Mark J. Mulligan, MD; David I. Bernstein, MD, MA; Patricia Winokur, MD; et al.
free access
JAMA. 2014;312(14):1409-1419. doi:10.1001/jama.2014.12854
This randomized trial reports point-of-use mixing and administration of 2 doses of H7N9 vaccine at the lowest tested antigen dose with MF59 adjuvant, producing seroconversion in participants.
Robert B. Belshe, MD; Sharon E. Frey, MD; Irene L. Graham, MD; et al.
free access
JAMA. 2014;312(14):1420-1428. doi:10.1001/jama.2014.12609
This randomized trial reports that receipt of a single dose of influenza A(H5N1) vaccine was associated with sufficient immunologic priming to facilitate response to a different H5N1 antigen using a low dose of booster vaccine; in participants not previously vaccinated, low-dose vaccine plus adjuvant was more immunogenic compared with higher doses of unadjuvanted vaccine.
Caring for the Critically Ill Patient
Evelien A. N. Oostdijk, MD, PhD; Jozef Kesecioglu, MD, PhD; Marcus J. Schultz, MD, PhD; et al.
free access
JAMA. 2014;312(14):1429-1437. doi:10.1001/jama.2014.7247
This randomized crossover trial reports that selective oropharyngeal decontamination, vs selective decontamination of the digestive tract, was associated with lower prevalence of antibiotic-resistant gram-negative bacteria.
Shelley S. Magill, MD, PhD; Jonathan R. Edwards, MStat; Zintars G. Beldavs, MS; et al.
free access
has multimedia
has audio
JAMA. 2014;312(14):1438-1446. doi:10.1001/jama.2014.12923
A cross-sectional study of 1-day prevalence surveys conducted in 183 US acute care hospitals in 10 states found that antimicrobial drugs were used was 49.9% of the time and use of broad-spectrum drugs was common.
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Podcast:
Prevalence of Antimicrobial Use in US Acute Care Hospitals, May-September 2011
Lauren Epstein, MD, MSc; Jennifer C. Hunter, DrPH; M. Allison Arwady, MD; et al.
free access
JAMA. 2014;312(14):1447-1455. doi:10.1001/jama.2014.12720
Epstein and coauthors identify a source for, and interrupt transmission of, New Delhi metallo-尾-lactamase (NDM)鈥損roducing carbapenem-resistant Enterobacteriaceae (CRE) in northeastern Illinois.