November 12, 2014 Issue of JAMA

November 12, 2014, Vol 312, No. 18, Pages 1831-1942

This Week in JAMA

Highlights

Abstract Full Text

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JAMA. 2014;312(18):1831-1833. doi:10.1001/jama.2013.279823

Podcast: Clinical exome sequencing, hospice and health services use, treatment of syphilis, and more.

Original Investigation

Molecular Findings Among Patients Referred for Clinical Whole-Exome Sequencing

Yaping Yang, PhD; Donna M. Muzny, MS; Fan Xia, PhD; et al.

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JAMA. 2014;312(18):1870-1879. doi:10.1001/jama.2014.14601

This observation trial reports that whole-exome sequencing provides a potential molecular diagnosis for patients referred for evaluation of suspected genetic conditions, including detection of rare genetic events and new mutations, contributing to disease.

Editorial
Genome-Scale Sequencing in Clinical Care: Establishing Molecular Diagnoses and Measuring Value
Jonathan S. Berg, MD, PhD

JAMA

Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders

Hane Lee, PhD; Joshua L. Deignan, PhD; Naghmeh Dorrani, MS, CGC; et al.

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JAMA. 2014;312(18):1880-1887. doi:10.1001/jama.2014.14604

Lee and coauthors report on initial clinical indications for clinical exome sequencing referrals and molecular diagnostic rates for different indications and for different test types.

Editorial
Genome-Scale Sequencing in Clinical Care: Establishing Molecular Diagnoses and Measuring Value
Jonathan S. Berg, MD, PhD

JAMA

Association Between the Medicare Hospice Benefit and Health Care Utilization and Costs for Patients With Poor-Prognosis Cancer

Ziad Obermeyer, MD, MPhil; Maggie Makar, BS; Samer Abujaber, MBBCh; et al.

Abstract Full Text

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JAMA. 2014;312(18):1888-1896. doi:10.1001/jama.2014.14950

This cohort study of patients with poor prognosis cancer receiving hospice care vs those who do not reports lower rates of hospitalization, intensive care unit admission, and invasive procedures at the end of life, along with significantly lower total costs during the last year of life.

Podcast: Medicare Hospice Benefit and Poor-Prognosis Cancer

Editorial
Quality and Costs of End-of-Life Care: The Need for Transparency and Accountability
Joan M. Teno, MD, MS; Pedro L. Gozalo, PhD

JAMA

Evaluation of the Association of Maternal Pertussis Vaccination With Obstetric Events and Birth Outcomes

Elyse O. Kharbanda, MD, MPH; Gabriela Vazquez-Benitez, PhD; Heather S. Lipkind, MD, MS; et al.

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JAMA. 2014;312(18):1897-1904. doi:10.1001/jama.2014.14825

This retrospective study found that Tdap vaccination during pregnancy was not associated with increased risk of hypertensive disorders preterm or small-for-gestational age births.

Research Letter

Life Expectancy in Patients With Chronic HCV Infection and Cirrhosis Compared With a General Population

Adriaan J. van der Meer, MD, PhD; Heiner Wedemeyer, MD, PhD; Jordan J. Feld, MD; et al.

Abstract Full Text

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JAMA. 2014;312(18):1927-1928. doi:10.1001/jama.2014.12627

Viewpoint

Should Life Insurers Have Access to Genetic Test Results?

Robert Klitzman, MD; Paul S. Appelbaum, MD; Wendy K. Chung, MD, PhD

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JAMA. 2014;312(18):1855-1856. doi:10.1001/jama.2014.13301

This Viewpoint discusses the issues involved in granting insurance companies access to consumers鈥� genetic information.

Podcast: Life Insurers鈥� Access to Genetic Test Results

Overcoming the Reimbursement Barriers for Clinical Sequencing

Patricia A. Deverka, MD, MS; David Kaufman, PhD; Amy L. McGuire, JD, PhD

Abstract Full Text

JAMA. 2014;312(18):1857-1858. doi:10.1001/jama.2014.14915

This Viewpoint discusses an approach to reimbursement and coding challenges posed by next-generation genomic sequencing techniques.

The Ebola Outbreak, Fragile Health Systems, and Quality as a Cure

Andrew S. Boozary, MD, MPP; Paul E. Farmer, MD, PhD; Ashish K. Jha, MD, MPH

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JAMA. 2014;312(18):1859-1860. doi:10.1001/jama.2014.14387

This Viewpoint examines the infrastructure and quality of health systems in West Africa against the backdrop of the Ebola outbreak.

Selecting a Specialist: Adding Evidence to the Clinical Practice of Making Referrals

Niteesh K. Choudhry, MD, PhD; Joshua M. Liao, MD; Allan S. Detsky, MD, PhD

Abstract Full Text

JAMA. 2014;312(18):1861-1862. doi:10.1001/jama.2014.12963

This Viewpoint discusses data about consultants becoming available to referring physicians and patients in an effort to improve the selection of specialists.

A Piece of My Mind

The Quality of Mercy: Will You Be My Doctor?

Timothy P. Daaleman, DO, MPH

Abstract Full Text

JAMA. 2014;312(18):1863-1864. doi:10.1001/jama.2014.12933

Editorial

Genome-Scale Sequencing in Clinical Care: Establishing Molecular Diagnoses and Measuring Value

Jonathan S. Berg, MD, PhD

Abstract Full Text

JAMA. 2014;312(18):1865-1867. doi:10.1001/jama.2014.14665

This Editorial discusses possible contributions of genomic sequencing to progress in clinical care, from molecular diagnosis to improved outcomes.

Quality and Costs of End-of-Life Care: The Need for Transparency and Accountability

Joan M. Teno, MD, MS; Pedro L. Gozalo, PhD

Abstract Full Text

JAMA. 2014;312(18):1868-1869. doi:10.1001/jama.2014.14949

Review

Treatment of Syphilis: A Systematic Review

Meredith E. Clement, MD; N. Lance Okeke, MD; Charles B. Hicks, MD

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JAMA. 2014;312(18):1905-1917. doi:10.1001/jama.2014.13259

This Review article concludes that the mainstay of syphilis treatment is parenteral penicillin G despite the relatively modest clinical trial data that support its use.

Podcast: Management of Syphilis in 2018

From the 糖心vlog

Food Marketing to Youth: Serious Business

H. Mollie Grow, MD, MPH; Marlene B. Schwartz, PhD

Abstract Full Text

JAMA. 2014;312(18):1918-1919. doi:10.1001/jama.2014.8951

JAMA Clinical Guidelines Synopsis

Use of HPV Vaccine in Males and Females

Adam S. Cifu, MD; Andrew M. Davis, MD, MPH

Abstract Full Text

JAMA. 2014;312(18):1920-1921. doi:10.1001/jama.2014.12274

JAMA Diagnostic Test Interpretation

RPR and the Serologic Diagnosis of Syphilis

Meredith E. Clement, MD; Charles B. Hicks, MD

Abstract Full Text

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JAMA. 2014;312(18):1922-1923. doi:10.1001/jama.2014.2087

Podcast: Management of Syphilis in 2018

Medical News & Perspectives

IOM Report Calls for Transformation of End-of-Life Care

Judith Graham, MSJ

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JAMA. 2014;312(18):1845-1847. doi:10.1001/jama.2014.13254

The JAMA Forum

A To-Do List for the New CEO of the Federal Health Insurance Marketplace

Larry Levitt, MPP

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JAMA. 2014;312(18):1847-1848. doi:10.1001/jama.2014.14527

Visualizing Health Policy

Recent Trends in Employer-Sponsored Insurance

Kaiser Family Foundation

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JAMA. 2014;312(18):1849. doi:10.1001/jama.2014.13248

News From the Centers for Disease Control and Prevention

Mass Exposure to Bats at Air Force Base Leads to Group Screening

Abstract Full Text

JAMA. 2014;312(18):1851. doi:10.1001/jama.2014.14224

Vaccination Rates Among Children Remained Stable in 2013

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JAMA. 2014;312(18):1851. doi:10.1001/jama.2014.14234

Capitol Health Call

Republicans Report Disputes Between and Within Agencies Over HealthCare.gov

Rita Rubin, MA

Abstract Full Text

JAMA. 2014;312(18):1850. doi:10.1001/jama.2014.14524

Integrating Care for Younger Disabled Does Not Improve Spending

Rita Rubin, MA

Abstract Full Text

JAMA. 2014;312(18):1850. doi:10.1001/jama.2014.15167

Obama Signs Law to Improve Postacute Care for Medicare Patients

Rita Rubin, MA

Abstract Full Text

JAMA. 2014;312(18):1850. doi:10.1001/jama.2014.15168

GAO: Demand for Caregiver Support Far Greater Than VA Expected

Rita Rubin, MA

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JAMA. 2014;312(18):1850. doi:10.1001/jama.2014.15169

The Art of JAMA

Liberty Loan Parade: Arthur Clifton Goodwin

Jeanette M. Smith, MD

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JAMA. 2014;312(18):1840-1841. doi:10.1001/jama.2013.279825

Poetry and Medicine

Nets

Dorian Kotsiopoulos

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JAMA. 2014;312(18):1933. doi:10.1001/jama.2014.8866

JAMA Revisited

The Etiology of Syphilis

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JAMA. 2014;312(18):1935. doi:10.1001/jama.2013.279832

JAMA Patient Page

Ebola Virus Disease

Jill Jin, MD, MPH

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JAMA. 2014;312(18):1942. doi:10.1001/jama.2014.13759

Comment & Response

Erythropoietin for Traumatic Brain Injury

Alistair Nichol, MB, BCh, PhD; Lorraine Little, BHSc (Nursing), MBioethics; Craig French, MBBS

Abstract Full Text

JAMA. 2014;312(18):1928-1929. doi:10.1001/jama.2014.12738

Erythropoietin for Traumatic Brain Injury鈥擱eply

Claudia S. Robertson, MD; Jose-Miguel Yamal, PhD; Barbara C. Tilley, PhD

Abstract Full Text

JAMA. 2014;312(18):1929. doi:10.1001/jama.2014.12744

Time Since Stroke and Risk of Adverse Outcomes After Surgery

William J. Powers, MD

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JAMA. 2014;312(18):1930. doi:10.1001/jama.2014.13422

Time Since Stroke and Risk of Adverse Outcomes After Surgery鈥擱eply

Mads E. Jørgensen, MB; Gunnar H. Gislason, MD, PhD; Charlotte Andersson, MD, PhD

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JAMA. 2014;312(18):1930-1931. doi:10.1001/jama.2014.13428

Medicalization of Marijuana

Amanda Reiman, PhD, MSW; Sunil Kumar Aggarwal, MD, PhD; Craig Reinarman, PhD

Abstract Full Text

JAMA. 2014;312(18):1931. doi:10.1001/jama.2014.12563

Medicalization of Marijuana鈥擱eply

Samuel T. Wilkinson, MD; Deepak Cyril D鈥橲ouza, MBBS, MD

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JAMA. 2014;312(18):1931-1932. doi:10.1001/jama.2014.12569

Correction

Incorrect Complication Description in Table

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JAMA. 2014;312(18):1932. doi:10.1001/jama.2014.14402

Typographical Errors

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JAMA. 2014;312(18):1932. doi:10.1001/jama.2014.14740

Author Missing From Byline and Additional Information

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JAMA. 2014;312(18):1932. doi:10.1001/jama.2014.8030

Incorrect Degree and Data

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JAMA. 2014;312(18):1932. doi:10.1001/jama.2014.9918

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November 12, 2014, Vol 312, No. 18, Pages 1831-1942

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