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September 2013, Vol 70, No. 9, Pages 1089-1201

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
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JAMA Neurol. 2013;70(9):1089-1091. doi:10.1001/jamaneurol.2013.2882
Viewpoint

Upcoming Challenges for Neurologists in the United States

Abstract Full Text
JAMA Neurol. 2013;70(9):1097-1098. doi:10.1001/jamaneurol.2013.3299

We Cannot Cure Ataxia, We Can Only Eradicate It

Abstract Full Text
JAMA Neurol. 2013;70(9):1099. doi:10.1001/jamaneurol.2013.3026
Editorial

The Road Not Taken: Antigen-Specific Therapy and Neuroinflammatory Disease

Abstract Full Text
JAMA Neurol. 2013;70(9):1100-1101. doi:10.1001/jamaneurol.2013.3553

Individualized Rituximab Treatment for Neuromyelitis Optica Spectrum Disorders

Abstract Full Text
JAMA Neurol. 2013;70(9):1102-1104. doi:10.1001/jamaneurol.2013.3583
Original Investigation

Transdermal Application of Myelin Peptides in Multiple Sclerosis Treatment

Abstract Full Text
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JAMA Neurol. 2013;70(9):1105-1109. doi:10.1001/jamaneurol.2013.3022

Walczak et al assess the safety and efficacy of transdermally applied myelin peptides in patients with relapsing-remitting multiple sclerosis.

A 5-Year Follow-up of Rituximab Treatment in Patients With Neuromyelitis Optica Spectrum Disorder

Abstract Full Text
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JAMA Neurol. 2013;70(9):1110-1117. doi:10.1001/jamaneurol.2013.3071

Kim et al reported the results of rituximab treatment in patients with relapsing neuromyelitis optica or neuromyelitis optica spectrum disorder for a median of 60 months. See the by McKeon and Pittock.

Aquaporin 4 Expression and Tissue Susceptibility to Neuromyelitis Optica

Abstract Full Text
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JAMA Neurol. 2013;70(9):1118-1125. doi:10.1001/jamaneurol.2013.3124

Matiello and colleagues evaluate tissue-specific messenger RNA and protein expression and supramolecular aggregation of aquaporin 4 (AQP4) in mouse, rat, and human tissues in an effort to understand the predilection for optic nerve and spinal cord pathologic changes in neuromyelitis optica (NMO).

Prehospital Triage to Primary Stroke Centers and Rate of Stroke Thrombolysis

Abstract Full Text
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JAMA Neurol. 2013;70(9):1126-1132. doi:10.1001/jamaneurol.2013.293

Prabhakaran et al evaluate the impact that a citywide policy recommending prehospital triage of patients with suspected stroke to the nearest primary stroke center had on intravenous tissue plasminogen activator (tPA) use in Chicago, Illinois.

Frequency and Characteristics of Isolated Psychiatric Episodes in Anti鈥N-Methyl-d-Aspartate Receptor Encephalitis

Abstract Full Text
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JAMA Neurol. 2013;70(9):1133-1139. doi:10.1001/jamaneurol.2013.3216

Kayser et al determine the frequency, symptoms, and outcome of isolated psychiatric episodes in a cohort of patients with anti鈥N-methyl-d-aspartate (NMDAR) encephalitis.

Neuronal Surface and Glutamic Acid Decarboxylase Autoantibodies in Nonparaneoplastic Stiff Person Syndrome

Abstract Full Text
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JAMA Neurol. 2013;70(9):1140-1147. doi:10.1001/jamaneurol.2013.3499

Chang et al investigate the characteristics and potential pathogenicity of glutamic acid decarboxylase autoantibodies in patients with stiff person syndrome and related disorders.

Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology

Abstract Full Text
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JAMA Neurol. 2013;70(9):1150-1157. doi:10.1001/jamaneurol.2013.2815

Shulman et al investigate whether Alzheimer disease susceptibility loci from genome-wide association studies affect neuritic plaque pathology and additionally aim to identify novel risk loci for this trait.

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

Abstract Full Text
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JAMA Neurol. 2013;70(9):1158-1166. doi:10.1001/jamaneurol.2013.136

Vossel et al describe common clinical characteristics and treatment outcomes of patients with amnestic mild cognitive impairment or early AD who also have epilepsy or subclinical epileptiform activity.

Glucose Intolerance, Insulin Resistance, and Pathological Features of Alzheimer Disease in the Baltimore Longitudinal Study of Aging

Abstract Full Text
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JAMA Neurol. 2013;70(9):1167-1172. doi:10.1001/jamaneurol.2013.284

Thambisetty et al investigate the association between glucose intolerance and insulin resistance and in vivo brain 尾-amyloid burden, measured with carbon 11鈥搇abeled Pittsburgh Compound B and pathological features of Alzheimer disease at autopsy.

Case Report/Case Series

Vascular Complications of Fungal Meningitis Attributed to Injections of Contaminated Methylprednisolone Acetate

Abstract Full Text
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JAMA Neurol. 2013;70(9):1173-1176. doi:10.1001/jamaneurol.2013.3586

In a case series of 3 patients with acute ischemic stroke who later received a diagnosis of fungal meningitis attributed to epidural injections of contaminated methylprednisolone acetate, Kleinfeld and coauthors describe how these patients presented with ischemic infarction in differing vascular distributions.

Mitochondrial Encephalomyopathy Due to a Novel Mutation in ACAD9

Abstract Full Text
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JAMA Neurol. 2013;70(9):1177-1179. doi:10.1001/jamaneurol.2013.3197

Mendelian forms of complex I deficiency are usually associated with fatal infantile encephalomyopathy. Application of 鈥淢itoExome鈥 sequencing allowed Garone and coauthors to reveal an unusual clinical variant of complex I deficiency due to a novel homozygous mutation in ACAD9. The patient had an infantile-onset but slowly progressive encephalomyopathy and responded favorably to riboflavin therapy.

Unusual Clinical and Molecular-Pathological Profile of Gerstmann-Str盲ussler-Scheinker Disease Associated With a Novel PRNP Mutation (V176G)

Abstract Full Text
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JAMA Neurol. 2013;70(9):1180-1185. doi:10.1001/jamaneurol.2013.165

Simpson and colleagues reported the unusual clinical and molecular-neuropathological profile in a case of Gerstmann-Str盲ussler-Scheinker (GSS) disease associated with a novel prion protein gene (PRNP) mutation.

Review

Next-Generation Phenotyping Using the Parkin Example: Time to Catch Up With Genetics

Abstract Full Text
JAMA Neurol. 2013;70(9):1186-1191. doi:10.1001/jamaneurol.2013.488

Using 15 years鈥 experience with parkin-associated Parkinson disease, Gr眉newald and colleagues evaluate type, quality, and quantity of genetic and phenotypic data and elucidate clinical or genetic features impacting genetic testing and counseling.

Images in Neurology

A Rare Presentation of Hypertrophic Olivary Degeneration Secondary to Primary Central Nervous System Lymphoma

Abstract Full Text
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JAMA Neurol. 2013;70(9):1192-1193. doi:10.1001/2013.jamaneurol.218

Kernohan-Woltman Notch Phenomenon in Acute Subdural Hematoma

Abstract Full Text
JAMA Neurol. 2013;70(9):1194-1195. doi:10.1001/2013.jamaneurol.54

Thoracic Epidural Cavernous Hemangioma: Imaging and Pathology

Abstract Full Text
JAMA Neurol. 2013;70(9):1196-1197. doi:10.1001/2013.jamaneurol.188
Research Letter

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

Abstract Full Text
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JAMA Neurol. 2013;70(9):1198-1200. doi:10.1001/jamaneurol.2013.3841
Comment & Response

Should CLIPPERS Be Considered a Prelymphoma State or a New Inflammatory Disease?

Abstract Full Text
JAMA Neurol. 2013;70(9):1200-1201. doi:10.1001/jamaneurol.2013.3652

Should CLIPPERS Be Considered a Prelymphoma State or a New Inflammatory Disease?鈥擱eply

Abstract Full Text
JAMA Neurol. 2013;70(9):1201. doi:10.1001/jamaneurol.2013.3855
Correction

Error in Text

Abstract Full Text
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JAMA Neurol. 2013;70(9):1201. doi:10.1001/jamaneurol.2013.3927
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2013;70(9):1092. doi:10.1001/jamaneurol.2013.2880
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