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November 2024 - July 1883

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February 16, 2021, Vol 325, No. 7, Pages 605-702

This Week in JAMA

Audio Highlights

Abstract Full Text
free access online only has audio
JAMA. 2021;325(7):e2017797. doi:10.1001/jama.2020.17797
Original Investigation

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(7):632-644. doi:10.1001/jama.2021.0202

This randomized clinical trial compares the effects of 3 doses of bamlanivimab monotherapy (700 vs 2800 vs 7000 mg) vs combination bamlanivimab and etesevimab vs placebo on change in day 11 severe acute respiratory syndrome coronavirus 2 viral load in patients with mild to moderate coronavirus disease 2019 (COVID-19).

Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial

Abstract Full Text
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JAMA. 2021;325(7):646-657. doi:10.1001/jama.2021.0411

This randomized trial compares the effects of high- vs low-intensity strength training vs control on 18-mo knee pain and knee joint compressive force among adults with knee pain and radiographic evidence of osteoarthritis.

Associations of Maternal Cardiovascular Health in Pregnancy With Offspring Cardiovascular Health in Early Adolescence

Abstract Full Text
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JAMA. 2021;325(7):658-668. doi:10.1001/jama.2021.0247

This international cohort study examines associations between the cardiovascular (CV) health of pregnant women (defined by 5 CV risk factors) and CV health of their offspring at ages 10 to 14 years.

Research Letter

Changes in Abortion in Texas Following an Executive Order Ban During the Coronavirus Pandemic

Abstract Full Text
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JAMA. 2021;325(7):691-693. doi:10.1001/jama.2020.24096

This study assesses changes in abortions performed and at what gestational age following a Texas order postponing non–medically necessary surgeries due to the COVID-19 pandemic compared with abortions performed during the same months in 2019.

Viewpoint

Health Policy

A Blueprint for Comprehensive Medicaid Reform

Abstract Full Text
JAMA. 2021;325(7):619-620. doi:10.1001/jama.2021.0013

This Viewpoint proposes broad principles to guide Medicaid reform as a means to advance health equity, including stabilization of its funding and coverage; coordination of its infrastructure; alignment of health care and social spending at the point of care; and a value-based approach to benefits.

Health Policy

Declining Life Expectancy in the United States: The Need for Social Policy as Health Policy

Abstract Full Text
JAMA. 2021;325(7):621-622. doi:10.1001/jama.2020.26339

This Viewpoint reviews the social and economic drivers of declines in longevity in the US, especially among lower socioeconomic status groups, and proposes policy options for the Biden-Harris administration to mitigate the trend, including an increase in the federally mandated minimum wage.

Recalibrating the Use of Race in Medical Research

Abstract Full Text
free access has audio
JAMA. 2021;325(7):623-624. doi:10.1001/jama.2021.0003

This Viewpoint reviews the way race has been used and misused in medical research and urges careful consideration by investigators of how its use might ameliorate or worsen health inequalities.

Race and Pharmacogenomics—Personalized Medicine or Misguided Practice?

Abstract Full Text
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JAMA. 2021;325(7):625-626. doi:10.1001/jama.2020.25473

This Viewpoint uses examples of recommendations for race-based pharmacogenetic testing to discuss flaws and inconsistencies with race and ethnicity as surrogates for biology, and the consequences of those deficiencies for clinical decision-making.

Addressing Systemic Racism Through Clinical Preventive Service Recommendations From the US Preventive Services Task Force

Abstract Full Text
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JAMA. 2021;325(7):627-628. doi:10.1001/jama.2020.26188

This Viewpoint discusses ways the US Preventive Services Task Force (USPSTF) is working to identify contributions of systemic racism to differences in health outcomes, and to develop evidence-based recommendations to mitigate the effects of social, economic, and structural disadvantage on disease and its related sequelae.

A Piece of My Mind

Enjoy the Vase

Abstract Full Text
JAMA. 2021;325(7):629. doi:10.1001/jama.2020.26876

In this narrative medicine essay, a psychiatrist finally at peace after his wife's death to cancer learns that his prostate-specific antigen levels have begun to rise, reminding him to embrace uncertainty, a loss of control, and change.

Editorial

Maternal Cardiovascular Health: A Critical Period for Offspring Lifetime Cardiovascular Health?

Abstract Full Text
JAMA. 2021;325(7):630-631. doi:10.1001/jama.2021.0134
Review

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Abstract Full Text
JAMA. 2021;325(7):669-685. doi:10.1001/jama.2021.0106

This narrative review summarizes treatment options for patients with unresectable metastatic colorectal cancer, focusing on the importance of genomic profiling to identify KRAS/NRAS/BRAF variants to guide immunotherapy.

JAMA Guide to Statistics and Methods

Immortal Time Bias in Observational Studies

Abstract Full Text
has audio
JAMA. 2021;325(7):686-687. doi:10.1001/jama.2020.9151

This JAMA Guide to Statistics and Medicine explains immortal time bias, an error in estimating the association between an exposure and an outcome that results from misclassification or exclusion of time intervals; explains how this misclassification or exclusion can occur; and presents approaches to minimize or avoid immortal time bias.

JAMA Insights

Diagnosis and Treatment of Anal Fissures in 2021

Abstract Full Text
JAMA. 2021;325(7):688-689. doi:10.1001/jama.2020.16705

This JAMA Insights Clinical Update reviews the diagnosis and management of anal fissures, including use of supportive, topical, injection, and surgical treatment options.

Editor's Note

Neutralizing Monoclonal Antibody for Mild to Moderate COVID-19

Abstract Full Text
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JAMA. 2021;325(7):644-645. doi:10.1001/jama.2021.0585
Medical News & Perspectives

Quick Uptakes

Hospital Clowns Ease Children’s Symptoms, Review Shows

Abstract Full Text
JAMA. 2021;325(7):610-611. doi:10.1001/jama.2020.26433

This Medical News article describes a review of studies that examine whether hospital clowns can help alleviate pediatric patients’ symptoms such stress, anxiety, and pain.

News From the Food and Drug Administration

Advice for n-of-1 Drug Developers

Abstract Full Text
JAMA. 2021;325(7):613. doi:10.1001/jama.2021.0921

Generic Glucagon Approved for Severe Hypoglycemia

Abstract Full Text
JAMA. 2021;325(7):613. doi:10.1001/jama.2021.0383

More Scrutiny for Laparoscopic Power Morcellator Procedures

Abstract Full Text
JAMA. 2021;325(7):613. doi:10.1001/jama.2021.0923
Global Health

High-Income Countries Have Secured the Bulk of COVID-19 Vaccines

Abstract Full Text
free access
JAMA. 2021;325(7):612. doi:10.1001/jama.2021.0189

Clinical Trials Overlook Diseases of Low-Income Countries

Abstract Full Text
JAMA. 2021;325(7):612. doi:10.1001/jama.2021.0842

Global Partnership Aims to Improve Infant HIV Care

Abstract Full Text
JAMA. 2021;325(7):612. doi:10.1001/jama.2021.0844
Poetry and Medicine

Hospital Vigil

Abstract Full Text
JAMA. 2021;325(7):697. doi:10.1001/jama.2020.23843
JAMA Revisited

Current Comment

Abstract Full Text
JAMA. 2021;325(7):698. doi:10.1001/jama.2020.17798
JAMA Patient Page

Lateral Internal Sphincterotomy

Abstract Full Text
free access
JAMA. 2021;325(7):702. doi:10.1001/jama.2020.16708

This JAMA Patient Page explains lateral internal sphincterotomy, a surgical procedure used for treatment of anal fissures unresponsive to supportive or medical therapy.

Comment & Response

Wound Dressings for Obese Women After Cesarean Delivery

Abstract Full Text
JAMA. 2021;325(7):693. doi:10.1001/jama.2020.24195

Wound Dressings for Obese Women After Cesarean Delivery—Reply

Abstract Full Text
JAMA. 2021;325(7):693. doi:10.1001/jama.2020.24198

The Advantages of Medicare Advantage

Abstract Full Text
JAMA. 2021;325(7):693-694. doi:10.1001/jama.2020.24281

The Advantages of Medicare Advantage—Reply

Abstract Full Text
JAMA. 2021;325(7):694. doi:10.1001/jama.2020.24284

Geographic Differences in Uncontrolled Chronic Medical Conditions

Abstract Full Text
JAMA. 2021;325(7):694. doi:10.1001/jama.2020.24598

Geographic Differences in Uncontrolled Chronic Medical Conditions—Reply

Abstract Full Text
JAMA. 2021;325(7):694-695. doi:10.1001/jama.2020.24604

Database Updates and Resulting Changes in Data in Study of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy

Abstract Full Text
JAMA. 2021;325(7):695-696. doi:10.1001/jama.2021.0477
Correction

Error in Results Section

Abstract Full Text
free access
JAMA. 2021;325(7):696. doi:10.1001/jama.2021.0535
JAMA Masthead

JAMA

Abstract Full Text
free access
JAMA. 2021;325(7):605-606. doi:10.1001/jama.2020.17795
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