January 12, 2021 Issue of JAMA

January 12, 2021, Vol 325, No. 2, Pages 105-195

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2021;325(2):e2017737. doi:10.1001/jama.2020.17737

Podcast: Sodium Nitrite and OHCA Survival, Neonatal Abstinence Syndrome and Maternal Opioid Use, Glaucoma Review, and more

Original Investigation

Effect of Out-of-Hospital Sodium Nitrite on Survival to Hospital Admission After Cardiac Arrest: A Randomized Clinical Trial

Francis Kim, MD; Charles Maynard, PhD; Cameron Dezfulian, MD; et al.

Abstract Full Text

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JAMA. 2021;325(2):138-145. doi:10.1001/jama.2020.24326

This randomized trial compares the effects of paramedic-administered parenteral sodium nitrite (45 mg vs 60 mg) vs placebo on survival to hospital admission among adult patients with out-of-hospital pulseless collapse and cardiac arrest.

Neonatal Abstinence Syndrome and Maternal Opioid-Related Diagnoses in the US, 2010-2017

Ashley H. Hirai, PhD; Jean Y. Ko, PhD; Pamela L. Owens, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(2):146-155. doi:10.1001/jama.2020.24991

This study uses US national hospital database data to update estimates of prevalence of neonatal abstinence syndrome and maternal opioid-related diagnoses between 2010 and 2017, and to describe state-level variation and associated lengths of stay and costs.

Association of Fresh Embryo Transfers Compared With Cryopreserved-Thawed Embryo Transfers With Live Birth Rate Among Women Undergoing Assisted Reproduction Using Freshly Retrieved Donor Oocytes

Iris G. Insogna, MD, MBE; Andrea Lanes, PhD; Malinda S. Lee, MD, MBA; et al.

Abstract Full Text

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JAMA. 2021;325(2):156-163. doi:10.1001/jama.2020.23718

This cohort study uses US national registry data to compare the association of fresh vs cryopreserved-thawed embryo transfer and live birth rates among women undergoing assisted reproduction technology (ART) procedures using freshly retrieved donor oocytes between 2014 and 2017.

Research Letter

Influenza, Varicella, and Mumps Outbreaks in US Migrant Detention Centers

Nathan C. Lo, MD, PhD; Sindiso Nyathi, BA; Lloyd A. C. Chapman, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(2):180-182. doi:10.1001/jama.2020.20539

This study uses US Immigration and Customs Enforcement (ICE) Health Service Corps data to describe incident cases and outbreaks of influenza, varicella, and mumps in 22 US ICE detention centers between 2017 and March 2020.

COVID-19 Testing and Cases in Immigration Detention Centers, April-August 2020

Parsa Erfani, BA; Nishant Uppal, BS; Caroline H. Lee, BA; et al.

Abstract Full Text

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JAMA. 2021;325(2):182-184. doi:10.1001/jama.2020.21473

This study describes monthly test, test positivity, and case rates for coronavirus disease 2019 (COVID-19) among individuals detained by US Immigration and Customs Enforcement (ICE) between April and August 2020.

Clinical Implications of Removing Race From Estimates of Kidney Function

James A. Diao, BS; Gloria J. Wu, BS; Herman A. Taylor, MD; et al.

Abstract Full Text

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JAMA. 2021;325(2):184-186. doi:10.1001/jama.2020.22124

This study uses NHANES data to compare estimated glomerular filtration rate from serum creatinine (eGFRcr) values calculated with vs without race as a variable, and to estimate the number of patients for whom nephrologist referrals and drug and renal replacement recommendations would change as a result according to KDIGO guidelines and Medicare benefit policies.

Editorial
Removal of Race From Estimates of Kidney Function: First, Do No Harm
Keith C. Norris, MD; Nwamaka D. Eneanya, MD, MPH; L. Ebony Boulware, MD, MPH

JAMA

Viewpoint

COVID-19 as the Leading Cause of Death in the United States

Steven H. Woolf, MD, MPH; Derek A. Chapman, PhD; Jong Hyung Lee, MS

Abstract Full Text

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JAMA. 2021;325(2):123-124. doi:10.1001/jama.2020.24865

This Viewpoint uses CDC data to compare the COVID-19 mortality rate in 2020 with prior leading causes of death (heart disease, cancer, lung disease, and injury) to put into context the cost of the infection in loss of life in the United States.

Editorial
Deaths From COVID-19
Howard K. Koh, MD, MPH; Alan C. Geller, RN, MPH; Tyler J. VanderWeele, PhD

JAMA

Behaviorally Informed Strategies for a National COVID-19 Vaccine Promotion Program

Kevin G. Volpp, MD, PhD; George Loewenstein, PhD; Alison M. Buttenheim, PhD, MBA

Abstract Full Text

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JAMA. 2021;325(2):125-126. doi:10.1001/jama.2020.24036

This Viewpoint proposes behavioral economic and social marketing strategies to motivate coronavirus disease 2019 (COVID-19) vaccination among the public, including making the vaccine free and accessible, requiring it for access to valued activities or settings, and securing public endorsements from leaders or celebrities to ease perceptions of safety and acceptability.

Video: Coronavirus Vaccine FDA Update

Conversations with Dr Bauchner: Coronavirus Vaccine FDA Update

Editorial
Reassuring the Public and Clinical Community About the Scientific Review and Approval of a COVID-19 Vaccine
Howard Bauchner, MD; Preeti N. Malani, MD, MSJ; Joshua Sharfstein, MD

JAMA
- Video: Coronavirus Vaccine Update With Anthony Fauci
- Video: Coronavirus Update With Anthony Fauci - October 28, 2020
- Video: Coronavirus Q&A With Anthony Fauci, MD 鈥� September 25, 2020
- Video: Coronavirus Update With Michael T. Osterholm, PhD, MPH
- Video: COVID-19 Vaccine Approval and the FDA
- Conversations with Dr Bauchner: COVID-19 Vaccine Approval and the FDA
- Conversations with Dr Bauchner: Coronavirus Update With Michael T. Osterholm, PhD, MPH
- Conversations with Dr Bauchner: Coronavirus Q&A With Anthony Fauci, MD 鈥� September 25, 2020
- Conversations with Dr Bauchner: Coronavirus Update With Anthony Fauci - October 28, 2020
- Conversations with Dr Bauchner: Coronavirus Vaccine Update With Anthony Fauci

Digital Health鈥擳he Need to Assess Benefits, Risks, and Value

Eric Perakslis, PhD; Geoffrey S. Ginsburg, MD, PhD

Abstract Full Text

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JAMA. 2021;325(2):127-128. doi:10.1001/jama.2020.22919

This Viewpoint reviews the regulatory, ethical, and security issues attending the explosive growth in digital health technologies (apps, devices, and systems) and proposes a framework for evaluating the benefits, risks, and value of these new tools before recommending them for routine clinical care.

Conversations with Dr Bauchner: Digital Health鈥擳he Need to Assess Benefits, Risks, and Value

Building a Better Clinician Value-Based Payment Program in Medicare

Kenton J. Johnston, PhD; Jason M. Hockenberry, PhD; Karen E. Joynt Maddox, MD, MPH

Abstract Full Text

JAMA. 2021;325(2):129-130. doi:10.1001/jama.2020.22924

This Viewpoint reviews problems and successes to date in Medicare鈥檚 value-based payment programs, and argues for global payment structures across populations, settings, and episodes of care to improve quality, patient-centered outcomes, and efficiency while not disadvantaging safety-net clinicians.

A Piece of My Mind

Hummingbird Lessons

Jessica Nutik Zitter, MD, MPH

Abstract Full Text

JAMA. 2021;325(2):131-132. doi:10.1001/jama.2020.24862

In this narrative medicine essay, a critical care and palliative care physician draws a valuable lesson about the limits and beauty of last-ditch interventions after failing to save a fledgling hummingbird chick in its nest.

Editorial

Deaths From COVID-19

Howard K. Koh, MD, MPH; Alan C. Geller, RN, MPH; Tyler J. VanderWeele, PhD

Abstract Full Text

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JAMA. 2021;325(2):133-134. doi:10.1001/jama.2020.25381

Removal of Race From Estimates of Kidney Function: First, Do No Harm

Keith C. Norris, MD; Nwamaka D. Eneanya, MD, MPH; L. Ebony Boulware, MD, MPH

Abstract Full Text

JAMA. 2021;325(2):135-137. doi:10.1001/jama.2020.23373

Review

Glaucoma in Adults鈥擲creening, Diagnosis, and Management: A Review

Joshua D. Stein, MD, MS; Anthony P. Khawaja, MBBS, PhD; Jennifer S. Weizer, MD

Abstract Full Text

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JAMA. 2021;325(2):164-174. doi:10.1001/jama.2020.21899

This narrative review provides an update on the epidemiology, pathophysiology, screening, diagnosis, treatment, and prognosis of glaucoma.

Podcast: Glaucoma Diagnosis and Treatment

JAMA Insights

The Pharmacologic Treatment of Schizophrenia鈥�2021

Donald C. Goff, MD

Abstract Full Text

JAMA. 2021;325(2):175-176. doi:10.1001/jama.2020.19048

This JAMA Insights review summarizes medication options for patients with schizophrenia, including formulations and adverse effects of first- and second-generation antipsychotic drugs, and the psychosocial and rehabilitation interventions to improve treatment adherence and outcomes.

From The Medical Letter on Drugs and Therapeutics

Glaucoma

Abstract Full Text

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JAMA. 2021;325(2):177-178. doi:10.1001/jama.2020.10269

This Medical Letter review summarizes topical drug treatments for glaucoma by class, formulation, dosage, and cost.

Podcast: Glaucoma Diagnosis and Treatment

Medical News & Perspectives

Pandemic Spotlights In-home Colon Cancer Screening Tests

Mary Chris Jaklevic, MSJ

Abstract Full Text

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JAMA. 2021;325(2):116-118. doi:10.1001/jama.2020.22466

This article describes efforts to increase the use of in-home stool-based colon cancer screening during the COVID-19 pandemic.

Podcast: January 2021 Medical News Summary

The JAMA Forum

Postelection Prospects for Expanding Health Care Coverage

Andrew Bindman, MD

Abstract Full Text

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JAMA. 2021;325(2):119-120. doi:10.1001/jama.2020.24932

News From the Centers for Disease Control and Prevention

COVID-19 Precautions Hamper Breastfeeding Support

Bridget M. Kuehn, MSJ

Abstract Full Text

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JAMA. 2021;325(2):122. doi:10.1001/jama.2020.25241

Health Workers鈥� Antibody Levels Wane After SARS-CoV-2 Infection

Bridget M. Kuehn, MSJ

Abstract Full Text

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JAMA. 2021;325(2):122. doi:10.1001/jama.2020.25457

Biotech Innovations

Promising Strategies for Sickle Cell Disease and 尾-Thalassemia

Jennifer Abbasi

Abstract Full Text

JAMA. 2021;325(2):121. doi:10.1001/jama.2020.26232

Broad, Durable Antibody Response in Universal Flu Vaccine Trial

Jennifer Abbasi

Abstract Full Text

JAMA. 2021;325(2):121. doi:10.1001/jama.2020.25670

Mixed Findings in Pediatric Neuroblastoma CAR-T Therapy Trial

Jennifer Abbasi

Abstract Full Text

JAMA. 2021;325(2):121. doi:10.1001/jama.2020.26233

The Arts and Medicine

鈥淭he Guts to Really Look at It鈥濃€擬edicine and Race in Robert Colescott鈥檚 Emergency Room

Kamna S. Balhara, MD, MA; Nathan Irvin, MD, MSHPR

Abstract Full Text

JAMA. 2021;325(2):113-115. doi:10.1001/jama.2020.20888

This Arts and Medicine feature describes the use of the painting Emergency Room, by Robert Colescott, to broach uncomfortable discussions with emergency medicine trainees and faculty about organized medicine鈥檚 contribution to racial injustice and inequity, past and present.

Poetry and Medicine

Partners and Pardners

Sydney Lea, PhD

Abstract Full Text

JAMA. 2021;325(2):189. doi:10.1001/jama.2020.20213

JAMA Revisited

The Prevention of Diabetes Mellitus

Abstract Full Text

JAMA. 2021;325(2):190. doi:10.1001/jama.2020.17738

JAMA Patient Page

Prolactinomas

Pauline P. Huynh, BA; Lisa E. Ishii, MD, MHS; Masaru Ishii, MD, PhD

Abstract Full Text

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JAMA. 2021;325(2):195. doi:10.1001/jama.2020.3744

This JAMA Patient Page describes the symptoms of prolactinomas, benign tumors of the pituitary gland, and explains how they are diagnosed and treated.

Comment & Response

Long-term Complications of Bariatric Surgery

Daniel Weiss, MD

Abstract Full Text

JAMA. 2021;325(2):186. doi:10.1001/jama.2020.22478

Long-term Complications of Bariatric Surgery鈥擱eply

David E. Arterburn, MD, MPH; Robert F. Kushner, MD; Anita P. Courcoulas, MD, MPH

Abstract Full Text

JAMA. 2021;325(2):186-187. doi:10.1001/jama.2020.22487

Postoperative Atrial Fibrillation After Noncardiac Surgery and Stroke

Shi-Min Hu, PhD; Xiang-Hua Fang, PhD; Hai-Feng Li, MD, PhD

Abstract Full Text

JAMA. 2021;325(2):187. doi:10.1001/jama.2020.22481

Postoperative Atrial Fibrillation After Noncardiac Surgery and Stroke鈥擱eply

Konstantinos C. Siontis, MD; Bernard J. Gersh, MB, ChB, DPhil; Alanna M. Chamberlain, PhD

Abstract Full Text

JAMA. 2021;325(2):187-188. doi:10.1001/jama.2020.22484

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January 12, 2021, Vol 325, No. 2, Pages 105-195

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