US medical training pipelines and the health care workforce, and urges actions to dismantle structural barriers to Black medical school enrollment and achieve racial parity in the profession.

Video: Diversifying Medical Education

Conversations with Dr Bauchner: Diversifying Medical Education

Editorial
Diversity in Medical Schools鈥擭eed for a New Bold Approach
Clyde W. Yancy, MD; Howard Bauchner, MD

JAMA
- Video: Diversifying Medical Education
- Conversations with Dr Bauchner: Diversifying Medical Education

Presidents鈥� Health and Medical Confidentiality

Robert Klitzman, MD

Abstract Full Text

JAMA. 2021;325(1):25-26. doi:10.1001/jama.2020.23476

This Viewpoint discusses the modern history of US presidential disability and efforts to balance the chief executive鈥檚 confidentiality with the public鈥檚 right to know, and calls for clearer guidelines from trusted physician organizations to inform bipartisan cabinet and congressional assessments of physical and psychiatric fitness to hold office.

A Piece of My Mind

The Highest Bidder

Anne Jacobson, MD, MPH

Abstract Full Text

JAMA. 2021;325(1):27-28. doi:10.1001/jama.2020.24483

In this narrative medicine essay, a physician explores a persistent memory of a high school peer who staked all on creativity as a value that physicians and future physicians ought to tap into to resolve today鈥檚 strife as healers.

Editorial

A Medical and Scientific New Year鈥檚 Wish List

Howard Bauchner, MD

Abstract Full Text

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JAMA. 2021;325(1):29-30. doi:10.1001/jama.2020.23346

Diversity in Medical Schools鈥擭eed for a New Bold Approach

Clyde W. Yancy, MD; Howard Bauchner, MD

Abstract Full Text

free access has multimedia has audio

JAMA. 2021;325(1):31-32. doi:10.1001/jama.2020.23601

Video: Diversifying Medical Education

Conversations with Dr Bauchner: Diversifying Medical Education

Influenza Vaccine for Patients With High-risk Cardiovascular Disease

Manish M. Patel, MD, MS; Timothy M. Uyeki, MD, MPH, MPP

Abstract Full Text

JAMA. 2021;325(1):33-35. doi:10.1001/jama.2020.23948

Adjuvant Capecitabine in Triple-Negative Breast Cancer: New Strategies for Tailoring Treatment Recommendations

Heather A. Parsons, MD, MPH; Harold J. Burstein, MD, PhD

Abstract Full Text

JAMA. 2021;325(1):36-38. doi:10.1001/jama.2020.23371

Review

Management of Crohn Disease: A Review

Kelly Cushing, MD, MSCI; Peter D. R. Higgins, MD, PhD, MSc

Abstract Full Text

has audio

JAMA. 2021;325(1):69-80. doi:10.1001/jama.2020.18936

This review discusses the diagnosis and management of Crohn disease, including the importance of disease severity and risk stratification when determining a treatment strategy, the importance of maintenance therapy, and the adverse effects of treatment options.

Podcast: Crohn Disease Management

JAMA Clinical Guidelines Synopsis

Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA

AbdulRahman Dia, MD; Adam S. Cifu, MD; Atman P. Shah, MD

Abstract Full Text

has audio

JAMA. 2021;325(1):81-82. doi:10.1001/jama.2020.22176

This Clinical Guidelines Synopsis summarizes the American Academy of Neurology鈥檚 practice advisory update on management of patients with a patent foramen ovale who have a history of stroke or transient ischemic attack.

Podcast: Patent Foramen Ovale and Secondary Stroke Prevention

JAMA Clinical Challenge

A Patient With Dizziness, Chest Pain, Rash, and Nail Changes

Myron Zhang, MD; Shari R. Lipner, MD, PhD

Abstract Full Text

JAMA. 2021;325(1):83-84. doi:10.1001/jama.2020.15176

A 40-year-old woman with dizziness and imbalance, a petechial rash on her palms and soles, and a right thumbnail splinter hemorrhage had acute right cerebellar infarcts with a left atrial mass on CT angiogram. What is the diagnosis and what would you do next?

Medical News & Perspectives

Surgeon Fills COVID-19 Testing Gap in Philadelphia鈥檚 Black Neighborhoods

Mary Chris Jaklevic, MSJ

Abstract Full Text

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JAMA. 2021;325(1):14-16. doi:10.1001/jama.2020.22796

In this Medical News article, Ala Stanford, MD, founder of Philadelphia鈥檚 Black Doctors COVID-19 Consortium, explains how she established COVID-19 testing sites for the city鈥檚 Black residents.

Video: Bringing Free Coronavirus Testing to Black Neighborhoods

Podcast: Surgeon Creates Barrier-Free COVID-19 Testing Service for Philadelphia's Black Residents

News From the Food and Drug Administration

Antiviral Drug Approved for Postexposure Flu Prevention

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2021;325(1):20. doi:10.1001/jama.2020.25618

First Progeria Drug Is Approved

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2021;325(1):20. doi:10.1001/jama.2020.24348

New Tool Offers Faster Notice of Foodborne Illness Outbreaks

Rebecca Voelker, MSJ

Abstract Full Text

JAMA. 2021;325(1):20. doi:10.1001/jama.2020.25620

The JAMA Forum

A 7-Point Action Agenda to End the COVID-19 Pandemic for President-elect Biden

Lawrence O. Gostin, JD

Abstract Full Text

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JAMA. 2021;325(1):17-18. doi:10.1001/jama.2020.23848

Bench to Bedside

Could Baking Soda Fight Leukemia Relapse After Stem Cell Transplant?

Tracy Hampton, PhD

Abstract Full Text

JAMA. 2021;325(1):19. doi:10.1001/jama.2020.24504

The Arts and Medicine

The Art of Losing鈥擳hree Poems for the COVID-19 Pandemic

Rafael Campo, MA, MD; Elisa New, PhD

Abstract Full Text

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JAMA. 2021;325(1):12-13. doi:10.1001/jama.2020.24699

This Arts and Medicine essay features 3 poems鈥擡lizabeth Bishop鈥檚鈥淥ne Art,鈥� Marilyn Chin鈥檚鈥淗ospital in Oregon,鈥� and Edward Hirsch鈥檚鈥淲hat the Last Evening Will Be Like鈥濃€攁s sources of wisdom and insight in the turmoil and pain of the COVID-19 pandemic.

Video: One Art, by Elizabeth Bishop
Video: Edward Hirsch on Poetry as 鈥楴ecessary Speech鈥�

Poetry and Medicine

Sewing a Mask

Wynne Morrison, MD

Abstract Full Text

JAMA. 2021;325(1):91. doi:10.1001/jama.2020.20200

JAMA Revisited

Current Comment

Abstract Full Text

JAMA. 2021;325(1):92. doi:10.1001/jama.2020.17726

JAMA Patient Page

Bisphosphonates for Postmenopausal Osteoporosis

Kristine E. Ensrud, MD

Abstract Full Text

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JAMA. 2021;325(1):96. doi:10.1001/jama.2020.2923

This JAMA Patient Page summarizes the benefits and possible harms of taking bisphosphonates for postmenopausal osteoporosis (age-related thinning of bones).

Comment & Response

Postexercise Ankle-Brachial Index Testing to Diagnose Peripheral Artery Disease

Guillaume Mahé, MD, PhD; Damien Lanéelle, MD; Alexis Le Faucheur, PhD

Abstract Full Text

JAMA. 2021;325(1):89. doi:10.1001/jama.2020.22475

Postexercise Ankle-Brachial Index Testing to Diagnose Peripheral Artery Disease鈥擱eply

Anurag Mehta, MD; Laurence S. Sperling, MD; Bryan J. Wells, MD

Abstract Full Text

JAMA. 2021;325(1):89-90. doi:10.1001/jama.2020.22490

Correction

Incorrect Data in Table and in Results Section

Abstract Full Text

free access

JAMA. 2021;325(1):90. doi:10.1001/jama.2020.25021

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January 5, 2021, Vol 325, No. 1, Pages 9-96

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