November 1, 2022 Issue of JAMA Neurology

November 2022, Vol 79, No. 11, Pages 1094-1206

Viewpoint

The Current Status of Next-Generation Sequencing for Diagnosis of Central Nervous System Infections

Michael R. Wilson, MD; Kenneth L. Tyler, MD

Abstract Full Text

JAMA Neurol. 2022;79(11):1095-1096. doi:10.1001/jamaneurol.2022.2287

This Viewpoint discusses the ability of next-generation sequencing to diagnose central nervous system (CNS) infections as well as the complexity of such technology and the need to develop programs to help clinicians select, interpret, and respond to test results more accurately.

What Should the Goals Be for Diverse Recruitment in Alzheimer Clinical Trials?

Joshua D. Grill, PhD; Reisa A. Sperling, MD; Rema Raman, PhD

Abstract Full Text

JAMA Neurol. 2022;79(11):1097-1098. doi:10.1001/jamaneurol.2022.2274

This Viewpoint discusses why it鈥檚 important for Alzheimer clinical trials to be inclusive and enroll diverse populations that include underrepresented racial, ethnic, and sociocultural groups.

On the Brain

Seeing Ellen and the Platinum Rule

Harvey Max Chochinov, OC, OM, MD, PhD

Abstract Full Text

JAMA Neurol. 2022;79(11):1099. doi:10.1001/jamaneurol.2022.2400

This essay discusses basing care decisions on what the patient wants and not presuming to know what is in the patient鈥檚 best interest based on what we would want in their circumstances.

Editorial

Rituximab in Newly Diagnosed Generalized Myasthenia Gravis: A New Treatment Paradigm?

Miguel Chuquilin, MD; Richard Barohn, MD

Abstract Full Text

JAMA Neurol. 2022;79(11):1100-1102. doi:10.1001/jamaneurol.2022.2311

Broadening Our SCOPE of Understanding Patent Foramen Ovale High-risk Features and Stroke鈥擯rogress and Nuance

Arielle P. Davis, MD; David L. Tirschwell, MD

Abstract Full Text

JAMA Neurol. 2022;79(11):1102-1104. doi:10.1001/jamaneurol.2022.2127

Original Investigation

Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial

Fredrik Piehl, MD, PhD; Ann Eriksson-Dufva, MD; Anna Budzianowska, MD, PhD; et al.

Abstract Full Text

open access

JAMA Neurol. 2022;79(11):1105-1112. doi:10.1001/jamaneurol.2022.2887

This randomized clinical trial investigates the efficacy and safety of rituximab compared vs placebo as an add-on with standard of care for myasthenia gravis.

Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials

Susanne Ostrowitzki, MD; Tobias Bittner, PhD; Kaycee M. Sink, MD; et al.

Abstract Full Text

open access

JAMA Neurol. 2022;79(11):1113-1121. doi:10.1001/jamaneurol.2022.2909

These randomized clinical trials evaluate the safety and efficacy of crenezumab vs placebo in individuals with early Alzheimer disease.

Association Between Traumatic Brain Injury and Subsequent Cardiovascular Disease Among Post-9/11鈥揈ra Veterans

Ian J. Stewart, MD; Megan E. Amuan, MPH; Chen-Pin Wang, PhD; et al.

Abstract Full Text

open access

JAMA Neurol. 2022;79(11):1122-1129. doi:10.1001/jamaneurol.2022.2682

This cohort study investigates the association of traumatic brain injury with subsequent risk of cardiovascular disease in veterans of the recent conflicts in Iraq and Afghanistan.

Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy

Håkon Magne Vegrim, MD; Julie Werenberg Dreier, PhD; Silje Alvestad, MD, PhD; et al.

Abstract Full Text

open access has audio

JAMA Neurol. 2022;79(11):1130-1138. doi:10.1001/jamaneurol.2022.2977

This cohort study uses nationwide register data from 3 Nordic countries to examine the association between risk of childhood cancer and high-dose folic acid supplementation in mothers with epilepsy.

Podcast: Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy

Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia: A Secondary Analysis of the Imaging Dementia鈥揈vidence for Amyloid Scanning (IDEAS) Cohort Study

Consuelo H. Wilkins, MD, MSCI; Charles C. Windon, MD; Peggye Dilworth-Anderson, PhD; et al.

Abstract Full Text

open access

JAMA Neurol. 2022;79(11):1139-1147. doi:10.1001/jamaneurol.2022.3157

This cohort study evaluates differences by race and ethnicity in participants with mild cognitive impairment or dementia.

Risk of Suicide After Dementia Diagnosis

Danah Alothman, BMBCh, MPH; Timothy Card, FRCP, PhD; Sarah Lewis, PhD; et al.

Abstract Full Text

free access

JAMA Neurol. 2022;79(11):1148-1154. doi:10.1001/jamaneurol.2022.3094

This case-control study investigates the association between dementia diagnosis and suicide risk.

Distinguishing Frontotemporal Lobar Degeneration Tau From TDP-43 Using Plasma Biomarkers

Katheryn A. Q. Cousins, PhD; Leslie M. Shaw, PhD; Alice Chen-Plotkin, MD; et al.

Abstract Full Text

free access

JAMA Neurol. 2022;79(11):1155-1164. doi:10.1001/jamaneurol.2022.3265

This cross-sectional study tests whether plasma biomarkers glial fibrillary acidic protein, neurofilament light chain, or their ratio differ between molecular forms of frontotemporal lobar degeneration.

Effect of an 18-Month Meditation Training on Regional Brain Volume and Perfusion in Older Adults: The Age-Well Randomized Clinical Trial

Gael Chételat, PhD; Antoine Lutz, PhD; Olga Klimecki, PhD; et al.

Abstract Full Text

open access

JAMA Neurol. 2022;79(11):1165-1174. doi:10.1001/jamaneurol.2022.3185

This randomized clinical trial investigates the effects of meditation training on brain integrity in older adults.

Brief Report

Association of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure

Jean-Louis Mas, MD; Jeffrey L. Saver, MD; Scott E. Kasner, MD; et al.

Abstract Full Text

JAMA Neurol. 2022;79(11):1175-1179. doi:10.1001/jamaneurol.2022.3248

This individual patient data meta-analysis evaluates the association of patent foramen ovale closure on stroke recurrence according to shunt size and/or the presence of an atrial septal aneurysm.

Review

Neurologic Complications of Smallpox and Monkeypox: A Review

B. Jeanne Billioux, MD; Oliver Tshiani Mbaya, MD; James Sejvar, MD; et al.

Abstract Full Text

free access has active quiz

JAMA Neurol. 2022;79(11):1180-1186. doi:10.1001/jamaneurol.2022.3491

This narrative review discusses the known neurologic complications of smallpox, the complications of smallpox vaccination, and the known neurologic complications of monkeypox.

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review

Hugh S. Markus, DM; Wiesje M. van Der Flier, PhD; Eric E. Smith, MD; et al.

Abstract Full Text

has active quiz

JAMA Neurol. 2022;79(11):1187-1198. doi:10.1001/jamaneurol.2022.2262

This narrative review discusses the Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE), which offers guidelines for optimizing design of clinical trials in small vessel disease.

Images in Neurology

Neurogenic Unilateral Leg Edema

Howard Feit, MD, PhD; Jeffrey Solway, DPM; Mokbel K. Chedid, MD

Abstract Full Text

has active quiz

JAMA Neurol. 2022;79(11):1199. doi:10.1001/jamaneurol.2022.2933

This case report describes neurogenic unilateral leg edema that was a consequence of chronic regional pain syndrome induced by an S1 radiculopathy.

Diffuse Cortical Injury and Basal Ganglia High Signals on Diffusion-Weighted Imaging in Neuronal Intranuclear Inclusion Disease

Xuejun Guo, MD; Zhaoxia Wang, MD; Fan Li, MD

Abstract Full Text

has active quiz

JAMA Neurol. 2022;79(11):1200-1201. doi:10.1001/jamaneurol.2022.2970

This case report describes a patient who was admitted to the hospital owing to sudden-onset involuntary and irregular movements of his left limbs.

JAMA Neurology Clinical Challenge

A Conflicting Case of Ophthalmoparesis

Newman Cheng, MBBS, S鈥檖ore, MRCP(UK), MRCP(UK) (Neurology)

Abstract Full Text

has active quiz

JAMA Neurol. 2022;79(11):1202-1203. doi:10.1001/jamaneurol.2022.3149

A 37-year-old man with no known medical or drug history presented with an insidious onset of left-eye ptosis. He did not complain of headaches, facial numbness, dysarthria, facial droop, dysphagia, limb weakness or numbness. What is your diagnosis?

Comment & Response

Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease鈥擡stimating the True Value

Edward R. Scheffer Cliff, MBBS, MPH; Amar H. Kelkar, MD

Abstract Full Text

JAMA Neurol. 2022;79(11):1204. doi:10.1001/jamaneurol.2022.3101

Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease鈥擡stimating the True Value

Soeren Mattke, MD, DSc

Abstract Full Text

JAMA Neurol. 2022;79(11):1204-1205. doi:10.1001/jamaneurol.2022.3104

Effectiveness鈥擡ssential for Cost-effectiveness鈥擱eply

Eric L. Ross, MD; Marc S. Weinberg, MD, PhD; Steven E. Arnold, MD

Abstract Full Text

JAMA Neurol. 2022;79(11):1205-1206. doi:10.1001/jamaneurol.2022.3107

Correction

Error in Open Access Status

Abstract Full Text

free access

JAMA Neurol. 2022;79(11):1206. doi:10.1001/jamaneurol.2022.3960

Error in Figure Caption

Abstract Full Text

free access

JAMA Neurol. 2022;79(11):1206. doi:10.1001/jamaneurol.2022.4371

糖心vlog

October 2024 - July 1959

Decade

Year

Issue

November 2022, Vol 79, No. 11, Pages 1094-1206

The Current Status of Next-Generation Sequencing for Diagnosis of Central Nervous System Infections

What Should the Goals Be for Diverse Recruitment in Alzheimer Clinical Trials?

Seeing Ellen and the Platinum Rule

Rituximab in Newly Diagnosed Generalized Myasthenia Gravis: A New Treatment Paradigm?

Broadening Our SCOPE of Understanding Patent Foramen Ovale High-risk Features and Stroke鈥擯rogress and Nuance

Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial

Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials

Association Between Traumatic Brain Injury and Subsequent Cardiovascular Disease Among Post-9/11鈥揈ra Veterans

Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy

Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia: A Secondary Analysis of the Imaging Dementia鈥揈vidence for Amyloid Scanning (IDEAS) Cohort Study

Risk of Suicide After Dementia Diagnosis

Distinguishing Frontotemporal Lobar Degeneration Tau From TDP-43 Using Plasma Biomarkers

Effect of an 18-Month Meditation Training on Regional Brain Volume and Perfusion in Older Adults: The Age-Well Randomized Clinical Trial

Association of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure

Neurologic Complications of Smallpox and Monkeypox: A Review

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review

Neurogenic Unilateral Leg Edema

Diffuse Cortical Injury and Basal Ganglia High Signals on Diffusion-Weighted Imaging in Neuronal Intranuclear Inclusion Disease

A Conflicting Case of Ophthalmoparesis

Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease鈥擡stimating the True Value

Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease鈥擡stimating the True Value

Effectiveness鈥擡ssential for Cost-effectiveness鈥擱eply

Error in Open Access Status

Error in Figure Caption

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