Yann Le Guen, PhD; Michael E. Belloy, PhD; Benjamin Grenier-Boley, MSc; et al.
free access
JAMA Neurol. 2022;79(7):652-663. doi:10.1001/jamaneurol.2022.1166
This genetic association study evaluates whether rare missense variants on APOE are associated with Alzheimer disease risk.
Angelos G. Kolias, MD, PhD; Hadie Adams, MD; Ivan S. Timofeev, PhD; et al.
free access
JAMA Neurol. 2022;79(7):664-671. doi:10.1001/jamaneurol.2022.1070
This randomized clinical trial uses Extended Glasgow Outcome Scale scores to evaluate 24-month outcomes for patients with traumatic intracranial hypertension who received a decompressive craniectomy vs standard medical treatment.
Marte-Helene Bjørk, MD, PhD; Helga Zoega, PhD; Maarit K. Leinonen, MD, PhD; et al.
open access
has audio
JAMA Neurol. 2022;79(7):672-681. doi:10.1001/jamaneurol.2022.1269
This cohort study evaluates whether children exposed prenatally to antiseizure medications in mono- and duotherapy have increased risk of neurodevelopmental disorders.
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Podcast:
Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability
Alessandro Cagol, MD; Sabine Schaedelin, MSc; Muhamed Barakovic, PhD; et al.
open access
JAMA Neurol. 2022;79(7):682-692. doi:10.1001/jamaneurol.2022.1025
This cohort study examines magnetic resonance imaging scans to determine changes in regional and total brain volume among patients with relapsing multiple sclerosis who have disease progression without relapse activity.
Takashi Kurashige, MD, PhD; Hiroyuki Morino, MD, PhD; Tomomi Murao, MD; et al.
open access
JAMA Neurol. 2022;79(7):693-701. doi:10.1001/jamaneurol.2022.1113
This dual case-control and cohort study assesses for a characteristic pathological hallmark in the muscle tissues of patients with amyotrophic lateral sclerosis.
Jingwei Sim, MRCP; Huihua Li, PhD; Shahul Hameed, MD; et al.
free access
JAMA Neurol. 2022;79(7):702-709. doi:10.1001/jamaneurol.2022.1133
This case-control study investigates clinical features that distinguish early-onset dementia with Lewy bodies from late-onset dementia with Lewy bodies and from early-onset Alzheimer disease (AD) dementia.
Leroy L. Cooper, PhD, MPH; Adrienne O’Donnell, BA; Alexa S. Beiser, PhD; et al.
free access
JAMA Neurol. 2022;79(7):710-719. doi:10.1001/jamaneurol.2022.1261
This cross-sectional study evaluates the association of aortic stiffness and pressure pulsatility with global amyloid-β and regional tau burden among middle-aged and older Framingham Heart Study Third Generation participants without dementia.