Hillary D. Protas, PhD; Kewei Chen, PhD; Jessica B. S. Langbaum, PhD; et al.
free access
has audio
JAMA Neurol. 2013;70(3):320-325. doi:10.1001/2013.jamaneurol.286
In a cross-sectional comparison of measurements of cerebral glucose metabolism and brain volume in cognitively normal, late-middle-aged persons, Protas and coauthors characterize and compare the measurements so as to distinguish these persons with 2, 1, or 0 copies of the APOE 系4 allele, reflecting 3 levels of risk for late-onset Alzheimer disease. See editorial by Jagust.
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Podcast:
Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease, and Apolipoprotein E, Neurodegeneration, and Alzheimer Diseas
John Hart Jr, MD; Michael A. Kraut, MD, PhD; Kyle B. Womack, MD; et al.
free access
JAMA Neurol. 2013;70(3):326-335. doi:10.1001/2013.jamaneurol.340
Hart et al assessed the prevalence of cognitive impairment and depression in a sample of former National Football League (NFL) players and identified neuroimaging correlates of these dysfunctions. See also the editorial by Diaz-Arrastia.
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Editorial
Cognitive Dysfunction and Contact Sports
Ramon Diaz-Arrastia, MD, PhD; Daniel Perl, MD
JAMA Neurol
Ebru Erbayat Altay, MD; Elizabeth Fisher, PhD; Stephen E. Jones, MD, PhD; et al.
free access
JAMA Neurol. 2013;70(3):338-344. doi:10.1001/2013.jamaneurol.211
In an observational study, Erbayat Altay et al assess the reliability of new magnetic resonance imaging lesion counts by clinicians in a multiple sclerosis specialty clinic.
Lucas Schirmer, MD; Veit Rothhammer, MD; Bernhard Hemmer, MD; et al.
free access
JAMA Neurol. 2013;70(3):345-351. doi:10.1001/2013.jamaneurol.409
Schirmer et al investigate the expression of CD161 (KLRB1) and CCR6 on human 纬未d T cells in blood and cerebrospinal fluid of patients with a clinically isolated syndrome and multiple sclerosis in relapse.
Leonard L. L. Yeo, MBBS, MRCP; Prakash Paliwal, MBBS, MRCP; Hock L. Teoh, MBChB, MRCP; et al.
free access
JAMA Neurol. 2013;70(3):353-358. doi:10.1001/2013.jamaneurol.547
Yeo and colleagues conducted a longitudinal cohort study of consecutive intravenous tissue plasminogen activator-treated patients with acute ischemic stroke (AIS) from 2007 through 2010 to examine the timing and impact of recanalization on functional outcomes in AIS.
Madeline C. Fields, MD; Daniel L. Labovitz, MD; Jacqueline A. French, MD
free access
has audio
JAMA Neurol. 2013;70(3):360-364. doi:10.1001/2013.jamaneurol.337
Fields and coworkers used a retrospective medical record review to analyze hospital-onset seizure patterns, medication use, and outcomes in 218 patients admitted to the hospital for nonseizure reasons.
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Podcast:
Hospital-Onset Seizures: An Inpatient Study
Tim Van Langenhove, MD; Julie van der Zee, PhD; Ilse Gijselinck, PhD; et al.
free access
JAMA Neurol. 2013;70(3):365-373. doi:10.1001/2013.jamaneurol.181
Van Langenhove and colleagues conducted a study to characterize patients with frontotemporal lobar degeneration (FTLD) with a repeat expansion mutation in the gene C9orf72, and to determine whether there are differences in the clinical presentation compared with FTLD carriers of a mutation in GRN or MAPT or with patients with FTLD without mutation.
Rosebud O. Roberts, MB, ChB, MS; Yonas E. Geda, MD, MSc; David S. Knopman, MD; et al.
free access
JAMA Neurol. 2013;70(3):374-382. doi:10.1001/jamaneurol.2013.607
In a prospective, population-based, cohort study of 2719 participants with a median 4.0 years of follow-up, Roberts and coworkers investigate the association of cardiac disease with amnestic and nonamnestic mild cognitive impairment.
Edo Richard, MD, PhD; Christiane Reitz, MD, PhD; Lawrence H. Honig, MD, PhD; et al.
free access
JAMA Neurol. 2013;70(3):383-389. doi:10.1001/jamaneurol.2013.603
Richard et al evaluate the association of late-life depression with mild cognitive impairment and dementia in a multiethnic community cohort including 2160 individuals aged 65 years or older.