E. Matthew Hoffman, DO, PhD; James C. Watson, MD; Jennifer St Sauver, PhD; et al.
free access
JAMA Neurol. 2017;74(7):773-779. doi:10.1001/jamaneurol.2017.0486
This population-based cohort study quantifies the prevalence of long-term opioid use among patients with polyneuropathy and assesses the association of long-term opioid use with functional status, adverse outcomes, and mortality.
Aree Witoelar, PhD; Iris E. Jansen, PhD; Yunpeng Wang, PhD; et al.
free access
JAMA Neurol. 2017;74(7):780-792. doi:10.1001/jamaneurol.2017.0469
This study of combination of genome-wide association data with case-control replication tests the hypothesis that there are common genetic risk variants conveying risk of both Parkinson disease and autoimmune diseases (ie, pleiotropy) and identifies new shared genetic variants and their pathways by applying a novel statistical framework in a genome-wide approach.
Ryan A. McTaggart, MD; Shadi Yaghi, MD; Shawna M. Cutting, MD, MS; et al.
free access
JAMA Neurol. 2017;74(7):793-800. doi:10.1001/jamaneurol.2017.0477
This cohort study reports on the association of a primary stroke center protocol with the efficiency of care and the outcomes of patients with suspected emergent large-vessel occlusion who first present to a primary stroke center.
Kelly D. Flemming, MD; Jonathan Graff-Radford, MD; Jeremiah Aakre, MPH; et al.
free access
JAMA Neurol. 2017;74(7):801-805. doi:10.1001/jamaneurol.2017.0439
This population-based study analyzes the magnetic resonance imaging brain scans of participants in the Mayo Clinic Study of Aging to determine the prevalence of cerebral cavernous malformation in adults aged 50 to 89 years.
Katja Lohmann, PhD; Claire Redin, PhD; Holger Tönnies, PhD; et al.
free access
JAMA Neurol. 2017;74(7):806-812. doi:10.1001/jamaneurol.2017.0666
This case series elucidates the causal genetic variant in a large US family with co-occurrence of dopa-responsive dystonia as well as skeletal and eye abnormalities (ie, ptosis, myopia, and retina detachment).
Jorge Sepulcre, MD, PhD; Michel J. Grothe, PhD; Mert Sabuncu, PhD; et al.
free access
JAMA Neurol. 2017;74(7):813-820. doi:10.1001/jamaneurol.2017.0263
This cross-sectional study examines the spatial distributions of tau and Aβ deposits in the brains of elderly, cognitively normal individuals.
Christine L. Mac Donald, PhD; Jason Barber, MS; Mary Jordan, MA; et al.
free access
JAMA Neurol. 2017;74(7):821-829. doi:10.1001/jamaneurol.2017.0143
This longitudinal case-control study examines 5-year clinical outcomes among active duty military personnel with concussive blast traumatic brain injuries.
Michelle E. Farrell, BA; Kristen M. Kennedy, PhD; Karen M. Rodrigue, PhD; et al.
open access
JAMA Neurol. 2017;74(7):830-838. doi:10.1001/jamaneurol.2017.0892
This longitudinal cohort study explores how the magnitude of baseline amyloid burden predicts the rate of cognitive decline over 4 years in cognitively normal adults while controlling for dichotomized amyloid status.
Rodolfo Savica, MD, PhD; Brandon R. Grossardt, MS; James H. Bower, MD, MSc; et al.
free access
JAMA Neurol. 2017;74(7):839-846. doi:10.1001/jamaneurol.2017.0603
This population-based study compares patients with synucleinopathies with sex- and age-matched participants without parkinsonism to determine the risk of death for each type of synucleinopathy, the median time from diagnosis to death, and the causes of death.
Benjamin Knier, MD; Gildas Leppenetier, MSc; Carmen Wetzlmair, CandMed; et al.
free access
JAMA Neurol. 2017;74(7):847-856. doi:10.1001/jamaneurol.2017.0377
This cohort study assesses whether retinal layer volumes correlate with immune cell subsets and immunoglobulin indices in cerebrospinal fluid and are associated with disease activity in patients with relapsing-remitting multiple sclerosis.
Manuel M. Montero-Odasso, MD, PhD, FRCPC; Yanina Sarquis-Adamson, PhD; Mark Speechley, PhD; et al.
free access
JAMA Neurol. 2017;74(7):857-865. doi:10.1001/jamaneurol.2017.0643
This cohort study determines whether a dual-task gait test is associated with incident dementia in mild cognitive impairment.