Robert W. Haley, MD; Elizabeth Charuvastra, RN; William E. Shell, MD; et al.
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JAMA Neurol. 2013;70(2):191-200. doi:10.1001/jamaneurol.2013.596
Haley et al tested the hypothesis that symptoms among Gulf War veterans, such as chronic diarrhea, dizziness, fatigue, and sexual dysfunction, are due to cholinergic autonomic dysfunction. They evaluated outcomes in representative samples meeting a validated case definition of Gulf War illness, with 3 variants and a control group.
Leah Winer, BA; Dushyanth Srinivasan, BA; Seung Chun, BA; et al.
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JAMA Neurol. 2013;70(2):201-207. doi:10.1001/jamaneurol.2013.593
Winer and coauthors determine whether the SOD1 protein in cerebral spinal fluid may be a pharmacodynamic marker for antisense oligonucleotide therapy and a disease marker for amyotrophic lateral sclerosis.
Amy S. Y. Zheng, BSc(Hons); Leonid Churilov, PhD; Ruth E. Colley, BSc(Hons); et al.
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JAMA Neurol. 2013;70(2):208-213. doi:10.1001/jamaneurol.2013.601
In a prospective single-center survey, Zheng et al investigate the relationship between aspirin resistance and clinical and neuroimaging measures of stroke severity in acute stroke patients.
Antonio Scalfari, MD; Anneke Neuhaus, MSc; Martin Daumer, PhD; et al.
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JAMA Neurol. 2013;70(2):214-222. doi:10.1001/jamaneurol.2013.599
Scalfari et al study a cohort with multiple sclerosis and frequent early attacks to elucidate the relationship among early relapses, onset of progression, and severe disability.
Debby Tsuang, MD, MSc; James B. Leverenz, MD; Oscar L. Lopez, MD; et al.
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JAMA Neurol. 2013;70(2):223-228. doi:10.1001/jamaneurol.2013.600
Tsuang and colleagues conducted a genetic case-control study to test for an association between the apolipoprotein E (APOE) 蔚4 allele and dementias with synucleinopathy.
Christopher J. Klein, MD; Vanda A. Lennon, MD, PhD; Paula A. Aston, MD; et al.
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JAMA Neurol. 2013;70(2):229-234. doi:10.1001/jamaneurol.2013.592
Klein and colleagues aimed to determine, in patients seropositive for neuronal voltage-gated potassium channel (VGKC) complex autoantibodies, the spectrum of clinical presentations and frequency of leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated proteinlike 2 (CASPR2) as defined antigenic neuronal targets in the VGKC macromolecular complex.
José Barros, MD; Joana Damásio, MD; Assunção Tuna, MD, Msc; et al.
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JAMA Neurol. 2013;70(2):235-240. doi:10.1001/jamaneurol.2013.591
Barros et al document and discuss the broad phenotypic variability in a Portuguese family with cerebellar ataxia, hemiplegic migraine, and related syndromes caused by missense mutation c.1748 (p.R583Q) in the CACNA1A gene.
David A. Ziegler, PhD; Julien S. Wonderlick, MD; Paymon Ashourian, PhD; et al.
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JAMA Neurol. 2013;70(2):241-247. doi:10.1001/jamaneurol.2013.597
To test the hypothesis that the degeneration of the substantia nigra pars compacta (SNc) precedes that of the cholinergic basal forebrain (BF) in PD, Ziegler and colleagues performed a matched case-control study among 29 patients with PD (Hoehn and Yahr stages 1-3) and 27 matched healthy control subjects. They used new multispectral structural MR imaging tools to measure the volumes of the SNc and BF.