June 18, 2014 Issue of JAMA

糖心vlog

June 18, 2014, Vol 311, No. 23, Pages 2355-2452

This Week in JAMA

Highlights

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JAMA. 2014;311(23):2355-2357. doi:10.1001/jama.2013.279556

Podcast: Trial of physical activity for older adults, TNF inhibitors and cancer in IBD patients, diagnosing exudative pleural effusion, and more.

Original Investigation

Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial

Marco Pahor, MD; Jack M. Guralnik, MD, PHD; Walter T. Ambrosius, PhD; et al.

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JAMA. 2014;311(23):2387-2396. doi:10.1001/jama.2014.5616

Pahor and coauthors test the hypothesis that a long-term, structured physical activity program is more effective than a health education program in reducing the risk of major mobility disability among 1635 US men and women aged 70 to 89 years who had physical limitations.

Podcast: Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial

Effect of Selumetinib vs Chemotherapy on Progression-Free Survival in Uveal Melanoma: A Randomized Clinical Trial

Richard D. Carvajal, MD; Jeffrey A. Sosman, MD; Jorge Fernando Quevedo, MD; et al.

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JAMA. 2014;311(23):2397-2405. doi:10.1001/jama.2014.6096

Carvajal and coauthors conducted a randomized clinical trial to assess the efficacy of selumetinib, a selective, non鈥揳denosine triphosphate competitive inhibitor of the mitogen-activated protein kinase kinase (MEK) enzymes MEK1 and MEK2, among 120 patients with metastatic uveal melanoma.

Association Between Tumor Necrosis Factor-伪 Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

Nynne Nyboe Andersen, MD; Björn Pasternak, MD, PhD; Saima Basit, MSc; et al.

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JAMA. 2014;311(23):2406-2413. doi:10.1001/jama.2014.5613

Podcast: Association Between Tumor Necrosis Factor-a Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

Thrombolysis for Pulmonary Embolism and Risk of All-Cause Mortality, Major Bleeding, and Intracranial Hemorrhage: A Meta-analysis

Saurav Chatterjee, MD; Anasua Chakraborty, MD; Ido Weinberg, MD; et al.

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JAMA. 2014;311(23):2414-2421. doi:10.1001/jama.2014.5990

Chatterjee and coauthors performed a meta-analysis to determine benefits and risks associated with thrombolytic therapy vs anticoagulation in acute pulmonary embolism, including the subset of hemodynamically stable patients with right ventricular dysfunction. In an Editorial, Beckman discusses how to assess the net clinical benefit of thrombolysis for patients with pulmonary embolism.

Editorial
Thrombolytic Therapy for Pulmonary Embolism
Joshua A. Beckman, MD

JAMA

Research Letter

Changes in Health and Medical Spending Among Young Adults Under Health Reform

Kao-Ping Chua, MD; Benjamin D. Sommers, MD, PhD

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JAMA. 2014;311(23):2437-2439. doi:10.1001/jama.2014.2202

Viewpoint

Physicians, Medical Ethics, and Execution by Lethal Injection

Robert D. Truog, MD; I. Glenn Cohen, JD; Mark A. Rockoff, MD

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JAMA. 2014;311(23):2375-2376. doi:10.1001/jama.2014.6425

Podcast: JAMA: 2014-06-17, Vol. 311, No. 23, Author Reading

Problems With the Medicalization of Marijuana

Samuel T. Wilkinson, MD; Deepak Cyril D鈥橲ouza, MBBS, MD

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JAMA. 2014;311(23):2377-2378. doi:10.1001/jama.2014.6175

Management of Comorbid Diabetes Mellitus and Worsening Heart Failure

Sadiya S. Khan, MD; Javed Butler, MD, MPH; Mihai Gheorghiade, MD

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JAMA. 2014;311(23):2379-2380. doi:10.1001/jama.2014.4115

Ethics and Regulatory Complexities for Pragmatic Clinical Trials

Jeremy Sugarman, MD, MPH, MA; Robert M. Califf, MD

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JAMA. 2014;311(23):2381-2382. doi:10.1001/jama.2014.4164

A Piece of My Mind

Keeping the Pace

Elizabeth B. Fortescue, MD, MPH

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JAMA. 2014;311(23):2383-2384. doi:10.1001/jama.2014.4962

Editorial

Thrombolytic Therapy for Pulmonary Embolism

Joshua A. Beckman, MD

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JAMA. 2014;311(23):2385-2386. doi:10.1001/jama.2014.5993

The Rational Clinical Examination

Does This Patient Have an Exudative Pleural Effusion?The Rational Clinical Examination Systematic Review

M. Elizabeth Wilcox, MD, MPH; Christopher A. K. Y. Chong, MD; Matthew B. Stanbrook, MD, PhD; et al.

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JAMA. 2014;311(23):2422-2431. doi:10.1001/jama.2014.5552

To prevent complications when thoracentesis is performed to find the cause of pleural effusion, Wilcox and colleagues assessed randomized and observational studies of adults undergoing the procedure that examined diagnostic tests for differentiating exudates from transudates.

JAMA Clinical Evidence Synopsis

Exercise for Depression

Gary Cooney, AB, MBChB; Kerry Dwan, PhD; Gillian Mead, FRCP

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JAMA. 2014;311(23):2432-2433. doi:10.1001/jama.2014.4930

JAMA Clinical Challenge

Lung Opacification

Wan-Yee Teo, MBBS, MRCPCH (UK); Robin Y. Dulman, MD; Tuyethoa Vinh, MD

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JAMA. 2014;311(23):2434-2435. doi:10.1001/jama.2013.286226

Medical News & Perspectives

Guidelines, Online Training Aim to Teach Physicians to Weigh Costs of Care, Become Better Stewards of Medical Resources

Bridget M. Kuehn, MSJ

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JAMA. 2014;311(23):2368-2370. doi:10.1001/jama.2014.5756

Task Force Recommends Screening High-Risk Individuals for Hepatitis B Infection

Bridget M. Kuehn, MSJ

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JAMA. 2014;311(23):2370. doi:10.1001/jama.2014.7129

News From the Centers for Disease Control and Prevention

Global Health

Spontaneous Abortions in Mongolia Linked to High Air Pollutant Levels

M. J. Friedrich

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JAMA. 2014;311(23):2372. doi:10.1001/jama.2014.6622

WHO Declares Polio an International Health Emergency

M. J. Friedrich

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JAMA. 2014;311(23):2372. doi:10.1001/jama.2014.7241

Marker for Iron-Deficiency Anemia?

M. J. Friedrich

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JAMA. 2014;311(23):2372. doi:10.1001/jama.2014.7242

Effect of Repeated Communal Violence on Mental Health

M. J. Friedrich

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JAMA. 2014;311(23):2372. doi:10.1001/jama.2014.7243

news@JAMA

From JAMA鈥檚 Daily News Site

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JAMA. 2014;311(23):2370. doi:10.1001/jama.2014.7073

Lab, Field, & Clinic

CDC App Aims to Help Track, Curb Ebola Outbreaks

Bridget M. Kuehn, MSJ

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JAMA. 2014;311(23):2371. doi:10.1001/jama.2014.5831

The Art of JAMA

Black on Red: Florence Arnold

Jeanette M. Smith, MD

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JAMA. 2014;311(23):2362-2363. doi:10.1001/jama.2013.279558

Poetry and Medicine

Malignant Melanoma

Susan Christy Mirabal

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JAMA. 2014;311(23):2443. doi:10.1001/jama.2013.285846

JAMA Revisited

Landmarks in Simple Pleural Effusions

Julius Kaunitz, M.D.

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JAMA. 2014;311(23):2444. doi:10.1001/jama.2013.279594

JAMA Patient Page

Gastroesophageal Reflux Disease

Deborah Tolmach Sugerman, MSW

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JAMA. 2014;311(23):2452. doi:10.1001/jama.2014.3122

Comment & Response

Number of Human Papillomavirus Vaccine Doses and Condyloma

Aimée R. Kreimer, PhD; Mahboobeh Safaeian, PhD; Allan Hildesheim, PhD

Abstract Full Text

JAMA. 2014;311(23):2439. doi:10.1001/jama.2014.5009

Number of Human Papillomavirus Vaccine Doses and Condyloma鈥擱eply

Alexander Ploner, PhD; Eva Herweijer, MSc; Lisen Arnheim-Dahlström, PhD

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JAMA. 2014;311(23):2439-2440. doi:10.1001/jama.2014.5012

Home-Based Exercise and Hip Fracture Rehabilitation

Umut Safer, MD; Ilker Tasci, MD; Vildan Binay Safer, MD

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JAMA. 2014;311(23):2440. doi:10.1001/jama.2014.5170

Home-Based Exercise and Hip Fracture Rehabilitation鈥擱eply

Nancy K. Latham, PhD, PT; Jonathan F. Bean, MD, MS, MPH; Alan M. Jette, PhD, PT

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JAMA. 2014;311(23):2440-2441. doi:10.1001/jama.2014.5173

Withdrawal of Personal Genome Service

Leo G. M. van Rossum, PhD

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JAMA. 2014;311(23):2441. doi:10.1001/jama.2014.5570

Withdrawal of Personal Genome Service鈥擱eply

Nicholas S. Downing, AB; Joseph S. Ross, MD, MHS

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JAMA. 2014;311(23):2441-2442. doi:10.1001/jama.2014.5584

Correction

Error in Quote

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JAMA. 2014;311(23):2442. doi:10.1001/jama.2014.6178

Incorrect Painting Title and Omission of Copyright Information

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JAMA. 2014;311(23):2442. doi:10.1001/jama.2014.6706

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June 18, 2014, Vol 311, No. 23, Pages 2355-2452

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