Bruno Dubois, MD, MSc; Nicolas Villain, MD, PhD; Lon Schneider, MD, MSc; et al.
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JAMA Neurol. Published online November 1, 2024. doi:10.1001/jamaneurol.2024.3770
This Special Communication discusses a recent revision of the Alzheimer Association (AA) criteria to define Alzheimer disease (AD) as a purely biological entity, which raises concerns that if diagnosis of AD can be reduced to the sole presence of AD core 1 biomarkers, major uncertainty and variability in the clinical prognosis of patients diagnosed with AD may be introduced.
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Podcast:
Alzheimer Disease as a Clinical-Biological Construct