ÌÇÐÄvlog

Saidha and colleagues conducted a cross-sectional study to determine the relationships between conventional and segmentation-derived optical coherence tomography retinal layer thickness measures with intracranial volume and brain substructure volumes in multiple sclerosis (MS). The study involved patients with MS and 24 healthy control subjects. CNS indicates central nervous system. Ari J. Green provides a related editorial.

McKeon and colleagues explored whether glycine receptor a1 subunit-specific autoantibodies (GlyRa1-IgG) occur in a broader spectrum of brainstem and spinal hyperexcitability disorders than the progressive encephalomyelitis with rigidity and myoclonus phenotype. The study involved 81 patients with stiff-man syndrome (SMS) phenotype. David Pleasure, MD, writes an accompanying editorial.

To investigate the yield of diagnostic tests, neuroimaging findings, and treatment of ischemic strokes in young adults, Ji and colleagues retrospectively reviewed data on 215 consecutive inpatients, aged 18 to 45 years, with ischemic stroke/transient ischemic attack (TIA) captured in their Get with the Guidelines– Stroke database from 2005-2010.

To test the hypothesis that acute silent cerebral ischemic events (ASCIEs) are frequent and potentially transient, Quinn and colleagues conducted a cross-sectional and cohort study of children with sickle cell anemia screened by magnetic resonance imaging of the brain.

In a retrospective case study, Lo et al determine if a specific intracerebral hemorrhage ratio predicts poor outcome; whether predictors of outcome in adults predict outcome in childhood hemorrhagic stroke; and whether the cause of hemorrhagic stroke predicts outcome.

In a retrospective analysis Hocker et al further characterize the demographics, outcomes, and prognostic factors for refractory status epilepticus.

Guerreiro et al identify new genes and risk factors associated with frontotemporal dementia.

Deep brain stimulation (DBS) has been used to treat medication-refractory tics in Tourette syndrome. Okun et al studied the efficacy and safety of a scheduled DBS paradigm in 5 patients.

In 24 patients with Parkinson disease, Cooper et al performed serial quantitative assessments of bradykinesia during a defined period following cessation of subthalamic nucleus deep brain stimulation (STN DBS). They determined if a correlation exists between clinical characteristics of patients and the washout rate for bradykinesia when STN DBS is discontinued.

Prodoehl and coauthors compare differences in functional brain activity between tremor- and nontremor-dominant subtypes of Parkinson disease using functional magnetic resonance imaging.

Bullain and coauthors examine the cross-sectional relationship between physical performance and dementia in the oldest-old.