March 7, 2023 Issue of JAMA

March 7, 2023, Vol 329, No. 9, Pages 695-772

This Week in JAMA

Audio Highlights

Abstract Full Text

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JAMA. 2023;329(9):e2215818. doi:10.1001/jama.2022.15818

Podcast: Intrapartum Azithromycin and Neonatal and Maternal Outcomes, Olamkicept for Ulcerative Colitis, FDA Mandate Limiting Acetaminophen in Combination Opioid Products and Liver Failure, and more

Original Investigation

Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death: A Randomized Clinical Trial

Anna Roca, PhD; Bully Camara, MD; Joel D. Bognini, MD; et al.

Abstract Full Text

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JAMA. 2023;329(9):716-724. doi:10.1001/jama.2022.24388

This randomized trial compares the efficacy of intrapartum azithromycin vs placebo to reduce neonatal sepsis or mortality, as well as neonatal and maternal infections, among birthing parents and their infants in West Africa.

Editorial
Still Looking for a Simple, Effective Prevention Measure for Neonatal Sepsis in High-Mortality Settings
Stephanie J. Schrag, DPhil; Cynthia G. Whitney, MD, MPH

JAMA

Effect of Induction Therapy With Olamkicept vs Placebo on Clinical Response in Patients With Active Ulcerative Colitis: A Randomized Clinical Trial

Shenghong Zhang, MD; Baili Chen, MD; Bangmao Wang, MD; et al.

Abstract Full Text

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JAMA. 2023;329(9):725-734. doi:10.1001/jama.2023.1084

This randomized clinical trial compares clinical response at 12 weeks with olamkicept vs placebo in treating adult patients with active ulcerative colitis.

Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure

Babak J. Orandi, MD, PhD; M. Chandler McLeod, PhD; Paul A. MacLennan, PhD; et al.

Abstract Full Text

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JAMA. 2023;329(9):735-744. doi:10.1001/jama.2023.1080

This interrupted time-series analysis uses data from the National Inpatient Sample and the Acute Liver Failure Study Group to assess the odds of hospitalization and the proportion of acute liver failure cases with acetaminophen and opioid toxicity prior to and after the US Food and Drug Administration mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications.

Video: Acetaminophen (Paracetamol) and Acute Liver Failure

Podcast: Limiting Acetaminophen in Prescription Combination Opioid Products

Editorial
Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity
Marc G. Ghany, MD, MHSc; Paul B. Watkins, MD

JAMA
- Video: Acetaminophen (Paracetamol) and Acute Liver Failure
- Podcast: Limiting Acetaminophen in Prescription Combination Opioid Products

DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant

Laura W. Dillon, PhD; Gege Gui, ScM; Kristin M. Page, MD; et al.

Abstract Full Text

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JAMA. 2023;329(9):745-755. doi:10.1001/jama.2023.1363

In this observational study, targeted deep DNA sequencing was performed to test the hypothesis that detection of specific residual AML-associated variants in the blood of patients in first remission prior to allogeneic hematopoietic cell transplant would be associated with higher rates of relapse and mortality after transplant

Research Letter

Association Between Preapproval Confirmatory Trial Initiation and Conversion to Traditional Approval or Withdrawal in the FDA Accelerated Approval Pathway

Mahnum Shahzad, BA; Huseyin Naci, MHS, PhD; Anita K. Wagner, PharmD, MPH, DrPH

Abstract Full Text

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JAMA. 2023;329(9):760-761. doi:10.1001/jama.2023.0625

This study examines the Food and Drug Administration鈥檚 accelerated approval pathway and whether preapproval initiation was associated with faster conversion to traditional approval or withdrawal for drugs with nononcology indications.

States鈥� Methods for Capturing and Reporting Local Responses to Suspected Nonfatal Drug Overdoses

Christian Johnson, MPH; Megan Catlin, MS; Lisa Sinow, MS; et al.

Abstract Full Text

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JAMA. 2023;329(9):761-763. doi:10.1001/jama.2023.0169

This study examines the available data used to surveil state-level drug overdoses and characterizes them based on their timeliness, drug involvement, and specification of nonfatal outcomes.

Viewpoint

Implementing the White House鈥檚 Strategic Plan to Save Lives Amid the Opioid Crisis: Reaching for the 鈥淣orth Star鈥�

Michael A. Incze, MD, MSEd; A. Taylor Kelley, MD, MPH, MSc; Phillip M. Singer, PhD, MHSA

Abstract Full Text

JAMA. 2023;329(9):705-706. doi:10.1001/jama.2023.1041

This Viewpoint discusses the goals of the inaugural National Drug Control Strategy, which as the ambitious agenda of emphasizing harm reduction practices, medications for treating opioid use disorder, and criminal justice reform, as well as supporting long-term recovery and interrupting illicit drug trafficking.

A 2023 Agenda for Substance Use Prevention and Treatment in the US

Rahul Gupta, MD, MPH, MBA; Nicholas F. Wright, PhD; David R. Holtgrave, PhD

Abstract Full Text

JAMA. 2023;329(9):707-708. doi:10.1001/jama.2023.1090

In this Viewpoint, officials from the White House Office of National Drug Control Policy describe 3 actions that health care personnel can take to expand prevention and treatment of substance misuse and overdose.

A Piece of My Mind

Finding Answers

Anna-Maija Tolppanen, PhD

Abstract Full Text

JAMA. 2023;329(9):709-710. doi:10.1001/jama.2023.0343

In this narrative medicine essay, a pharmacoepidemiologist worries that her brother鈥檚 lifelong neurological challenges may have been caused by a heritable genetic variant and that she possibly passed it to her young son, who looks uncannily like his uncle.

Editorial

Still Looking for a Simple, Effective Prevention Measure for Neonatal Sepsis in High-Mortality Settings

Stephanie J. Schrag, DPhil; Cynthia G. Whitney, MD, MPH

Abstract Full Text

JAMA. 2023;329(9):711-712. doi:10.1001/jama.2022.24139

Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity

Marc G. Ghany, MD, MHSc; Paul B. Watkins, MD

Abstract Full Text

has multimedia has audio

JAMA. 2023;329(9):713-715. doi:10.1001/jama.2023.1002

Video: Acetaminophen (Paracetamol) and Acute Liver Failure

Podcast: Limiting Acetaminophen in Prescription Combination Opioid Products

JAMA Insights

Women's Health

Pregnancy After Bariatric Surgery

Stephanie A. Fisher, MD, MPH, MS; Bethany T. Stetson, MD; Michelle A. Kominiarek, MD, MS

Abstract Full Text

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JAMA. 2023;329(9):758-759. doi:10.1001/jama.2023.1442

This JAMA Insights Clinical Update discusses general adaptations for pregnancy after bariatric surgery, including recommendations regarding nutrition, maternal health, and fetal and neonatal risks.

JAMA Clinical Guidelines Synopsis

Management of Thoracic Aortic Dissection

Irbaz Hameed, MD; Adam S. Cifu, MD; Prashanth Vallabhajosyula, MD, MS

Abstract Full Text

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JAMA. 2023;329(9):756-757. doi:10.1001/jama.2023.0265

This JAMA Clinical Guidelines Synopsis summarizes the 2021 guidelines from the American Association for Thoracic Surgery and the Society of Thoracic Surgeons on management of type A and type B thoracic aortic dissection.

Medical News & Perspectives

Questions Remain About What SARS-CoV-2 Variants Should Go Into the Annual COVID-19 Vaccines Proposed by the FDA

Rita Rubin, MA

Abstract Full Text

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JAMA. 2023;329(9):697-700. doi:10.1001/jama.2022.22285

This Medical News story examines the US Food and Drug Administration鈥檚 proposed plans for an annual COVID-19 vaccination.

Podcast: February 2023 Medical News Summary

News From the 糖心vlog

Long COVID Linked With Unemployment in New Analysis

Melissa Suran, PhD, MSJ

Abstract Full Text

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JAMA. 2023;329(9):701-702. doi:10.1001/jama.2023.0157

This Medical News article discusses new research on the association between long COVID and employment status.

Podcast: February 2023 Medical News Summary

Medical News in Brief

Marburg Vaccine Safe, Immunogenic in Phase 1 Trial

Emily Harris

Abstract Full Text

JAMA. 2023;329(9):703. doi:10.1001/jama.2023.1343

Meta-analysis: Vitamin D Therapy Reduced Type 2 Diabetes

Emily Harris

Abstract Full Text

JAMA. 2023;329(9):703. doi:10.1001/jama.2023.1550

Financial Coaching for Parents Increases Visits to Pediatrician

Emily Harris

Abstract Full Text

JAMA. 2023;329(9):703. doi:10.1001/jama.2023.1551

WHO Revises List of Stockpiled Drugs for Nuclear Emergencies

Emily Harris

Abstract Full Text

JAMA. 2023;329(9):703. doi:10.1001/jama.2023.1552

Editorial
Reducing the Risks of Nuclear War鈥擳he Role of Health Professionals
Kamran Abbasi; Parveen Ali; Virginia Barbour; Kirsten Bibbins-Domingo; Marcel G.M. Olde Rikkert; Andy Haines; Ira Helfand; Richard Horton; Bob Mash; Arun Mitra; Carlos Monteiro; Elena N. Naumova; Eric J. Rubin; Tilman Ruff; Peush Sahni; James Tumwine; Paul Yonga; Chris Zielinski

JAMA