October 26, 2021 Issue of JAMA

October 26, 2021, Vol 326, No. 16, Pages 1565-1642

This Week in JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2021;326(16):e2018193. doi:10.1001/jama.2020.18193

Podcast: Vasopressin+Methylprednisolone for In-Hospital Cardiac Arrest, Platelet-Rich Plasma Injection for Ankle Osteoarthritis, Guillain-Barre Syndrome Following Janssen COVID-19 Vaccine, and more

Original Investigation

Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial

Lars W. Andersen, MD, MPH, PhD, DMSc; Dan Isbye, MD, PhD; Jesper Kjærgaard, MD, PhD, DMSc; et al.

Abstract Full Text

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JAMA. 2021;326(16):1586-1594. doi:10.1001/jama.2021.16628

This randomized trial compares the effectiveness of the combination of vasopressin and methylprednisolone vs placebo administered during in-hospital cardiac arrest on return of spontaneous circulation.

Video: Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
Video: Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

Editorial
Vasopressin and Steroids as Adjunctive Treatment for In-Hospital Cardiac Arrest
Jason Haukoos, MD, MSc; Ivor S. Douglas, MD; Comilla Sasson, MD, PhD

JAMA
- Video: Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
- Video: Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle Osteoarthritis: A Randomized Clinical Trial

Liam D. A. Paget, MD; Gustaaf Reurink, PhD; Robert-Jan de Vos, PhD; et al.

Abstract Full Text

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JAMA. 2021;326(16):1595-1605. doi:10.1001/jama.2021.16602

This randomized clinical trial assessed the efficacy of platelet-rich plasma injections, compared with placebo, in ankle (tibiotalar) osteoarthritis.

Editorial
Platelet-Rich Plasma for Osteoarthritis and Achilles Tendinitis
Jeffrey N. Katz, MD, MSc

JAMA

Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barr茅 Syndrome, February-July 2021

Emily Jane Woo, MD, MPH; Adamma Mba-Jonas, MD, MPH; Rositsa B. Dimova, PhD; et al.

Abstract Full Text

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JAMA. 2021;326(16):1606-1613. doi:10.1001/jama.2021.16496

Based on the Vaccine Adverse Event Reporting System, this article reports on the prevalence of presumptive Guillain-Barr茅 syndrome among recipients of the Ad26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccine.

Research Letter

Representativeness of Participants Eligible to Be Enrolled in Clinical Trials of Aducanumab for Alzheimer Disease Compared With Medicare Beneficiaries With Alzheimer Disease and Mild Cognitive Impairment

Timothy S. Anderson, MD, MAS; John Z. Ayanian, MD, MPP; Jeffrey Souza, MA; et al.

Abstract Full Text

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JAMA. 2021;326(16):1627-1629. doi:10.1001/jama.2021.15286

This study evaluates whether patients enrolled in trials of aducanumab, EMERGE and ENGAGE, were representative of patients with dementia enrolled in Medicare by estimating the proportions of Medicare beneficiaries with Alzheimer disease (AD) or mild cognitive impairment (MCI) who would have been excluded from these trials.

Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy

Elyse O. Kharbanda, MD, MPH; Jacob Haapala, MPH; Malini DeSilva, MD, MPH; et al.

Abstract Full Text

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JAMA. 2021;326(16):1629-1631. doi:10.1001/jama.2021.15494

This study presents findings from case-control surveillance of COVID-19 vaccination during pregnancy and spontaneous abortion.

Trends in Mortality Among Pregnant and Recently Pregnant Women in the US, 2015-2019

Jeffrey T. Howard, PhD; Corey S. Sparks, PhD; Alexis R. Santos-Lozada, PhD; et al.

Abstract Full Text

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JAMA. 2021;326(16):1631-1633. doi:10.1001/jama.2021.13971

This study uses National Center for Health Statistics data to assess mortality rates and their annual percentage changes for pregnancy-related and other causes among pregnant and recently pregnant women from 2015 to 2019, compared with cause-specific mortality rates in the total US female population of childbearing age.

Special Communication

Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement

Veronika W. Skrivankova, PhD; Rebecca C. Richmond, PhD; Benjamin A. R. Woolf, MSc; et al.

Abstract Full Text

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JAMA. 2021;326(16):1614-1621. doi:10.1001/jama.2021.18236

This Special Communication describes the development of the STROBE-MR Statement and includes the checklist of recommended items for inclusion in reports of mendelian randomization studies.

Viewpoint

What鈥檚 Wrong With Advance Care Planning?

R. Sean Morrison, MD; Diane E. Meier, MD; Robert M. Arnold, MD

Abstract Full Text

JAMA. 2021;326(16):1575-1576. doi:10.1001/jama.2021.16430

This Viewpoint posits that advance care planning does not achieve the stated goal of end-of-life care nor serve as a reliable indicator of an end-of-life discussion.

Health Care Professionals鈥� Spirituality and COVID-19: Meaning, Compassion, Relationship

Anne L. Dalle Ave, MD, MS; Daniel P. Sulmasy, MD, PhD

Abstract Full Text

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JAMA. 2021;326(16):1577-1578. doi:10.1001/jama.2021.16769

This Viewpoint explores several spiritual considerations that may support clinicians in their work and also presents resources that may help clinicians in their professional and personal lives not only during the pandemic but also throughout their careers.

Paying for Cancer Drugs That Prove Their Benefit

Richard G. Frank, PhD; Ezekiel J. Emanuel, MD, PhD

Abstract Full Text

JAMA. 2021;326(16):1579-1580. doi:10.1001/jama.2021.18308

This Viewpoint describes the Center for Medicare and Medicaid Innovation鈥檚 proposed project called Pay for Drugs That Work, which would aim to restrain high prices for drugs that receive accelerated approval from the US Food and Drug Administration.

A Piece of My Mind

Marketing Medicine's Diversity: Issuing Promissory Notes for Health Care Equity

Michael O. Mensah, MD, MPH

Abstract Full Text

JAMA. 2021;326(16):1581-1582. doi:10.1001/jama.2021.17995

In this narrative medicine essay, a psychiatrist ponders whether photographs accompanying a feature article focusing on antiracist efforts will make health care more accessible or will only be used as an image-promoting piece.

Editorial

Vasopressin and Steroids as Adjunctive Treatment for In-Hospital Cardiac Arrest

Jason Haukoos, MD, MSc; Ivor S. Douglas, MD; Comilla Sasson, MD, PhD

Abstract Full Text

has multimedia

JAMA. 2021;326(16):1583-1585. doi:10.1001/jama.2021.15460

Video: Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial
Video: Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest

JAMA Insights

Women's Health

Serial Bone Density Measurement for Osteoporosis Screening

William D. Leslie, MD, MSc; Carolyn J. Crandall, MD, MS

Abstract Full Text

JAMA. 2021;326(16):1622-1623. doi:10.1001/jama.2021.9858

This JAMA Insights describes the association between low bone mineral density and fracture risk and summarizes methods for accurate diagnosis of osteoporosis and monitoring of bone mineral density over time.

JAMA Clinical Guidelines Synopsis

Gastrointestinal Evaluation of Iron Deficiency Anemia

Nabil M. Abou Baker, MD; Andrew M. Davis, MD, MPH

Abstract Full Text

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JAMA. 2021;326(16):1624-1625. doi:10.1001/jama.2021.11604

This JAMA Guidelines Synopsis summarizes the American Gastroenterological Association鈥檚 2020 guideline on gastrointestinal evaluation of iron deficiency anemia in adults.

Podcast: Evaluation of Iron Deficiency Anemia

Medical News & Perspectives

COVID-19 Crisis Advances Efforts to Reimagine Nursing Homes

Jennifer Abbasi

Abstract Full Text

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JAMA. 2021;326(16):1568-1570. doi:10.1001/jama.2021.13326

This Medical News article is a discussion with elder care expert Terry Fulmer, PhD, RN, about how the US nursing home model can evolve to better serve residents and support workers.

Podcast: A New Vision for Nursing Homes
Podcast: October 2021 Medical News Summary

News From the Centers for Disease Control and Prevention

Assessing a Veterinary Sedative鈥檚 Role in Drug Overdose Deaths

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2021;326(16):1573. doi:10.1001/jama.2021.18416

Aspergillosis Is Common Among COVID-19 Patients in the ICU

Bridget M. Kuehn, MSJ

Abstract Full Text

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JAMA. 2021;326(16):1573. doi:10.1001/jama.2021.17973

Clinical Trials Update

Salt Substitute Cut Disease and Death Rates in Large Trial

Anita Slomski

Abstract Full Text

JAMA. 2021;326(16):1572. doi:10.1001/jama.2021.17441

Prompting Outpatients to Complete Advance Care Planning

Anita Slomski

Abstract Full Text

JAMA. 2021;326(16):1572. doi:10.1001/jama.2021.18589

Polypill for Initial Hypertension Treatment Is Promising

Anita Slomski

Abstract Full Text

JAMA. 2021;326(16):1572. doi:10.1001/jama.2021.18590

Bacterial Immunotherapy Reduced Kids鈥� Wheezing

Anita Slomski

Abstract Full Text

JAMA. 2021;326(16):1572. doi:10.1001/jama.2021.18591

Health Agencies Update

Improving Contact Tracing Phone Apps

Rita Rubin, MA

Abstract Full Text

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JAMA. 2021;326(16):1571. doi:10.1001/jama.2021.17661

Studying How Genomic Variation Affects Human Health

Rita Rubin, MA

Abstract Full Text

JAMA. 2021;326(16):1571. doi:10.1001/jama.2021.18645

Coordinating Diet-Related Efforts to Reduce Obesity

Rita Rubin, MA

Abstract Full Text

JAMA. 2021;326(16):1571. doi:10.1001/jama.2021.18646

Poetry and Medicine

Lucid

Jonathan H. Marks, MA, BCL

Abstract Full Text

JAMA. 2021;326(16):1638. doi:10.1001/jama.2021.12033

JAMA Revisited

Mellon Issues Beer Regulations

Abstract Full Text

JAMA. 2021;326(16):1639. doi:10.1001/jama.2020.18194

The Recording and Reproduction of Cardiac and Respiratory Sounds

Abstract Full Text

JAMA. 2021;326(16):1639. doi:10.1001/jama.2021.15202

JAMA Patient Page

Durable Power of Attorney for Health Care

Kristin Walter, MD, MS

Abstract Full Text

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JAMA. 2021;326(16):1642. doi:10.1001/jama.2021.15882

This JAMA Patient Page describes the process of creating a durable power of attorney for health care document and the reasons for having such documentation.

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