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November 2024, Vol 81, No. 11, Pages 1122-1230

Viewpoint

The Nontrivial Ethics of Brain Biopsies for Research

Abstract Full Text
JAMA Neurol. 2024;81(11):1123-1124. doi:10.1001/jamaneurol.2024.3018

This Viewpoint advocates for adapting and expanding informed consent protocols for brain biopsies for research purposes.

Risks of Expanded Medicare Coverage of Carotid Artery Stenting

Abstract Full Text
JAMA Neurol. 2024;81(11):1125-1126. doi:10.1001/jamaneurol.2024.3237

This Viewpoint describes the potential harms associated with increased coverage of carotid artery stenting by the Centers for Medicare & Medicaid Services.

Editorial

Perceived CTE and Suicidality—Is Perception Reality?

Abstract Full Text
JAMA Neurol. 2024;81(11):1127-1129. doi:10.1001/jamaneurol.2024.3078
Original Investigation

Perceived Chronic Traumatic Encephalopathy and Suicidality in Former Professional Football Players

Abstract Full Text
open access has audio
JAMA Neurol. 2024;81(11):1130-1139. doi:10.1001/jamaneurol.2024.3083

This cross-sectional study gathered data using surveys from former professional players of American-style football to gauge how many perceive that they have chronic traumatic encephalopathy and determine clinically relevant correlates, including suicidality.

Efficacy and Safety of Erenumab for Nonopioid Medication Overuse Headache in Chronic Migraine: A Phase 4, Randomized, Placebo-Controlled Trial

Abstract Full Text
open access
JAMA Neurol. 2024;81(11):1140-1149. doi:10.1001/jamaneurol.2024.3043

This study assesses erenumab efficacy and safety in patients with nonopioid chronic migraine and medication overuse headaches.

Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation

Abstract Full Text
JAMA Neurol. 2024;81(11):1150-1158. doi:10.1001/jamaneurol.2024.2882

This cohort study examines data from an international collaboration for patients with atrial fibrillation who have ischemic stroke despite taking oral anticoagulation therapy to compare percutaneous left atrial appendage occlusion with continuing oral anticoagulation therapy alone for stroke prevention.

Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures

Abstract Full Text
JAMA Neurol. 2024;81(11):1159-1169. doi:10.1001/jamaneurol.2024.3189

This cohort study examines factors and outcomes associated with antiseizure medication use in patients with confirmed or suspected acute symptomatic seizures.

Comorbidity and Disease Activity in Multiple Sclerosis

Abstract Full Text
open access
JAMA Neurol. 2024;81(11):1170-1177. doi:10.1001/jamaneurol.2024.2920

This cohort study uses a meta-analytic approach with data from phase 3 clinical trials of disease-modifying therapies to evaluate the association of comorbidities with disease activity in people with multiple sclerosis.

Antiseizure Medications and Cardiovascular Events in Older People With Epilepsy

Abstract Full Text
JAMA Neurol. 2024;81(11):1178-1186. doi:10.1001/jamaneurol.2024.3210

This cohort study investigates the association between risk of cardiovascular events (CVEs) and use of enzyme-inducing antiseizure medication in older adults with epilepsy.

Directly Isolated Allogeneic Virus–Specific T Cells in Progressive Multifocal Leukoencephalopathy

Abstract Full Text
open access
JAMA Neurol. 2024;81(11):1187-1198. doi:10.1001/jamaneurol.2024.3324

This case series investigates if directly isolated allogenic virus–specific T cells are associated with a therapeutic outcome in patients with progressive multifocal leukoencephalopathy (PML).

Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy

Abstract Full Text
JAMA Neurol. 2024;81(11):1199-1209. doi:10.1001/jamaneurol.2024.2952

This case-control study evaluates the association between areas of atrophy in the hippocampus and distant neuroimaging alterations and neurostimulation.

Review

Differential Diagnosis of Suspected Multiple Sclerosis in Pediatric and Late-Onset Populations: A Review

Abstract Full Text
has active quiz
JAMA Neurol. 2024;81(11):1210-1222. doi:10.1001/jamaneurol.2024.3062

This narrative review evaluates biological factors associated with multiple sclerosis in pediatric and late-onset populations.

Images in Neurology

Parkinsonism Following Chimeric Antigen Receptor T Cell Therapy

Abstract Full Text
has active quiz
JAMA Neurol. 2024;81(11):1223-1224. doi:10.1001/jamaneurol.2024.2506

This case report describes a 67-year-old woman who had received adoptive immunotherapy with chimeric antigen receptor T cells for multiple myeloma and was experiencing parkinsonism-like symptoms.

A Unique Case of Opioid-Induced Myoclonus

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. 2024;81(11):1225. doi:10.1001/jamaneurol.2024.2780

This case report describes a case of opioid-induced myoclonus.

Research Letter

Intracranial Pressure Elevation and MOGAD

Abstract Full Text
JAMA Neurol. 2024;81(11):1226-1228. doi:10.1001/jamaneurol.2024.2945

This cross-sectional study examines the frequency of increased intracranial pressure and its association with myelin oligodendrocyte glycoprotein antibody-associated disease in patients of various ages.

Four-Repeat Tau Seeding in the Skin of Patients With Progressive Supranuclear Palsy

Abstract Full Text
JAMA Neurol. 2024;81(11):1228-1230. doi:10.1001/jamaneurol.2024.3162

This study discusses 4-repeat tau seeding in the skin of patients with progressive supranuclear palsy.

JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2024;81(11):1122. doi:10.1001/jamaneurol.2023.3791
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