May 18, 2021 Issue of JAMA

May 18, 2021, Vol 325, No. 19, Pages 1921-2026

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2021;325(19):e2019093. doi:10.1001/jama.2020.19093

Podcast: Phosphate Binders and CVD in Hemodialysis Patients, Memory Decline After CABG vs PCI, USPSTF Guideline on Colorectal Cancer Screening, and more

Original Investigation

Effect of Treating Hyperphosphatemia With Lanthanum Carbonate vs Calcium Carbonate on Cardiovascular Events in Patients With Chronic Kidney Disease Undergoing Hemodialysis: The LANDMARK Randomized Clinical Trial

Hiroaki Ogata, MD; Masafumi Fukagawa, MD; Hideki Hirakata, MD; et al.

Abstract Full Text

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JAMA. 2021;325(19):1946-1954. doi:10.1001/jama.2021.4807

This clinical trial compared cardiovascular events among patients receiving hemodialysis with at least at 1 risk factor for vascular calcification and treated with a calcium-free phosphate binder, lanthanum carbonate, or calcium carbonate

Association of Coronary Artery Bypass Grafting vs Percutaneous Coronary Intervention With Memory Decline in Older Adults Undergoing Coronary Revascularization

Elizabeth L. Whitlock, MD, MSc; L. Grisell Diaz-Ramirez, MS; Alexander K. Smith, MD, MPH; et al.

Abstract Full Text

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JAMA. 2021;325(19):1955-1964. doi:10.1001/jama.2021.5150

This cohort study compares the change in the rate of memory decline after coronary artery bypass grafting (CABG) vs percutaneous coronary intervention (PCI) in older adults.

Editorial
Coronary Revascularization and Cognitive Decline: The Patient or the Procedure?
Rebecca F. Gottesman, MD, PhD; Michelle C. Johansen, MD, PhD

JAMA

Research Letter

SARS-CoV-2鈥揝pecific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women

Sivan Haia Perl, MD; Atara Uzan-Yulzari, MSc; Hodaya Klainer, BSc; et al.

Abstract Full Text

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JAMA. 2021;325(19):2013-2014. doi:10.1001/jama.2021.5782

This prospective study investigated whether antibodies from SARS-CoV-2 immunization of nursing mothers transferred to infants as a potentially protective effect.

Invited Commentary
Protecting Pregnant Women and Their Infants From COVID-19: Clues From Maternal Viral Loads, Antibody Responses, and Placentas
Denise J. Jamieson, MD, MPH; Sonja A. Rasmussen, MD, MS

JAMA Netw Open

Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers

Sebastian Havervall, MD; Axel Rosell, MD; Mia Phillipson, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(19):2015-2016. doi:10.1001/jama.2021.5612

This cohort study describes COVID-19鈥搑elated symptoms persisting 8 months after SARS-CoV-2 infection among Swedish health care workers and self-reported effects of the residual symptoms on respondents鈥� home, work, and social function.

Consistency Between State Medical License Applications and Recommendations Regarding Physician Mental Health

Daniel Saddawi-Konefka, MD, MBA; Ariel Brown, PhD; Isabella Eisenhart, BS; et al.

Abstract Full Text

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JAMA. 2021;325(19):2017-2018. doi:10.1001/jama.2021.2275

This study examines the consistency of medical license applications with recommendations from the Federation of State Medical Boards on physician wellness and burnout.

US Preventive Services Task Force

Recommendation Statement

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force

Abstract Full Text

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JAMA. 2021;325(19):1965-1977. doi:10.1001/jama.2021.6238

This 2021 Recommendation Statement from the US Preventive Services Task Force recommends screening for colorectal cancer in all adults aged 50 to 75 years (A recommendation), screening for colorectal cancer in adults aged 45 to 49 years (B recommendation), and that clinicians selectively offer screening for colorectal cancer in adults aged 76 to 85 years (C recommendation).

Podcast: USPSTF Recommendation: Screening for Colorectal Cancer

Editorial
US Preventive Services Task Force Recommendations for Colorectal Cancer Screening: Forty-Five Is the New Fifty
Kimmie Ng, MD, MPH; Folasade P. May, MD, PhD, MPhil; Deborah Schrag, MD, MPH

JAMA
- Podcast: USPSTF Recommendation: Screening for Colorectal Cancer
Colorectal Cancer Screening Starting at Age 45 Years鈥擡nsuring Benefits Are Realized by All
Shivan J. Mehta, MD, MBA, MSHP; Arden M. Morris, MD, MPH; Sonia S. Kupfer, MD

JAMA Netw Open
Updated USPSTF Guidelines for Colorectal Cancer Screening: The Earlier the Better
David B. Stewart, MD

JAMA Surg

Evidence Report

Screening for Colorectal Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Jennifer S. Lin, MD; Leslie A. Perdue, MPH; Nora B. Henrikson, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(19):1978-1998. doi:10.1001/jama.2021.4417

This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening for colorectal cancer summarizes published evidence on the benefits and harms of screening for colorectal cancer in asymptomatic, community-dwelling adults.

Podcast: USPSTF Recommendation: Screening for Colorectal Cancer

Editorial
US Preventive Services Task Force Recommendations for Colorectal Cancer Screening: Forty-Five Is the New Fifty
Kimmie Ng, MD, MPH; Folasade P. May, MD, PhD, MPhil; Deborah Schrag, MD, MPH

JAMA
- Podcast: USPSTF Recommendation: Screening for Colorectal Cancer
Colorectal Cancer Screening Starting at Age 45 Years鈥擡nsuring Benefits Are Realized by All
Shivan J. Mehta, MD, MBA, MSHP; Arden M. Morris, MD, MPH; Sonia S. Kupfer, MD

JAMA Netw Open
Updated USPSTF Guidelines for Colorectal Cancer Screening: The Earlier the Better
David B. Stewart, MD

JAMA Surg

Modeling Study

Colorectal Cancer Screening: An Updated Modeling Study for the US Preventive Services Task Force

Amy B. Knudsen, PhD; Carolyn M. Rutter, PhD; Elisabeth F. P. Peterse, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(19):1998-2011. doi:10.1001/jama.2021.5746

This simulation study models the benefits, burden, and harms associated with colorectal cancer screening strategies based on a range of screening ages, intervals, and modalities.

Podcast: USPSTF Recommendation: Screening for Colorectal Cancer

Editorial
US Preventive Services Task Force Recommendations for Colorectal Cancer Screening: Forty-Five Is the New Fifty
Kimmie Ng, MD, MPH; Folasade P. May, MD, PhD, MPhil; Deborah Schrag, MD, MPH

JAMA
- Podcast: USPSTF Recommendation: Screening for Colorectal Cancer
Colorectal Cancer Screening Starting at Age 45 Years鈥擡nsuring Benefits Are Realized by All
Shivan J. Mehta, MD, MBA, MSHP; Arden M. Morris, MD, MPH; Sonia S. Kupfer, MD

JAMA Netw Open
Updated USPSTF Guidelines for Colorectal Cancer Screening: The Earlier the Better
David B. Stewart, MD

JAMA Surg

Viewpoint

Digital Health Passes in the Age of COVID-19: Are 鈥淰accine Passports鈥� Lawful and Ethical?

Lawrence O. Gostin, JD; I. Glenn Cohen, JD; Jana Shaw, MD, MPH

Abstract Full Text

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JAMA. 2021;325(19):1933-1934. doi:10.1001/jama.2021.5283

This Viewpoint discusses digital health passes (DHPs) that would grant access to work, entertainment, shopping, and travel with confirmation of COVID-19 immunity, and the scientific, legal, ethical, and equity considerations that must be worked through for DHPs to be considered effective and fair.

Remote Research and Clinical Trial Integrity During and After the Coronavirus Pandemic

Mary M. McDermott, MD; Anne B. Newman, MD, MPH

Abstract Full Text

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JAMA. 2021;325(19):1935-1936. doi:10.1001/jama.2021.4609

This Viewpoint outlines the challenges posed by the COVID-19 pandemic in conducting clinical trials and offers some solutions to those barriers.

Editor's Note
Setting Expectations for Clinical Research During the COVID-19 Pandemic
James W Salazar, MD, MAS; J. Michael McWilliams Jr, MD, PhD; Tracy Y. Wang, MD, MHS, MSc

JAMA Intern Med

Incorporating Adult Evidence Into Pediatric Research and Practice: Bayesian Designs to Expedite Obtaining Child-Specific Evidence

Srinivas Murthy, MD, CM, MHSc; Patricia Fontela, MD; Scott Berry, PhD

Abstract Full Text

JAMA. 2021;325(19):1937-1938. doi:10.1001/jama.2020.25007

This Viewpoint proposes ways to use bayesian methods to integrate evidence from adult clinical trials into the conduct, interpretation, and application of pediatric trials to generate scientifically robust and clinically actionable data for the care of children at a pace comparable with that for adults.

A Piece of My Mind

A Place of Memory and Learning

Adam S. Cifu, MD

Abstract Full Text

JAMA. 2021;325(19):1939-1940. doi:10.1001/jama.2021.6691

In this narrative medicine essay, a primary care physician describes a binder in which he keeps the face sheet, cards, obituaries, and notes on the patients who died while in his care鈥攁 memory book that marks the arc of his career and the impermanence of life.

Editorial

Coronary Revascularization and Cognitive Decline: The Patient or the Procedure?

Rebecca F. Gottesman, MD, PhD; Michelle C. Johansen, MD, PhD

Abstract Full Text

JAMA. 2021;325(19):1941-1942. doi:10.1001/jama.2021.5816

US Preventive Services Task Force Recommendations for Colorectal Cancer Screening: Forty-Five Is the New Fifty

Kimmie Ng, MD, MPH; Folasade P. May, MD, PhD, MPhil; Deborah Schrag, MD, MPH

Abstract Full Text

has audio

JAMA. 2021;325(19):1943-1945. doi:10.1001/jama.2021.4133

Podcast: USPSTF Recommendation: Screening for Colorectal Cancer

Editorial
Colorectal Cancer Screening Starting at Age 45 Years鈥擡nsuring Benefits Are Realized by All
Shivan J. Mehta, MD, MBA, MSHP; Arden M. Morris, MD, MPH; Sonia S. Kupfer, MD

JAMA Netw Open
Updated USPSTF Guidelines for Colorectal Cancer Screening: The Earlier the Better
David B. Stewart, MD

JAMA Surg

Medical News & Perspectives

Neurologist Faces His Alzheimer Diagnosis Determined to Lessen Stigma Surrounding the Disease

Rita Rubin, MA

Abstract Full Text

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JAMA. 2021;325(19):1926-1928. doi:10.1001/jama.2021.5333

This Medical News feature profiles neurologist Daniel Gibbs, MD, PhD, who went from treating Alzheimer disease to living with it.

Podcast: Neurologist Faces His Alzheimer Diagnosis Determined to Lessen Stigma Surrounding the Disease
Podcast: What a Neurologist With Alzheimer Disease Wants People to Know