February 23, 2021 Issue of JAMA

February 23, 2021, Vol 325, No. 8, Pages 705-798

This Week in JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2021;325(8):e2017809. doi:10.1001/jama.2020.17809

Podcast: Baclofen for ICU Alcohol Withdrawal, Vitamin C and Thiamine for Sepsis, Multiple Sclerosis Review, and more

Original Investigation

Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial

Mickael Vourc鈥檋, MD; Charlotte Garret, MD; Arnaud Gacouin, MD; et al.

Abstract Full Text

free access has multimedia

JAMA. 2021;325(8):732-741. doi:10.1001/jama.2021.0658

This randomized clinical trial compares the effects of high-dose baclofen vs placebo on agitation-related events among adults in the ICU with unhealthy alcohol use receiving mechanical ventilation.

Video: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder

Editorial
Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU
Michael C. Reade, MBBS, DPhil

JAMA

Caring for the Critically Ill Patient

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial

Jonathan E. Sevransky, MD, MHS; Richard E. Rothman, MD, PhD; David N. Hager, MD, PhD; et al.

Abstract Full Text

free access

JAMA. 2021;325(8):742-750. doi:10.1001/jama.2020.24505

This randomized trial compares the effect of vitamin C, thiamine, and hydrocortisone vs matching placebo on 30-day ventilator- and vasopressor-free days among patients with sepsis-induced respiratory and/or cardiovascular dysfunction.

Editorial
Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter
Kristin L. Walter, MD, MS; Christopher W. Seymour, MD, MSc

JAMA
Editor's Note
Funding and DSMB Membership in the VICTAS Clinical Trial
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD

JAMA

Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye

The Genetics of Exfoliation Syndrome Partnership

Abstract Full Text

free access

JAMA. 2021;325(8):753-764. doi:10.1001/jama.2021.0507

This case-control study uses whole-exome sequencing to identify coding-sequence genetic variants associated with exfoliation syndrome, a form of glaucoma caused by abnormal fibrillar protein aggregates in the anterior eye.

Research Letter

All-Cause Excess Mortality and COVID-19鈥揜elated Mortality Among US Adults Aged 25-44 Years, March-July 2020

Jeremy Samuel Faust, MD, MS; Harlan M. Krumholz, MD, SM; Chengan Du, PhD; et al.

Abstract Full Text

free access has multimedia has audio

JAMA. 2021;325(8):785-787. doi:10.1001/jama.2020.24243

This study compares all-cause excess mortality and COVID-19鈥搑elated mortality during the early pandemic period (March-July 2020) with unintentional drug overdoses, the usual leading cause of death in young adults, during the same period in 2018 among adults aged 25 to 44 years.

Video: Coronavirus Update With CDC Director Rochelle Walensky, MD

Conversations with Dr Bauchner: Coronavirus Update With CDC Director Rochelle Walensky

Viewpoint

Health Policy

Surprise Billing鈥擜 Flashpoint for Major Policy Issues in Health Care

Carrie Colla, PhD

Abstract Full Text

JAMA. 2021;325(8):715-716. doi:10.1001/jama.2020.26779

This Viewpoint discusses the unexpected large billing that can occur when a patient receives care from an out-of-network physician or center (surprise billing)鈥攊ts root causes and recent legislation that will provide some patients with protection, but not all.

Editorial
Health Care Is a Right, Not a Privilege: A New Series on US Health Care and Health Policy
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Karen Joynt Maddox, MD, MPH

JAMA
- Video: Health Care Reform in the Biden Era
- Conversations with Dr Bauchner: Health Care Reform in the Biden Era

Health Policy

From Digitization to Digital Transformation: Policy Priorities for Closing the Gap

Julia Adler-Milstein, PhD

Abstract Full Text

JAMA. 2021;325(8):717-718. doi:10.1001/jama.2020.27014

This Viewpoint lays out policy priorities for advancing the digital transformation of US health information systems, including funding of infrastructure and enforcement of standards for EHR interoperability, data sharing, and usability.

Editorial
Health Care Is a Right, Not a Privilege: A New Series on US Health Care and Health Policy
Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Karen Joynt Maddox, MD, MPH

JAMA
- Video: Health Care Reform in the Biden Era
- Conversations with Dr Bauchner: Health Care Reform in the Biden Era

Racial and Ethnic Health Disparities Related to COVID-19

Leo Lopez III, MD, MHS; Louis H. Hart III, MD; Mitchell H. Katz, MD

Abstract Full Text

free access has audio

JAMA. 2021;325(8):719-720. doi:10.1001/jama.2020.26443

This Viewpoint reviews data demonstrating worse risk and outcomes for non-White patients with coronavirus disease 2019 (COVID-19) and makes policy proposals to mitigate the disparities, including expansion of Medicaid eligibility to expand health care access, multilingual and culturally appropriate communication and outreach, and easing accessibility to social services through health care contacts to address housing, food, legal, and economic stressors.

Podcast: Racial and Ethnic Disparities in COVID-19

A Viral Pandemic, Vaccine Safety, and Compensation for Adverse Events

H. Cody Meissner, MD

Abstract Full Text

free access

JAMA. 2021;325(8):721-722. doi:10.1001/jama.2020.26792

This Viewpoint reviews the system in place to compensate US residents for proven vaccine injury via the Countermeasures Injury Compensation Program and emphasizes that the benefit of COVID-19 vaccines outweighs any potential harm.

Editorial
Reassuring the Public and Clinical Community About the Scientific Review and Approval of a COVID-19 Vaccine
Howard Bauchner, MD; Preeti N. Malani, MD, MSJ; Joshua Sharfstein, MD

JAMA
- Video: Coronavirus Vaccine Update With Anthony Fauci
- Video: Coronavirus Update With Anthony Fauci - October 28, 2020
- Video: Coronavirus Q&A With Anthony Fauci, MD 鈥� September 25, 2020
- Video: Coronavirus Update With Michael T. Osterholm, PhD, MPH
- Video: COVID-19 Vaccine Approval and the FDA
- Conversations with Dr Bauchner: COVID-19 Vaccine Approval and the FDA
- Conversations with Dr Bauchner: Coronavirus Update With Michael T. Osterholm, PhD, MPH
- Conversations with Dr Bauchner: Coronavirus Q&A With Anthony Fauci, MD 鈥� September 25, 2020
- Conversations with Dr Bauchner: Coronavirus Update With Anthony Fauci - October 28, 2020
- Conversations with Dr Bauchner: Coronavirus Vaccine Update With Anthony Fauci

When Physicians Engage in Practices That Threaten the Nation鈥檚 Health

Philip A. Pizzo, MD; David Spiegel, MD; Michelle M. Mello, JD, PhD

Abstract Full Text

free access has audio

JAMA. 2021;325(8):723-724. doi:10.1001/jama.2021.0122

This Viewpoint proposes response options for specialty societies, medical licensing boards, academic leadership, and faculty and colleagues when physician public health leaders spread misinformation detrimental to patients鈥� or the public鈥檚 health, as happened in the first year of the COVID-19 pandemic.

Conversations with Dr Bauchner: When Physicians Engage in Practices That Threaten the Nation鈥檚 Health

A Piece of My Mind

COVID-19 Communication鈥擳he Need for Humanity, Empathy, and Grace

Lisa M. Meeks, PhD

Abstract Full Text

free access

JAMA. 2021;325(8):725-726. doi:10.1001/jama.2021.0119

In this narrative medicine essay, a medical school professor expresses gratitude for the caring and empathy expressed by the team caring for her mother hospitalized with COVID-19 and emphasizes the importance of humanity and compassion over facts and statistics for families physically separated from their critically ill loved ones.

Editorial

Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU

Michael C. Reade, MBBS, DPhil

Abstract Full Text

JAMA. 2021;325(8):727-729. doi:10.1001/jama.2021.0597

Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter

Kristin L. Walter, MD, MS; Christopher W. Seymour, MD, MSc

Abstract Full Text

JAMA. 2021;325(8):730-731. doi:10.1001/jama.2020.26029

Review

Diagnosis and Treatment of Multiple Sclerosis: A Review

Marisa P. McGinley, DO; Carolyn H. Goldschmidt, DO; Alexander D. Rae-Grant, MD

Abstract Full Text

has audio

JAMA. 2021;325(8):765-779. doi:10.1001/jama.2020.26858

This narrative review discusses the epidemiology and pathophysiology of multiple sclerosis and summarizes current evidence on its diagnosis and treatment using disease-modifying therapies and nonpharmacological interventions.

Podcast: Diagnosis and Treatment of Multiple Sclerosis鈥擜 Review

JAMA Insights

Clinical Update

Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine

Tom Shimabukuro, MD, MPH, MBA; Narayan Nair, MD

Abstract Full Text

free access has audio

JAMA. 2021;325(8):780-781. doi:10.1001/jama.2021.0600

This JAMA Insights review provides clinical details of anaphylactic reactions reported to and verified by the CDC in the first week of use of the Pfizer-BioNTech COVID-19 vaccine in the US, December 14-23, 2020.

Podcast: COVID-19 Vaccine Safety鈥揂naphylaxis and Allergic Reactions

JAMA Clinical Challenge

A Purpuric Rash

Kevin D. He, MD; Ken He, MD; Paul B. Cornia, MD

Abstract Full Text

JAMA. 2021;325(8):782-783. doi:10.1001/jama.2020.19186

A 48-year-old man had erythema without warmth over his right ankle and dorsomedial foot, with nontender, nonpalpable purpura over the foot dorsum and scattered petechiae over the right lower leg 6 weeks after immobilization for an ankle fracture; temperature was 38.2掳C (100.8掳F) and the erythema faded when he elevated his leg above heart level. What is the diagnosis and what would you do next?

Editor's Note

Funding and DSMB Membership in the VICTAS Clinical Trial

Howard Bauchner, MD; Phil B. Fontanarosa, MD, MBA; Robert M. Golub, MD

Abstract Full Text

free access

JAMA. 2021;325(8):751-752. doi:10.1001/jama.2020.25952

Medical News & Perspectives

鈥淚mportant Conversations鈥� Are Needed to Explain the Nocebo Effect

Anita Slomski, MA

Abstract Full Text

has audio

JAMA. 2021;325(8):707-709. doi:10.1001/jama.2020.25840

This Medical News article describes how clinicians can explain to patients that their adverse effects may be due to the nocebo effect, which has more to do with negative perceptions than with a drug鈥檚 pharmacological action.

Podcast: Live from AHA 2020: Highlights from the American Heart Association鈥檚 Virtual Scientific Sessions
Podcast: February 2021 Medical News Summary

The JAMA Forum

From Economic Recovery to Health Resilience

Dave A. Chokshi, MD, MSc

Abstract Full Text

free access

JAMA. 2021;325(8):710-711. doi:10.1001/jama.2020.24936

News From the Centers for Disease Control and Prevention

COVID-19 Rates Increased Where In-Person College Classes Were Held

Bridget M. Kuehn, MSJ

Abstract Full Text

free access

JAMA. 2021;325(8):714. doi:10.1001/jama.2021.0621

Drug-Resistant Yeast Infections Spread in COVID-19 Unit

Bridget M. Kuehn, MSJ

Abstract Full Text

free access

JAMA. 2021;325(8):714. doi:10.1001/jama.2021.1031

Clinical Trials Update

Oral Rimegepant Safe, Effective for Migraine Prevention

Anita Slomski, MA

Abstract Full Text

JAMA. 2021;325(8):713. doi:10.1001/jama.2021.0651

Finerenone for Patients With CKD and Type 2 Diabetes

Anita Slomski, MA

Abstract Full Text

JAMA. 2021;325(8):713. doi:10.1001/jama.2021.1255

Common Weight Loss Surgeries鈥� Benefits Sustained at Year 7

Anita Slomski, MA

Abstract Full Text

JAMA. 2021;325(8):713. doi:10.1001/jama.2021.1257

Navigators Improve Autism Evaluations but Not Referrals to Care

Anita Slomski, MA

Abstract Full Text

JAMA. 2021;325(8):713. doi:10.1001/jama.2021.1259

Physician Videos Improve COVID-19 Knowledge Among Minorities

Anita Slomski, MA

Abstract Full Text

free access

JAMA. 2021;325(8):713. doi:10.1001/jama.2021.1261

Health Agencies Update

Collecting Data About COVID-19鈥揜elated Brain Symptoms

Rita Rubin, MA

Abstract Full Text

free access

JAMA. 2021;325(8):712. doi:10.1001/jama.2021.0791

Detecting Heart Transplant Rejection Earlier, More Easily

Rita Rubin, MA

Abstract Full Text

JAMA. 2021;325(8):712. doi:10.1001/jama.2021.1228

Locating COVID-19 Monoclonal Antibody Therapies

Rita Rubin, MA

Abstract Full Text

free access

JAMA. 2021;325(8):712. doi:10.1001/jama.2021.1230

Poetry and Medicine

Knows

Mark Dow

Abstract Full Text

JAMA. 2021;325(8):792. doi:10.1001/jama.2020.23939

JAMA Revisited

The Worth of a Miracle

Abstract Full Text

JAMA. 2021;325(8):793. doi:10.1001/jama.2020.17810

JAMA Patient Page

Nystagmus

Malcolm M. Kates, BS, BA; Casey J. Beal, MD

Abstract Full Text

free access

JAMA. 2021;325(8):798. doi:10.1001/jama.2020.3911

This JAMA Patient Page describes the types, causes, and treatment of nystagmus, a rhythmic involuntary movement of the eyes.

Comment & Response

Risk of Spinal Hematoma After Lumbar Puncture

Tao Xu, PhD; You Wang, MD; Yangmei Chen, PhD

Abstract Full Text

JAMA. 2021;325(8):787. doi:10.1001/jama.2020.24595

Risk of Spinal Hematoma After Lumbar Puncture

Chloe Kimi Nobuhara, BS; Miles Berger, MD, PhD

Abstract Full Text

JAMA. 2021;325(8):787-788. doi:10.1001/jama.2020.24601

Risk of Spinal Hematoma After Lumbar Puncture鈥擱eply

Jacob Bodilsen, MD, PhD; Henrik Nielsen, MD, DMSci

Abstract Full Text

JAMA. 2021;325(8):788. doi:10.1001/jama.2020.24607

The Effect of Surgical Treatment on Obstructive Sleep Apnea

Vanessa Alderman, MBBS; Joshua Agbetile, MD

Abstract Full Text

JAMA. 2021;325(8):788-789. doi:10.1001/jama.2020.25121

The Effect of Surgical Treatment on Obstructive Sleep Apnea鈥擱eply

Stuart MacKay, MD; R. Doug McEvoy, MD; Edward M. Weaver, MD, MPH

Abstract Full Text

JAMA. 2021;325(8):789-790. doi:10.1001/jama.2020.25124

Cervical Cancer Screening in Low- and Middle-Income Countries

Miriam Cremer, MD, MPH; Karla Alfaro, MD, MPH; Rachel Masch, MD, MPH

Abstract Full Text

JAMA. 2021;325(8):790. doi:10.1001/jama.2020.25214

Cervical Cancer Screening in Low- and Middle-Income Countries鈥擱eply

Pascal Geldsetzer, MBChB, ScD, MPH; Julia M. Lemp, MSc

Abstract Full Text

JAMA. 2021;325(8):790-791. doi:10.1001/jama.2020.25217

November 2024 - July 1883

Decade

Year

Issue

February 23, 2021, Vol 325, No. 8, Pages 705-798

Caring for the Critically Ill Patient

Health Policy

Health Policy

Clinical Update

Latest from the USPSTF