Kara N. Stevens, PhD; Siobhan Creanor, BSc; Alison Jeffery, PhD; et al.
open access
has audio
JAMA Neurol. 2022;79(12):1232-1241. doi:10.1001/jamaneurol.2022.3718
This randomized clinical trial evaluates whether simvastatin has potential as a disease-modifying treatment for patients with moderate Parkinson disease.
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Podcast:
Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients With Parkinson Disease
Jennifer J. Manly, PhD; Richard N. Jones, ScD; Kenneth M. Langa, MD, PhD; et al.
free access
JAMA Neurol. 2022;79(12):1242-1249. doi:10.1001/jamaneurol.2022.3543
This cross-sectional study estimates the prevalence of dementia and mild cognitive impairment in the US in 2016 by age, race, ethnicity, and sex.
Michael J. Pontecorvo, PhD; Ming Lu, MD, MS, MPH; Samantha C. Burnham, PhD; et al.
open access
JAMA Neurol. 2022;79(12):1250-1259. doi:10.1001/jamaneurol.2022.3392
This secondary analysis of a randomized clinical trial investigates the association of donanemab treatment with plasma biomarkers associated with Alzheimer disease.
Kazutaka Uchida, MD, PhD; Seigo Shindo, MD, PhD; Shinichi Yoshimura, MD, PhD; et al.
free access
JAMA Neurol. 2022;79(12):1260-1266. doi:10.1001/jamaneurol.2022.3285
This secondary analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism—Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) evaluates the safety and efficacy of endovascular therapy in patients with acute large ischemic stroke by Alberta Stroke Program Early Computed Tomography Score.
Dianalee McKnight, PhD; Ana Morales, MS; Kathryn E. Hatchell, PhD; et al.
open access
JAMA Neurol. 2022;79(12):1267-1276. doi:10.1001/jamaneurol.2022.3651
This cross-sectional study investigates if genetic diagnoses in patients with epilepsy are associated with changes in clinical management and subsequent outcomes.
Shahram Oveisgharan, MD; Robert J. Dawe, PhD; Lei Yu, PhD; et al.
free access
JAMA Neurol. 2022;79(12):1277-1286. doi:10.1001/jamaneurol.2022.3472
This cohort study identifies participants without Alzheimer disease and other neurodegenerative pathologies and determines the extent to which cerebrovascular disease pathologies were associated with cognitive impairment.
Siddharth Srivastava, MD; Sara A. Lewis, PhD; Julie S. Cohen, ScM, CGC; et al.
free access
JAMA Neurol. 2022;79(12):1287-1295. doi:10.1001/jamaneurol.2022.3549
This systematic review and meta-analysis investigates the molecular diagnostic yield of exome sequencing and chromosomal microarray in cerebral palsy.
Corinna Doege, MD; Mark Luedde, MD; Karel Kostev, DMSc, PhD, MA
free access
JAMA Neurol. 2022;79(12):1296-1302. doi:10.1001/jamaneurol.2022.3413
This cohort study assesses whether the use of angiotensin receptor blocker therapy is associated with a reduced incidence of epilepsy in patients with hypertension.
Bernard P. H. Cho, MSc; Eric L. Harshfield, PhD; Maha Al-Thani, MSc; et al.
open access
JAMA Neurol. 2022;79(12):1303-1311. doi:10.1001/jamaneurol.2022.3832
This cohort study examines data from UK Biobank participants who had whole-exome sequencing to determine the frequency of pathogenic variants in the 3 most common monogenic cerebral small vessel diseases and their associations with prevalent and incident stroke and dementia.