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October 2024 - July 1959

Decade

Year

Issue

December 2022, Vol 79, No. 12, Pages 1217-1320

Viewpoint

Timing of Physical Therapy Sessions for Individuals With Parkinson Disease May Unlock Benefits

Abstract Full Text
JAMA Neurol. 2022;79(12):1219-1220. doi:10.1001/jamaneurol.2022.2649

This Viewpoint advocates for careful consideration in the timing of physical therapy for individuals with Parkinson disease as a possible avenue toward improved outcomes.

Racial and Ethnic Equity in Neuromuscular Care—Time for Our Action to Live Up to Potential

Abstract Full Text
JAMA Neurol. 2022;79(12):1221-1222. doi:10.1001/jamaneurol.2022.2808

This Viewpoint discusses the need to improve the quality of care in neuromuscular disease for all individuals, no matter their race and ethnicity.

Tackling the Unmet Therapeutic Needs in Nonsurgical Treatments for Epilepsy

Abstract Full Text
JAMA Neurol. 2022;79(12):1223-1224. doi:10.1001/jamaneurol.2022.2635

This Viewpoint discusses unmet therapeutic needs among patients with epilepsy and evaluates the trajectory of treatment development.

On the Brain

Oscillating Between Guilt and Gratitude—Reflections of a Mother and Intensivist

Abstract Full Text
JAMA Neurol. 2022;79(12):1225-1226. doi:10.1001/jamaneurol.2022.2848

This essay discusses balancing the guilt and gratitude of being a mother and a physician.

Editorial

Genetic Testing in Patients With Epilepsy May Impact Treatments and Improve Outcomes

Abstract Full Text
JAMA Neurol. 2022;79(12):1227-1228. doi:10.1001/jamaneurol.2022.3391

Monogenic Stroke—Can We Overcome Nature With Nurture?

Abstract Full Text
JAMA Neurol. 2022;79(12):1229-1231. doi:10.1001/jamaneurol.2022.3994
Original Investigation

Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients With Parkinson Disease: A Randomized Clinical Trial

Abstract Full Text
open access has audio
JAMA Neurol. 2022;79(12):1232-1241. doi:10.1001/jamaneurol.2022.3718

This randomized clinical trial evaluates whether simvastatin has potential as a disease-modifying treatment for patients with moderate Parkinson disease.

Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project

Abstract Full Text
free access
JAMA Neurol. 2022;79(12):1242-1249. doi:10.1001/jamaneurol.2022.3543

This cross-sectional study estimates the prevalence of dementia and mild cognitive impairment in the US in 2016 by age, race, ethnicity, and sex.

Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ Randomized Clinical Trial

Abstract Full Text
open access
JAMA Neurol. 2022;79(12):1250-1259. doi:10.1001/jamaneurol.2022.3392

This secondary analysis of a randomized clinical trial investigates the association of donanemab treatment with plasma biomarkers associated with Alzheimer disease.

Association Between Alberta Stroke Program Early Computed Tomography Score and Efficacy and Safety Outcomes With Endovascular Therapy in Patients With Stroke From Large-Vessel Occlusion: A Secondary Analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism—Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT)

Abstract Full Text
free access
JAMA Neurol. 2022;79(12):1260-1266. doi:10.1001/jamaneurol.2022.3285

This secondary analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism—Japan Large Ischemic Core Trial (RESCUE-Japan LIMIT) evaluates the safety and efficacy of endovascular therapy in patients with acute large ischemic stroke by Alberta Stroke Program Early Computed Tomography Score.

Genetic Testing to Inform Epilepsy Treatment Management From an International Study of Clinical Practice

Abstract Full Text
open access
JAMA Neurol. 2022;79(12):1267-1276. doi:10.1001/jamaneurol.2022.3651

This cross-sectional study investigates if genetic diagnoses in patients with epilepsy are associated with changes in clinical management and subsequent outcomes.

Frequency and Underlying Pathology of Pure Vascular Cognitive Impairment

Abstract Full Text
free access
JAMA Neurol. 2022;79(12):1277-1286. doi:10.1001/jamaneurol.2022.3472

This cohort study identifies participants without Alzheimer disease and other neurodegenerative pathologies and determines the extent to which cerebrovascular disease pathologies were associated with cognitive impairment.

Molecular Diagnostic Yield of Exome Sequencing and Chromosomal Microarray in Cerebral Palsy: A Systematic Review and Meta-analysis

Abstract Full Text
free access
JAMA Neurol. 2022;79(12):1287-1295. doi:10.1001/jamaneurol.2022.3549

This systematic review and meta-analysis investigates the molecular diagnostic yield of exome sequencing and chromosomal microarray in cerebral palsy.

Association Between Angiotensin Receptor Blocker Therapy and Incidence of Epilepsy in Patients With Hypertension

Abstract Full Text
free access
JAMA Neurol. 2022;79(12):1296-1302. doi:10.1001/jamaneurol.2022.3413

This cohort study assesses whether the use of angiotensin receptor blocker therapy is associated with a reduced incidence of epilepsy in patients with hypertension.

Association of Vascular Risk Factors and Genetic Factors With Penetrance of Variants Causing Monogenic Stroke

Abstract Full Text
open access
JAMA Neurol. 2022;79(12):1303-1311. doi:10.1001/jamaneurol.2022.3832

This cohort study examines data from UK Biobank participants who had whole-exome sequencing to determine the frequency of pathogenic variants in the 3 most common monogenic cerebral small vessel diseases and their associations with prevalent and incident stroke and dementia.

Review

Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(12):1312-1318. doi:10.1001/jamaneurol.2022.3282

This narrative review discusses aspects of clinical trial design that may be important in discerning efficacy of treatments for amyotrophic lateral sclerosis (ALS).

Images in Neurology

Anti-LGI1–Associated Myopathy in the Setting of Neuromuscular Hyperexcitability Syndrome

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(12):1319-1320. doi:10.1001/jamaneurol.2022.3479

This case report describes a patient with anti–leucine-rich glioma-inactivated 1 (LGI1)–associated hyperexcitability syndrome associated with myopathy.

JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2022;79(12):1217. doi:10.1001/jamaneurol.2021.3803
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