April 13, 2021 Issue of JAMA

April 13, 2021, Vol 325, No. 14, Pages 1369-1480

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2021;325(14):e2017881. doi:10.1001/jama.2020.17881

Podcast: Semaglutide for Weight Loss, Ivermectin for Mild COVID-19, USPSTF Guideline on Screening for Vitamin D Deficiency, and more

Original Investigation

Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial

Thomas A. Wadden, PhD; Timothy S. Bailey, MD; Liana K. Billings, MD, MMSc; et al.

Abstract Full Text

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JAMA. 2021;325(14):1403-1413. doi:10.1001/jama.2021.1831

This randomized clinical trial compares the effects of once-weekly subcutaneous semaglutide vs placebo for weight management as an adjunct to intensive behavioral therapy with initial low-calorie diet in adults with overweight or obesity.

Video: Pharmacotherapy for Obesity

Podcast: Semaglutide for Weight Loss

Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial

Domenica Rubino, MD; Niclas Abrahamsson, MD; Melanie Davies, MD; et al.

Abstract Full Text

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JAMA. 2021;325(14):1414-1425. doi:10.1001/jama.2021.3224

This randomized trial compares the effects of continuing weekly treatment with subcutaneous semaglutide vs switching to placebo on change in body weight over 48 weeks among adults with overweight or obesity who completed a 20-week run-in period with semaglutide.

Video: Pharmacotherapy for Obesity

Podcast: Semaglutide for Weight Loss

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial

Eduardo López-Medina, MD, MSc; Pío López, MD; Isabel C. Hurtado, MD; et al.

Abstract Full Text

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JAMA. 2021;325(14):1426-1435. doi:10.1001/jama.2021.3071

This randomized trial compares the effects of ivermectin vs placebo on time to symptom resolution within 21 days among patients with mild COVID-19.

Research Letter

Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2

Saman Saadat, PhD; Zahra Rikhtegaran Tehrani, PhD; James Logue, BS; et al.

Abstract Full Text

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JAMA. 2021;325(14):1467-1469. doi:10.1001/jama.2021.3341

This study compares titers of binding and neutralizing antibodies after a single mRNA coronavirus vaccine dose in health care workers previously infected with SARS-CoV-2.

Discriminant Accuracy of the SOFA Score for Determining the Probable Mortality of Patients With COVID-19 Pneumonia Requiring Mechanical Ventilation

Robert A. Raschke, MD; Sumit Agarwal, MBBS, MBA; Pooja Rangan, MBBS, MPH; et al.

Abstract Full Text

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JAMA. 2021;325(14):1469-1470. doi:10.1001/jama.2021.1545

This cohort study characterizes the accuracy of the Sequential Organ Failure Assessment (SOFA) score to discriminate death from survival in patients with COVID-19 pneumonia receiving oxygen therapy for 4 hours or longer before undergoing endotracheal intubation.

US Preventive Services Task Force

Recommendation Statement

Screening for Vitamin D Deficiency in Adults: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force

Abstract Full Text

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JAMA. 2021;325(14):1436-1442. doi:10.1001/jama.2021.3069

This 2021 US Preventive Services Task Force Recommendation Statement concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement).

Editorial
The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues
Sherri-Ann M. Burnett-Bowie, MD, MPH; Anne R. Cappola, MD, ScM

JAMA
Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency
Erin D. Michos, MD, MHS; Rita R. Kalyani, MD, MHS; Jodi B. Segal, MD, MPH

JAMA Netw Open

Evidence Report

Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Leila C. Kahwati, MD, MPH; Erin LeBlanc, MD, MPH; Rachel Palmieri Weber, PhD; et al.

Abstract Full Text

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JAMA. 2021;325(14):1443-1463. doi:10.1001/jama.2020.26498

This systematic review to support the 2021 US Preventive Services Task Force Recommendation Statement on screening for vitamin D deficiency summarizes published evidence on the benefits and harms of screening and interventions for vitamin D deficiency in asymptomatic, community-dwelling adults.

Editorial
The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues
Sherri-Ann M. Burnett-Bowie, MD, MPH; Anne R. Cappola, MD, ScM

JAMA
Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency
Erin D. Michos, MD, MHS; Rita R. Kalyani, MD, MHS; Jodi B. Segal, MD, MPH

JAMA Netw Open

Viewpoint

Health Policy

How the Biden Administration Can Improve Health Equity for Racial and Ethnic Minority Populations

Karen E. Joynt Maddox, MD, MPH; Cara V. James, PhD

Abstract Full Text

JAMA. 2021;325(14):1387-1388. doi:10.1001/jama.2021.3046

This Viewpoint outlines actions that the new federal administration could consider related to health care access and quality, and social determinants of health, to meaningfully improve health equity for racial/ethnic minority populations.

Editorial
Moving Patient Care Forward in the Biden Era
Robert Steinbrook, MD; Mitchell H. Katz, MD; Rita F. Redberg, MD, MSc

JAMA Intern Med
- Video: Health Care Reform in the Biden Era
- Conversations with Dr Bauchner: Health Care Reform in the Biden Era

COVID-19 in 2021鈥擟ontinuing Uncertainty

Carlos del Rio, MD; Preeti Malani, MD, MSJ

Abstract Full Text

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JAMA. 2021;325(14):1389-1390. doi:10.1001/jama.2021.3760

This Viewpoint summarizes the current best evidence about COVID-19 vaccines, immunity, and whether SARS-CoV-2 will become an endemic or seasonal virus.

Video: Coronavirus Update With Carlos del Rio and Preeti Malani
Video: Frequently Asked COVID Vaccine Questions

Conversations with Dr Bauchner: Coronavirus Update With Carlos del Rio and Preeti Malani

National Initiatives to Prevent Myocardial Infarction and Stroke

Thomas R. Frieden, MD, MPH; Kathryn E. Foti, PhD, MPH

Abstract Full Text

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JAMA. 2021;325(14):1391-1392. doi:10.1001/jama.2021.0905

This Viewpoint discusses the Million Hearts initiative, a national effort that aims to prevent a million myocardial infarctions and strokes over 5 years, and proposes actions and strategies federal agencies can take to advance tobacco control, sodium reduction, trans fat elimination, hypertension control, and centering the US health care system on primary care.

Conversations with Dr Bauchner: National Initiatives to Prevent Myocardial Infarction and Stroke

A Piece of My Mind

On Mentoring

Howard Bauchner, MD

Abstract Full Text

JAMA. 2021;325(14):1393. doi:10.1001/jama.2021.4070

In this narrative medicine essay, 闯础惭础鈥檚 editor in chief remembers his career mentors and their selflessness as they guided him in his early and mid-career and later became friends and colleagues.

Editorial

The Near-Term Future of Health Care Reform

Ezekiel J. Emanuel, MD, PhD

Abstract Full Text

JAMA. 2021;325(14):1394-1397. doi:10.1001/jama.2021.1472

Editorial
Crucial Questions for US Health Policy in the Next Decade
John Z. Ayanian, MD, MPP

JAMA
Confronting Challenges in the US Health Care System: Potential Opportunity in a Time of Crisis
Melinda B. Buntin, PhD

JAMA

Crucial Questions for US Health Policy in the Next Decade

John Z. Ayanian, MD, MPP

Abstract Full Text

JAMA. 2021;325(14):1397-1399. doi:10.1001/jama.2021.1470

Editorial
The Near-Term Future of Health Care Reform
Ezekiel J. Emanuel, MD, PhD

JAMA
Confronting Challenges in the US Health Care System: Potential Opportunity in a Time of Crisis
Melinda B. Buntin, PhD

JAMA

Confronting Challenges in the US Health Care System: Potential Opportunity in a Time of Crisis

Melinda B. Buntin, PhD

Abstract Full Text

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JAMA. 2021;325(14):1399-1400. doi:10.1001/jama.2021.1471

Editorial
The Near-Term Future of Health Care Reform
Ezekiel J. Emanuel, MD, PhD

JAMA
Crucial Questions for US Health Policy in the Next Decade
John Z. Ayanian, MD, MPP

JAMA

The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues

Sherri-Ann M. Burnett-Bowie, MD, MPH; Anne R. Cappola, MD, ScM

Abstract Full Text

JAMA. 2021;325(14):1401-1402. doi:10.1001/jama.2021.2227

Editorial
Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency
Erin D. Michos, MD, MHS; Rita R. Kalyani, MD, MHS; Jodi B. Segal, MD, MPH

JAMA Netw Open

JAMA Insights

Identifying COVID-19 Risk Through Observational Studies to Inform Control Measures

Mark W. Tenforde, MD, PhD; Kiva A. Fisher, PhD, MPH; Manish M. Patel, MD, MSc

Abstract Full Text

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JAMA. 2021;325(14):1464-1465. doi:10.1001/jama.2021.1995

This JAMA Insights Clinical Update from the CDC鈥檚 COVID-19 Response Team discusses the importance of observational data for identifying behaviors associated with SARS-CoV-2 transmission, and presents data suggesting that indoor eating or drinking poses the highest risk, presumably because of prolonged exposure to unmasked, non鈥損hysically distanced companions.

Medical News & Perspectives

How the US Failed to Prioritize SARS-CoV-2 Variant Surveillance

Jennifer Abbasi

Abstract Full Text

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JAMA. 2021;325(14):1380-1382. doi:10.1001/jama.2021.3368

This Medical News article discusses genomic sequencing to detect and track virus variants during the COVID-19 pandemic.

Video: Coronavirus Variants and Vaccines

The JAMA Forum

Time to Rethink Nursing Homes

Stuart M. Butler, PhD

Abstract Full Text

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JAMA. 2021;325(14):1383-1384. doi:10.1001/jama.2021.2567

News From the Centers for Disease Control and Prevention

COVID-19 Precautions Are Scarce in Non鈥揌ealth Care Workplaces

Bridget M. Kuehn, MSJ

Abstract Full Text

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JAMA. 2021;325(14):1386. doi:10.1001/jama.2021.4844

Disparities in Suicide Persist Despite Overall Dip in US Rate

Bridget M. Kuehn, MSJ

Abstract Full Text

JAMA. 2021;325(14):1386. doi:10.1001/jama.2021.4131

Biotech Innovations

Data Leak Exposes Early COVID-19 Vaccine Manufacturing Hiccups

Jennifer Abbasi

Abstract Full Text

free access

JAMA. 2021;325(14):1385. doi:10.1001/jama.2021.5002

Teplizumab Improves Beta Cell Function, Delays Type 1 Diabetes

Jennifer Abbasi

Abstract Full Text

JAMA. 2021;325(14):1385. doi:10.1001/jama.2021.4628

Wearable Bilirubin Measurement Device for Neonatal Jaundice

Jennifer Abbasi

Abstract Full Text

JAMA. 2021;325(14):1385. doi:10.1001/jama.2021.5004

The Arts and Medicine

COVID-19 Postage Stamps鈥擬essages in a Message

Bertrand Lefrère, Msc; Amélie Recoing, PharmD, MSc; Hervé Delacour, PharmD, MSc

Abstract Full Text

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JAMA. 2021;325(14):1377-1379. doi:10.1001/jama.2021.2139

This Arts and Medicine feature presents global postage and commemorative stamps issued by countries and nongovernmental organizations in 2020 featuring coronavirus pandemic-related themes.

Poetry and Medicine

Winter of Fear

Allison Coffelt, MA

Abstract Full Text

JAMA. 2021;325(14):1474. doi:10.1001/jama.2021.1609

JAMA Revisited

Neurology in Art

Abstract Full Text

JAMA. 2021;325(14):1475. doi:10.1001/jama.2020.17882

JAMA Patient Page

Screening for Vitamin D Deficiency in Adults

Jill Jin, MD, MPH

Abstract Full Text

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JAMA. 2021;325(14):1480. doi:10.1001/jama.2021.4606

This JAMA Patient Page summarizes the US Preventive Services Task Force鈥檚 2021 recommendation that current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults (I statement).