Simon Witzel, MD; André Maier, MD; Robert Steinbach, MD; et al.
free access
JAMA Neurol. 2022;79(2):121-130. doi:10.1001/jamaneurol.2021.4893
This multicenter cohort study uses real-world clinical data to compare the long-term safety and effectiveness of intravenous edaravone plus riluzole therapy vs propensity score–matched controls receiving riluzole therapy alone among patients with amyotrophic lateral sclerosis.
Richard Gray, MSc; Smitaa Patel, MSc; Natalie Ives, MSc; et al.
open access
JAMA Neurol. 2022;79(2):131-140. doi:10.1001/jamaneurol.2021.4736
This randomized clinical trial assesses the long-term effects on patient-rated quality of life of adjuvant treatment with dopamine reuptake inhibitors compared with dopamine agonists among patients with motor complications of Parkinson disease that are inadequately controlled by levodopa therapy.
Ronda Lun, MD; Shan Dhaliwal, BSc; Gabriele Zitikyte, BSc; et al.
free access
JAMA Neurol. 2022;79(2):141-148. doi:10.1001/jamaneurol.2021.4514
This network meta-analysis compares ticagrelor and aspirin with clopidogrel and aspirin in patients with acute minor ischemic stroke or transient ischemic attack in the prevention of recurrent strokes or death.
Antoine Leuzy, PhD; Ruben Smith, MD, PhD; Nicholas C. Cullen, BSc; et al.
open access
JAMA Neurol. 2022;79(2):149-158. doi:10.1001/jamaneurol.2021.4654
This cohort study describes longitudinal tau positron emission tomography findings using [18F]RO948 across the different clinical stages of Alzheimer disease.
Messoud Ashina, MD, PhD, DMSc; Peter J. Goadsby, MD, PhD; David W. Dodick, MD; et al.
open access
has active quiz
has audio
JAMA Neurol. 2022;79(2):159-168. doi:10.1001/jamaneurol.2021.4678
This post hoc secondary analysis of 4 randomized clinical trials evaluates changes in migraine frequency, medication use, and patient-reported outcomes associated with erenumab use.
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Podcast:
Assessment of Erenumab Safety and Efficacy in Migraine With and Without Aura
David Larsson, MD; Arton Baftiu, PhD; Cecilie Johannessen Landmark, PhD; et al.
free access
has active quiz
JAMA Neurol. 2022;79(2):169-175. doi:10.1001/jamaneurol.2021.4584
This cohort study uses data from linked registers in Sweden to investigate whether mortality varies with specific antiseizure medications among patients with poststroke epilepsy.
Baixue Jia, MD; Xuelei Zhang, MD; Ning Ma, MD; et al.
free access
JAMA Neurol. 2022;79(2):176-184. doi:10.1001/jamaneurol.2021.4804
This randomized clinical trial evaluates the rate of in-stent restenosis and the risk of stroke recurrence after the placement of a drug-eluting stent vs standard bare-metal stent among patients with symptomatic high-grade intracranial atherosclerotic stenosis.
Calwing Liao, BSc; Charles-Etienne Castonguay, BSc; Karl Heilbron, PhD; et al.
open access
JAMA Neurol. 2022;79(2):185-193. doi:10.1001/jamaneurol.2021.4781
This genome-wide association study identifies common variants associated with risk of essential tremor.