Yuesong Pan, PhD; Xia Meng, MD, PhD; Aoming Jin, PhD; et al.
free access
JAMA Neurol. 2022;79(8):739-745. doi:10.1001/jamaneurol.2022.1457
This secondary analysis of the Ticagrelor or Clopidogrel With Aspirin in High-risk Patients With Acute Nondisabling Cerebrovascular Events II (CHANCE-2) randomized clinical trial evaluates the time course for benefits and risks with ticagrelor and aspirin after minor stroke or transient ischemic attack in individuals who carry CYP2C19 loss-of-function alleles.
Donald D. McGeary, PhD; Patricia A. Resick, PhD; Donald B. Penzien, PhD; et al.
open access
JAMA Neurol. 2022;79(8):746-757. doi:10.1001/jamaneurol.2022.1567
This randomized clinical trial investigates if cognitive behavioral therapies for posttraumatic stress disorder (PTSD) and posttraumatic headache improve headache-related disability and PTSD symptom severity in US veterans compared with treatment per usual.
Edmond Teng, MD, PhD; Paul T. Manser, PhD; Karen Pickthorn, DVM; et al.
open access
JAMA Neurol. 2022;79(8):758-767. doi:10.1001/jamaneurol.2022.1375
This randomized clinical trial evaluates the safety and efficacy of the monoclonal anti-tau antibody semorinemab in individuals with prodromal to mild Alzheimer disease.
Eric E. Smith, MD, MPH; Charlotte Zerna, MD, PhD; Nicole Solomon, PhD; et al.
free access
JAMA Neurol. 2022;79(8):768-776. doi:10.1001/jamaneurol.2022.1413
This cohort study investigates the outcomes of combination endovascular thrombectomy with alteplase compared with endovascular thrombectomy alone for the treatment of patients with acute ischemic stroke attributable to large vessel occlusion.
Yu-Chu Shen, PhD; Nandita Sarkar, PhD; Renee Y. Hsia, MD, MSc
free access
has audio
JAMA Neurol. 2022;79(8):777-786. doi:10.1001/jamaneurol.2022.1621
This cohort study examines differences in hospitals鈥� likelihood of adopting stroke care certification between historically underserved and general communities.
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Podcast:
Structural Inequities for Historically Underserved Communities in the Adoption of Stroke Certification in the US
Kathryn Atherton, BA; Xudong Han, MS; Jaeyoon Chung, PhD; et al.
open access
JAMA Neurol. 2022;79(8):787-796. doi:10.1001/jamaneurol.2022.1634
This genetic association study tests the association between APOE genotype and chronic traumatic encephalopathy neuropathology and related endophenotypes.
Shorena Janelidze, PhD; Bradley T. Christian, PhD; Julie Price, PhD; et al.
open access
JAMA Neurol. 2022;79(8):797-807. doi:10.1001/jamaneurol.2022.1740
This cross-sectional study analyzes data from participants in the Alzheimer鈥檚 Biomarker Consortium鈥揇own Syndrome study to determine which plasma biomarker combinations can accurately detect Alzheimer disease鈥搑elated tau pathological brain changes in individuals with Down syndrome.
Divyanshu Dubey, MD; Grayson Beecher, MD; M. Bakri Hammami, MD; et al.
open access
has multimedia
JAMA Neurol. 2022;79(8):808-816. doi:10.1001/jamaneurol.2022.1357
This cohort study evaluates caveolae-associated protein 4 as a potential biomarker of immune-mediated rippling muscle disease.