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October 2024 - July 1959

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April 2022, Vol 79, No. 4, Pages 321-420

On the Brain

Light Reading—The Gravity of Postoperative Care

Abstract Full Text
JAMA Neurol. 2022;79(4):323-324. doi:10.1001/jamaneurol.2021.5213

This essay describes the author’s experience with craniotomy and recovery from the procedure.

Editorial

Early Posttraumatic Seizures—Putting Things in Perspective

Abstract Full Text
JAMA Neurol. 2022;79(4):325-326. doi:10.1001/jamaneurol.2021.5419

Addressing Vulnerability and Dementia in the Era of COVID-19

Abstract Full Text
free access
JAMA Neurol. 2022;79(4):327-328. doi:10.1001/jamaneurol.2021.5330

Low-Density Lipoprotein Cholesterol Level After a Stroke—Reducing It by Any Means

Abstract Full Text
JAMA Neurol. 2022;79(4):329-330. doi:10.1001/jamaneurol.2021.5586

Identifying Parkinson Risk Markers in Primary Care—Old Associations and New Insights

Abstract Full Text
JAMA Neurol. 2022;79(4):331-333. doi:10.1001/jamaneurol.2021.5542
Original Investigation

Risk Factors and Prognosis of Early Posttraumatic Seizures in Moderate to Severe Traumatic Brain Injury

Abstract Full Text
free access has audio
JAMA Neurol. 2022;79(4):334-341. doi:10.1001/jamaneurol.2021.5420

This cohort study examines data from 15 152 adult patients who had moderate to severe traumatic brain injury to assess risk factors for and outcomes from early posttraumatic seizures.

Trends in Mortality Rates Among Medicare Enrollees With Alzheimer Disease and Related Dementias Before and During the Early Phase of the COVID-19 Pandemic

Abstract Full Text
free access
JAMA Neurol. 2022;79(4):342-348. doi:10.1001/jamaneurol.2022.0010

This cross-sectional study uses data from 53.6 million Medicare beneficiaries to assess whether there is an association between regional rates of COVID-19 infection and excess mortality among older adults with or without Alzheimer disease and related dementias residing in the community or nursing homes.

Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention: A Meta-analysis of Randomized Clinical Trials

Abstract Full Text
open access
JAMA Neurol. 2022;79(4):349-358. doi:10.1001/jamaneurol.2021.5578

This meta-analysis of randomized clinical trials evaluates the association of more intensive vs less intensive low-density lipoprotein cholesterol–lowering statin-based therapies with outcomes for patients with ischemic stroke.

Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population

Abstract Full Text
free access
JAMA Neurol. 2022;79(4):359-369. doi:10.1001/jamaneurol.2022.0003

This case-control study examines the presence of prediagnostic signs and symptoms of PD in the primary care setting and individuals of diverse ethnicity and deprived socioeconomic status.

Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study

Abstract Full Text
free access
JAMA Neurol. 2022;79(4):370-379. doi:10.1001/jamaneurol.2021.5487

This cohort study investigates changes in dose-normalized concentrations of the antiseizure medications lamotrigine, levetiracetam, lacosamide, oxcarbazepine, and zonisamide during pregnancy among women with epilepsy.

Association of Intensive vs Standard Blood Pressure Control With Cerebral Blood Flow: Secondary Analysis of the SPRINT MIND Randomized Clinical Trial

Abstract Full Text
free access
JAMA Neurol. 2022;79(4):380-389. doi:10.1001/jamaneurol.2022.0074

This secondary analysis of a randomized clinical trial evaluates longitudinal arterial spin labeled data to test the hypothesis that long-term intensive treatment does not reduce cerebral blood flow compared with standard treatment.

Neurologic Prognostication After Cardiac Arrest Using Brain Biomarkers: A Systematic Review and Meta-analysis

Abstract Full Text
free access
JAMA Neurol. 2022;79(4):390-398. doi:10.1001/jamaneurol.2021.5598

This systematic review and meta-analysis evaluates the use of bloodborne brain injury biomarkers for neurologic prognostication in patients with hypoxic ischemic brain injury after cardiac arrest.

Brief Report

Omicron-Specific Cytotoxic T-Cell Responses After a Third Dose of mRNA COVID-19 Vaccine Among Patients With Multiple Sclerosis Treated With Ocrelizumab

Abstract Full Text
free access has active quiz
JAMA Neurol. 2022;79(4):399-404. doi:10.1001/jamaneurol.2022.0245

This cohort study evaluates T-cell responses to the Omicron spike protein in anti-CD20–treated patients with multiple sclerosis (MS) before and after a third messenger RNA COVID-19 vaccination.

Review

Multicenter Consensus Approach to Evaluation of Neonatal Hypotonia in the Genomic Era: A Review

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(4):405-413. doi:10.1001/jamaneurol.2022.0067

This narrative review provides an overview of the role of genomic evaluation in the diagnosis and management of common causes of neonatal hypotonia drawing on the collective diagnostic experience of academic centers in Australia, Canada, the UK, and the US.

Images in Neurology

Pulsatile Superficial Temporal Artery: A Sign of Carotid Dissection With Stroke

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(4):414-415. doi:10.1001/jamaneurol.2021.5382

This case report describes a man who had pulsatile tinnitus in his left ear, a left-sided retro-orbital headache, and blurred vision after he cracked his neck.

Reversal of Imaging Findings of Idiopathic Intracranial Hypertension After Lumbar Puncture

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(4):416-417. doi:10.1001/jamaneurol.2022.0085

This case report describes neuroimaging and diagnosis of idiopathic intracranial hypertension in a patient who underwent lumbar puncture for progressive vision changes.

Comment & Response

Data Do Not Support Selection by Target Perfusion Mismatch of Patients for Endovascular Stroke Treatment Within the 16- to 24-Hour Interval

Abstract Full Text
JAMA Neurol. 2022;79(4):418. doi:10.1001/jamaneurol.2021.5402

Data Do Not Support Selection by Target Perfusion Mismatch of Patients for Endovascular Stroke Treatment Within the 16- to 24-Hour Interval—Reply

Abstract Full Text
JAMA Neurol. 2022;79(4):418-419. doi:10.1001/jamaneurol.2021.5405

Inducers and Cardiovascular Risk—Potential Role for Lowered Drug Exposure

Abstract Full Text
JAMA Neurol. 2022;79(4):419. doi:10.1001/jamaneurol.2022.0041

Inducers and Cardiovascular Risk—Potential Role for Lowered Drug Exposure—Reply

Abstract Full Text
JAMA Neurol. 2022;79(4):419-420. doi:10.1001/jamaneurol.2022.0044
Correction

Error in Figure

Abstract Full Text
free access
JAMA Neurol. 2022;79(4):420. doi:10.1001/jamaneurol.2022.0022
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2022;79(4):321. doi:10.1001/jamaneurol.2021.3763
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