ÌÇÐÄvlog

Tsuji reviews high-throughput genome sequencing technologies, the availability of which is expected to revolutionize our understanding of not only hereditary neurological diseases but also sporadic neurological diseases. It will be a new era of datacentric clinical practice.

In recent years, neurogenetics research had made some remarkable advances owing to the advent of genotyping arrays and next-generation sequencing. Pittman and Hardy review how these technological advances have changed the approaches being used to study the genetic basis of neurological disease and how the research findings will be translated into clinical utility.

Qureshi and Mehler highlight emerging paradigms for linking epigenetic machinery and processes with neurological disease states.

Akbarian and colleagues provide an overview of age-related changes in the brain’s chromatin structures, highlight potential epigenetic drug targets for cognitive decline and age-related neurodegenerative disease, and discuss opportunities and challenges when studying epigenetic biomarkers in aging research.

De Jager and Bennett review the current understanding of the genetic architecture of 4 common neurodegenerative diseases and use them to highlight successful strategies for gene discovery as well as emerging strategies being deployed to address the next series of challenges in investigating the pathophysiological basis of these diseases.