November 23, 2021 Issue of JAMA

November 23/30, 2021, Vol 326, No. 20, Pages 1995-2087

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2021;326(20):e2018241. doi:10.1001/jama.2020.18241

Podcast: Platelet-Rich Plasma Injection for Knee Osteoarthritis, Bariatric Surgery for Nonalcoholic Steatohepatitis and Liver and Cardiac Outcomes, mRNA Vaccination and COVID-19 Hospitalizations, and more

Original Investigation

Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial

Kim L. Bennell, PhD; Kade L. Paterson, PhD; Ben R. Metcalf, BSc; et al.

Abstract Full Text

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JAMA. 2021;326(20):2021-2030. doi:10.1001/jama.2021.19415

This randomized trial assesses the effect of injections of platelet-rich plasma vs saline placebo on 12-month changes in knee pain scores and medial tibial cartilage volume among patients with symptomatic mild to moderate knee osteoarthritis.

Editorial
Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis
Jeffrey N. Katz, MD, MSc

JAMA

Association of Bariatric Surgery With Major Adverse Liver and Cardiovascular Outcomes in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis

Ali Aminian, MD; Abbas Al-Kurd, MD; Rickesha Wilson, MD; et al.

Abstract Full Text

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JAMA. 2021;326(20):2031-2042. doi:10.1001/jama.2021.19569

This cohort study investigates the association between bariatric surgery and incident major adverse liver outcomes and major adverse cardiovascular events in patients with obesity and biopsy-proven fibrotic NASH without cirrhosis.

Editorial
Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic Steatohepatitis
Kathleen E. Corey, MD, MPH, MMSc; Zoe Nicole Memel, MD

JAMA

Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity

Mark W. Tenforde, MD, PhD; Wesley H. Self, MD, MPH; Katherine Adams, MPH; et al.

Abstract Full Text

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JAMA. 2021;326(20):2043-2054. doi:10.1001/jama.2021.19499

This case-control study explores the association between vaccination with mRNA COVID-19 vaccines and hospitalization for COVID-19, and, among patients hospitalized with COVID-19, the association with progression to critical disease in adults from 18 US states.

Editorial
Understanding Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination
Michael Klompas, MD, MPH

JAMA

Research Letter

Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years, 1976-2018

Alejandra Ellison-Barnes, MD, MPH; Sara Johnson, PhD, MPH; Kimberly Gudzune, MD, MPH

Abstract Full Text

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JAMA. 2021;326(20):2073-2074. doi:10.1001/jama.2021.16685

This study uses nationally representative data from the National Health and Nutrition Examination Survey to examine changes in obesity prevalence in the US over the last 4 decades among adults aged 18 through 25 years.

Incidence of Pancreatic Cancer by Age and Sex in the US, 2000-2018

Srinivas Gaddam, MD, MPH; Yazan Abboud, MD; Janice Oh, MD; et al.

Abstract Full Text

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JAMA. 2021;326(20):2075-2077. doi:10.1001/jama.2021.18859

This study uses data from the Surveillance Epidemiology and End Results database to perform an age- and sex-specific time trend analysis of pancreatic cancer incidence rates in US adults.

Viewpoint

The Self-directed Medical Student Curriculum

Joseph H. Wu, PhD; Philip A. Gruppuso, MD; Eli Y. Adashi, MD, MS

Abstract Full Text

JAMA. 2021;326(20):2005-2006. doi:10.1001/jama.2021.16312

This Viewpoint discusses the growing role of medical students in shaping their own education and outlines the measures needed to ensure that medical student鈥揹irected learning remains aligned with the educational aims of the medical discipline.

Contraception Requirements in Clinical Trials: Considerations From Studies on Sexually Transmitted Infections

Jennifer E. Balkus, PhD; Jodie Dionne-Odom, MD; Harold C. Wiesenfeld, MD, CM

Abstract Full Text

JAMA. 2021;326(20):2007-2008. doi:10.1001/jama.2021.19473

This Viewpoint proposes a risk-based approach toward contraception use in clinical trials of investigational products, which could improve access and inclusivity for individuals with pregnancy potential who are at risk for the outcomes of interest.

Twenty Years After the Anthrax Terrorist Attacks of 2001: Lessons Learned and Unlearned for the COVID-19 Response

Lawrence O. Gostin, JD; Jennifer B. Nuzzo, DrPH, SM

Abstract Full Text

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JAMA. 2021;326(20):2009-2010. doi:10.1001/jama.2021.19292

This Viewpoint discusses the public health emergency preparedness response strategies instituted in the US after the anthrax attacks of 2001 in the context of the gaps in public health readiness that were exposed by the COVID-19 pandemic.

A Piece of My Mind

Taking Down the Shingle

Diane Roston, MD

Abstract Full Text

JAMA. 2021;326(20):2011. doi:10.1001/jama.2021.20106

In this narrative medicine essay, a psychiatrist reflects on the lasting effects of her practice after it closes, understanding that its memory will be preserved by her patients.

Editorial

Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis

Jeffrey N. Katz, MD, MSc

Abstract Full Text

JAMA. 2021;326(20):2012-2014. doi:10.1001/jama.2021.19540

Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic Steatohepatitis

Kathleen E. Corey, MD, MPH, MMSc; Zoe Nicole Memel, MD

Abstract Full Text

JAMA. 2021;326(20):2015-2017. doi:10.1001/jama.2021.17451

Understanding Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination

Michael Klompas, MD, MPH

Abstract Full Text

free access

JAMA. 2021;326(20):2018-2020. doi:10.1001/jama.2021.19063

Review

Management of Acne Vulgaris: A Review

Dawn Z. Eichenfield, MD, PhD; Jessica Sprague, MD; Lawrence F. Eichenfield, MD

Abstract Full Text

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JAMA. 2021;326(20):2055-2067. doi:10.1001/jama.2021.17633

This review summarizes the characteristics of comedonal, inflammatory, and nodulocystic acne and describes current methods of treatment.

Podcast: Management of Acne Vulgaris

JAMA Guide to Statistics and Methods

Use of Confidence Intervals in Interpreting Nonstatistically Significant Results

Alexander T. Hawkins, MD, MPH; Lauren R. Samuels, PhD

Abstract Full Text

JAMA. 2021;326(20):2068-2069. doi:10.1001/jama.2021.16172

This Guide to Statistics and Methods describes how confidence intervals can be used to help in the interpretation of nonsignificant findings across all study designs.

JAMA Clinical Challenge

Back Pain, Fever, and Cough in a 46-Year-Old Man

Aaron Richterman, MD, MPH; Melissa Richard-Greenblatt, PhD; Kathryn Whitaker, MD

Abstract Full Text

JAMA. 2021;326(20):2070-2071. doi:10.1001/jama.2021.17584

A 46-year-old man with a history of travel to India had 3 months of upper back pain and 2 weeks of dry cough and subjective fevers that did not improve with empirical azithromycin. Chest CT showed a dense consolidation in the left lower lobe; MRI showed a paraspinal mass with extensive contrast enhancement in the lower thoracic vertebral bodies and relative sparing of the disks. What is the diagnosis and what would you do next?

Medical News & Perspectives

Trials Test Mushrooms and Herbs as Anti鈥揅OVID-19 Agents

Anita Slomski

Abstract Full Text

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JAMA. 2021;326(20):1997-1999. doi:10.1001/jama.2021.19388

This Medical News article describes trials that are examining whether medicinal mushrooms and Chinese herbs can improve treatment and vaccine responses against COVID-19.

Podcast: November 2021 Medical News Summary

News From the Food and Drug Administration

Compounded Drug Guidance for Hospital and Health System Pharmacies

Rita Rubin, MA

Abstract Full Text

JAMA. 2021;326(20):2003. doi:10.1001/jama.2021.20539

New Clinical Trial Grants for Rare Diseases

Rita Rubin, MA

Abstract Full Text

JAMA. 2021;326(20):2003. doi:10.1001/jama.2021.20256

First Thymus Tissue Product Approved for Rare Disease

Rita Rubin, MA

Abstract Full Text

JAMA. 2021;326(20):2003. doi:10.1001/jama.2021.20538

News From the Centers for Disease Control and Prevention

COVID-19 Vaccine Highly Effective Against Adolescent Hospitalizations

Bridget M. Kuehn, MSJ

Abstract Full Text

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JAMA. 2021;326(20):2002. doi:10.1001/jama.2021.20143

Unhygienic Practices Lead to Routine Vaccination-Linked Infections

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2021;326(20):2002. doi:10.1001/jama.2021.20171

Clinical Trials Update

Pembrolizumab Boosts Breast and Cervical Cancer Survival

Anita Slomski

Abstract Full Text

JAMA. 2021;326(20):2001. doi:10.1001/jama.2021.19200

Daily COVID-19 Tests Compared With Isolation After School Exposure

Anita Slomski

Abstract Full Text

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JAMA. 2021;326(20):2001. doi:10.1001/jama.2021.20471

Intensive Blood Pressure Control Lowers Cardiovascular Risk

Anita Slomski

Abstract Full Text

JAMA. 2021;326(20):2001. doi:10.1001/jama.2021.20472

Virtual Care Mitigates Pain and Drug Errors After Surgery

Anita Slomski

Abstract Full Text

JAMA. 2021;326(20):2001. doi:10.1001/jama.2021.20473

Health Agencies Update

Substance Use Disorders and COVID-19 Vaccine Response

Rita Rubin, MA

Abstract Full Text

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JAMA. 2021;326(20):2000. doi:10.1001/jama.2021.19977

Support for Primary Care Clinicians in Underserved Areas

Rita Rubin, MA

Abstract Full Text

JAMA. 2021;326(20):2000. doi:10.1001/jama.2021.20454

The Cost of Rare Diseases

Rita Rubin, MA

Abstract Full Text

JAMA. 2021;326(20):2000. doi:10.1001/jama.2021.20455

Poetry and Medicine

first death

Jordynn Klein, BAS

Abstract Full Text

JAMA. 2021;326(20):2082. doi:10.1001/jama.2021.16531

JAMA Revisited

Bacterially Tainted Money

Abstract Full Text

JAMA. 2021;326(20):2083. doi:10.1001/jama.2020.18242

JAMA Patient Page

Acne Treatment

Raj Chovatiya, MD, PhD

Abstract Full Text

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JAMA. 2021;326(20):2087. doi:10.1001/jama.2021.16599

This JAMA Patient Page describes acne and the various forms of treatment for this skin condition.

Podcast: Management of Acne Vulgaris

Comment & Response

Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine

David G. Strauss, MD, PhD; Jeffry Florian, PhD; David Keire, PhD

Abstract Full Text

JAMA. 2021;326(20):2077. doi:10.1001/jama.2021.16261

Editorial
Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation
C. Michael White, PharmD; Adrian V. Hernandez, MD, PhD

JAMA

Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine鈥擱eply

C. Michael White, PharmD; Adrian V. Hernandez, MD, PhD

Abstract Full Text

JAMA. 2021;326(20):2077-2078. doi:10.1001/jama.2021.16264

Editorial
Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation
C. Michael White, PharmD; Adrian V. Hernandez, MD, PhD

JAMA

The Role of Lipoprotein(a) in Cardiovascular Diseases

Margaret Nachtigall, MD; Richard H. Nachtigall, MD

Abstract Full Text

JAMA. 2021;326(20):2078. doi:10.1001/jama.2021.16747

The Role of Lipoprotein(a) in Cardiovascular Diseases鈥擱eply

Pradeep Natarajan, MD, MMSc; Hannah Miksenas, BA; James L. Januzzi Jr, MD

Abstract Full Text

JAMA. 2021;326(20):2078-2079. doi:10.1001/jama.2021.16750

Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection

Joel Goldberg, MD; John H. Powers III, MD

Abstract Full Text

JAMA. 2021;326(20):2079. doi:10.1001/jama.2021.16735

Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection

Sunn Hoah Kelvin Yap, BSc

Abstract Full Text

JAMA. 2021;326(20):2079-2080. doi:10.1001/jama.2021.16741

Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection

Haroon Ahmed, PhD; David Gillespie, PhD; Emma Thomas-Jones, PhD

Abstract Full Text

JAMA. 2021;326(20):2080. doi:10.1001/jama.2021.16738

Effect of 7 vs 14 Days of Antibiotics Among Afebrile Men With Urinary Tract Infection鈥擱eply

Dimitri M. Drekonja, MD, MS; Barbara Trautner, MD, PhD; James R. Johnson, MD

Abstract Full Text

JAMA. 2021;326(20):2080-2081. doi:10.1001/jama.2021.16744

Correction

Error in Box

Abstract Full Text

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JAMA. 2021;326(20):2081. doi:10.1001/jama.2021.19984

Incorrect Laboratory Value and Reference

Abstract Full Text

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JAMA. 2021;326(20):2081. doi:10.1001/jama.2021.20138

November 2024 - July 1883

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November 23/30, 2021, Vol 326, No. 20, Pages 1995-2087

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